Tetrahydrobiopterin, a cofactor for nitric oxide synthase, produces endothelium-dependent dilation of mouse pial arterioles.

abstract：BACKGROUND AND PURPOSE:We hypothesize that in acute middle cerebral artery stroke, thrombus lengths measured in thin-slice nonenhanced CT images define a limit beyond which systemic thrombolysis will fail to recanalize occluded arteries. METHODS:In 138 patients who presented with acute middle cerebral artery stroke an...

journal_title：Stroke

authors： Riedel CH,Zimmermann P,Jensen-Kondering U,Stingele R,Deuschl G,Jansen O

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Endothelial progenitor cells (EPCs) migrate from bone marrow to systemic circulation in response to tissue ischemia where they differentiate into mature endothelial cells for angiogenesis in situ. This study tested the hypothesis that the level of circulating EPCs is substantially increased and p...

journal_title：Stroke

authors： Yip HK,Chang LT,Chang WN,Lu CH,Liou CW,Lan MY,Liu JS,Youssef AA,Chang HW

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To evaluate the periprocedural outcome after carotid artery stenting with embolic brain protection (EBP+) versus without embolic brain protection (EBP-). METHODS:We retrospectively reviewed data from a prospective nonrandomized database of 357 patients who underwent carotid artery stenting in th...

journal_title：Stroke

authors： Tallarita T,Rabinstein AA,Cloft H,Kallmes D,Oderich GS,Brown RD,Lanzino G

更新日期：2011-07-01 00:00:00

abstract：:The plasma concentrations of protein C, an anticoagulant protein, and fibrinopeptide A were measured in 37 patients with acute hemispheric stroke and in age-matched controls with nonvascular neurologic diseases. In 11 stroke patients who died within 15 days after the onset (nonsurvivors) protein C antigen concentratio...

journal_title：Stroke

authors： D'Angelo A,Landi G,Vigano'D'Angelo S,Nobile Orazio E,Boccardi E,Candelise L,Mannucci PM

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients with arteriovenous malformations are younger individuals who are at risk of a stroke or have experienced one. Our objective was to determine these patients' perceptions of quality of life with a stroke by eliciting utility values. METHODS:Utility values were obtained with the standard g...

journal_title：Stroke

authors： Shin AY,Porter PJ,Wallace MC,Naglie G

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) have been used increasingly in recent years to evaluate acute stroke in the emergency setting. In the present study, we compared DWI and PWI findings in acute stroke patients with and without severe extracranial internal caroti...

journal_title：Stroke

authors： Neumann-Haefelin T,Wittsack HJ,Fink GR,Wenserski F,Li TQ,Seitz RJ,Siebler M,Mödder U,Freund HJ

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transient ischemic attack (TIA) initiates an ischemic cascade without resulting in frank infarction and, as such, represents a novel model to study the effects of this ischemic cascade and secondary neurodegeneration in humans. METHODS:Patients with suspected TIA underwent acute brain perfusion ...

journal_title：Stroke

authors： Bivard A,Lillicrap T,Maréchal B,Garcia-Esperon C,Holliday E,Krishnamurthy V,Levi CR,Parsons M

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Visual assessment of cerebrospinal fluid (CSF) for xanthochromia (yellow color) is practiced by the majority of laboratories worldwide as a means of diagnosing intracranical bleeds. METHODS:Colorimetric and spectrophotometric analysis of CSF samples for recognizing the presence of bilirubin either in low co...

journal_title：Stroke

authors： Petzold A,Keir G,Sharpe TL

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral ischemia and stroke are leading causes of morbidity and mortality. An approach to protecting the brain during ischemia is to try to increase the delivery of oxygen via the residual blood flow through and around ischemic tissue. To test this hypothesis, we used a novel oxygen delivery age...

journal_title：Stroke

authors： Watson JC,Doppenberg EM,Bullock MR,Zauner A,Rice MR,Abraham D,Young HF

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:Timing of carotid endarterectomy after stroke in a patient with a fixed neurological deficit remains an important but unresolved question. Early surgery has been associated with cerebral hemorrhage and infarct extension. Delayed endarterectomy exposes the patient to recurrent stroke and carotid occlusion. Th...

journal_title：Stroke

authors： Pritz MB

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The combination of low-dose aspirin and dipyridamole is more effective than aspirin alone in reducing the risk of recurrent stroke and other major cardiovascular events in patients with a recent transient ischemic attack or minor stroke. It is unknown whether this also applies to patients with a ...

journal_title：Stroke

authors： Dippel DW,Maasland L,Halkes P,Kappelle LJ,Koudstaal PJ,Algra A,ESPRIT Study Group and the ESPS-2 Investigators.

