Abstract:
BACKGROUND AND PURPOSE:Cerebral blood flow after cardiac arrest is reduced during the delayed hypoperfusion phase, while cerebral metabolic rate of oxygen returns to baseline values. Hypocapnia can induce cerebral ischemia in neurosurgical patients who already have reduced cerebral blood flow. The purpose of the present study was to determine whether comatose patients resuscitated from a cardiac arrest have a normal cerebrovascular reactivity to changes in PaCO2 and whether hypocapnia causes cerebral ischemia. METHODS:We measured mean flow velocity (MFV) and pulsatility index (PI) in the middle cerebral artery, jugular bulb oxygen saturation (SjbO2), and arterial-jugular lactate difference (AJLD) during normo-, hypo-, and hyperventilation in 10 comatose patients resuscitated from a cardiac arrest. The first measurements were made within 6 hours after cardiac arrest and repeated 6, 12, and 24 hours later. RESULTS:During hypoventilation we observed a significant decrease in PI and an increase in MFV and SjbO2. During hyperventilation PI and MFV did not change, but SjbO2 showed a significant decrease. This was accompanied by an increase in AJLD, suggesting cerebral ischemia. In four patients the SjbO2 decreased below the ischemic threshold of 55%. CONCLUSIONS:The cerebrovascular reactivity to changes in arterial carbon dioxide tension is preserved in comatose patients resuscitated from a cardiac arrest. Hyperventilation may induce cerebral ischemia in the postresuscitation period.
journal_name
Strokejournal_title
Strokeauthors
Buunk G,van der Hoeven JG,Meinders AEdoi
10.1161/01.str.28.8.1569subject
Has Abstractpub_date
1997-08-01 00:00:00pages
1569-73issue
8eissn
0039-2499issn
1524-4628journal_volume
28pub_type
杂志文章相关文献
STROKE文献大全abstract::A retrospective analysis of 248 patients with stroke (average age 67, range 17-98) admitted to a stroke rehabilitation unit over a sixteen month period showed that 80% of these patients were able to return home after an average length of stay (LOS) of 43 days. At discharge 85% of the group were ambulatory and 56% requ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.8.6.651
更新日期:1977-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Three-dimensional MRI segmentation may be useful to better understand the physiopathology of lacunar infarctions. Using this technique, the distribution of lacunar infarctions volumes has been recently reported in patients with cerebral autosomal-dominant arteriopathy with subcortical infarcts an...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.520825
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to investigate the mechanisms for oxidative injury caused by subarachnoid hemolysate, a pro-oxidant. METHODS:Injection of 50 microL of subarachnoid hemolysate or saline was performed in CD1 mice (n=75), mutant mice deficient in Mn-superoxide dismutase (Sod2+/-; n=23), and their wild-ty...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.32.2.506
更新日期:2001-02-01 00:00:00
abstract::Background and Purpose- Hyperglycemia is a negative prognostic factor after acute ischemic stroke but is not known whether glucose is associated with the effects of endovascular thrombectomy (EVT) in patients with large-vessel stroke. In a pooled-data meta-analysis, we analyzed whether serum glucose is a treatment mod...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.118.023769
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Comparative effectiveness and safety of oral anticoagulants in patients with atrial fibrillation and high polypharmacy are unknown. METHODS:We used Medicare administrative data to evaluate patients with new atrial fibrillation diagnosis from 2015 to 2017, who initiated an oral anticoagulant with...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.029541
更新日期:2020-07-01 00:00:00
abstract::Spontaneous dissections of the extracranial internal carotid artery are diagnosed more frequently as their clinical and angiographic features are more widely recognized. Familial occurrence of spontaneous dissection of the internal carotid artery has not been previously reported. We describe the occurrence of this ent...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.1.246
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several studies have reported poor outcomes in patients too good to treat with intravenous thrombolysis because of mild or rapidly improving symptoms. We sought to determine baseline clinical and imaging predictors of poor outcome in these patients. METHODS:Among 3950 consecutive stroke admissio...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.014871
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Studies of the cerebroprotective effects of selective brain cooling have failed to show amelioration of ischemic injury in the cerebral cortex. This study was designed to test the hypothesis that mild-to-moderate selective brain cooling initiated after the onset of global brain ischemia in rats p...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.12.1792
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Develop achievable benchmarks for 9 stroke performance measures (PM) and to identify organizational factors associated with adherence. METHODS:Adherence rates and achievable benchmarks were determined for 9 PM within a study of patients (n=2294) admitted with acute ischemic stroke at 17 hospital...
