Abstract:
:Background and Purpose- The use of oral anticoagulants (OAC) is considered a contra-indication for intravenous thrombolytics as acute treatment of ischemic stroke. However, little is known about the risks and benefits of endovascular treatment in patients on prior OAC. We aim to compare outcomes after endovascular treatment between patients with and without prior use of OAC. Methods- Data of patients with acute ischemic stroke caused by an intracranial anterior circulation occlusion, included in the nationwide, prospective, MR CLEAN Registry between March 2014 and November 2017, were analyzed. Outcomes of interest included symptomatic intracranial hemorrhage and functional outcome at 90 days (modified Rankin Scale score). Outcomes between groups were compared with (ordinal) logistic regression analyses, adjusted for prognostic factors. Results- Three thousand one hundred sixty-two patients were included in this study, of whom 502 (16%) used OAC. There was no significant difference in the occurrence of symptomatic intracranial hemorrhage between patients with and without prior OACs (5% versus 6%; adjusted odds ratio, 0.63 [95% CI, 0.38-1.06]). Patients on OACs had worse functional outcomes than patients without OACs (common odds ratio, 0.57 [95% CI, 0.47-0.66]). However, this observed difference in functional outcome disappeared after adjustment for prognostic factors (adjusted common odds ratio, 0.91 [95% CI, 0.74-1.13]). Conclusions- Prior OAC use in patients treated with endovascular treatment for ischemic stroke is not associated with an increased risk of symptomatic intracranial hemorrhage or worse functional outcome compared with no prior OAC use. Therefore, prior OAC use should not be a contra-indication for endovascular treatment.
journal_name
Strokejournal_title
Strokeauthors
Goldhoorn RB,van de Graaf RA,van Rees JM,Lingsma HF,Dippel DWJ,Hinsenveld WH,Postma A,van den Wijngaard I,van Zwam WH,van Oostenbrugge RJ,Roozenbeek B,MR CLEAN Registry Investigators—Group Authors.doi
10.1161/STROKEAHA.119.028675subject
Has Abstractpub_date
2020-06-01 00:00:00pages
1781-1789issue
6eissn
0039-2499issn
1524-4628journal_volume
51pub_type
杂志文章,多中心研究,随机对照试验相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Uric acid (UA) is a neuroprotective antioxidant that improves the benefits of alteplase in experimental ischemia. However, it is unknown whether endogenous UA also influences the response to thrombolysis in patients with stroke. METHODS:A total of 317 consecutive patients treated with thrombolys...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/STROKEAHA.110.596528
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This study was conducted to analyze the association between reported risk factors for Alzheimer's disease, apolipoprotein E epsilon4 allele, and cardiovascular disease and neuropathological changes essential for the diagnosis of Alzheimer's disease. METHODS:Our data are based on clinical and pos...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.3.613
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Reaching movements made with the affected arm in hemiparetic patients are often accompanied by compensatory trunk or shoulder girdle movements, which extend the reach of the arm. We investigated the effects of the suppression of these compensatory movements on reaching ability in hemiparetic indi...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.32.8.1875
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Three-dimensional MRI segmentation may be useful to better understand the physiopathology of lacunar infarctions. Using this technique, the distribution of lacunar infarctions volumes has been recently reported in patients with cerebral autosomal-dominant arteriopathy with subcortical infarcts an...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.520825
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to determine the recovery of cortical auditory discrimination in aphasic, left-hemisphere-stroke patients by using an electrophysiological response called mismatch negativity (MMN) and speech-comprehension tests. METHODS:MMN in 8 left-hemisphere stroke patients was recorded in response...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.STR.0000078836.26328.3B
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although the resting regional cerebral blood flow (rCBF) in aphasic patients has been thoroughly investigated with positron emission tomography (PET) and single-photon emission CT, and PET studies in normal subjects have elucidated the functional localization of language processing, little is kno...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.5.897
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Because thromboembolic events are frequently observed in primary antiphospholipid syndrome (PAPS), we assessed the risk factors for new thrombotic episodes. METHODS:Fifty-six PAPS patients (mean age, 37+/-10 years) were prospectively studied for 5 years. The preliminary Sapporo classification cr...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000170645.40562.09
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Availability of neurointerventional procedures is recommended as a necessary component of a comprehensive stroke center by various regulatory guidelines that also emphasize adequate procedural volumes. We studied the volumes of neurointerventional procedures performed in various hospitals across ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.636076
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Ventricular assist devices (VADs) have advanced the management of end-stage heart failure. However, these devices are associated with hemorrhagic and thrombotic complications, including stroke. We assessed the incidence, risk factors, and outcomes of ischemic and hemorrhagic stroke after VAD plac...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.014049
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Copeptin has been associated with recurrent cerebrovascular events after transient ischemic attack (TIA). In an independent cohort, we evaluated copeptin for the prediction of recurrent cerebrovascular events within 3 months after TIA and assessed the incremental value of copeptin compared with t...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/STROKEAHA.114.005584
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Many studies have reported frequent cognitive deficits associated with subarachnoid hemorrhage (SAH) and aneurysm repair. One study found more severe cognitive deficits after clipping than coiling of aneurysms, raising the possibility that deficits are due to surgery instead of SAH itself. This p...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.STR.0000087787.38080.B8
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Accumulating evidence indicates that a variety of infections contribute to the pathogenesis of atherosclerosis, but there is controversy concerning the impact of Helicobacter pylori infections in atherosclerosis. METHODS:We evaluated seropositivity to H pylori and to its cytotoxin-associated gen...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000058481.82639.EF
