Abstract:
BACKGROUND AND PURPOSE:Aspirin is preventive against stroke not only because of its antithrombotic properties but also by other direct effects. The aim of this study was to elucidate its direct neuroprotective effects. METHODS:Viability parameters, glutamate release and uptake, and ATP levels were measured in cultured cortical neurons exposed to oxygen-glucose deprivation (OGD). In addition, ATP levels and oxygen consumption were studied in isolated brain mitochondria or submitochondrial particles. RESULTS:Aspirin inhibited OGD-induced neuronal damage at concentrations lower (0.3 mmol/L) than those reported to act via inhibition of the transcription factor nuclear factor-kappaB (which are >1 mmol/L), an effect that correlated with the inhibition caused by aspirin on glutamate release. This effect was shared by sodium salicylate but not by indomethacin, thus excluding the involvement of cyclooxygenase. A pharmacological dissection of the components involved indicated that aspirin selectively inhibits the increase in extracellular glutamate concentration that results from reversal of the glutamate transporter, a component of release that is due to ATP depletion. Moreover, aspirin-afforded neuroprotection occurred in parallel with a lesser decrease in ATP levels after OGD. Aspirin elevated ATP levels not only in intact cortical neurons but also in isolated brain mitochondria, an effect concomitant with an increase in NADH-dependent respiration by brain submitochondrial particles. CONCLUSIONS:Taken together, our present findings show a novel mechanism for the neuroprotective effects of aspirin, which takes place at concentrations in the antithrombotic-analgesic range, useful in the management of patients with high risk of ischemic events.
journal_name
Strokejournal_title
Strokeauthors
De Cristóbal J,Cárdenas A,Lizasoain I,Leza JC,Fernández-Tomé P,Lorenzo P,Moro MAdoi
10.1161/hs0102.101299subject
Has Abstractpub_date
2002-01-01 00:00:00pages
261-7issue
1eissn
0039-2499issn
1524-4628journal_volume
33pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Apolipoprotein E (apoE) epsilon 4 allele has been associated with a high risk for coronary heart disease. Increased frequency of the epsilon 4 allele has also been reported in patients with late-onset familial and sporadic Alzheimer's disease (AD). The aim of this study was to investigate the deg...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.5.743
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Transcranial color-coded duplex sonography (TCCS) enables visualization of the intracranial parenchymal structures and measurement of blood flow velocity in the basal cerebral arteries. The present study aims to evaluate prospectively the clinical usefulness of TCCS in patients with acute stroke....
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.11.2061
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:lipoprotein(a) [Lp(a)] level is an established risk factor for coronary artery disease and has been implicated in carotid artery disease (CAAD). The relationship between genetic variation in the LPA gene region and CAAD risk remains unknown. METHODS:we genotyped single nucleotide polymorphisms (...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.110.591230
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We previously reported increased incidence of ischemic stroke among both blacks and whites with diabetes mellitus, especially in those aged <55 years. With rising prevalence of diabetes mellitus in the past decade, we revisit the impact of diabetes mellitus on stroke incidence in the same populat...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.113.001318
更新日期:2013-06-01 00:00:00
abstract::Background and Purpose- Preterm neonates with intraventricular hemorrhage (IVH) are at risk for posthemorrhagic hydrocephalus and poor neurological outcomes. Iron has been implicated in ventriculomegaly, hippocampal injury, and poor outcomes following IVH. We hypothesized that levels of cerebrospinal fluid blood break...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.119.028744
更新日期:2020-06-01 00:00:00
abstract::In an attempt to determine the usefulness of evoked potentials as a measure of focal cerebral ischemia, we examined somatosensory evoked potentials (SEP's) and morphological neuronal changes in cats following unilateral middle cerebral artery (MCA) occlusion. Fifteen adult cats underwent transorbital occlusion of the ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.6.1193
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Whether newly diagnosed atrial fibrillation (nAF) after stroke reflects underlying heart disease and represents an increased risk of cardioembolic stroke, or whether it is triggered by neurogenic mechanisms remains uncertain. We investigated, whether cardiovascular risk factors and echocardiograp...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.011465
更新日期:2016-02-01 00:00:00
abstract::Hemodynamic changes were examined with an ultrasonic Doppler flowmeter and with a sound-spectrograph in 5 patients with internal carotid giant aneurysms or with recurrent laryngeal cancer undergoing gradual carotid occlusion. The ultrasonic Doppler technique was useful for preoperative assessment of intracranial cross...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.12.2.177
更新日期:1981-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The rarity of intracranial vascular malformations (IVMs) and the infrequency of their outcomes make large, prolonged cohort studies the best means to evaluate their frequency and prognosis. METHODS:The Scottish Intracranial Vascular Malformation Study (SIVMS) is a prototype prospective, populati...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.STR.0000069012.23858.69
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A full appreciation of the presence of cerebral vascular lesions in cognitively impaired patients can be ultimately reached at the neuropathological level. However, there are no detailed guidelines regarding what neuropathologists should look for at autopsy in cases of suspected vascular dementia...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.STR.0000206445.97511.ae
更新日期:2006-04-01 00:00:00
abstract:UNLABELLED:The pathophysiology of postischemic encephalopathy is complex, and includes tissue acidosis, edema, hypoperfusion, membrane dysfunction, impaired energy production, and possibly hypermetabolism. We tested the hypothesis that this multifactorial clinical problem must be approached with multifaceted therapy, w...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.15.5.803
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is an inverse association between dairy food consumption and the incidence of stroke in observational studies. However, it is unknown whether the relationship is causal or, if so, what components in milk are responsible for reducing the incidence of stroke. METHODS:Stroke-prone spontaneous...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.618496
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Whether and how the arterial pathology underlying lacunar ischemic stroke differs from the atherothrombotic processes causing most other ischemic strokes is still debated. Different risks of recurrent stroke and MI after lacunar versus nonlacunar ischemic stroke may support a distinct lacunar art...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.558221
