Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.

abstract：BACKGROUND AND PURPOSE:Intracranial atherosclerosis is one of the main causes of stroke, and high-resolution magnetic resonance imaging provides useful imaging biomarkers related to the risk of ischemic events. This study aims to evaluate differences in histogram features between culprit and nonculprit intracranial ath...

journal_title：Stroke

authors： Shi Z,Li J,Zhao M,Peng W,Meddings Z,Jiang T,Liu Q,Teng Z,Lu J

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carotid endarterectomy reduces the risk of carotid territory ischemic stroke ipsilateral to a recently symptomatic severe carotid stenosis. However, the benefit is limited by the risks of stroke and death associated with the operation. Although reported surgical risks vary enormously, there has b...

journal_title：Stroke

authors： Rothwell PM,Slattery J,Warlow CP

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pial arterioles transiently dilate during cortical spreading depression (CSD), although the mechanisms are unclear. We tested the hypothesis that increased production of nitric oxide (NO) promotes arteriolar dilation. METHODS:Urethane-anesthetized rabbits were equipped with cranial windows, and ...

journal_title：Stroke

authors： Colonna DM,Meng W,Deal DD,Busija DW

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Several studies have found a morning peak in onset of stroke. A similar peak has been suggested for subarachnoid hemorrhage (SAH), which seems in contradiction with the physical activities associated with aneurysmal rupture. Most studies included only a few patients with SAH. We analyzed time of ...

journal_title：Stroke

authors： Vermeer SE,Rinkel GJ,Algra A

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Hyperpolarization of vascular muscle in response to activation of potassium channels is a major mechanism of vasodilatation. In cerebral blood vessels, four different potassium channels have been described: ATP-sensitive potassium channels, calcium-activated potassium channels, delayed rectifier potassium ch...

journal_title：Stroke

authors： Kitazono T,Faraci FM,Taguchi H,Heistad DD

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The neuroprotective role of mild therapeutic hypothermia was established in animal models of cerebral ischemia. Still, several issues, including optimal target temperature, remain unclear. The optimal depth of hypothermia in a rat model of focal cerebral ischemia was investigated. METHODS:Eighty...

journal_title：Stroke

authors： Kollmar R,Blank T,Han JL,Georgiadis D,Schwab S

更新日期：2007-05-01 00:00:00

abstract：:Background and Purpose- Case reports suggest that unruptured intracranial aneurysms may serve as a nidus for thrombus formation and downstream embolic stroke. However, few data exist to support an association between unruptured aneurysms and ischemic stroke. Methods- We conducted a within-subjects case-control study o...

journal_title：Stroke

authors： Chen ML,Gupta A,Chatterjee A,Khazanova D,Dou E,Patel H,Gialdini G,Merkler AE,Navi BB,Kamel H

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Following our treatment of a patient with hypoglycemia-induced brain stem symptoms, we examined the possible mechanisms for hypoglycemia presenting as basilar artery disease. CASE DESCRIPTION:We describe a patient who had progressive brain stem symptoms due to a diet-induced hypoglycemia initial...

journal_title：Stroke

authors： Röther J,Schreiner A,Wentz KU,Hennerici M

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aimed to clarify the association of chronic kidney disease (CKD) with carotid atherosclerosis and the impact of CKD on carotid atherosclerosis according to blood pressure categories in an urban general population. METHODS:We studied 3466 Japanese individuals (35-93 years old) in the Suita Stu...

journal_title：Stroke

authors： Ohara T,Kokubo Y,Toyoda K,Watanabe M,Koga M,Nakamura S,Nagatsuka K,Minematsu K,Nakagawa M,Miyamoto Y

更新日期：2013-12-01 00:00:00

abstract：:Background and Purpose- The GLX (glycocalyx) is a protein/polysaccharide meshwork at the cellular surface. Consisting largely of glycosaminoglycans and proteoglycans, the GLX can shed in response to stress. In this study, we assay 11 components of the GLX in plasma from patients with ischemic stroke from a longitudina...

