Pretreatment with U74006F improves neurologic outcome following complete cerebral ischemia in dogs.

abstract：BACKGROUND AND PURPOSE:We have previously shown that 17beta-estradiol reduces infarction volume in female rats. The present study determined whether single injection or chronic implantation of estrogen confers neuroprotection in male animals with middle cerebral artery occlusion (MCAO) and whether there is an interacti...

journal_title：Stroke

authors： Toung TJ,Traystman RJ,Hurn PD

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Downregulation of the tumor suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), is thought to be a novel neuroprotective strategy in ischemic stroke, but the underlying mechanisms remain unclear. In this study, we aimed to validate the use of PTEN regulation of gamma-amino...

journal_title：Stroke

authors： Liu B,Li L,Zhang Q,Chang N,Wang D,Shan Y,Li L,Wang H,Feng H,Zhang L,Brann DW,Wan Q

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral intraventricular infusion of acidic or basic fibroblast growth factor has been shown to attenuate ischemic damage to hippocampal CA1 neurons in the gerbil. The purpose of the present study was to determine if the basic fibroblast growth factor transgenic mouse has an enhanced ability to ...

journal_title：Stroke

authors： MacMillan V,Judge D,Wiseman A,Settles D,Swain J,Davis J

更新日期：1993-11-01 00:00:00

abstract：:Background and Purpose- This ARISTOPHANES study (Anticoagulants for Reduction in Stroke: Observational Pooled Analysis on Health Outcomes and Experience of Patients) used multiple data sources to compare stroke/systemic embolism (SE) and major bleeding (MB) among a large number of nonvalvular atrial fibrillation patie...

journal_title：Stroke

authors： Lip GYH,Keshishian A,Li X,Hamilton M,Masseria C,Gupta K,Luo X,Mardekian J,Friend K,Nadkarni A,Pan X,Baser O,Deitelzweig S

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Mechanisms involved in stroke progression are incompletely understood. Ischemic brain injury is characterized by acute local inflammatory response mediated by cytokines. Anti-inflammatory cytokines act in a feedback loop to inhibit continued proinflammatory cytokine production. We assessed the implication of...

journal_title：Stroke

authors： Vila N,Castillo J,Dávalos A,Esteve A,Planas AM,Chamorro A

更新日期：2003-03-01 00:00:00

abstract：:Patients with chronic aphasia were assigned randomly to a group to receive either conventional aphasia therapy or constraint-induced (CI) aphasia therapy, a new therapeutic technique requiring intense practice over a relatively short period of consecutive days. CI aphasia therapy is realized in a communicative therape...

journal_title：Stroke

authors： Pulvermüller F,Neininger B,Elbert T,Mohr B,Rockstroh B,Koebbel P,Taub E

更新日期：2001-07-01 00:00:00

abstract：:An anecdotal series of nine patients (three men and six women with an average age of 57 years) presented with progressive neurologic deterioration while on medical therapy for large right hemispheric cerebral infarction. Clinical signs of uncal herniation (anisocoria or fixed and dilated pupils, and/or left hemiplegia...

journal_title：Stroke

authors： Delashaw JB,Broaddus WC,Kassell NF,Haley EC,Pendleton GA,Vollmer DG,Maggio WW,Grady MS

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The results of previous studies suggest that early goal-directed fluid therapy (EGDT) reduces delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage, but the effects of EGDT on clinical outcomes are still unclear. This study aimed to determine whether EGDT improves outcomes comp...

journal_title：Stroke

authors： Mutoh T,Kazumata K,Terasaka S,Taki Y,Suzuki A,Ishikawa T

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The spontaneously hypertensive stroke-prone rat (SHRSP) is an animal model for a complex form of cerebrovascular pathology. MRI provides an efficient and noninvasive tool for studying the time course of brain damage. The aim of this study was to gain new insights into the pathological phenomena r...

journal_title：Stroke

authors： Guerrini U,Sironi L,Tremoli E,Cimino M,Pollo B,Calvio AM,Paoletti R,Asdente M

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We examined sex-specific relationships of smoking with risk of total stroke and stroke subtypes in Asian populations because of the limited data available. METHODS:A total of 19,782 men and 21,500 women aged 40 to 59 years who were free of prior diagnosis of stroke, coronary heart disease, or ca...

journal_title：Stroke

authors： Mannami T,Iso H,Baba S,Sasaki S,Okada K,Konishi M,Tsugane S,Japan Public Health Center-Based Prospective Study on Cancer and Cardiovascular Disease Group.

