Postmortem examination of vascular lesions in cognitive impairment: a survey among neuropathological services.

Abstract:

BACKGROUND AND PURPOSE:A full appreciation of the presence of cerebral vascular lesions in cognitively impaired patients can be ultimately reached at the neuropathological level. However, there are no detailed guidelines regarding what neuropathologists should look for at autopsy in cases of suspected vascular dementia or vascular cognitive impairment. We aimed at surveying the postmortem neuropathological procedures used in different centers in examining brain lesions of presumable or possible vascular origin in cognitively impaired patients. METHODS:Thirteen laboratories participated in the survey by filling in a semistructured questionnaire. We reviewed sampling and histology procedures in use and the neuropathological definitions of some of these lesions. Neuropathological criteria for the definition of a vascular origin of the dementing process were also surveyed. RESULTS:A large variability across centers was observed in the procedures used for the neuropathological examination and the histology techniques. Heterogeneity existed also in the definition of commonly found lesions (eg, white matter alterations, small vessel disease), interpretation of whether or not the lesions were reputed to be of vascular origin, and consequently in the interpretation of the cause of cognitive decline. CONCLUSIONS:The appreciation of the presence of neuropathologically verified vascular lesions in cognitively impaired cases may be heavily influenced by the laboratory tools used and also by the heterogeneity of the criteria applied in different centers. Harmonization of neuropathological procedures is badly needed in the field of vascular dementia and vascular cognitive impairment to better understand the association between various vascular lesions and clinical symptoms such as cognitive impairment.

journal_name

Stroke

journal_title

Stroke

authors

Pantoni L,Sarti C,Alafuzoff I,Jellinger K,Munoz DG,Ogata J,Palumbo V

doi

10.1161/01.STR.0000206445.97511.ae

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

1005-9

issue

4

eissn

0039-2499

issn

1524-4628

pii

01.STR.0000206445.97511.ae

journal_volume

37

pub_type

杂志文章,多中心研究

相关文献

STROKE文献大全
  • Blend Sign on Computed Tomography: Novel and Reliable Predictor for Early Hematoma Growth in Patients With Intracerebral Hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Early hematoma growth is not uncommon in patients with intracerebral hemorrhage and is an independent predictor of poor functional outcome. The purpose of our study was to report and validate the use of our newly identified computed tomographic (CT) blend sign in predicting early hematoma growth....

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.115.009185

    authors: Li Q,Zhang G,Huang YJ,Dong MX,Lv FJ,Wei X,Chen JJ,Zhang LJ,Qin XY,Xie P

    更新日期:2015-08-01 00:00:00

  • Endovascular Treatment for Acute Ischemic Stroke in Patients on Oral Anticoagulants: Results From the MR CLEAN Registry.

    abstract::Background and Purpose- The use of oral anticoagulants (OAC) is considered a contra-indication for intravenous thrombolytics as acute treatment of ischemic stroke. However, little is known about the risks and benefits of endovascular treatment in patients on prior OAC. We aim to compare outcomes after endovascular tre...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/STROKEAHA.119.028675

    authors: Goldhoorn RB,van de Graaf RA,van Rees JM,Lingsma HF,Dippel DWJ,Hinsenveld WH,Postma A,van den Wijngaard I,van Zwam WH,van Oostenbrugge RJ,Roozenbeek B,MR CLEAN Registry Investigators—Group Authors.

    更新日期:2020-06-01 00:00:00

  • The relevance of in vitro smooth muscle experiments to cerebral vasospasm.

    abstract::An overview of the possible factors that might contribute to the development of cerebral vasospasm is presented, with particular emphasis on the possibility that spasm arises from a malfunction of the regulatory or contractile processes in smooth muscle cells. This possibility is emphasized because the evidence for ce...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/01.str.16.4.573

    authors: Wellum GR,Peterson JW,Zervas NT

    更新日期:1985-07-01 00:00:00

  • Association of prestroke statin use and lipid levels with outcome of intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:It is unclear whether blood lipid profiles and statin use before intracerebral hemorrhage (ICH) are associated with its outcome. METHODS:The Helsinki ICH Study, a single-center observational registry of consecutive ICH patients, was used to study the associations between premorbid statin use, ba...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.113.001829

    authors: Mustanoja S,Strbian D,Putaala J,Meretoja A,Curtze S,Haapaniemi E,Sairanen T,Hietikko R,Sirén J,Kaste M,Tatlisumak T

