Toll-like receptor 7 preconditioning induces robust neuroprotection against stroke by a novel type I interferon-mediated mechanism.

abstract：:Background and Purpose- Low ankle-brachial index (ABI) identifies a stroke subgroup with high risk of recurrent stroke, cardiovascular events, and death. However, limited data exist on the relationship between low ABI and stroke in low and middle-income countries. Therefore, we evaluated the prevalence of ABI ≤0.90 (w...

journal_title：Stroke

authors： Abboud H,Monteiro Tavares L,Labreuche J,Arauz A,Bryer A,Lavados PM,Massaro A,Munoz Collazos M,Steg PG,Yamout BI,Vicaut E,Amarenco P

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The influence of a nocturnal blood pressure dip on stroke recurrence has not yet been clarified. In this pilot study, we attempted to establish a correlation of the nocturnal blood pressure dip with stroke recurrence and development of new silent ischemic lesions in patients with chronic ischemic...

journal_title：Stroke

authors： Nakamura K,Oita J,Yamaguchi T

更新日期：1995-08-01 00:00:00

abstract：:MRI is becoming the imaging modality of choice in patients with ischemic cerebrovascular disease although CT is still the test of choice to exclude acute hemorrhagic stroke. We have briefly reviewed characteristic features of ischemic and hemorrhagic cerebrovascular disease as well as vascular anomalies as seen on MRI...

journal_title：Stroke

authors： Ramadan NM,Deveshwar R,Levine SR

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The trends in stroke incidence reported so far have not been entirely consistent, although declining trends in mortality from stroke have been reported from a number of studies around the world. This study aims to evaluate the 10-year trends (from 1983 through 1992) in incidence, attack rate, and...

journal_title：Stroke

authors： Tuomilehto J,Rastenyte D,Sivenius J,Sarti C,Immonen-Räihä P,Kaarsalo E,Kuulasmaa K,Narva EV,Salomaa V,Salmi K,Torppa J

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this study was to investigate whether the Framingham Cardiovascular Risk Profile and carotid artery intima-media thickness are associated with cortical volume and thickness. METHODS:Consecutive subjects participating in a prospective cohort study of aging and mild cognitive impair...

journal_title：Stroke

authors： Cardenas VA,Reed B,Chao LL,Chui H,Sanossian N,DeCarli CC,Mack W,Kramer J,Hodis HN,Yan M,Buonocore MH,Carmichael O,Jagust WJ,Weiner MW

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A ruptured intracranial aneurysm (IA) is the leading cause of a subarachnoid hemorrhage. This study seeks to define a specific gene whose mutation leads to disease. METHODS:More than 500 IA probands and 100 affected families were enrolled and clinically characterized. Whole exome sequencing was ...

journal_title：Stroke

authors： Santiago-Sim T,Fang X,Hennessy ML,Nalbach SV,DePalma SR,Lee MS,Greenway SC,McDonough B,Hergenroeder GW,Patek KJ,Colosimo SM,Qualmann KJ,Hagan JP,Milewicz DM,MacRae CA,Dymecki SM,Seidman CE,Seidman JG,Kim DH

更新日期：2016-12-01 00:00:00

abstract：:Background and Purpose- The purpose of this study was to assess recent trends in the admission and mortality rates for subarachnoid hemorrhage in Canada. Methods- This retrospective cross-sectional study was based on data retrieved from the Canadian Institute for Health Information for all patients diagnosed with suba...

journal_title：Stroke

authors： Chan V,Lindsay P,McQuiggan J,Zagorski B,Hill MD,O'Kelly C

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND AND PURPOSE:Cannabidiol has been reported to be a neuroprotectant, but the neuroprotective mechanism of cannabidiol remains unclear. We studied the neuroprotective mechanism of cannabidiol in 4-hour middle cerebral artery (MCA) occlusion mice. METHODS:Male MCA occluded mice were treated with cannabidiol, ab...

journal_title：Stroke

authors： Mishima K,Hayakawa K,Abe K,Ikeda T,Egashira N,Iwasaki K,Fujiwara M

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:One of the reasons for the failure of trials of neuroprotection in stroke may be the lack of white matter (WM) protection. However, whether patients entered into typical neuroprotection trials have WM involved in the ischemic process is unknown. We studied patients who were enrolled in neuroprote...

