Brain temperature modulations during global ischemia fail to influence extracellular lactate levels in rats.


BACKGROUND AND PURPOSE:While brain tissue lactate increases during cerebral ischemia and is known to be important in the pathogenesis of ischemic brain injury, patterns of extracellular lactate accumulation have been less well characterized, and the influence of brain temperature has not been previously investigated. Mild brain temperature modulations are known to affect the outcome of ischemia dramatically. This study examined changes of extracellular lactate during and after global cerebral ischemia, in which intraischemic brain temperature was held at either 30 degrees C, 37 degrees C, or 39 degrees C. METHODS:Halothane-anesthetized fasted male Wistar rats underwent 20 minutes of global cerebral ischemia produced by bilateral carotid artery occlusions plus systemic hypotension (40 to 50 mm Hg). Rectal temperature was maintained at 37 degrees C throughout, and intraischemic brain temperature was held at either 30 degrees C (n = 6), 37 degrees C (n = 5), or 39 degrees C (n = 5). Before and after the ischemic insult, brain temperature was maintained at 37 degrees C in all groups. A microdialysis cannula was implanted in the right dorsolateral striatum and perfused with Ringer's solution. Dialysate samples were collected at 10-minute intervals before, during, and after ischemia and were analyzed for lactate by enzymatic-fluorometric techniques. RESULTS:In all groups, extracellular lactate rose during ischemia and peaked at 10 to 30 minutes of recirculation. Maximal extracellular lactate elevations were sevenfold, eightfold, and eightfold above control in the 30 degrees C, 37 degrees C, 39 degrees C groups, respectively. Significant elevations with respect to control were observed in all groups at 10 to 30 minutes of recirculation. In the 30 degrees C group, these elevations above control were also significant at the 10- and 20-minute ischemic time points (P = .001). At 30 minutes of recirculation, however, lactate levels were lower in the 30 degrees C rats than in the other groups. CONCLUSIONS:These data provide evidence that extracellular lactate accumulation is not a crucial determinant of ischemic brain injury. Our results suggest that the increased lactate release during ischemia and the accelerated clearance of lactate during recirculation might contribute in part to the neuroprotection of intraischemic hypothermia.






Lin B,Busto R,Globus MY,Martinez E,Ginsberg MD




Has Abstract


1995-09-01 00:00:00














  • Functional and motor outcome 5 years after stroke is equivalent to outcome at 2 months: follow-up of the collaborative evaluation of rehabilitation in stroke across Europe.

    abstract:BACKGROUND AND PURPOSE:Recovery of patients within the first 6 months after stroke is well documented, but there has been little research on long-term recovery. The aim of this study was to analyze functional and motor recovery between admission to rehabilitation centres and 5 years after stroke. METHODS:This follow-u...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Meyer S,Verheyden G,Brinkmann N,Dejaeger E,De Weerdt W,Feys H,Gantenbein AR,Jenni W,Laenen A,Lincoln N,Putman K,Schuback B,Schupp W,Thijs V,De Wit L

    更新日期:2015-06-01 00:00:00

  • Inhibition of NADPH oxidase attenuates vasospasm after experimental subarachnoid hemorrhage in rats.

    abstract:BACKGROUND AND PURPOSE:The purpose of this study is to investigate whether apocynin, an NADPH oxidase inhibitor, attenuates vasospasm after experimental subarachnoid hemorrhage (SAH) in rats. METHODS:Rats were subjected to endovascular perforation of the right anterior cerebral artery or sham surgery. Beginning 2 hour...


    pub_type: 杂志文章,收录出版


    authors: Zheng JS,Zhan RY,Zheng SS,Zhou YQ,Tong Y,Wan S

    更新日期:2005-05-01 00:00:00

  • The effect of a simulated subarachnoid hemorrhage on cerebral blood flow in the monkey.

    abstract::The hydrogen clearance method was used to measure local and total cerebral blood flow (CBF) in the rhesus monkey before and for five hours after a simulated subarachnoid hemorrhage (SAH). CBF remained stable after SAH unless SAH was associated with a fall in cerebral perfusion pressure. In addition, cerebrovascular re...