    更新日期:2013-08-01 00:00:00

  • Leptomeningeal Collateral Flow Modifies Endovascular Treatment Efficacy on Large-Vessel Occlusion Strokes.

    abstract:BACKGROUND AND PURPOSE:We aim to evaluate if good collateral flow (CF) modifies endovascular therapy (EVT) efficacy on large-vessel stroke. To do that, we used final degree of reperfusion and number of device-passes performed, factors previously associated with better functional outcome, as main outcome measures. METH...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.120.031338

    authors: García-Tornel Á,Ciolli L,Rubiera M,Requena M,Muchada M,Pagola J,Rodriguez-Luna D,Deck M,Juega J,Rodríguez-Villatoro N,Boned S,Olivé-Gadea M,Sanjuan E,Tomasello A,Piñana C,Hernández D,Álvarez-Sabin J,Molina CA,Ribó M

    更新日期:2021-01-01 00:00:00

  • Predictors of long-term mortality in patients with ischemic stroke referred for transesophageal echocardiography.

    abstract:BACKGROUND AND PURPOSE:Findings on transesophageal echocardiography (TEE) after ischemic stroke predict recurrent embolic events and prompt therapy; however, the additive predictive power of TEE findings on long-term mortality is unknown. Our goal was to study the impact of TEE findings on all cause mortality in ischem...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000196939.12313.16

    authors: Ward RP,Don CW,Furlong KT,Lang RM

    更新日期:2006-01-01 00:00:00

  • Ten-year trends in stroke incidence and mortality in the FINMONICA Stroke Study.

    abstract:BACKGROUND AND PURPOSE:The trends in stroke incidence reported so far have not been entirely consistent, although declining trends in mortality from stroke have been reported from a number of studies around the world. This study aims to evaluate the 10-year trends (from 1983 through 1992) in incidence, attack rate, and...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.27.5.825

    authors: Tuomilehto J,Rastenyte D,Sivenius J,Sarti C,Immonen-Räihä P,Kaarsalo E,Kuulasmaa K,Narva EV,Salomaa V,Salmi K,Torppa J

    更新日期:1996-05-01 00:00:00

  • D-4F Decreases White Matter Damage After Stroke in Mice.

    abstract:BACKGROUND AND PURPOSE:Stroke-induced neuroinflammation and white matter damage are associated with neurological deficits. Whether D-4F, an apolipoprotein A-I mimetic peptide, treatment of stroke decreases neuroinflammation and white matter damage and improves functional outcome has not been investigated. METHODS:Adul...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.115.011046

    authors: Cui X,Chopp M,Zacharek A,Cui C,Yan T,Ning R,Chen J

    更新日期:2016-01-01 00:00:00

  • Total cerebral ischemia: application of a new model system to studies of cerebral microcirculation.

    abstract::Reduction in cerebral blood flow (CBF) following global ischemia has been implicated as a pathogenetic mechanism in progressive brain damage seen after restoration of effective cardiac action and cerebral perfusion pressure. There are serious limitations to many of the techniques for measuring regional cerebral blood ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.12.1.66

    authors: Jackson DL,Dole WP,McGloin J,Rosenblatt JI

    更新日期:1981-01-01 00:00:00

  • Role of transcranial Doppler and stump pressure during carotid endarterectomy.

    abstract:BACKGROUND AND PURPOSE:The aim of our study was to clarify the pathophysiology of perioperative cerebral complications during carotid endarterectomy in our series. METHODS:By means of transcranial Doppler ultrasonography and stump pressure measurement, we monitored 112 patients who underwent carotid endarterectomy und...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.12.2448

    authors: Finocchi C,Gandolfo C,Carissimi T,Del Sette M,Bertoglio C

    更新日期:1997-12-01 00:00:00

  • Functional walk tests in individuals with stroke: relation to perceived exertion and myocardial exertion.