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Coated-platelets, a subset of procoagulant platelets observed on dual agonist stimulation with collagen and thrombin, support a robust prothrombinase activity and provide a unique measure of platelet thrombotic potential. Coated-platelet levels are increased in large artery stroke, and higher lev...

journal_title：Stroke

authors： Kirkpatrick AC,Tafur AJ,Vincent AS,Dale GL,Prodan CI

更新日期：2014-10-01 00:00:00

abstract：:We used 44 splenectomized dogs to study the effects of isovolemic hemodilution with a crystalloid solution. The dogs were randomly divided into a hemodilution and a control group. In each group, 17 dogs were subjected to 6 hours of internal carotid and middle cerebral artery occlusion, and five dogs received sham oper...

journal_title：Stroke

authors： Hyodo A,Heros RC,Tu YK,Ogilvy C,Graichen R,Lagree K,Korosue K

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It is not known what fraction of patients with symptomatic cerebral aneurysms are misdiagnosed at initial medical presentation. It is also not clear whether misdiagnosed patients more frequently deteriorate before definitive aneurysm diagnosis and therapy or achieve a poorer outcome than correctl...

journal_title：Stroke

authors： Mayer PL,Awad IA,Todor R,Harbaugh K,Varnavas G,Lansen TA,Dickey P,Harbaugh R,Hopkins LN

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Iron overload has been associated with greater oxidative stress and brain injury in experimental cerebral ischemia and reperfusion. This study investigates whether high serum ferritin levels, as an index of increased cellular iron stores, are associated with poor outcome, hemorrhagic transformati...

journal_title：Stroke

authors： Millan M,Sobrino T,Castellanos M,Nombela F,Arenillas JF,Riva E,Cristobo I,García MM,Vivancos J,Serena J,Moro MA,Castillo J,Dávalos A

更新日期：2007-01-01 00:00:00

abstract：:Background and Purpose- Perihemorrhagic edema (PHE) is associated with poor outcome after intracerebral hemorrhage (ICH). Infiltration of immune cells is considered a major contributor of PHE. Recent studies suggest that immunomodulation via S1PR (sphingosine-1-phosphate receptor) modulators improve outcome in ICH. Si...

journal_title：Stroke

authors： Bobinger T,Manaenko A,Burkardt P,Beuscher V,Sprügel MI,Roeder SS,Bäuerle T,Seyler L,Nagel AM,Linker RA,Engelhorn T,Dörfler A,Horsten SV,Schwab S,Huttner HB

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Fish consumption has been postulated to reduce the risk of stroke. We conducted a dose-response meta-analysis to summarize the evidence from prospective studies regarding the association between fish consumption and stroke risk. METHODS:Pertinent studies were identified by searching Embase and P...

journal_title：Stroke

authors： Larsson SC,Orsini N

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Studies on cardiovascular disease have preferentially involved men because of the lower frequency of the disease in preelderly women. The aim of this analysis was to examine, with the use of a standardized ultrasound protocol, a cohort of women to differentiate early atherosclerotic lesions in di...

journal_title：Stroke

authors： Rubba P,Panico S,Bond MG,Covetti G,Celentano E,Iannuzzi A,Galasso R,Belisario MA,Pastinese A,Sacchetti L,Mancini M,Salvatore F

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Risk-factor modeling has been proposed to identify patients with carotid stenosis who will most benefit from surgery. Validation by independent institutions performing carotid endarterectomy is necessary to determine the applicability of such models to the individual patient. METHODS:A series of...

journal_title：Stroke

authors： Barth A,Bassetti C

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Quality of life (QoL) is important to stroke survivors yet is often recorded as a secondary measure in acute stroke randomized controlled trials. We examined whether commonly used stroke outcome measures captured aspects of QoL. METHODS:We examined primary outcomes by National Institutes of Heal...

journal_title：Stroke

authors： Ali M,Fulton R,Quinn T,Brady M,VISTA Collaboration.

