Leonurine protects middle cerebral artery occluded rats through antioxidant effect and regulation of mitochondrial function.

abstract：:Cystatin C, a protein inhibitor of lysosomal cysteine proteinases, was demonstrated by immunohistochemical techniques to be present in the birefringent amyloid deposits of the small arteries in the cerebrum, cerebellum, and leptomeninges of 10 Icelandic individuals with hereditary cerebral hemorrhage with amyloidosis....

journal_title：Stroke

authors： Löfberg H,Grubb AO,Nilsson EK,Jensson O,Gudmundsson G,Blöndal H,Arnason A,Thorsteinsson L

更新日期：1987-03-01 00:00:00

abstract：:We describe a patient with transient ischemic attacks secondary to a giant aneurysm who showed increased activity on platelet scintigrams at the origin of the left vertebral artery. This is assumed to be the first report of a presumed embolizing aneurysm with positive activity of labeled platelets. Platelet scintigrap...

journal_title：Stroke

authors： Maruyama M,Asai T,Kuriyama Y,Sawada T,Ogata J,Nishimura T,Omae T

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A low ankle-brachial blood pressure index (ABI) is an established risk marker for cardiovascular disease and mortality in the general population, but little is known about its prognostic value in individuals with acute ischemic stroke or transient ischemic attack (TIA). METHODS:An inception coho...

journal_title：Stroke

authors： Busch MA,Lutz K,Röhl JE,Neuner B,Masuhr F

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:the Penumbra Pivotal Stroke Trial reported a 25% good outcome (modified Rankin scale score ≤ 2) despite an 81% recanalization rate. We evaluated the association of a favorable initial noncontrast CT and a short time to recanalization in predicting good outcome. METHODS:data were from the Penumbr...

journal_title：Stroke

authors： Goyal M,Menon BK,Coutts SB,Hill MD,Demchuk AM,Penumbra Pivotal Stroke Trial Investigators, Calgary Stroke Program, and the Seaman MR Research Center.

更新日期：2011-01-01 00:00:00

abstract：:In 100 consecutive patients with acute cerebrovascular accident, due to cerebral thrombosis in 72, cerebral hemorrhage in 12, embolus in 6, and subarachnoid hemorrhage in 10, there were 90 who had electrocardiographic abnormalities during the first three days after admission, compared to 50% in a control group. The pa...

journal_title：Stroke

authors： Dimant J,Grob D

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Accumulation of iron after intracerebral hemorrhage causes free radical formation and oxidative damage resulting in liquefaction. The aim of this study was the investigation of molecular mechanisms underlying estrogen-mediated neuroprotective effect against iron-induced brain injury in vivo. MET...

journal_title：Stroke

authors： Chen TY,Tsai KL,Lee TY,Chiueh CC,Lee WS,Hsu C

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Urinary incontinence (UI) is a common and distressing problem after stroke. Although there is evidence of new, effective UI poststroke rehabilitation intervention, it is unknown whether occupational therapists (OTs)' and physical therapists (PTs)' actual practices reflect best practices. We sough...

journal_title：Stroke

authors： Dumoulin C,Korner-Bitensky N,Tannenbaum C

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Cerebral fat embolism syndrome is a rare, but potentially lethal, complication of long bone fractures. Neurological symptoms are variable, and the clinical diagnosis is difficult. The purpose of this case study is to demonstrate the value of diffusion-weighted MRI of the brain for early diagnosis of fat embo...

journal_title：Stroke

authors： Parizel PM,Demey HE,Veeckmans G,Verstreken F,Cras P,Jorens PG,De Schepper AM

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Thrombolytic therapy with recombinant tissue plasminogen activator (rtPA) after stroke increases risk of hemorrhagic transformation, particularly in areas with blood-brain barrier leakage. Our aim was to characterize acute effects of rtPA administration on the integrity of microvascular barriers....

journal_title：Stroke

authors： Dijkhuizen RM,Asahi M,Wu O,Rosen BR,Lo EH

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Improved neurological outcome with postarrest hypertensive hemodilution in an earlier study could be the result of more homogeneous cerebral perfusion and improved O2 delivery. We explored global, regional, and local cerebral blood flow by stable xenon-enhanced computed tomography and global cerebral metabol...

journal_title：Stroke

authors： Leonov Y,Sterz F,Safar P,Johnson DW,Tisherman SA,Oku K

更新日期：1992-01-01 00:00:00

abstract：:The relationship between normal aging and regional cerebral blood flow (rCBF) computed as initial slope index (ISI) by Fourier method was investigated in 105 right-handed healthy volunteers (132 measurements) by Xe-133 inhalation method, and age-matched normal values were calculated. Mean brain ISI values showed signi...