journal_title:Stroke
pub_type: 信件,多中心研究
doi:10.1161/STROKEAHA.107.496570
更新日期:2008-05-01 00:00:00
abstract::Fundus fluorescein angiography was performed in 10 cases of occlusive carotid artery disease at presentation and after surgery or medical treatment. An improvement in the microcirculation of the retina was observed in 4 cases after carotid endarterectomy and in 1 case after carotid endarterectomy and extracranial-intr...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.3.585
更新日期:1987-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Limited data are available on management of outpatients with stroke or transient ischemic attack (TIA) and on clinicians' reasons for withholding procedures recommended by guidelines. We assessed to what extent guidelines are appropriately applied after ischemic stroke or TIA, in admitted patient...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.STR.0000226463.17988.a3
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The typical magnetic resonance imaging picture of arterial dissection, namely, a narrowed eccentric signal void surrounded by a semilunar signal hyper-intensity (corresponding to the mural hematoma) on T1- and T2-weighted images, has been repeatedly reported, but the sensitivity of magnetic reson...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.3.576
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Thick cisternal clot on CT is a well-recognized risk factor for delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). Whether intraventricular hemorrhage (IVH) or intracerebral hemorrhage (ICH) predisposes to DCI is unclear. The Fisher CT grading scale identifies thick SAH but does...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/hs0901.095677
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The presence of known restriction fragment length polymorphisms in the apoprotein A-I-C-III gene cluster, which encodes their respective apoproteins, was investigated using the restriction enzymes Sac I and Pst I to determine the potential role of genetic variations for stroke risk in an American...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.9.1257
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hemodynamic insult by bilateral common carotid artery ligation has been shown to induce aneurysmal remodeling at the basilar terminus in a rabbit model. To characterize critical hemodynamics that initiate this remodeling, we applied a novel hemodynamics-histology comapping technique. METHODS:Eig...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.585992
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Gene transfer to peripheral arteries has been accomplished with catheter-based approaches. Recently, gene transfer to the carotid artery and intracranial vessels has been achieved both in vitro and in vivo. Although gene therapy for cerebral vascular disease may not be accomplished for years, currently avail...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.27.9.1688
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Apraxia of speech (AOS) is a motor speech disorder, which is clinically characterized by the combination of phonemic segmental changes and articulatory distortions. AOS has been believed to arise from impairment in motor speech planning/programming and differentiated from both aphasia and dysarth...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.010402
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Acupuncture may be a promising treatment for poststroke paralysis. We conducted a meta-analysis, assessing the efficacy of acupuncture with and without stroke rehabilitation. METHODS:We identified randomized trials comparing acupuncture with no acupuncture within 6 months of stroke by searching ...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/01.str.0000035908.74261.c9
更新日期:2002-11-01 00:00:00
abstract::Background and Purpose- The importance of weight change for the risk of stroke is not well known. We examined the associations between early- and mid-life weight change and risks of stroke and death during long-term follow-up of healthy men. Methods- We recruited healthy men aged between 40 and 59 years and performed ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.027233
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this study was to assess the costs and cost-effectiveness of intravenous thrombolysis treatment with alteplase (Actilyse) of acute ischemic stroke with 24-hour in-house neurology coverage and use of magnetic resonance imaging. METHODS:A health economic model was designed to calculate ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000251790.19419.a8
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Chronic ocular ischemia is a rare form of ischemia of the eye in patients with carotid artery occlusion (CAO). The early and often asymptomatic stage of chronic ocular ischemia is referred to as venous stasis retinopathy (VSR). The aim of this study was to gain insight into the prevalence, cause,...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/hs0302.104619
更新日期:2002-03-01 00:00:00
abstract::We looked at FiO2, choice of anesthetic, nutritional status, and body temperature in a gerbil model of forebrain ischemia to determine their effect on data interpretation, ischemic outcome, and extent of pharmacologic protection. We subjected 484 gerbils to 5 minutes of forebrain ischemia under different experimental ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.11.1545
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Aspirin is preventive against stroke not only because of its antithrombotic properties but also by other direct effects. The aim of this study was to elucidate its direct neuroprotective effects. METHODS:Viability parameters, glutamate release and uptake, and ATP levels were measured in cultured...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/hs0102.101299
更新日期:2002-01-01 00:00:00
abstract::Experimental subarachnoid hemorrhage was induced in 52 adult male Wistar rats by microsurgical transclival basilar artery puncture. Telencephalic blood flow measured in 24 rats with subarachnoid hemorrhage was compared with that in 23 sham-operated rats and 10 unoperated control rats using the [14C]butanol indicator f...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.4.577
更新日期:1990-04-01 00:00:00
abstract::To compare the diagnostic yields of transesophageal and transthoracic echocardiography in the detection of potential cardiac sources of embolism, 63 patients (mean +/- SD age 63 +/- 15 [range 18-87] years) with transient ischemic attacks or stroke underwent both procedures. Transthoracic echocardiography revealed a po...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.6.727
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intravascular bridges, resulting from developmental anomalies of brain arteries, are now better known as arterial fenestrations. Their tendency to develop aneurysms, similar to arterial bifurcations, makes their anatomy and microstructure important for study. METHODS:Six segments of artery, each...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.9.1799
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Endothelial progenitor cells (EPCs) migrate from bone marrow to systemic circulation in response to tissue ischemia where they differentiate into mature endothelial cells for angiogenesis in situ. This study tested the hypothesis that the level of circulating EPCs is substantially increased and p...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.489401
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There have been few community-based studies of long-term prognosis after acute stroke. This study aims to provide precise estimates of the absolute and relative risks of stroke recurrence in an unselected cohort of patients with a first-ever stroke. METHODS:Six hundred seventy-five patients were...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.2.333
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Efforts to increase the availability and shorten the time delivery of intravenous thrombolysis in patients with acute ischemic stroke carry the potential for tissue plasminogen activator administration in patients with diseases other than stroke, that is, stroke mimics (SMs). We aimed to determin...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.609339
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Previous studies reported that Tat-NR2B9c, a peptide disrupting the N-methyl-d-aspartate receptor-postsynaptic density protein-95 interaction, reduced ischemic damage in the acute phase after stroke. However, its effect in the subacute phase is unknown. The aim of this study is to determine wheth...
journal_title:Stroke
pub_type: 杂志文章,收录出版
doi:10.1161/STROKEAHA.115.008886
更新日期:2015-05-01 00:00:00