Siponimod (BAF-312) Attenuates Perihemorrhagic Edema And Improves Survival in Experimental Intracerebral Hemorrhage.

abstract：BACKGROUND AND PURPOSE:Clinical development of novel neuroprotection therapies for the treatment of brain injury has been unsuccessful. One critical limitation is the lack of a viable therapeutic treatment window (TW). In this study, we evaluated the neuroprotection TW for the proteosome inhibitor MLN519 after ischemia...

journal_title：Stroke

authors： Williams AJ,Berti R,Dave JR,Elliot PJ,Adams J,Tortella FC

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transient ischemic attack (TIA) initiates an ischemic cascade without resulting in frank infarction and, as such, represents a novel model to study the effects of this ischemic cascade and secondary neurodegeneration in humans. METHODS:Patients with suspected TIA underwent acute brain perfusion ...

journal_title：Stroke

authors： Bivard A,Lillicrap T,Maréchal B,Garcia-Esperon C,Holliday E,Krishnamurthy V,Levi CR,Parsons M

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Different distributions of cerebral microbleeds (CMBs) are associated with distinct pathological mechanisms. Lobar CMBs are thought to be related to cerebral amyloid angiopathy, whereas deep or infratentorial CMBs are related to hypertensive vasculopathy. The present study aimed to evaluate the e...

journal_title：Stroke

authors： Chung CP,Chou KH,Chen WT,Liu LK,Lee WJ,Chen LK,Lin CP,Wang PN

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Coated-platelets, a subset of procoagulant platelets observed on dual agonist stimulation with collagen and thrombin, support a robust prothrombinase activity and provide a unique measure of platelet thrombotic potential. Coated-platelet levels are increased in large artery stroke, and higher lev...

journal_title：Stroke

authors： Kirkpatrick AC,Tafur AJ,Vincent AS,Dale GL,Prodan CI

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:National Institutes of Health Stroke Scale (NIHSS) item profiles that were recently proposed and validated may prove useful for clinical prognostication and research studies. We aimed to validate the NIHSS item profiles in hyper-acute stroke patients who received thrombolysis treatment (tissue-ty...

journal_title：Stroke

authors： Abdul-Rahim AH,Fulton RL,Sucharew H,Kleindorfer D,Khatri P,Broderick JP,Lees KR,SITS-MOST Steering Committee.

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Increased amount of therapy seems to be beneficial for motor recovery after stroke. The primary aim of the present study was to evaluate the effect of a 4-week community-based intensive motor training program combined with early supported discharge after initial treatment in a comprehensive strok...

journal_title：Stroke

authors： Askim T,Mørkved S,Engen A,Roos K,Aas T,Indredavik B

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Adequate control of blood pressure (BP) is a cornerstone in stroke prevention. This study explored the risk of stroke in relation to the quality of BP control in a population-based cohort and whether control of hypertension was related to background characteristics of patients. METHODS:A total o...

journal_title：Stroke

authors： Li C,Engström G,Hedblad B,Berglund G,Janzon L

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is currently no consensus on (1) the percentage of patients who develop spasticity after ischemic stroke, (2) the relation between spasticity and initial clinical findings after acute stroke, and (3) the impact of spasticity on activities of daily living and health-related quality of life. ...

journal_title：Stroke

authors： Urban PP,Wolf T,Uebele M,Marx JJ,Vogt T,Stoeter P,Bauermann T,Weibrich C,Vucurevic GD,Schneider A,Wissel J

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Enlarged perivascular spaces in the brain are common but generally overlooked and of uncertain pathophysiology. They may reflect underlying cerebral small vessel disease. We determined whether enlarged perivascular spaces were associated with lacunar stroke subtype and white matter hyperintensiti...

journal_title：Stroke

authors： Doubal FN,MacLullich AM,Ferguson KJ,Dennis MS,Wardlaw JM

更新日期：2010-03-01 00:00:00

abstract：:Background and Purpose- Patients with intracerebral hemorrhage (ICH) and atrial fibrillation (AF) are at risk for ischemic events. While risk calculators (CHA2DS2-VASc and HAS-BLED) have been validated to assess risk for ischemic stroke and major bleeding in AF patients, decisions about anticoagulation must consider t...

journal_title：Stroke

authors： Stanton RJ,Eckman MH,Woo D,Moomaw CJ,Haverbusch M,Flaherty ML,Kleindorfer DO