journal_title：Stroke

authors： Matsuda H,Maeda T,Yamada M,Gui LX,Tonami N,Hisada K

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Middle cerebral artery (MCA) stenosis is a relatively rare occlusive disease with an annual stroke risk of approximately 7% to 8%. However, the frequent coincidence of cardiac or ipsilateral carotid artery disease may lead to difficulties in identifying the relevant embolizing source in symptomat...

journal_title：Stroke

authors： Nabavi DG,Georgiadis D,Mumme T,Zunker P,Ringelstein EB

更新日期：1996-08-01 00:00:00

abstract：:The effect of cigarette smoking on extracranial carotid atherosclerosis was studies by obtaining cigarette smoking histories and information on other potential risk factors from consecutive patients undergoing carotid arteriography. At least on extracranial carotid artery was visualized in 752 patients in whom the ext...

journal_title：Stroke

authors： Whisnant JP,Homer D,Ingall TJ,Baker HL Jr,O'Fallon WM,Wievers DO

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We obtained magnetization transfer imaging (MTI) scans from individuals with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (1) to investigate the presence, extent, and nature of pathology in white and gray matter outside proton density (PD)-v...

journal_title：Stroke

authors： Iannucci G,Dichgans M,Rovaris M,Brüning R,Gasser T,Giacomotti L,Yousry TA,Filippi M

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Language training success in chronic aphasia remains only moderate. Electric brain stimulation may be a viable way to enhance treatment efficacy. METHODS:In a randomized, double-blind, sham-controlled crossover trial, we assessed if anodal transcranial direct current stimulation compared to cath...

journal_title：Stroke

authors： Flöel A,Meinzer M,Kirstein R,Nijhof S,Deppe M,Knecht S,Breitenstein C

更新日期：2011-07-01 00:00:00

abstract：:In a case-control study of 73 cases of cerebral hematoma diagnosed by CT scan, significant risk factors were history of hypertension, chronic alcoholism, evidence of hepatic disease, EKG abnormalities and high hematocrit values. Initial blood pressure was significantly higher in cases, but blood pressure on the third ...

journal_title：Stroke

authors： Calandre L,Arnal C,Ortega JF,Bermejo F,Felgeroso B,del Ser T,Vallejo A

更新日期：1986-11-01 00:00:00

abstract：:Background and Purpose- The diagnosis of transient ischemic attack is challenging. Evidence of acute ischemia on MRI diffusion-weighted imaging is highly variable and confirmed in only about one-third of patients. This study investigated the significance of blood-brain barrier dysfunction (BBBD) mapping in patients wi...

journal_title：Stroke

authors： Serlin Y,Ofer J,Ben-Arie G,Veksler R,Ifergane G,Shelef I,Minuk J,Horev A,Friedman A

更新日期：2019-05-01 00:00:00

abstract：:Background and Purpose- The complexity and heterogeneity of stroke, as well as the associated comorbidities, may render neuroprotective drugs less efficacious in clinical practice. Therefore, the development of targeted therapies to specific patient subsets has become a high priority in translational stroke research. ...

journal_title：Stroke

authors： Jiang Y,Liu N,Wang Q,Yu Z,Lin L,Yuan J,Guo S,Ahn BJ,Wang XJ,Li X,Lo EH,Sun X,Wang X

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) caused by ruptured intracranial aneurysm affects approximately 16 000 Americans annually, and almost 40% of affected patients die within 30 days despite the best current therapy. Prevention of SAH is therefore of paramount importance. We present a preliminary analysi...

journal_title：Stroke

authors： Kissela BM,Sauerbeck L,Woo D,Khoury J,Carrozzella J,Pancioli A,Jauch E,Moomaw CJ,Shukla R,Gebel J,Fontaine R,Broderick J

更新日期：2002-05-01 00:00:00

abstract：:Background and Purpose- Cerebral small vessel disease (SVD) is associated with increased stroke risk and poor stroke outcomes. We aimed to evaluate whether chronic SVD burden is associated with poor recruitment of collaterals in large-vessel occlusive stroke. Methods- Consecutive patients with middle cerebral artery o...