    pub_type: 杂志文章


    authors: Martins AN,Doyle TF,Newby N,Kobrine AI,Ramirez A

    更新日期:1975-11-01 00:00:00

  • Genetics of cerebrovascular disease.

    abstract::Stroke is a complex disease, with both genetic and environmental factors having a role in its pathogenesis. A review of past studies shows some evidence of genetic influences in the development of stroke. This is supported by studies of cardiovascular disease, which indicate major genetic influences at several levels ...


    pub_type: 杂志文章,评审


    authors: Alberts MJ

    更新日期:1990-11-01 00:00:00

  • Sensory symptoms and signs and results of quantitative sensory thermal testing in patients with lacunar infarct syndromes.

    abstract:BACKGROUND AND PURPOSE:Quantitative data on sensory impairment in stroke patients are limited. We measured the perception thresholds for temperature and thermal pain in patients with different lacunar syndromes, correlated the results with clinical and magnetic resonance imaging (MRI) findings, and studied the long-ter...


    pub_type: 杂志文章


    authors: Samuelsson M,Samuelsson L,Lindell D

    更新日期:1994-11-01 00:00:00

  • Stroke Incidence and Outcomes in Northeastern Greece: The Evros Stroke Registry.

    abstract:BACKGROUND AND PURPOSE:Data are scarce on both stroke incidence rates and outcomes in Greece and in rural areas in particular. We performed a prospective population-based study evaluating the incidence of first-ever stroke in the Evros prefecture, a region of a total 147 947 residents located in North Eastern Greece. ...


    pub_type: 杂志文章


    authors: Tsivgoulis G,Patousi A,Pikilidou M,Birbilis T,Katsanos AH,Mantatzis M,Asimis A,Papanas N,Skendros P,Terzoudi A,Karamanli A,Kouroumichakis I,Zebekakis P,Maltezos E,Piperidou C,Vadikolias K,Heliopoulos I

    更新日期:2018-02-01 00:00:00

  • Flow and compartmental weight in relation to the cours of stroke.

    abstract::Using a scintillation camera system, hemispheric and regional cerebral blood flow was measured repeatedly during the course after a stroke. In 20 patients who improved clinically mean hemispheric and regional flow and relative weight of rapidly perfused compartment increased, while these values decreased in 15 patient...


    pub_type: 杂志文章


    authors: Heiss WD,Zeiler K,Turnheim M,Podreka I

    更新日期:1976-07-01 00:00:00

  • Age-related changes in release of endothelium-derived relaxing factor from the carotid artery.

    abstract:BACKGROUND AND PURPOSE:The goal of this study was to determine whether release of endothelium-derived relaxing factor (EDRF) from carotid artery in response to acetylcholine is altered by aging. METHODS:Responses were examined in arteries from Wistar rats 6 to 8 months old (young rats), 24 to 26 months old (old rats),...


    pub_type: 杂志文章


    authors: Paternò R,Faraci FM,Heistad DD

    更新日期:1994-12-01 00:00:00

  • Siponimod (BAF-312) Attenuates Perihemorrhagic Edema And Improves Survival in Experimental Intracerebral Hemorrhage.

    abstract::Background and Purpose- Perihemorrhagic edema (PHE) is associated with poor outcome after intracerebral hemorrhage (ICH). Infiltration of immune cells is considered a major contributor of PHE. Recent studies suggest that immunomodulation via S1PR (sphingosine-1-phosphate receptor) modulators improve outcome in ICH. Si...


    pub_type: 杂志文章


    authors: Bobinger T,Manaenko A,Burkardt P,Beuscher V,Sprügel MI,Roeder SS,Bäuerle T,Seyler L,Nagel AM,Linker RA,Engelhorn T,Dörfler A,Horsten SV,Schwab S,Huttner HB

    更新日期:2019-11-01 00:00:00

  • Timing of Percutaneous Endoscopic Gastrostomy for Acute Ischemic Stroke: An Observational Study From the US Nationwide Inpatient Sample.

    abstract:BACKGROUND AND PURPOSE:Stroke guidelines recommend time-limited trials of nasogastric feeding prior to percutaneous endoscopic gastrostomy (PEG) tube placement. We sought to describe timing of PEG placement and identify factors associated with early PEG for acute ischemic stroke. METHODS:We designed a retrospective ob...


