Abstract:
BACKGROUND AND PURPOSE:The spontaneously hypertensive stroke-prone rat (SHRSP) is an animal model for a complex form of cerebrovascular pathology. MRI provides an efficient and noninvasive tool for studying the time course of brain damage. The aim of this study was to gain new insights into the pathological phenomena responsible for the occurrence of brain injury in SHRSP with the use of the apparent diffusion coefficient of water (ADC), one of the most efficient MRI parameters for detecting brain abnormalities. To this end, the pattern of ADC variation observed in SHRSP was compared with that of focal ischemia induced in both SHRSP and Sprague-Dawley rats. METHODS:Four groups of animals were studied: SHRSP developing spontaneous brain lesions fed with a salt-loaded (n=15, group 1) or standard diet (n=3, group 2) and Sprague-Dawley rats (n=8, group 3) and SHRSP (n=8, group 4) with permanent middle cerebral artery occlusion. ADC maps and T2-weighted images of brains were performed by MRI. After the rats were killed, the brains were removed and histologically processed. RESULTS:There was no decrease in ADC during spontaneous stroke in the SHRSP fed with a normal or salt-enriched diet, while both the SHRSP and Sprague-Dawley rats with middle cerebral artery occlusion showed a marked decrease that lasted for 24 to 48 hours. CONCLUSIONS:Cerebral ischemia cannot be considered a major factor in the onset of spontaneous brain lesions in SHRSP, which show only vasogenic edema after the beginning of the damage with no evidence of metabolic impairment.
journal_name
Strokejournal_title
Strokeauthors
Guerrini U,Sironi L,Tremoli E,Cimino M,Pollo B,Calvio AM,Paoletti R,Asdente Mdoi
10.1161/hs0302.104111subject
Has Abstractpub_date
2002-03-01 00:00:00pages
825-30issue
3eissn
0039-2499issn
1524-4628journal_volume
33pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:The decision to proceed with surgery in cerebellar infarct with mass effect (CIMASS) in deteriorating patients is based on clinical features. The potential role of neuroimaging in predicting deterioration has not been systematically studied. In this study we determine the role of neuroimaging in ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.9.2062
更新日期:2000-09-01 00:00:00
abstract::MRI is becoming the imaging modality of choice in patients with ischemic cerebrovascular disease although CT is still the test of choice to exclude acute hemorrhagic stroke. We have briefly reviewed characteristic features of ischemic and hemorrhagic cerebrovascular disease as well as vascular anomalies as seen on MRI...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.20.9.1279
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recent studies have shown the antiapoptotic neuroprotective effects of lecithinized superoxide dismutase (PC-SOD) in different forms of brain injury. We tested the effects of PC-SOD in focal cerebral ischemia in the rat middle cerebral artery occlusion model (MCAO). METHODS:Adult male Sprague-Da...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000257978.70312.1d
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is unclear whether blood lipid profiles and statin use before intracerebral hemorrhage (ICH) are associated with its outcome. METHODS:The Helsinki ICH Study, a single-center observational registry of consecutive ICH patients, was used to study the associations between premorbid statin use, ba...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001829
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dipyridamole increases the concentration of circulating adenosine, which is a potent vasodilator, by inhibition of uptake of adenosine into the erythrocytes, and hence produces coronary vasodilation. However, the effects of dipyridamole on cerebral circulation is not pronounced. This study invest...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.8.1616
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Obvious cardiac dysfunction, including ECG abnormalities and left ventricular asynergy, is known to develop after subarachnoid hemorrhage (SAH). To clarify the close relationship between myocardial damage and sympathetic nervous activity immediately after SAH, a novel experimental animal model wa...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000016327.74392.02
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dysregulation of vessel wall formation, growth, and maintenance may confer susceptibility of stroke. METHODS:We tested the hypothesis that variants in 2 genes encoding vascular endothelial growth factor and vascular endothelial growth factor receptor-2 are associated with susceptibility to strok...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.109.554394
更新日期:2009-08-01 00:00:00
abstract::Background and Purpose- In this era of endovascular therapy (EVT) with early, complete recanalization and reperfusion, we have observed an even more rapid apparent diffusion coefficient (ADC) normalization within the acute ischemic lesion compared with the natural history or IV-tPA-treated patient. In this study, we a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.025784
更新日期:2019-08-01 00:00:00
abstract::In this retrospective analysis we report our treatment experience in 65 consecutive patients with clinical signs of severe brainstem ischemia with angiographically demonstrated thrombotic vertebrobasilar artery occlusions who received either local intra-arterial thrombolytic therapy (urokinase or streptokinase) (43 pa...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.10.1216
更新日期:1988-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Our aim was to estimate the cost-effectiveness of transferring patients with intracerebral hemorrhage from centers without specialized neurological intensive care units (neuro-ICUs) to centers with neuro-ICUs. METHODS:Decision analytic models were developed for the lifetime horizons. Model input...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.006653
更新日期:2015-01-01 00:00:00
abstract:UNLABELLED:The pathophysiology of postischemic encephalopathy is complex, and includes tissue acidosis, edema, hypoperfusion, membrane dysfunction, impaired energy production, and possibly hypermetabolism. We tested the hypothesis that this multifactorial clinical problem must be approached with multifaceted therapy, w...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.15.5.803
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A pulsatility index (PI) represents vascular resistance distal to an examined artery. The purpose of the present study was to evaluate an association between plasma total homocysteine (tHcy) and PIs of the cerebral arteries in patients with ischemic stroke. METHODS:Consecutive patients with isch...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.558403
更新日期:2009-10-01 00:00:00
abstract::Background and Purpose- Ischemic stroke impairs endoplasmic reticulum (ER) function, causes ER stress, and activates the unfolded protein response. The unfolded protein response consists of 3 branches controlled by ER stress sensor proteins, which include PERK (protein kinase RNA-like ER kinase). Activated PERK phosph...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.029071