journal_title：Stroke

authors： Ho PW,Reutens DC,Phan TG,Wright PM,Markus R,Indra I,Young D,Donnan GA

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Thrombolytic Therapy in Acute Ischemic Stroke Study, which started in August of 1991, was designed to assess the efficacy and safety of intravenous rtPA (alteplase) in patients with acute (0 to 6 hours) ischemic stroke. In October 1993 enrollment was halted because of Safety Committee (DMSB) ...

journal_title：Stroke

authors： Clark WM,Albers GW,Madden KP,Hamilton S

更新日期：2000-04-01 00:00:00

abstract：:In this retrospective analysis we report our treatment experience in 65 consecutive patients with clinical signs of severe brainstem ischemia with angiographically demonstrated thrombotic vertebrobasilar artery occlusions who received either local intra-arterial thrombolytic therapy (urokinase or streptokinase) (43 pa...

journal_title：Stroke

authors： Hacke W,Zeumer H,Ferbert A,Brückmann H,del Zoppo GJ

更新日期：1988-10-01 00:00:00

abstract：:Life table analysis is a powerful statistical tool that has become the preferred technique for studying both the natural history of and the effect of treatment on disease outcome. We have found only one report using life table analysis to study rehabilitation outcome after stroke. We assessed the recovery of both inde...

journal_title：Stroke

authors： Reding MJ,Potes E

更新日期：1988-11-01 00:00:00

abstract：:Of 171 patients evaluated prospectively and consecutively for cerebral ischemia, 26 (15%) developed symptoms while hospitalized. Cerebral ischemia complicated operative procedures in 12 patients, unsuccessful cardioversion in one and coronary angiography in another. Twelve patients had apparent cerebral embolism and 1...

journal_title：Stroke

authors： Kelley RE,Kovacs AG

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The goal of this study was to determine whether release of endothelium-derived relaxing factor (EDRF) from carotid artery in response to acetylcholine is altered by aging. METHODS:Responses were examined in arteries from Wistar rats 6 to 8 months old (young rats), 24 to 26 months old (old rats),...

journal_title：Stroke

authors： Paternò R,Faraci FM,Heistad DD

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Timing of carotid endarterectomy after stroke in a patient with a fixed neurological deficit remains an important but unresolved question. Early surgery has been associated with cerebral hemorrhage and infarct extension. Delayed endarterectomy exposes the patient to recurrent stroke and carotid occlusion. Th...

journal_title：Stroke

authors： Pritz MB

更新日期：1997-12-01 00:00:00

abstract：:Cerebral blood flow was studied in rabbits immediately following complete circulatory stasis of varying duration. Systemic arterial pressure was measured continuously. The postischemic circulation was examined both by an infusion of carbon black and, in separate experiments, by injection of 14C-antipyrine into the blo...

journal_title：Stroke

authors： Fischer EG,Ames A 3rd,Lorenzo AV

更新日期：1979-07-01 00:00:00

abstract：:The present study deals with the factors affecting the prognosis in the acute stage of 29 cases with hypertensive thalamic hemorrhage diagnosed by CT scan. It was thought that the following factors were significantly related to the outcome of the patients who were unable to lead daily life, remained in vegetative stat...

journal_title：Stroke

authors： Kwak R,Kadoya S,Suzuki T

更新日期：1983-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Chinese patients largely experience acute ischemic stroke (AIS) because of large artery atherosclerosis rather than cardioembolism, and whether tirofiban is safe and effective in these patients treated with endovascular thrombectomy (ET) is unknown. This study evaluated the safety and efficacy of...

journal_title：Stroke

authors： Zhao W,Che R,Shang S,Wu C,Li C,Wu L,Chen J,Duan J,Song H,Zhang H,Ling F,Wang Y,Liebeskind D,Feng W,Ji X

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We have shown that acute treatment with candesartan in an experimental model of stroke resulted in vascular protection and improved outcomes at 24 hours poststroke, but the mechanisms are unknown. We now examine effects of candesartan on proangiogenic factors and 7-day outcomes using the same tre...

journal_title：Stroke

authors： Kozak A,Ergul A,El-Remessy AB,Johnson MH,Machado LS,Elewa HF,Abdelsaid M,Wiley DC,Fagan SC

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Familial aggregation of intracranial aneurysms (IAs) indicates a genetic role in the pathogenesis of this disease. Despite a number of reported susceptibility loci, no disease-causing gene variants have been identified. In this study, we used a parametric genomewide linkage approach to search for...

journal_title：Stroke

authors： Santiago-Sim T,Depalma SR,Ju KL,McDonough B,Seidman CE,Seidman JG,Kim DH