    pub_type: 杂志文章


    authors: George BP,Kelly AG,Albert GP,Hwang DY,Holloway RG

    更新日期:2017-02-01 00:00:00

  • Cerebrovascular disease in Saudi Arabia.

    abstract::We studied the pattern and outcome of strokes in 200 Saudi patients. Cerebral infarction constituted 87% of strokes, subarachnoid hemorrhage 4.5%, cerebral hemorrhage 6.5%, and venous infarction 2%. The vessel most commonly involved was part or all of the middle cerebral artery, constituting 52% (90) of the 174 arteri...


    pub_type: 杂志文章


    authors: Yaqub BA,Shamena AR,Kolawole TM,Patel PJ

    更新日期:1991-09-01 00:00:00

  • Neonatal cerebral sinovenous thrombosis from symptom to outcome.

    abstract:BACKGROUND AND PURPOSE:Cerebral sinovenous thrombosis is a rare disease with severe neurological sequelae. The aim of this retrospective multicenter study was to investigate the clinical course, possible risk factors, and outcome of a cohort of neonatal patients with sinovenous thrombosis and, second, to estimate the i...


    pub_type: 杂志文章,多中心研究


    authors: Berfelo FJ,Kersbergen KJ,van Ommen CH,Govaert P,van Straaten HL,Poll-The BT,van Wezel-Meijler G,Vermeulen RJ,Groenendaal F,de Vries LS,de Haan TR

    更新日期:2010-07-01 00:00:00

  • Rivaroxaban for stroke prevention in East Asian patients from the ROCKET AF trial.

    abstract:BACKGROUND AND PURPOSE:In Rivaroxaban Once Daily Oral Direct Factor Xa Inhibitor Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) trial, rivaroxaban was noninferior to dose-adjusted warfarin in preventing stroke or systemic embolism among patients with no...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Wong KS,Hu DY,Oomman A,Tan RS,Patel MR,Singer DE,Breithardt G,Mahaffey KW,Becker RC,Califf R,Fox KA,Berkowitz SD,Hacke W,Hankey GJ,Executive Steering Committee and the ROCKET AF Study Investigators.

    更新日期:2014-06-01 00:00:00

  • The pilot Stroke Data Bank: definition, design, and data.

    abstract::Four university centers collaborated to contribute 1158 patients with acute episodes of cerebrovascular disease to the pilot Stroke Data Bank, initiated by NINCDS in 1978. During the pilot project a standard set of data collection forms were developed and used at each of the collaborating centers. Data on clinical cou...


    pub_type: 杂志文章


    authors: Kunitz SC,Gross CR,Heyman A,Kase CS,Mohr JP,Price TR,Wolf PA

    更新日期:1984-07-01 00:00:00

  • Low carotid calcium score is associated with higher levels of glycosaminoglycans, tumor necrosis factor-alpha, and parathyroid hormone in human carotid plaques.

    abstract:BACKGROUND AND PURPOSE:Computed tomography (CT) is used to study coronary artery plaques, but little is known about its potential to characterize plaque composition. This study assesses the relation between carotid calcium score (CCS) by CT and plaque composition, namely extracellular matrix, inflammatory mediators, an...


    pub_type: 杂志文章


    authors: Edsfeldt A,Dias N,Elmståhl B,Müller MF,Berg K,Nitulescu M,Persson A,Ekberg O,Gonçalves I

    更新日期:2011-10-01 00:00:00

  • Impact of Low Ankle-Brachial Index on the Risk of Recurrent Vascular Events.

    abstract::Background and Purpose- Low ankle-brachial index (ABI) identifies a stroke subgroup with high risk of recurrent stroke, cardiovascular events, and death. However, limited data exist on the relationship between low ABI and stroke in low and middle-income countries. Therefore, we evaluated the prevalence of ABI ≤0.90 (w...


    pub_type: 杂志文章


    authors: Abboud H,Monteiro Tavares L,Labreuche J,Arauz A,Bryer A,Lavados PM,Massaro A,Munoz Collazos M,Steg PG,Yamout BI,Vicaut E,Amarenco P

    更新日期:2019-04-01 00:00:00

  • Endothelial dysfunction and arterial stiffness in ischemic stroke: the role of sleep-disordered breathing.