journal_title：Stroke

authors： Lin MP,Brott TG,Liebeskind DS,Meschia JF,Sam K,Gottesman RF

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The use of thrombolysis in acute minor ischemic stroke (MIS) remains controversial. We sought to determine the safety and efficacy of intravenous tissue-type plasminogen activator (IV-tPA) in acute MIS patients with demonstrable penumbra on computed tomographic perfusion study. METHODS:Consecuti...

journal_title：Stroke

authors： Ng FC,Coote S,Frost T,Bladin C,Choi PM

更新日期：2016-07-01 00:00:00

abstract：:Background and Purpose- Disturbance of endoplasmic reticulum (ER) Ca2+ homeostasis causes neuronal cell injury in stroke. By contrast, ischemic preconditioning (IPC)-a brief sublethal ischemic episode affording tolerance to a subsequent ischemic insult-restores ER Ca2+ homeostasis. Under physiological conditions, ER c...

journal_title：Stroke

authors： Secondo A,Petrozziello T,Tedeschi V,Boscia F,Vinciguerra A,Ciccone R,Pannaccione A,Molinaro P,Pignataro G,Annunziato L

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Outcome after acute stroke is determined to a large extent by poststroke complications. Nutritional status and metabolic balance may substantially contribute to outcome after stroke. Key mechanisms of stroke pathophysiology can induce systemic catabolic imbalance with impaired metabolic efficienc...

journal_title：Stroke

authors： Scherbakov N,Dirnagl U,Doehner W

更新日期：2011-12-01 00:00:00

abstract：:Transient visual disturbance following cardiac catheterization has been regarded as a benign and transient complication. We describe two cases of computed-tomography-documented occipital infarction after cardiac catheterization that emphasize a complication more serious than previously thought. ...

journal_title：Stroke

authors： Oliva A,Scherokman B

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although a genetic contribution to ischemic stroke is well recognized, only a handful of stroke loci have been identified by large-scale genetic association studies to date. Hypothesizing that genetic effects might be stronger for early- versus late-onset stroke, we conducted a 2-stage meta-analy...

journal_title：Stroke

authors： Cheng YC,Stanne TM,Giese AK,Ho WK,Traylor M,Amouyel P,Holliday EG,Malik R,Xu H,Kittner SJ,Cole JW,O'Connell JR,Danesh J,Rasheed A,Zhao W,Engelter S,Grond-Ginsbach C,Kamatani Y,Lathrop M,Leys D,Thijs V,Metso TM,

更新日期：2016-02-01 00:00:00

abstract：:Clinical and pathologic observations have suggested analogies between the developing nervous system of ferrets (Mustela putorius furo) and those of more traditional animal models employed in stroke research. Experimental work has demonstrated advantages of the ferret as a model of visual development. We performed in v...

journal_title：Stroke

authors： Atkinson CS,Press GA,Lyden P,Katz B

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Exposure to vascular risk factors has a gradual deleterious effect on brain MRI and cognitive measures. We explored whether a pattern of these measures exists that predicts stroke and Alzheimer disease (AD) risk. METHODS:A cognitive battery was administered to 1679 dementia and stroke-free Frami...

journal_title：Stroke

authors： Weinstein G,Beiser AS,Decarli C,Au R,Wolf PA,Seshadri S

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transient ischemic attack (TIA) initiates an ischemic cascade without resulting in frank infarction and, as such, represents a novel model to study the effects of this ischemic cascade and secondary neurodegeneration in humans. METHODS:Patients with suspected TIA underwent acute brain perfusion ...

journal_title：Stroke

authors： Bivard A,Lillicrap T,Maréchal B,Garcia-Esperon C,Holliday E,Krishnamurthy V,Levi CR,Parsons M

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A precise definition of genetic factors responsible for common forms of stroke is still lacking. The purpose of the present study was to investigate the contributory role of the genes encoding atrial natriuretic peptide (ANP) and type A natriuretic peptide receptor (NPRA) in humans' susceptibilit...

journal_title：Stroke

authors： Rubattu S,Stanzione R,Di Angelantonio E,Zanda B,Evangelista A,Tarasi D,Gigante B,Pirisi A,Brunetti E,Volpe M

更新日期：2004-04-01 00:00:00

abstract：:Regional cerebral blood flow (CBF) was measured (intra-arterial injections of 133Xe) and electroencephalograms (EEG) were recorded periodically before, for two hours during, and for one and one-fourth hours after middle cerebral artery (MCA) occlusion in 20 squirrel monkeys (Saimiri sciureus). A CBF-Paco2 response cur...

journal_title：Stroke

authors： Donley RF,Sundt TM,Anderson RE,Sharbrough FW

更新日期：1975-03-01 00:00:00