更新日期：2020-03-01 00:00:00

abstract：:Background and Purpose- Given inconclusive studies, it is debated whether clinical and imaging characteristics, as well as functional outcome, differ among patients with intracerebral hemorrhage (ICH) related to vitamin K antagonists (VKA) versus non-vitamin K antagonist (NOAC)-related ICH. Notably, clinical character...

journal_title：Stroke

authors： Gerner ST,Kuramatsu JB,Sembill JA,Sprügel MI,Hagen M,Knappe RU,Endres M,Haeusler KG,Sobesky J,Schurig J,Zweynert S,Bauer M,Vajkoczy P,Ringleb PA,Purrucker JC,Rizos T,Volkmann J,Müllges W,Kraft P,Schubert AL,Erbgut

更新日期：2019-06-01 00:00:00

abstract：:The plasma concentrations of protein C, an anticoagulant protein, and fibrinopeptide A were measured in 37 patients with acute hemispheric stroke and in age-matched controls with nonvascular neurologic diseases. In 11 stroke patients who died within 15 days after the onset (nonsurvivors) protein C antigen concentratio...

journal_title：Stroke

authors： D'Angelo A,Landi G,Vigano'D'Angelo S,Nobile Orazio E,Boccardi E,Candelise L,Mannucci PM

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Aphasia can result in an inability to communicate the presence, location, or intensity of pain. Although visual analogue scales (VASs) exist, it is unknown whether they are useful in assessing pain in individuals with aphasia. The objective was to determine whether those with poststroke aphasia c...

journal_title：Stroke

authors： Korner-Bitensky N,Kehayia E,Tremblay N,Mazer B,Singer F,Tarasuk J

更新日期：2006-02-01 00:00:00

abstract：:Nineteen unanesthetized sheep were given Evans blue dye or radionuclide and then were incrementally bled into hemorrhagic shock (BP less than 50/25) by withdrawal of blood over a period of approximately one hour. Four sheep served as controls for histologic data. Static nuclide brain scans performed in 6 bled sheep d...

journal_title：Stroke

authors： Bronshvag MM

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We studied six patients suffering from pure, unilateral brain stem infarction to explore the association of remote cerebral and cerebellar blood flow changes with damage at different sites of this region of the brain. METHODS:We used single-photon emission computed tomography and [123I]iodoamphe...

journal_title：Stroke

authors： Fazekas F,Payer F,Valetitsch H,Schmidt R,Flooh E

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aim to investigate whether histopathologic examination of thrombi retrieved from acute ischemic stroke patients undergoing endovascular treatment could distinguish cancer-related stroke from other etiologies. METHODS:Thrombi from patients undergoing endovascular treatment were analyzed. The e...

journal_title：Stroke

authors： Fu CH,Chen CH,Lin YH,Lee CW,Tsai LK,Tang SC,Shun CT,Jeng JS

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Some stroke patients complain of an unpleasant sensation of coldness in the hemiplegic arm. This study aimed to determine the prevalence of this symptom and any associated features. METHODS:A questionnaire about symptoms in the arms was sent to patients at least 12 months after stroke. Reflex sy...

journal_title：Stroke

authors： Wanklyn P,Forster A,Young J,Mulley G

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The collagen alpha2(I) gene (COL1A2) on chromosome 7q22.1, a positional and functional candidate for intracranial aneurysm (IA), was extensively screened for susceptibility in Japanese IA patients. METHODS:Twenty-one single nucleotide polymorphisms (SNPs) of COL1A2 were genotyped in genomic DNA ...

journal_title：Stroke

authors： Yoneyama T,Kasuya H,Onda H,Akagawa H,Hashiguchi K,Nakajima T,Hori T,Inoue I

更新日期：2004-02-01 00:00:00

abstract：:I used leg and arm paresis to predict outcome measured as extremity function in a prospective study of 75 consecutive hemiplegic patients admitted to an inpatient stroke rehabilitation unit. In each patient, extremity paresis was quantified according to the five-point scoring system advised by the Medical Research Cou...

journal_title：Stroke

authors： Olsen TS

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It is important to know the costs of hospitalization for patients undergoing endovascular embolectomy so that comparisons can be made with payments to hospitals. METHODS:Using the National Inpatient Sample, we evaluated the costs of hospitalization for patients treated with endovascular embolect...