更新日期：2009-03-01 00:00:00

abstract：:We investigated the temporal threshold for focal cerebral infarction in the spontaneously hypertensive rat. The right middle cerebral artery and common carotid artery were occluded for 0, 1, 2, 3, 4, or 24 hours, and all the animals were sacrificed 24 hours after the onset of ischemia. Cortical infarct volumes and ede...

journal_title：Stroke

authors： Kaplan B,Brint S,Tanabe J,Jacewicz M,Wang XJ,Pulsinelli W

更新日期：1991-08-01 00:00:00

abstract：:A new micro T-tube, 0.6 mm in outer diameter, has been constructed. Use of this tube has allowed 1-mm common carotid artery (CCA) bypass ofr periods of time up to 22 minutes. After bypass, scanning electron microscopic observation of sutured CCA endothelium showed widespread destruction, scattered attached platelets a...

journal_title：Stroke

authors： Gregorius FK,Rand RW

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The perfusion territories of the brain-feeding arteries are difficult to assess in vivo and therefore standard cerebral perfusion territory templates are often used to determine the relation between cerebral infarcts and the feeding vasculature. In the present study, we compared this infarct clas...

journal_title：Stroke

authors： Hendrikse J,Petersen ET,Chèze A,Chng SM,Venketasubramanian N,Golay X

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There are few studies analyzing stroke in women, taking into account the vascular risk factors, cause of stroke, clinical picture, and outcome. The purpose of this study was to analyze possible sex differences in patients suffering first-ever acute stroke. METHODS:From December 1995 to January 2...

journal_title：Stroke

authors： Roquer J,Campello AR,Gomis M

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although modern multisequence stroke MRI protocols are an emerging imaging routine for the diagnostic assessment of acute ischemic stroke, their sensitivity for intracerebral hemorrhage (ICH), the most important differential diagnosis, is still a matter of debate. We hypothesized that stroke MRI ...

journal_title：Stroke

authors： Fiebach JB,Schellinger PD,Gass A,Kucinski T,Siebler M,Villringer A,Olkers P,Hirsch JG,Heiland S,Wilde P,Jansen O,Röther J,Hacke W,Sartor K,Kompetenznetzwerk Schlaganfall B5.

更新日期：2004-02-01 00:00:00

abstract：:Background and Purpose- In this era of endovascular therapy (EVT) with early, complete recanalization and reperfusion, we have observed an even more rapid apparent diffusion coefficient (ADC) normalization within the acute ischemic lesion compared with the natural history or IV-tPA-treated patient. In this study, we a...

journal_title：Stroke

authors： Hsia AW,Luby M,Cullison K,Burton S,Armonda R,Liu AH,Leigh R,Nadareishvili Z,Benson RT,Lynch JK,Latour LL

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although the mechanisms that contribute to intracranial aneurysm (IA) formation and rupture are not totally elucidated, inflammation and matrix remodeling are incriminated. Because tPA (tissue-type plasminogen activator) controls both inflammatory and matrix remodeling processes, we hypothesized ...

journal_title：Stroke

authors： Labeyrie PE,Goulay R,Martinez de Lizarrondo S,Hébert M,Gauberti M,Maubert E,Delaunay B,Gory B,Signorelli F,Turjman F,Touzé E,Courthéoux P,Vivien D,Orset C

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Vasogenic brain edema is a frequent complication of ischemic stroke. The mechanism of the blood-brain barrier opening that underlies the edema formation is poorly understood. In the present study we examined the response of endothelial cells cultured from adult human brain to thrombogenic and fib...

journal_title：Stroke

authors： Nagy Z,Kolev K,Csonka E,Pék M,Machovich R

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The efficacy and safety of different antiplatelet regimes for prevention of stroke in patients at high risk were investigated in a systematic review and meta-analysis. METHODS:We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and Web of Science. Twenty-two studies comprisi...

journal_title：Stroke

authors： Gouya G,Arrich J,Wolzt M,Huber K,Verheugt FW,Gurbel PA,Pirker-Kees A,Siller-Matula JM

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cysteine could potentially lower the risk of stroke through antihypertensive and antioxidant effects. Our aim was to evaluate the hypothesis that cysteine intake is inversely associated with stroke incidence. METHODS:We used data from the Swedish Mammography Cohort, a population-based prospectiv...

journal_title：Stroke

authors： Larsson SC,Håkansson N,Wolk A

更新日期：2015-04-01 00:00:00