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of this investigation was to compare the respective efficacy of transcranial Doppler sonography (TCD) and magnetic resonance angiography (MRA) for the assessment of intracranial hemodynamics in patients with extracranial occlusion or severe stenosis of the internal carotid artery (ICA). ...

journal_title：Stroke

authors： Anzola GP,Gasparotti R,Magoni M,Prandini F

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Dichloroacetate facilitates a decrease in brain lactate during reperfusion after incomplete ischemia. This study examined the possible activation of pyruvate dehydrogenase enzyme by dichloroacetate to explain this effect. Because the duration of ischemia and hyperglycemia exacerbate ischemic brai...

journal_title：Stroke

authors： Dimlich RV,Nielsen MM

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Risk-factor modeling has been proposed to identify patients with carotid stenosis who will most benefit from surgery. Validation by independent institutions performing carotid endarterectomy is necessary to determine the applicability of such models to the individual patient. METHODS:A series of...

journal_title：Stroke

authors： Barth A,Bassetti C

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Little information is available regarding black-white differences in stroke incidence in young adults. METHODS:Cerebral infarction and intracerebral hemorrhage rates among adults 15 to 44 years of age were studied in Baltimore City and Baltimore County for 1988. Diagnoses were based on neurologi...

journal_title：Stroke

authors： Kittner SJ,McCarter RJ,Sherwin RW,Sloan MA,Stern BJ,Johnson CJ,Buchholz D,Seipp MJ,Price TR

更新日期：1993-12-01 00:00:00

abstract：:We compared 211 consecutive patients who had acute ischemic hemispheric stroke and atrial fibrillation with 837 consecutive patients who had stroke without atrial fibrillation. The atrial fibrillation group included a higher frequency of women, older subjects, and those with a severe neurologic deficit, abnormal compu...

journal_title：Stroke

authors： Candelise L,Pinardi G,Morabito A

更新日期：1991-02-01 00:00:00

abstract：:Platinum microelectrodes were used to measure H2 clearance in mouse brain, and the clearance curves were used to calculate regional cerebral blood flow (rCBF). The curves were usually biexponential, whether or not electrode placement was confined to the cortex. When calculated by the height over area method, rCBF in a...

journal_title：Stroke

authors： Rosenblum WI

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Acceleration of healing mechanisms is a promising approach to improve current limitations of endovascular aneurysm therapy with the use of platinum coils. We evaluated a new endovascular therapeutic, bioabsorbable polymeric material (BPM), which may promote cellular reaction in the aneurysms. ME...

journal_title：Stroke

authors： Murayama Y,Viñuela F,Tateshima S,Gonzalez NR,Song JK,Mahdavieh H,Iruela-Arispe L

更新日期：2002-04-01 00:00:00

abstract：:Cerebral autoregulation can be duplicated in vitro using the large middle cerebral arteries from a calf. The limits of autoregulation were between 50 and 150 mm Hg. Excessively high pressures may lead to the appearance of the "sausage- or bead-string" response followed by forced dilation. These results suggest the exi...

journal_title：Stroke

authors： Vinall PE,Simeone FA

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:This study aims to investigate the association between insulin resistance (IR) and silent lacunar infarction (SLI) in healthy adults. METHODS:We recruited 2326 healthy Korean adults who took health checkups, including a brain magnetic resonance imaging. SLI was defined as an infarction measuring...

journal_title：Stroke

authors： Lee JE,Shin DW,Yun JM,Kim SH,Nam YS,Cho B,Lim JS,Jeong HY,Kwon HM,Park JH

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cavernous malformations of the brain (CMs) cause intracranial hemorrhage, but its reported frequency varies, partly attributable to study design. To improve the validity of future research, we aimed to develop a robust definition of CM hemorrhage. METHODS:We systematically reviewed the published...

journal_title：Stroke

authors： Al-Shahi Salman R,Berg MJ,Morrison L,Awad IA,Angioma Alliance Scientific Advisory Board.