journal_title：Stroke

authors： DellaValle B,Hasseldam H,Johansen FF,Iversen HK,Rungby J,Hempel C

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Brain atrophy can be regarded as an end-organ effect of cumulative cardiovascular risk factors. Accelerated brain atrophy is described following ischemic stroke, but it is not known whether atrophy rates vary over the poststroke period. Examining rates of brain atrophy allows the identification o...

journal_title：Stroke

authors： Brodtmann A,Khlif MS,Egorova N,Veldsman M,Bird LJ,Werden E

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Subarachnoid hemorrhage caused by cerebral aneurysm rupture remains a life-threatening emergency despite advances in treatment. However, the mechanisms underlying aneurysm initiation, progression, and rupture remain unclear. We developed a method to induce experimental cerebral aneurysms in rats,...

journal_title：Stroke

authors： Moriwaki T,Takagi Y,Sadamasa N,Aoki T,Nozaki K,Hashimoto N

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Aphasia can result in an inability to communicate the presence, location, or intensity of pain. Although visual analogue scales (VASs) exist, it is unknown whether they are useful in assessing pain in individuals with aphasia. The objective was to determine whether those with poststroke aphasia c...

journal_title：Stroke

authors： Korner-Bitensky N,Kehayia E,Tremblay N,Mazer B,Singer F,Tarasuk J

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Oxidative damage of mitochondrial DNA (mtDNA) in the ischemic brain is expected after ischemia/reperfusion injury. A recent study demonstrated limited patterns of mtDNA deletion in the brain after ischemia/reperfusion. We studied the ischemia/reperfusion-induced global changes of mtDNA integrity ...

journal_title：Stroke

authors： Chen H,Hu CJ,He YY,Yang DI,Xu J,Hsu CY

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Prominent posterior cerebral artery (PCA) laterality upon 3-dimensional time-of-flight magnetic resonance angiography is often encountered in patients with middle cerebral artery occlusion. We hypothesized that this sign is correlated with improved functional outcome in patients with middle cereb...

journal_title：Stroke

authors： Ichijo M,Miki K,Ishibashi S,Tomita M,Kamata T,Fujigasaki H,Mizusawa H

更新日期：2013-02-01 00:00:00

abstract：:In 24 patients with cerebrovascular disease and 6 without organic brain lesions, the increased velocity of blood flow in both the internal carotid and vertebral arteries during a contralateral carotid compression was compared with the angiographic appearance of the circle of Willis. The flow velocity was measured usin...

journal_title：Stroke

authors： Yoneda S,Nukada T,Kimura K,Tanaka K,Ashida K,Asai T,Etani H,Imaizumi M,Abe H

更新日期：1981-07-01 00:00:00

abstract：:Background and Purpose- Delirium is a common and serious complication of acute illness. We describe delirium occurrence in an unselected, acute stroke population. Methods- We collected data from consecutive stroke admissions. We performed comprehensive cognitive assessment within the first week including Diagnostic St...

journal_title：Stroke

authors： Shaw R,Drozdowska B,Taylor-Rowan M,Elliott E,Cuthbertson G,Stott DJ,Quinn TJ

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Brain microbleeds (MBs) are considered to be associated with cognitive decline and can be pathologically and topographically classified as cerebral amyloid angiopathy-related (located in lobar regions) and hypertensive microangiopathy-related (located in deep regions). We examined whether differe...

journal_title：Stroke

authors： Yakushiji Y,Noguchi T,Hara M,Nishihara M,Eriguchi M,Nanri Y,Nishiyama M,Hirotsu T,Nakajima J,Kuroda Y,Hara H

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:beta-Blockers prevent vascular events in patients after myocardial infarction and lower blood pressure, the main risk factor for stroke. Hence, we assessed the effects of atenolol on the occurrence of death from vascular causes, stroke, or myocardial infarction and on blood pressure in patients a...

journal_title：Stroke

authors：

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To date, few studies have examined associations between the wide range of flavonoid subclasses and risk of ischemic, hemorrhagic, and total stroke. METHODS:We conducted a prospective study among 69 622 women from the Nurses' Health Study. Total flavonoid and subclass intakes were calculated from...