    abstract:BACKGROUND AND PURPOSE:Functional walk tests such as the 6- and 12-Minute Walk Test (ie, 6MWT and 12MWT, respectively) are submaximal measures used to determine functional capacity in individuals with compromised ability. The purpose of this study was to determine the relationship between these walk tests and measures ...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/hs0302.104195

    authors: Eng JJ,Chu KS,Dawson AS,Kim CM,Hepburn KE

    更新日期:2002-03-01 00:00:00

  • Changes in stroke mortality rates for 1950 to 1997: a great slowdown of decline trend in Japan.

    abstract:BACKGROUND AND PURPOSE:Stroke is the second leading cause of death in Japan. We sought to examine changes in stroke mortality rates by age, sex, and birth cohorts from 1950 to 1997. METHODS:The numbers of deaths from stroke and the population by age and sex in subjects aged 55 to 79 years between 1950 and 1997 were ob...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.32.8.1745

    authors: Liu L,Ikeda K,Yamori Y

    更新日期:2001-08-01 00:00:00

  • Ischemic neuroprotection with selective kappa-opioid receptor agonist is gender specific.

    abstract:BACKGROUND AND PURPOSE:We demonstrated previously that treatment with selective kappa-opioid receptor (KOR) agonist BRL 52537 hydrochloride [(+/-)-1-(3,4-dichlorophenyl) acetyl-2-(1-pyrrolidinyl) methylpiperidine] (1) has a long therapeutic window for providing ischemic neuroprotection, and (2) attenuates ischemia-evok...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000169928.76321.3d

    authors: Chen CH,Toung TJ,Hurn PD,Koehler RC,Bhardwaj A

    更新日期:2005-07-01 00:00:00

  • Impact of early blood pressure variability on stroke outcomes after thrombolysis: the SAMURAI rt-PA Registry.

    abstract:BACKGROUND AND PURPOSE:The present study determines associations between early blood pressure (BP) variability and stroke outcomes after intravenous thrombolysis. METHODS:In 527 stroke patients receiving intravenous alteplase (0.6 mg/kg), BP was measured 8 times within the first 25 hours. BP variability was determined...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.112.681007

    authors: Endo K,Kario K,Koga M,Nakagawara J,Shiokawa Y,Yamagami H,Furui E,Kimura K,Hasegawa Y,Okada Y,Okuda S,Namekawa M,Miyagi T,Osaki M,Minematsu K,Toyoda K

    更新日期:2013-03-01 00:00:00

  • The pilot Stroke Data Bank: definition, design, and data.

    abstract::Four university centers collaborated to contribute 1158 patients with acute episodes of cerebrovascular disease to the pilot Stroke Data Bank, initiated by NINCDS in 1978. During the pilot project a standard set of data collection forms were developed and used at each of the collaborating centers. Data on clinical cou...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.15.4.740

    authors: Kunitz SC,Gross CR,Heyman A,Kase CS,Mohr JP,Price TR,Wolf PA

    更新日期:1984-07-01 00:00:00

  • Leonurine protects middle cerebral artery occluded rats through antioxidant effect and regulation of mitochondrial function.

    abstract:BACKGROUND AND PURPOSE:Oxidative stress is known to be involved in ischemic stroke. Intense interest is drawn to the therapeutic potential of Chinese herbs on ischemic stroke because many of them contain antioxidant properties. Leonurine, 1 of the active compounds from purified Herba Leonuri, was studied to evaluate it...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.589895

    authors: Loh KP,Qi J,Tan BK,Liu XH,Wei BG,Zhu YZ

    更新日期:2010-11-01 00:00:00

  • Relation of laboratory and clinical variables to the grade of carotid atherosclerosis.

    abstract:BACKGROUND AND PURPOSE:To clarify diagnostic entities in ischemic stroke we analyzed the relation between the severity of carotid atherosclerosis, coagulation parameters, lipoproteins, neurological status, and risk factors in 232 patients. METHODS:Duplex ultrasonography, computed tomography scan, and laboratory invest...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.24.12.1811

    authors: Szirmai IG,Kamondi A,Magyar H,Juhász C

    更新日期:1993-12-01 00:00:00

  • Changes of neural activity correlate with the severity of cortical ischemia in patients with unilateral major cerebral artery occlusion.

