Preservation of GABAA receptor function by PTEN inhibition protects against neuronal death in ischemic stroke.

abstract：BACKGROUND AND PURPOSE:Carotid endarterectomy is an effective method for preventing strokes if patients do not suffer adverse perioperative outcomes. The purpose of this study was to identify preoperative patient risk factors for adverse outcomes (death or nonfatal stroke) after carotid endarterectomy through the use o...

journal_title：Stroke

authors： Tu JV,Wang H,Bowyer B,Green L,Fang J,Kucey D,Participants in the Ontario Carotid Endarterectomy Registry.

更新日期：2003-11-01 00:00:00

abstract：:We investigated seasonal variation in the incidence of cerebral stroke among the general population aged greater than or equal to 40 years in November of 1961 in Hisayama, Japan. During the 24-year follow-up period, 311 cases of cerebrovascular diseases occurred. The date or month of onset was determined in 308 cases,...

journal_title：Stroke

authors： Shinkawa A,Ueda K,Hasuo Y,Kiyohara Y,Fujishima M

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:5' adenosine monophosphate-dependent protein kinase (AMPK) acts as a metabolic sensor. AMPK is elevated under ischemic conditions, but the role of AMPK in ischemic brain remains controversial. In this study, we examined the effects of AMPK inhibition using both pharmacological and genetic approac...

journal_title：Stroke

authors： Li J,Zeng Z,Viollet B,Ronnett GV,McCullough LD

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The etiology of moyamoya disease (MMD) remains obscure. This study was undertaken to identify specific proteins associated with the pathogenesis of MMD. METHODS:We studied cerebrospinal fluid (CSF) from 20 patients with angiographically confirmed MMD (4 boys and 16 girls; age range, 3 to 13 year...

journal_title：Stroke

authors： Kim SK,Yoo JI,Cho BK,Hong SJ,Kim YK,Moon JA,Kim JH,Chung YN,Wang KC

更新日期：2003-12-01 00:00:00

abstract：:Background and Purpose- Many patients with acute ischemic stroke are not eligible for thrombolysis or mechanical reperfusion therapies due to contraindications, inaccessible vascular occlusions, late presentation, or large infarct core. Sphenopalatine ganglion (SPG) stimulation to enhance collateral flow and stabilize...

journal_title：Stroke

authors： Bornstein NM,Saver JL,Diener HC,Gorelick PB,Shuaib A,Solberg Y,Devlin T,Leung T,Molina CA,ImpACT-24A Investigators † .,ImpACT-24A Investigators include the Site Principal Investigators, DSMB members, and the Site Co-Investigators lis

更新日期：2019-05-23 00:00:00

abstract：BACKGROUND AND PURPOSE:Shoulder pain is a common complication after stroke that can impede participation in rehabilitation and has been associated with poorer outcomes. Evidence-based treatments for hemiplegic shoulder pain are limited. Suprascapular nerve block (SSNB) is a safe and effective treatment of shoulder pain...

journal_title：Stroke

authors： Adey-Wakeling Z,Crotty M,Shanahan EM

更新日期：2013-11-01 00:00:00

abstract：:Background and Purpose- The diagnosis of transient ischemic attack is challenging. Evidence of acute ischemia on MRI diffusion-weighted imaging is highly variable and confirmed in only about one-third of patients. This study investigated the significance of blood-brain barrier dysfunction (BBBD) mapping in patients wi...

journal_title：Stroke

authors： Serlin Y,Ofer J,Ben-Arie G,Veksler R,Ifergane G,Shelef I,Minuk J,Horev A,Friedman A

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:In 15% to 20% of patients with a spontaneous subarachnoid hemorrhage, no aneurysm is found on the first angiogram. This review emphasizes that this group of patients is in fact heterogeneous and describes the clinical features, pattern of hemorrhage on early computed tomographic (CT) scan, prognosis, and pro...

journal_title：Stroke

authors： Rinkel GJ,van Gijn J,Wijdicks EF

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Early neurological deterioration (END) occurs in ≥20% of single small subcortical infarctions (SSSIs; axial diameter ≤20 mm in the perforator territories) and deters functional recovery. Both microvasculopathies and atherosclerosis have been proposed to independently contribute to the occurrence ...

journal_title：Stroke

authors： Jeong HG,Kim BJ,Yang MH,Han MK,Bae HJ

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Early CT signs of cerebral ischemia are subtle. Little is known of which factors influence the detection of infarct signs. We compared neuroradiologists' scan readings with those of other specialists involved in the care of stroke patients. METHODS:We used the Internet to show 63 CT scans, all a...

journal_title：Stroke

authors： Wardlaw JM,Farrall AJ,Perry D,von Kummer R,Mielke O,Moulin T,Ciccone A,Hill M,Acute Cerebral CT Evaluation of Stroke Study (ACCESS) Study Group.