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Research on the relationship between caffeine-containing medicines (CCMs) and the risk of hemorrhagic stroke (HS) is sparse. The aim of this study is to evaluate the association between CCMs and the risk of HS. METHODS:We performed a multicenter case-control study in South Korea, from 2002 to 20...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.111.674077
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The modified Rankin Scale (mRS) is the recommended functional outcome assessment in stroke trials. Utility of mRS may be limited by interobserver variability. prestroke function, described using mRS, is often used as trial entry criterion. We assessed the reliability and validity of prestroke mRS...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.670422
更新日期:2012-12-01 00:00:00
abstract::The angiographic, clinical, and genetic characteristics of fibromuscular dysplasia (FMD) are reviewed in 37 patients (mean age 48 years) selected from a pool of 4000 angiograms of carotid or vertebral arteries. FMD was a neglected pathogenic factor in 28 patients with hemorrhagic or ischemic cerebral lesions. The aneu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.13.1.46
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hyperglycemia on admission is common after ischemic stroke. It is associated with unfavorable outcome after treatment with intravenous thrombolysis and after intra-arterial treatment. Whether hyperglycemia influences the effect of reperfusion treatment is unknown. We assessed whether increased ad...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.116.016071
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The effect of statins on progression of carotid intima-media complex thickness (IMT) has been shown exclusively in nonstroke Western patients. This study aimed to determine the effect of low-dose pravastatin on carotid IMT in Japanese patients with noncardioembolic ischemic stroke. METHODS:This ...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.117.018387
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Neonatal stroke is increasingly recognized with an estimated incidence of one in 4000 live births per year. Pathways involved in the pathophysiology of neonatal stroke are diverse and may include thrombosis and thrombolysis, vascular reactivity, and inflammation. METHODS:We compared frequencies ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000244810.91105.c9
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Physical and psychological characteristics in adolescence are associated with subsequent stroke risk. Our aim is to investigate their relevance to length of hospital stay and risk of second stroke. METHODS:Swedish men born between 1952 and 1956 (n=237 879) were followed from 1987 to 2010 using i...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.014265
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The success of gait rehabilitation after stroke depends on active walking exercises. However, the disabling after-effects of stroke often make such exercises impossible at the onset of therapy. To facilitate treadmill training of paraparetic patients, a robot-driven gait orthosis (Lokomat) was de...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/01.STR.0000254607.48765.cb
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke is a debilitating disease with long-term social and economic consequences. As new therapies for acute ischemic stroke are forthcoming, there is an increasing need to understand their long-term economic implications. To address this need, a stroke economic model was created. METHODS:The mo...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.12.2574
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Depression after stroke is common. Like stroke, transient ischemic attack (TIA) is a manifestation of long-term atherosclerotic damage to the brain. However, the risk of depression developing after a TIA is uncertain. We studied whether TIA increases the risk of incident late-life depression. ME...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.604405
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The neck clipping of cerebral aneurysms is a well-established treatment for subarachnoid hemorrhage (SAH) caused by aneurysmal rupture. However, it is still unclear how great a risk of recurrence patients with a successfully treated aneurysm carry over a long-term period. METHODS:Of 425 patients...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.12.2511
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Sleep-disordered breathing (SDB) represents a risk factor for cardiovascular morbidity after a cerebral ischemic event (acute ischemic event, ischemic stroke, or transient ischemic attack). In the present study, endothelial function and arterial stiffness were analyzed in patients who experienced...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/STROKEAHA.111.000112
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Carotid endarterectomy is an effective method for preventing strokes if patients do not suffer adverse perioperative outcomes. The purpose of this study was to identify preoperative patient risk factors for adverse outcomes (death or nonfatal stroke) after carotid endarterectomy through the use o...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.STR.0000092491.45227.0F
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral infarction in sickle cell disease is associated with arterial narrowing or occlusions of intracranial arteries. Primary stroke prevention would be feasible if a noninvasive screening test could be developed to detect intracranial disease in patients before symptoms develop. METHODS:To d...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.8.1073
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Elevated low density lipoprotein and reduced high density lipoprotein cholesterol may increase the risk of atherothrombotic brain infarction, but the metabolic mechanisms accounting for this relation are poorly understood. METHODS:The kinetic parameters of low density and high density lipoprotei...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.9.1265
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Embolism is believed to be the major cause of stroke in patients with nonvalvular atrial fibrillation (NVAF). The detection of asymptomatic embolic signals (ES) in individuals with NVAF might allow identification of patients at high risk of stroke and monitoring of therapy in individual subjects....
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.9.1810
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is evidence of unequal access to health care interventions even where universal health systems operate. We investigated associations between patients' sociodemographic characteristics and the provision of acute and longer-term stroke care in a multiethnic urban population. METHODS:We used ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000152332.32267.19
更新日期:2005-02-01 00:00:00