    abstract:BACKGROUND AND PURPOSE:In major cerebral arterial steno-occlusive diseases, there can be remarkably decreased hemodynamic reserve without marked neurological impairments. In such settings, it is not known whether the neural activity is well maintained or disturbed according to the severity of cerebral ischemia. The pre...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/hs0102.101816

    authors: Bundo M,Inao S,Nakamura A,Kato T,Ito K,Tadokoro M,Kabeya R,Sugimoto T,Kajita Y,Yoshida J

    更新日期:2002-01-01 00:00:00

  • Efficacy of Endovascular Therapy in Acute Ischemic Stroke Depends on Age and Clinical Severity.

    abstract:BACKGROUND AND PURPOSE:Efficacy of endovascular treatment (EVT) for ischemic stroke because of large vessel occlusion may depend on patients' age and stroke severity; we, therefore, developed a prognosis score based on these variables and examined whether EVT efficacy differs between patients with good, intermediate, o...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.020511

    authors: Le Bouc R,Clarençon F,Meseguer E,Lapergue B,Consoli A,Turc G,Naggara O,Duong DL,Servan J,Reiner P,Labeyrie MA,Fisselier M,Blanc R,Farhat W,Pires C,Zuber M,Obadia M,Mazighi M,Pico F,Mas JL,Amarenco P,Samson Y,P

    更新日期:2018-07-01 00:00:00

  • The measurement of cerebral blood flow in the rat.

    abstract::Cerebral blood flow (CBF) was determined in the rat under 70% nitrous oxide anesthesia and pentobarbital anesthesia. The application of the Fick principle technique of Kety et al. was modified utilizing 133Xe infused intravenously steadily for 30 seconds, at which time the animal was decapitated and the head frozen in...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.6.6.630

    authors: Matsumoto A,Namon R,Utsunomiya Y,Kogure K,Scheinberg P,Reinmuth OM

    更新日期:1975-11-01 00:00:00

  • Low serum calcium levels contribute to larger hematoma volume in acute intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:We investigate whether admission serum calcium levels are associated with hematoma volume, stroke severity, and outcomes in patients with acute intracerebral hemorrhage. METHODS:A total of 273 patients admitted within 24 hours after intracerebral hemorrhage onset was divided into quartiles based...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.113.001187

    authors: Inoue Y,Miyashita F,Toyoda K,Minematsu K

    更新日期:2013-07-01 00:00:00

  • Assessment of the Most Optimal Control Tissue for Intracranial Aneurysm Gene Expression Studies.

    abstract::Background and Purpose- Finding adequate control tissue for intracranial aneurysm (IA) pathophysiological studies, including gene expression studies, can be challenging. We compared gene expression profiles of superficial temporal, cortical, and circle of Willis (CoW) arteries and IA in search of the most optimal cont...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.119.024881

    authors: Laarman MD,Kleinloog R,Bakker MK,Rinkel GJE,Bakkers J,Ruigrok YM

    更新日期:2019-10-01 00:00:00

  • Circadian fluctuations in onset of subarachnoid hemorrhage. New data on aneurysmal and perimesencephalic hemorrhage and a systematic review.

    abstract:BACKGROUND AND PURPOSE:Several studies have found a morning peak in onset of stroke. A similar peak has been suggested for subarachnoid hemorrhage (SAH), which seems in contradiction with the physical activities associated with aneurysmal rupture. Most studies included only a few patients with SAH. We analyzed time of ...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/01.str.28.4.805

    authors: Vermeer SE,Rinkel GJ,Algra A

    更新日期:1997-04-01 00:00:00

  • Cerebral hemodynamic response to mental activation in normo- and hypercapnia.

    abstract::Changes of regional cerebral blood flow from rest to mental activation by a visually presented spatial reasoning test were measured during normo- and hypercapnia in 10 healthy subjects. Hypercapnia, elicited by inhalation of 6% CO2, resulted in similar flow increases in all 32 cortical regions measured. Increases of f...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.11.4.342

    authors: Maximilian VA,Prohovnik I,Risberg J

    更新日期:1980-07-01 00:00:00

  • Hemoglobin-induced cytotoxicity in rat cerebral cortical neurons: caspase activation and oxidative stress.