journal_title：Stroke

authors： Cassidy A,Rimm EB,O'Reilly EJ,Logroscino G,Kay C,Chiuve SE,Rexrode KM

更新日期：2012-04-01 00:00:00

abstract：:We studied the effects of the calcium channel blocker nicardipine on regional tissue Ca2+, Na+, K+, and water shifts in the brains of seven Sprague-Dawley rats after permanent occlusions of the middle cerebral artery. We also assessed the entry of [14C]nicardipine into the brains of five rats; the highest concentratio...

journal_title：Stroke

authors： Hadani M,Young W,Flamm ES

更新日期：1988-09-01 00:00:00

abstract：:The morphologic description and measurements of endarterectomy specimens are usually believed to be accurate and are used as the gold standard against which the findings of diagnostic procedures are judged. Pathology data on 289 endarterectomy specimens from five participating centers and the corresponding angiography...

journal_title：Stroke

authors： Schenk EA,Bond MG,Aretz TH,Angelo JN,Choi HY,Rynalski T,Gustafson NF,Berson AS,Ricotta JJ,Goodison MW

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In intracerebral hemorrhage (ICH), preexisting cognitive impairment has been identified as a risk factor for increased mortality and morbidity. However, previous studies examined predominantly White populations; therefore, the prevalence and effect of preICH cognitive impairment has not been stud...

journal_title：Stroke

authors： Sawyer RP,Yim E,Coleman E,Demel SL,Sekar P,Woo D

更新日期：2021-01-01 00:00:00

abstract：:We investigated the effects of phenytoin on the rate of enzymatic release of free fatty acids and on the levels of energy metabolites and nucleoside phosphates in ischemic brain. Phenytoin (10 mg/kg i.v.) was administered 30 minutes before the onset of ischemia induced in 30 male Wistar rats by occluding the basilar a...

journal_title：Stroke

authors： Kinouchi H,Imaizumi S,Yoshimoto T,Motomiya M

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:In 15% to 20% of patients with a spontaneous subarachnoid hemorrhage, no aneurysm is found on the first angiogram. This review emphasizes that this group of patients is in fact heterogeneous and describes the clinical features, pattern of hemorrhage on early computed tomographic (CT) scan, prognosis, and pro...

journal_title：Stroke

authors： Rinkel GJ,van Gijn J,Wijdicks EF

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Because no population-based estimates are available for asymptomatic retinal emboli, we aimed to assess prevalence and associations of this sign in a defined older Australian urban population. METHODS:A total of 3654 persons aged 49 years or older, representing 82% of residents in an urban area ...

journal_title：Stroke

authors： Mitchell P,Wang JJ,Li W,Leeder SR,Smith W

更新日期：1997-01-01 00:00:00

abstract：:Leukoaraiosis is a common finding in stroke patients and has been strongly associated with risk of incident stroke and dementia. Leukoaraiosis may also be an independent predictor of stroke outcomes. There is increasing evidence from neuroimaging to support the concept that some leukoaraiosis is caused by white matter...

journal_title：Stroke

authors： Smith EE

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Studies using animal models of stroke have shown that human serum albumin (HSA) significantly ameliorates cerebral ischemic injury after both transient and permanent ischemia, even when administered after the onset of ischemia or reperfusion. The mechanism of this effect remains uncertain, and pr...

journal_title：Stroke

authors： Gum ET,Swanson RA,Alano C,Liu J,Hong S,Weinstein PR,Panter SS

更新日期：2004-02-01 00:00:00

abstract：:Five patients studied by the authors and 28 mentioned in the literature indicate that recurrent stenosis occurs in no less than 0.6% of patients after carotid endarterectomy. The pathology of the recurrent stenosis was stated in only 10 cases indicating atherosclerotic disease in various stages of development in 7 and...

journal_title：Stroke

authors： French BN,Rewcastle NB

更新日期：1977-09-01 00:00:00

abstract：:Perforating branches of the middle cerebral arteries (MCA) were examined on the forebrain hemispheres of fourteen human brains. It was noticed that their intracerebral segments arose from the MCA main trunk, and its terminal and collateral (cortical) branches. They terminated in certain parts of the basal ganglia and ...

journal_title：Stroke

authors： Marinkovic SV,Milisavljevic MM,Kovacevic MS,Stevic ZD

更新日期：1985-11-01 00:00:00