Abstract:
BACKGROUND AND PURPOSE:Stroke is the leading cause of disability in the Western world; however, few therapies are at hand to decrease this burden. SUMMARY OF REVIEW:Endothelial progenitor cells (EPCs) have been introduced in cardiovascular medicine as factotums. EPCs can repair damaged endothelium and attenuate the development and progression of atherosclerosis. Also, EPCs can form new vessels in ischemic areas and thus promote recovery after ischemic events. In stroke, however, EPC research is limited. In our overview, we provide background information on EPC use as a risk marker and as a potential therapeutic agent. CONCLUSIONS:In our opinion, the lack of EPC studies in stroke should instigate vascular neurologists to participate in EPC research, as EPCs could also change pathophysiological concepts and improve clinical treatments in vascular neurology.
journal_name
Strokejournal_title
Strokeauthors
Rouhl RP,van Oostenbrugge RJ,Damoiseaux J,Tervaert JW,Lodder Jdoi
10.1161/STROKEAHA.107.507251subject
Has Abstractpub_date
2008-07-01 00:00:00pages
2158-65issue
7eissn
0039-2499issn
1524-4628pii
STROKEAHA.107.507251journal_volume
39pub_type
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