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Attained height, an indicator of genetic potential and childhood growth environment, is inversely associated with stroke, but the mechanisms are poorly understood. We investigated whether childhood height and growth are associated with ischemic stroke (IS) and intracerebral hemorrhage (ICH). MET...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.019880
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We previously reported increased incidence of ischemic stroke among both blacks and whites with diabetes mellitus, especially in those aged <55 years. With rising prevalence of diabetes mellitus in the past decade, we revisit the impact of diabetes mellitus on stroke incidence in the same populat...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.113.001318
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The chronological development and natural history of cerebral aneurysms (CAs) remain incompletely understood. We used (14)C birth dating of a main constituent of CAs, that is, collagen type I, as an indicator for biosynthesis and turnover of collagen in CAs in relation to human cerebral arteries ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/STROKEAHA.114.005461
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We tested the hypothesis that circulating microRNAs (miRNAs) present in plasma might display a specific signature in patients with intracerebral hemorrhage. METHODS:Global miRNA profiles were determined with the Agilent Human miRNA Microarray platform, and validated by quantitative polymerase ch...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.000835
更新日期:2013-06-01 00:00:00
abstract::The author reviewed electrocardiographic records of 150 patients with acute stroke and 150 age- and sex-matched controls, to assess the relative frequencies of ECG abnormalities among the pathophysiologic categories of stroke, and to distinguish new abnormalities at the time of the stroke from those noted on prior tra...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.10.3.253
更新日期:1979-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The role of the cerebral microcirculation in delayed ischemia after subarachnoid hemorrhage remains obscure. To test the hypothesis that cerebral arterioles have a reduced capacity to dilate after subarachnoid hemorrhage, we studied the microvascular responses to papaverine (PPV) in patients unde...
journal_title:Stroke
pub_type: 信件
doi:10.1161/STROKEAHA.108.522375
更新日期:2009-01-01 00:00:00
abstract::With the use of a new ultrasonic volume flow meter (VFM), over 8000 measurements of common carotid blood flow were made in 120 normal control subjects and 550 patients with various neurological disease. The accuracy of the flow meter in measuring blood flow on an experimental model ranged from 93 to 97%. In normal sub...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.14.2.256
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intake of fruits and vegetables has been related to lower risk of ischemic stroke, but nutrients responsible for this apparent benefit remain ill-defined. Tocopherols (vitamin E) have also been proposed to be protective. METHODS:We conducted a prospective, nested case-control analysis among male...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000132197.67350.bd
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Stroke is the third leading cause of death and the leading cause of long-term disability in the United States. Although a host of genetic, biochemical, physiological, anatomic, and histological factors have been implicated, to varying degrees, in the pathogenesis of stroke, biophysical factors are believed t...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.28.10.2067
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to characterize the spatial and temporal evolution of human cerebral infarction. Using a novel method of quantitatively mapping the distribution of hypoxic viable tissue identified by 18F-fluoromisonidazole (18F-FMISO) PET relative to the final infarct, we determined its evolution and s...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.STR.0000094422.74023.FF
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The sensitivity of the brain to brief periods of profound ischemia or prolonged periods of modest ischemia mandates an aggressive approach to acute stroke care. Past studies have shown that many stroke patients do not receive acute care in an urgent and timely fashion. The formation of acute stro...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.11.2318
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Disturbed cerebral autoregulation has been reported to correlate with an unfavorable outcome after head injury. Using transcranial Doppler ultrasonography, we investigated whether hemodynamic responses to spontaneous variations of cerebral perfusion pressure (CPP) provide reliable information on ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.10.1829
更新日期:1996-10-01 00:00:00
abstract::Abundant preclinical studies have identified multiple mechanisms of ischemic brain injury and have provided proof of principle that strategies designed to counter these mechanisms can protect the ischemic brain. This review article emphasizes the translation of these strategies from the laboratory to clinical trials. ...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.108.528877
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Autonomic nervous system diseases affect systemic blood pressure regulation. Patients with autonomic nervous system diseases have consistently larger drops in blood pressure associated with standing than the normal population. Autonomic dysfunction and/or these changes in blood pressure may affec...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.9.1686
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Collateral flow augmentation using partial aortic occlusion may improve cerebral perfusion in acute stroke. We assessed the safety and feasibility of partial aortic occlusion immediately after intravenous tissue plasminogen activator. METHODS:We conducted an open-label pilot study of partial aor...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/STROKEAHA.110.607846
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Gender differences in carotid endarterectomy (CEA) rates after transient ischemic attack are not well studied, although some reports suggest that eligible men are more likely to have CEA than women after stroke. METHODS:We retrospectively identified all patients diagnosed with transient ischemic...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.580977
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Our investigation sought to determine whether neonatal brain ischemic vascular and metabolic effects were altered by repeated episodes of ischemia. METHODS:We studied twelve piglets using in vivo magnetic resonance spectroscopy to obtain multiple, simultaneous measurements of cerebral blood flow...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.3.380
更新日期:1992-03-01 00:00:00