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We sought to identify the most powerful binary measures of the treatment effect of tissue plasminogen activator (tPA) in the National Institute of Neurological Disorders and Stroke (NINDS) rTPA Stroke Trial. METHODS:Using the Classification and Regression Tree (CART) algorithm, we evaluated bina...

journal_title：Stroke

authors： Broderick JP,Lu M,Kothari R,Levine SR,Lyden PD,Haley EC,Brott TG,Grotta J,Tilley BC,Marler JR,Frankel M

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ageing is associated with a decline in cerebral blood flow. Animal studies have shown that cholesterol-lowering therapy with statins might preserve cerebral blood flow (CBF). We examined the effect of 40 mg pravastatin on the decline in CBF and brain volume in a subset of elderly subjects partici...

journal_title：Stroke

authors： ten Dam VH,Box FM,de Craen AJ,van den Heuvel DM,Bollen EL,Murray HM,van Buchem MA,Westendorp RG,Blauw GJ,PROSPER Study Group.

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this study was to assess brain perfusion with an ultrasound contrast-specific imaging mode and to prove if the results are comparable between 2 centers using a standardized study protocol. METHODS:A total of 32 individuals without known cerebrovascular disease were included in the...

journal_title：Stroke

authors： Hölscher T,Wilkening W,Draganski B,Meves SH,Eyding J,Voit H,Bogdahn U,Przuntek H,Postert T

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The objective of this study was to determine the prevalence of intracranial plaques and stenoses and their causal role in patients with fatal stroke. Intracranial atherosclerosis is considered to be a rare condition with a severe prognosis. However, disease prevalence may be underestimated due to...

journal_title：Stroke

authors： Mazighi M,Labreuche J,Gongora-Rivera F,Duyckaerts C,Hauw JJ,Amarenco P

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The EuroQol and Medical Outcome Survey 36-item short-form health survey (SF-36) questionnaires have both been validated for the assessment of health-related quality of life after stroke. However, the relationship between these instruments has not been studied after stroke. We therefore sought to ...

journal_title：Stroke

authors： Dorman PJ,Dennis M,Sandercock P

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Stroke PROTECT (Preventing Recurrence Of Thromboembolic Events through Coordinated Treatment) program systematically implements, at the time of acute transient ischemic attack (TIA) or ischemic stroke admission, 8 medication/behavioral secondary prevention measures known to improve outcome in...

journal_title：Stroke

authors： Ovbiagele B,Saver JL,Fredieu A,Suzuki S,Selco S,Rajajee V,McNair N,Razinia T,Kidwell CS

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Fibrocartilaginous embolism from the nucleus pulposus has been reported as a rare cause of spinal cord ischemia. We were unable to find previous reports of embolism from this source to cerebral arteries. CASE DESCRIPTION:A previously healthy 17-year-old girl fell during a basketball game. Left h...

journal_title：Stroke

authors： Toro-González G,Navarro-Román L,Román GC,Cantillo J,Serrano B,Herrera M,Vergara I

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Diffusion-weighted imaging (DWI) is the most sensitive MR sequence in acute arterial ischemic stroke but has not yet been evaluated in venous cerebral ischemia. We describe a patient with DWI performed at the acute phase of a venous ischemic stroke. CASE DESCRIPTION:A rapid cerebral MRI including DWI and fa...

journal_title：Stroke

authors： Corvol JC,Oppenheim C,Manaï R,Logak M,Dormont D,Samson Y,Marsault C,Rancurel G

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It has been reported that National Institutes of Health Stroke Scale (NIHSS) scores correlate poorly with hypoperfused tissue measured by perfusion-weighted imaging (PWI) in nondominant hemisphere stroke. We conducted 2 studies to determine whether tests of hemispatial neglect provide a better me...

journal_title：Stroke

authors： Hillis AE,Wityk RJ,Barker PB,Ulatowski JA,Jacobs MA

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Because stroke management is aimed at facilitating community reintegration, it would be logical that the sooner the patient can be discharged home, the sooner reintegration can commence. The purpose of this study was to determine the effectiveness of prompt discharge combined with home rehabilita...

journal_title：Stroke

authors： Mayo NE,Wood-Dauphinee S,Côté R,Gayton D,Carlton J,Buttery J,Tamblyn R

更新日期：2000-05-01 00:00:00