journal_title：Stroke

authors： Brinjikji W,Kallmes DF,Rabinstein AA,Lanzino G,Cloft HJ

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:In 15% to 20% of patients with a spontaneous subarachnoid hemorrhage, no aneurysm is found on the first angiogram. This review emphasizes that this group of patients is in fact heterogeneous and describes the clinical features, pattern of hemorrhage on early computed tomographic (CT) scan, prognosis, and pro...

journal_title：Stroke

authors： Rinkel GJ,van Gijn J,Wijdicks EF

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In clinical trials and observational studies there is considerable inconsistency in the use of definitions to describe delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage. A major cause for this inconsistency is the combining of radiographic evidence of vasospasm with clinica...

journal_title：Stroke

authors： Vergouwen MD,Vermeulen M,van Gijn J,Rinkel GJ,Wijdicks EF,Muizelaar JP,Mendelow AD,Juvela S,Yonas H,Terbrugge KG,Macdonald RL,Diringer MN,Broderick JP,Dreier JP,Roos YB

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To verify the hemorheological effects of isovolemic hemodilution on hemodynamics and cerebral perfusion of normal humans, we tested the efficacy of isovolemic hemodilution in systemic hemodynamics and cerebral bood flow augmentation and its influences in vascular reserve. METHODS:Isovolemic hemo...

journal_title：Stroke

authors： Tu YK,Liu HM

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral blood flow after cardiac arrest is reduced during the delayed hypoperfusion phase, while cerebral metabolic rate of oxygen returns to baseline values. Hypocapnia can induce cerebral ischemia in neurosurgical patients who already have reduced cerebral blood flow. The purpose of the presen...

journal_title：Stroke

authors： Buunk G,van der Hoeven JG,Meinders AE

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Variation in the outcome after aneurysmal subarachnoid hemorrhage (SAH) is not fully explained by known prognostic factors. APOE genotype is the most important genetic determinant of susceptibility to Alzheimer's disease, and it is also shown to be associated with the outcome after traumatic brai...

journal_title：Stroke

authors： Niskakangas T,Ohman J,Niemelä M,Ilveskoski E,Kunnas TA,Karhunen PJ

更新日期：2001-05-01 00:00:00

abstract：:Background and Purpose- Stroke is the most frequent severe clinical event in patients with Fabry disease. We aimed to evaluate the cerebral magnetic resonance imaging findings of patients with Fabry disease and assess their association with future stroke risk after enzyme replacement therapy (ERT) induction. Methods- ...

journal_title：Stroke

authors： Yagita Y,Sakai N,Miwa K,Ohara N,Tanaka M,Sakaguchi M,Kitagawa K,Mochizuki H

更新日期：2019-09-01 00:00:00

abstract：:We tested the reproducibility of consecutive measurements of regional cerebral blood flow (rCBF) made in 13 areas of each hemisphere in patients with cerebrovascular diseases by the atraumatic 133Xe intravenous injection method. The data were analysed by a two-compartment model similar to that used in the Obrist inhal...

journal_title：Stroke

authors： Meric P,Luft A,Seylaz J,Mamo H

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Dysphagia can lead to pneumonia and subsequent death after acute stroke. However, no prospective study has demonstrated reduced pneumonia prevalence after implementation of a dysphagia screen. METHODS:We performed a single-center prospective interrupted time series trial of a quality initiative ...

journal_title：Stroke

authors： Titsworth WL,Abram J,Fullerton A,Hester J,Guin P,Waters MF,Mocco J

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aimed to determine the effect of intracisternal administration of an endothelin-A receptor antagonist (BQ-123) against vasospasm in a monkey model and to determine whether this drug would have adverse interactions with intracisternal tissue plasminogen activator (TPA). METHODS:Thirty-three mo...

journal_title：Stroke

authors： Kim CJ,Bassiouny M,Macdonald RL,Weir B,Johns LM

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hypothermia reduces neuronal damage in animal stroke models. Whether hypothermia is neuroprotective in patients with acute stroke remains to be clarified. In this case-control study, we evaluated the feasibility and safety of inducing modest hypothermia by a surface cooling method in awake patien...

journal_title：Stroke

authors： Kammersgaard LP,Rasmussen BH,Jørgensen HS,Reith J,Weber U,Olsen TS

更新日期：2000-09-01 00:00:00