    abstract:BACKGROUND AND PURPOSE:Sleep-disordered breathing (SDB) represents a risk factor for cardiovascular morbidity after a cerebral ischemic event (acute ischemic event, ischemic stroke, or transient ischemic attack). In the present study, endothelial function and arterial stiffness were analyzed in patients who experienced...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Cereda CW,Tamisier R,Manconi M,Andreotti J,Frangi J,Pifferini V,Bassetti CL

    更新日期:2013-04-01 00:00:00

  • Polymorphisms of coagulation factor XIII subunit A and risk of nonfatal hemorrhagic stroke in young white women.

    abstract:BACKGROUND AND PURPOSE:Although family studies have suggested a genetic influence on hemorrhagic stroke, the underlying genetic risk factors remain poorly defined. Coagulation factor XIII, which is involved in hemostasis, fibrinolysis, vascular remodeling, and tissue repair, represents a candidate gene for hemorrhagic ...


    pub_type: 杂志文章


    authors: Reiner AP,Schwartz SM,Frank MB,Longstreth WT Jr,Hindorff LA,Teramura G,Rosendaal FR,Gaur LK,Psaty BM,Siscovick DS

    更新日期:2001-11-01 00:00:00

  • Proportional Motor Recovery After Stroke: Implications for Trial Design.

    abstract:BACKGROUND AND PURPOSE:Recovery of upper-limb motor impairment after first-ever ischemic stroke is proportional to the degree of initial impairment in patients with a functional corticospinal tract (CST). This study aimed to investigate whether proportional recovery occurs in a more clinically relevant sample including...


    pub_type: 杂志文章


    authors: Stinear CM,Byblow WD,Ackerley SJ,Smith MC,Borges VM,Barber PA

    更新日期:2017-03-01 00:00:00

  • Detection of carotid stenosis. From NASCET results to clinical practice.

    abstract:BACKGROUND AND PURPOSE:Results from large multicenter studies have shown that carotid endarterectomy, performed with low perioperative morbidity and mortality, is beneficial for patients with symptomatic carotid stenosis > or = 70% as calculated according to strict angiographic criteria. To apply these results in clini...


    pub_type: 杂志文章


    authors: Chang YJ,Golby AJ,Albers GW

    更新日期:1995-08-01 00:00:00

  • Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia.

    abstract:BACKGROUND AND PURPOSE:Leptin is the major adipose hormone that regulates body weight and energy expenditure by activating leptin receptors in the hypothalamus. Leptin receptors are also present in other cell types, and a potent antiapoptotic effect for leptin has recently been reported. We investigated whether leptin ...


    pub_type: 杂志文章


    authors: Zhang F,Wang S,Signore AP,Chen J

    更新日期:2007-08-01 00:00:00

  • Prevention with low-dose aspirin plus dipyridamole in patients with disabling stroke.

    abstract:BACKGROUND AND PURPOSE:The combination of low-dose aspirin and dipyridamole is more effective than aspirin alone in reducing the risk of recurrent stroke and other major cardiovascular events in patients with a recent transient ischemic attack or minor stroke. It is unknown whether this also applies to patients with a ...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Dippel DW,Maasland L,Halkes P,Kappelle LJ,Koudstaal PJ,Algra A,ESPRIT Study Group and the ESPS-2 Investigators.

    更新日期:2010-11-01 00:00:00

  • Moyamoya disease in Europeans.

    abstract:BACKGROUND AND PURPOSE:We describe the clinical, diagnostic, and outcome features of a cohort of white patients with idiopathic moyamoya disease treated in a German institution. METHODS:Our cohort included 21 white patients with moyamoya disease. Clinical and diagnostic features were obtained by retrospective chart re...


    pub_type: 杂志文章


    authors: Kraemer M,Heienbrok W,Berlit P

    更新日期:2008-12-01 00:00:00

  • Dysphagia after stroke: incidence, diagnosis, and pulmonary complications.

    abstract:OBJECTIVE:To determine the incidence of dysphagia and associated pulmonary compromise in stroke patients through a systematic review of the published literature. METHODS:Databases were searched (1966 through May 2005) using terms "cerebrovascular disorders," "deglutition disorders," and limited to "humans" for origina...