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Enhanced angiogenesis facilitates neurovascular remodeling processes and promotes brain functional recovery after stroke. Previous studies from our laboratory demonstrated that valproate (VPA), a histone deacetylase inhibitor, protects against experimental brain ischemia. The present study invest...

journal_title：Stroke

authors： Wang Z,Tsai LK,Munasinghe J,Leng Y,Fessler EB,Chibane F,Leeds P,Chuang DM

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Purinergic nucleoside inosine elicits protection and regeneration during various injuries. The purpose of this study was to examine the protective effects of inosine against cerebral ischemia. METHODS:Adult Sprague-Dawley rats were anesthetized. Inosine, hypoxathine, or vehicle was administered ...

journal_title：Stroke

authors： Shen H,Chen GJ,Harvey BK,Bickford PC,Wang Y

更新日期：2005-03-01 00:00:00

abstract：:Of 564 consecutive patients with transient ischemic attack, 350 (62%) had cranial computed tomography performed. Except for date of admission and smoking history, there were few differences between the patients evaluated with computed tomography and the 214 who were not. Cerebral infarcts were found in 59 (17%) of the...

journal_title：Stroke

authors： Evans GW,Howard G,Murros KE,Rose LA,Toole JF

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Systemic administration of Toll-like receptor (TLR) 4 and TLR9 agonists before cerebral ischemia have been shown to reduce ischemic injury by reprogramming the response of the brain to stroke. Our goal was to explore the mechanism of TLR-induced neuroprotection by determining whether a TLR7 agoni...

journal_title：Stroke

authors： Leung PY,Stevens SL,Packard AE,Lessov NS,Yang T,Conrad VK,van den Dungen NN,Simon RP,Stenzel-Poore MP

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The epsilon4 allele of the apolipoprotein E (apoE) has been related to the occurrence of myocardial infarction, but its association with ischemic stroke is controversial. We have evaluated the relation between apoE alleles and the occurrence of cerebrovascular ischemia. METHODS:The apoE epsilon ...

journal_title：Stroke

authors： Margaglione M,Seripa D,Gravina C,Grandone E,Vecchione G,Cappucci G,Merla G,Papa S,Postiglione A,Di Minno G,Fazio VM

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aimed to determine if ischemia involving Broca area predicts Broca aphasia more reliably in acute or chronic stroke. METHODS:We included consecutive right-hand-dominant patients with left hemisphere ischemic stroke (<48 hours from onset for acute stroke or >6 months after stroke for chronic s...

journal_title：Stroke

authors： Ochfeld E,Newhart M,Molitoris J,Leigh R,Cloutman L,Davis C,Crinion J,Hillis AE

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Because the diagnosis and treatment of carotid artery disease may reduce the rate of stroke, the aim of this study was to determine whether a diet intervention was associated with incident carotid artery disease. METHODS:Participants were 48 835 postmenopausal women aged 50 to 79 years who were ...

journal_title：Stroke

authors： Allison MA,Aragaki A,Eaton C,Li W,Van Horn L,Daviglus ML,Berger JS

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To test the role of fibrinolysis in stroke, we used a mouse model in which preformed 2.5- to 3-microm-diameter fibrin microemboli are injected into the cerebral circulation. The microemboli lodge in the downstream precapillary vasculature and are susceptible to fibrinolysis. METHODS:We injected ...

journal_title：Stroke

authors： Atochin DN,Murciano JC,Gürsoy-Ozdemir Y,Krasik T,Noda F,Ayata C,Dunn AK,Moskowitz MA,Huang PL,Muzykantov VR

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Acupuncture may be a promising treatment for poststroke paralysis. We conducted a meta-analysis, assessing the efficacy of acupuncture with and without stroke rehabilitation. METHODS:We identified randomized trials comparing acupuncture with no acupuncture within 6 months of stroke by searching ...

journal_title：Stroke

authors： Sze FK,Wong E,Or KK,Lau J,Woo J

更新日期：2002-11-01 00:00:00

abstract：:An overview of the possible factors that might contribute to the development of cerebral vasospasm is presented, with particular emphasis on the possibility that spasm arises from a malfunction of the regulatory or contractile processes in smooth muscle cells. This possibility is emphasized because the evidence for ce...

journal_title：Stroke

authors： Wellum GR,Peterson JW,Zervas NT

更新日期：1985-07-01 00:00:00