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Type 2 diabetes is associated with a high cardiovascular morbidity and mortality. Recent advances of intervention studies in type 2 diabetes with use of carotid intima-media thickness (CIMT) measurement as a surrogate end point may allow for better understanding of the undetermined process of ath...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.STR.0000236632.58323.cd
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with unilateral significant carotid artery stenosis present with a variable intracranial hemodynamic status. In the majority of patients, hemodynamics are normal because of sufficient collateral flow. One subgroup shows poor ipsilateral hemodynamics because of a severely reduced blood su...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.10.1952
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The natural history of stroke is worse in women than in men. Controversial data have been published on the efficacy of thrombolysis with recombinant tissue plasminogen activator (rtPA) according to gender. We evaluated gender differences in the efficacy and safety outcomes of intravenous rtPA usi...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.108.546325
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Early carotid surgery or stenting after thrombolytic treatment for stroke has become more common during recent years. It is unclear whether this carries an increased risk of postoperative complications and death. The aim of this nationwide population-based study was, therefore, to investigate the...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.003763
更新日期:2014-03-01 00:00:00
abstract::Background and Purpose- Hemispheric stroke studies associating lateropulsion (pusher syndrome) with the location of brain lesions have had mixed results from small, unmatched samples. This study was designed to determine whether lateropulsion localizes to specific brain regions across patients with stroke using a case...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.023445
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Coronary artery bypass grafting (CABG) is a frequently performed surgical procedure that can be associated with neurological complications. Some studies have demonstrated that new focal brain lesions, detected by MRI, can develop after CABG. Furthermore, it has been suggested that the presence of...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.0000040408.75704.15
更新日期:2002-12-01 00:00:00
abstract::Glycosylated hemoglobin concentration (GHb), which is considered an indication of glycemia over the preceding several months, was examined in 50 patients hospitalized for recent stroke or transient ischemic attacks (TIA), and compared to that in several reference populations. Patients with stroke or TIA had GHb (mean ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.13.3.356
更新日期:1982-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Preclinical data suggest that cell-based therapies have the potential to improve stroke outcomes. METHODS:Eighteen patients with stable, chronic stroke were enrolled in a 2-year, open-label, single-arm study to evaluate the safety and clinical outcomes of surgical transplantation of modified bon...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.012995
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In Rivaroxaban Once Daily Oral Direct Factor Xa Inhibitor Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) trial, rivaroxaban was noninferior to dose-adjusted warfarin in preventing stroke or systemic embolism among patients with no...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.113.002968
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Cerebral venous sinus thrombosis is rare and can be promoted by various conditions. We report the case of cerebral venous thrombosis in a patient using androgens. CASE DESCRIPTION:A 31-year-old man using androgens for bodybuilding was admitted for headache and vomiting. He had cerebral venous sinus thrombos...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.1.212
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The vitamin K-dependent protein Z (PZ) has been shown to possess anticoagulant as well as procoagulant properties. Plasma levels of PZ show a broad interindividual variation, but it is unknown to which extent this variation is under genetic control. Recent clinical studies revealed contradictory ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000106909.75418.E4
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Telomerase reverse transcriptase (TERT) is tightly related to the resistance of cells to stress and injury. However, little is known about the roles of TERT in the nervous system. We try to investigate the effects of TERT on the function of astrocytes in developing rat brains subjected to hypoxia...
journal_title:Stroke
pub_type: 杂志文章,收录出版
doi:10.1161/STROKEAHA.111.626325
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Kawasaki disease is a febrile disease of children notable for systemic vasculitis. There have been many previous reports of various complications, including disorders of the central nervous system. We evaluated cerebral perfusion during the acute stage in patients with Kawasaki disease. METHODS:...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.7.1320
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The estimated prevalence of intracranial atherosclerotic disease (IAD) in patients with stenosis of the extracranial internal carotid artery (ICA) varies between 20% and 50%. The benefits of carotid endarterectomy (CE) in patients with both IAD and symptomatic extracranial ICA stenosis are uncert...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/01.str.30.2.282
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intracranial internal carotid artery calcification is associated with cerebrovascular risk factors and stroke, but few quantification methods are available. We tested the reliability of visual scoring, semiautomated Agatston score, and calcium volume measurement in patients with recent stroke. M...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.009716
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Deferoxamine reduces neuronal death in a piglet model of intracerebral hemorrhage (ICH). This study examined the effect of deferoxamine on perihematomal white matter edema in piglets. METHODS:ICH was induced by an injection of autologous blood into the right frontal lobe of piglets. In the first...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.003033
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Findings on transesophageal echocardiography (TEE) after ischemic stroke predict recurrent embolic events and prompt therapy; however, the additive predictive power of TEE findings on long-term mortality is unknown. Our goal was to study the impact of TEE findings on all cause mortality in ischem...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000196939.12313.16
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Little is known about the pattern of cerebrovascular disease (CVD) for diabetic and nondiabetic patients or about the cost of treatment for CVD in the United Kingdom. The purpose of this study was to extend previous work to describe the epidemiology and cost of acute care of CVD as a frequent com...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.6.1142
更新日期:1997-06-01 00:00:00