    pub_type: 杂志文章,评审


    authors: Martino R,Foley N,Bhogal S,Diamant N,Speechley M,Teasell R

    更新日期:2005-12-01 00:00:00

  • Intra- and interrater reliability of ischemic lesion volume measurements on diffusion-weighted, mean transit time and fluid-attenuated inversion recovery MRI.

    abstract:BACKGROUND AND PURPOSE:We investigated the intra- and interrater reliability of ischemic lesion volumes measurements assessed by different MRI sequences at various times from onset. METHODS:Ischemic lesion volumes were measured for intrarater reliability using diffusion-weighted (DWI), mean transit time (MTT) perfusio...


    pub_type: 杂志文章


    authors: Luby M,Bykowski JL,Schellinger PD,Merino JG,Warach S

    更新日期:2006-12-01 00:00:00

  • Beyond mismatch: evolving paradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging.

    abstract:BACKGROUND:The ability to quickly and efficiently identify the ischemic penumbra in the acute stroke clinical setting is an important goal for stroke researchers and clinicians. Early and accurate identification of potentially salvageable versus irreversibly infarcted brain tissue may enable selection of the most appro...


    pub_type: 杂志文章,评审


    authors: Kidwell CS,Alger JR,Saver JL

    更新日期:2003-11-01 00:00:00

  • Utilization of intravenous tissue-type plasminogen activator for ischemic stroke at academic medical centers: the influence of ethnicity.

    abstract:BACKGROUND AND PURPOSE:We sought to measure the overall rate of usage of tissue-type plasminogen activator (tPA) for ischemic stroke at academic medical centers, and to determine whether ethnicity was associated with usage. METHODS:Between June and December 1999, 42 academic medical centers in the United States each i...


    pub_type: 杂志文章,多中心研究


    authors: Johnston SC,Fung LH,Gillum LA,Smith WS,Brass LM,Lichtman JH,Brown AN

    更新日期:2001-05-01 00:00:00

  • ORAI1/STIM1 Interaction Intervenes in Stroke and in Neuroprotection Induced by Ischemic Preconditioning Through Store-Operated Calcium Entry.

    abstract::Background and Purpose- Disturbance of endoplasmic reticulum (ER) Ca2+ homeostasis causes neuronal cell injury in stroke. By contrast, ischemic preconditioning (IPC)-a brief sublethal ischemic episode affording tolerance to a subsequent ischemic insult-restores ER Ca2+ homeostasis. Under physiological conditions, ER c...


    pub_type: 杂志文章


    authors: Secondo A,Petrozziello T,Tedeschi V,Boscia F,Vinciguerra A,Ciccone R,Pannaccione A,Molinaro P,Pignataro G,Annunziato L

    更新日期:2019-05-01 00:00:00

  • Sphenopalatine Ganglion Stimulation to Augment Cerebral Blood Flow.

    abstract::Background and Purpose- Many patients with acute ischemic stroke are not eligible for thrombolysis or mechanical reperfusion therapies due to contraindications, inaccessible vascular occlusions, late presentation, or large infarct core. Sphenopalatine ganglion (SPG) stimulation to enhance collateral flow and stabilize...


    pub_type: 杂志文章


    authors: Bornstein NM,Saver JL,Diener HC,Gorelick PB,Shuaib A,Solberg Y,Devlin T,Leung T,Molina CA,ImpACT-24A Investigators † .,ImpACT-24A Investigators include the Site Principal Investigators, DSMB members, and the Site Co-Investigators lis

    更新日期:2019-05-23 00:00:00

  • Risk factors for spontaneous cerebral hematomas. Case-control study.

    abstract::In a case-control study of 73 cases of cerebral hematoma diagnosed by CT scan, significant risk factors were history of hypertension, chronic alcoholism, evidence of hepatic disease, EKG abnormalities and high hematocrit values. Initial blood pressure was significantly higher in cases, but blood pressure on the third ...


    pub_type: 杂志文章


    authors: Calandre L,Arnal C,Ortega JF,Bermejo F,Felgeroso B,del Ser T,Vallejo A

    更新日期:1986-11-01 00:00:00