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is no consensus on whether anticoagulation should be continued or temporarily stopped in patients suffering acute ischemic stroke while using anticoagulation. We assessed treatment variations and outcomes in these patients. METHODS:Post hoc analysis of PASS (Preventive Antibiotics in Strok...

journal_title：Stroke

authors： Groot AE,Vermeij JM,Westendorp WF,Nederkoorn PJ,van de Beek D,Coutinho JM

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Tetrahydrobiopterin (THBP) is an essential cofactor for nitric oxide synthase (NOS), which is responsible for the synthesis of the endothelium-derived relaxing factor (EDRF) responsible for mediating the vasorelaxation produced by acetylcholine (ACh). Previous publications suggest that EDRFACh is...

journal_title：Stroke

authors： Rosenblum WI

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Whether and how the arterial pathology underlying lacunar ischemic stroke differs from the atherothrombotic processes causing most other ischemic strokes is still debated. Different risks of recurrent stroke and MI after lacunar versus nonlacunar ischemic stroke may support a distinct lacunar art...

journal_title：Stroke

authors： Jackson CA,Hutchison A,Dennis MS,Wardlaw JM,Lewis SC,Sudlow CL

更新日期：2009-12-01 00:00:00

abstract：:Intravenously injected metaraminol induced a larger blood pressure increase in spontaneously hypertensive rats (SHR) than in normotensive controls (NR) when the pressure was raised from the same starting level. Cerebral blood flow (CBF) response in NR was either perfect autoregulation, partial autoregulation or "break...

journal_title：Stroke

authors： Johansson BB,Nilsson B

更新日期：1979-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Risk-standardized hospital readmission rates are used as publicly reported measures reflecting quality of care. Valid risk-standardized models adjust for differences in patient-level factors across hospitals. We conducted a systematic review of peer-reviewed literature to identify models that com...

journal_title：Stroke

authors： Lichtman JH,Leifheit-Limson EC,Jones SB,Watanabe E,Bernheim SM,Phipps MS,Bhat KR,Savage SV,Goldstein LB

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:"Incidental" MRI white matter (WM) lesions, comprising periventricular lesions (PVLs) and deep subcortical lesions (DSCLs), are common in the aging brain. Direct evidence of ischemia associated with incidental WM lesions (WMLs) has been lacking, and their pathogenesis is unresolved. METHODS:A po...

journal_title：Stroke

authors： Fernando MS,Simpson JE,Matthews F,Brayne C,Lewis CE,Barber R,Kalaria RN,Forster G,Esteves F,Wharton SB,Shaw PJ,O'Brien JT,Ince PG,MRC Cognitive Function and Ageing Neuropathology Study Group.

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We investigate whether admission serum calcium levels are associated with hematoma volume, stroke severity, and outcomes in patients with acute intracerebral hemorrhage. METHODS:A total of 273 patients admitted within 24 hours after intracerebral hemorrhage onset was divided into quartiles based...

journal_title：Stroke

authors： Inoue Y,Miyashita F,Toyoda K,Minematsu K

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Dipyridamole increases the concentration of circulating adenosine, which is a potent vasodilator, by inhibition of uptake of adenosine into the erythrocytes, and hence produces coronary vasodilation. However, the effects of dipyridamole on cerebral circulation is not pronounced. This study invest...

journal_title：Stroke

authors： Ito H,Kinoshita T,Tamura Y,Yokoyama I,Iida H

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Recovery from hemiparesis due to corticospinal tract infarction is well documented, but the mechanism of recovery is unknown. Functional MRI (fMRI) provides a means of identifying focal brain activity related to movement of a paretic hand. Although prior studies have suggested that supplementary ...

journal_title：Stroke

authors： Marshall RS,Perera GM,Lazar RM,Krakauer JW,Constantine RC,DeLaPaz RL

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients with intracerebral hemorrhage and intraventricular hemorrhage have a reported mortality of 50% to 80%. We evaluated a clot lytic treatment strategy for these patients in terms of mortality, ventricular infection, and bleeding safety events, and for its effect on the rate of intraventricu...