    abstract:BACKGROUND AND PURPOSE:Apoptotic-like pathways may contribute to brain cell death after intracerebral hemorrhage. In this study, we used a simplified in vitro model of hemoglobin neurotoxicity to map the caspase cascades involved and to document the role of oxidative stress. METHODS:Primary neuronal cultures were obta...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.0000020121.41527.5d

    authors: Wang X,Mori T,Sumii T,Lo EH

    更新日期:2002-07-01 00:00:00

  • Successful Reperfusion With Mechanical Thrombectomy Is Associated With Reduced Disability and Mortality in Patients With Pretreatment Diffusion-Weighted Imaging-Alberta Stroke Program Early Computed Tomography Score ≤6.

    abstract:BACKGROUND AND PURPOSE:In acute ischemic stroke patients, diffusion-weighted imaging (DWI)-Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is correlated with infarct volume and is an independent factor of functional outcome. Patients with pretreatment DWI-ASPECTS ≤6 were excluded or under-represented i...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.116.015202

    authors: Desilles JP,Consoli A,Redjem H,Coskun O,Ciccio G,Smajda S,Labreuche J,Preda C,Ruiz Guerrero C,Decroix JP,Rodesch G,Mazighi M,Blanc R,Piotin M,Lapergue B,ETIS (Endovascular Treatment in Ischemic Stroke) Research Investigator

    更新日期:2017-04-01 00:00:00

  • Safety and efficacy of transcranial direct current stimulation in acute experimental ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:Transcranial direct current stimulation is emerging as a promising tool for the treatment of several neurological conditions, including cerebral ischemia. The therapeutic role of this noninvasive treatment is, however, limited to chronic phases of stroke. We thus ought to investigate whether diff...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.113.001687

    authors: Peruzzotti-Jametti L,Cambiaghi M,Bacigaluppi M,Gallizioli M,Gaude E,Mari S,Sandrone S,Cursi M,Teneud L,Comi G,Musco G,Martino G,Leocani L

    更新日期:2013-11-01 00:00:00

  • Is the acetazolamide test valid for quantitative assessment of maximal cerebral autoregulatory vasodilation? An experimental study.

    abstract:BACKGROUND AND PURPOSE:The cerebral vasodilating effect of acetazolamide (ACZ) injection has been used as an index of the autoregulatory vasodilation (or cerebral perfusion reserve). The question of whether the ACZ test assesses the maximal autoregulatory vasodilating capacity is not definitely resolved. The effects of...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.31.2.508

    authors: Démolis P,Florence G,Thomas L,Tran Dinh YR,Giudicelli JF,Seylaz J,Alkayed NJ

    更新日期:2000-02-01 00:00:00

  • Adopting a Patient-Centered Approach to Primary Outcome Analysis of Acute Stroke Trials Using a Utility-Weighted Modified Rankin Scale.

    abstract:BACKGROUND AND PURPOSE:Although the modified Rankin Scale (mRS) is the most commonly used primary end point in acute stroke trials, its power is limited when analyzed in dichotomized fashion and its indication of effect size challenging to interpret when analyzed ordinally. Weighting the 7 Rankin levels by utilities ma...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析

    doi:10.1161/STROKEAHA.114.008547

    authors: Chaisinanunkul N,Adeoye O,Lewis RJ,Grotta JC,Broderick J,Jovin TG,Nogueira RG,Elm JJ,Graves T,Berry S,Lees KR,Barreto AD,Saver JL,DAWN Trial and MOST Trial Steering Committees.,Additional contributors from DAWN Trial Steering

    更新日期:2015-08-01 00:00:00

  • Incidental magnetic resonance diffusion-weighted imaging-positive lesions are rare in neurologically asymptomatic community-dwelling adults.

    abstract:BACKGROUND AND PURPOSE:Incidental magnetic resonance diffusion-weighted imaging (DWI)-positive lesions, considered to represent small acute infarcts, have been detected in patients with cerebral small vessel diseases or cognitive impairment, but the prevalence in the community population is unknown. METHODS:DWI sequen...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.005782

    authors: Batool S,O'Donnell M,Sharma M,Islam S,Dagenais GR,Poirier P,Lear SA,Wielgosz A,Teo K,Stotts G,McCreary CR,Frayne R,DeJesus J,Rangarajan S,Yusuf S,Smith EE,PURE Study Investigators.

    更新日期:2014-07-01 00:00:00