journal_title：Stroke

authors： Naff N,Williams MA,Keyl PM,Tuhrim S,Bullock MR,Mayer SA,Coplin W,Narayan R,Haines S,Cruz-Flores S,Zuccarello M,Brock D,Awad I,Ziai WC,Marmarou A,Rhoney D,McBee N,Lane K,Hanley DF Jr

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of the study was to determine the effects of thromboembolism and mechanical thrombectomy on the vessel wall magnetic resonance imaging (VW-MRI) appearance of the intracranial arterial wall. METHODS:This was a cross-sectional study of consecutive patients with acute intracranial arterial ...

journal_title：Stroke

authors： Power S,Matouk C,Casaubon LK,Silver FL,Krings T,Mikulis DJ,Mandell DM

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We obtained magnetization transfer imaging (MTI) scans from individuals with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (1) to investigate the presence, extent, and nature of pathology in white and gray matter outside proton density (PD)-v...

journal_title：Stroke

authors： Iannucci G,Dichgans M,Rovaris M,Brüning R,Gasser T,Giacomotti L,Yousry TA,Filippi M

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Treatment of cerebral sinus thrombosis with heparin is controversial. We conducted a double-blind, placebo-controlled multicenter trial to examine whether anticoagulant treatment improves outcome in patients with sinus thrombosis. METHODS:Patients were randomized between body weight-adjusted sub...

journal_title：Stroke

authors： de Bruijn SF,Stam J

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Screening for dysphagia is essential to the implementation of preventive therapies for patients with stroke. A systematic review was undertaken to determine the evidence-based validity of dysphagia screening items using instrumental evaluation as the reference standard. METHODS:Four databases fr...

journal_title：Stroke

authors： Daniels SK,Anderson JA,Willson PC

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:When carotid artery tandem lesions are present, the benefits of carotid endarterectomy (CEA) to reduce recurrent stroke remain uncertain. The present retrospective cohort study aimed to determine the clinical outcomes of CEA for carotid artery tandem stenosis that was diagnosed by contrast-enhanc...

journal_title：Stroke

authors： Han Y,Park H,Kwon SU,Kang DW,Lee DH,Kwon H,Kwon TW,Cho YP,Kim GE

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intravenous thrombolysis for acute ischemic stroke is usually based on clinical assessment, blood test results, and CT findings. Intravenous thrombolysis of stroke mimics may occur but has not been studied in detail. METHODS:We determined frequency, clinical characteristics, and outcome of mimic...

journal_title：Stroke

authors： Winkler DT,Fluri F,Fuhr P,Wetzel SG,Lyrer PA,Ruegg S,Engelter ST

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Large falls in blood pressure after meals have been demonstrated in fit and frail elderly subjects; these changes may be associated with an increased incidence of stroke. Postprandial falls in BP may be particularly deleterious after acute stroke, when normal baroreflex mechanisms and cerebral au...

journal_title：Stroke

authors： Robinson TG,Potter JF

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The *2 allele of the aldehyde dehydrogenase 2 gene (ALDH2) is the most common variant in Asian populations. The variant resulting in enzyme dysfunction was highly related to coronary artery disease. Recently, genome-wide association studies also discovered that the 12q24 locus near ALDH2 gene was...

journal_title：Stroke

authors： Sung YF,Lu CC,Lee JT,Hung YJ,Hu CJ,Jeng JS,Chiou HY,Peng GS

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The pivotal National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator trials excluded patients with ischemic stroke with specific minor presentations or rapidly improving symptoms. The recombinant tissue plasminogen activator product label notes that its use...

journal_title：Stroke

authors： Khatri P,Kleindorfer DO,Yeatts SD,Saver JL,Levine SR,Lyden PD,Moomaw CJ,Palesch YY,Jauch EC,Broderick JP

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:This study aims to investigate the association between insulin resistance (IR) and silent lacunar infarction (SLI) in healthy adults. METHODS:We recruited 2326 healthy Korean adults who took health checkups, including a brain magnetic resonance imaging. SLI was defined as an infarction measuring...

journal_title：Stroke

authors： Lee JE,Shin DW,Yun JM,Kim SH,Nam YS,Cho B,Lim JS,Jeong HY,Kwon HM,Park JH

更新日期：2016-12-01 00:00:00