Role of potassium channels in cerebral blood vessels.

abstract：BACKGROUND AND PURPOSE:Cerebral arteriolar dilation to N-methyl-D-aspartate (NMDA) is a neuronally mediated multistep process that is sensitive to cerebral hypoxia and ischemia (H/I). We tested the hypothesis that topical pretreatment with the selective potassium channel agonists NS1619 and aprikalim preserves the vasc...

journal_title：Stroke

authors： Veltkamp R,Domoki F,Bari F,Busija DW

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Increased mean platelet volume (MPV), indicating higher platelet reactivity, is associated with an increased risk of myocardial infarction. Higher levels of MPV have been found in patients with acute ischemic stroke than in control subjects. Data from smaller studies regarding an association betw...

journal_title：Stroke

authors： Greisenegger S,Endler G,Hsieh K,Tentschert S,Mannhalter C,Lalouschek W

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Perivascularly positioned cerebral mast cells (MC) have been shown to participate in acute blood-brain barrier disruption and expansive brain edema following experimental transient cerebral ischemia. However, the underlying molecular mechanisms remain unknown. Because proteolytic gelatinase enzym...

journal_title：Stroke

authors： Mattila OS,Strbian D,Saksi J,Pikkarainen TO,Rantanen V,Tatlisumak T,Lindsberg PJ

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hyperglycemia enhances the deleterious effect of global cerebral ischemia. One possible explanation is that increased anaerobic glycolysis leads to exaggeration of intracellular acidosis and increased postischemic edema. To examine the importance of this edema on postischemic cerebral perfusion d...

journal_title：Stroke

authors： Morimoto Y,Morimoto Y,Warner DS,Pearlstein RD

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Deferoxamine reduces neuronal death in a piglet model of intracerebral hemorrhage (ICH). This study examined the effect of deferoxamine on perihematomal white matter edema in piglets. METHODS:ICH was induced by an injection of autologous blood into the right frontal lobe of piglets. In the first...

journal_title：Stroke

authors： Xie Q,Gu Y,Hua Y,Liu W,Keep RF,Xi G

更新日期：2014-01-01 00:00:00

abstract：:Background and Purpose- In acute stroke patients with large vessel occlusion, the goal of intravenous thrombolysis (IVT) is to achieve early recanalization (ER). Apart from occlusion site and thrombus length, predictors of early post-IVT recanalization are poorly known. Better collaterals might also facilitate ER, for...

journal_title：Stroke

authors： Seners P,Roca P,Legrand L,Turc G,Cottier JP,Cho TH,Arquizan C,Bracard S,Ozsancak C,Ben Hassen W,Naggara O,Lion S,Debiais S,Berthezene Y,Costalat V,Richard S,Magni C,Mas JL,Baron JC,Oppenheim C

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Deteriorating glucose tolerance is associated with an increased cardiovascular disease (CVD) risk. The underlying mechanisms remain unclear. Arterial remodeling is the change in structural properties through time in response to atherogenic and/or hemodynamic alterations and aims to maintain circu...

journal_title：Stroke

authors： Henry RM,Kostense PJ,Dekker JM,Nijpels G,Heine RJ,Kamp O,Bouter LM,Stehouwer CD

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The impact of anesthesia technique on the outcomes of mechanical thrombectomy for acute ischemic stroke remains an issue of debate. We investigated the association of general anesthesia with outcomes in patients undergoing mechanical thrombectomy for ischemic stroke. METHODS:We performed a cohor...

journal_title：Stroke

authors： Bekelis K,Missios S,MacKenzie TA,Tjoumakaris S,Jabbour P

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Numerous studies indicate that mild hypothermia provides substantial neuroprotection. However, current systems transfer insufficient heat to rapidly vary core temperature. We thus evaluated the safety and efficacy of endovascular cooling and rewarming for the induction and reversal of hypothermia...

journal_title：Stroke

authors： Dae MW,Gao DW,Ursell PC,Stillson CA,Sessler DI

更新日期：2003-03-01 00:00:00

abstract：:During perinatal asphyxia, cerebral blood flow is markedly reduced in the gray and white matter of the telencephalon. Since previous work has implicated prostaglandins in the control of blood flow, we tested the hypothesis that a thromboxane synthesis inhibitor would improve cerebral blood flow and blunt the metabolic...

journal_title：Stroke

authors： Ment LR,Stewart WB,Petroff OA,Duncan CC

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:ASCOD phenotyping (A, atherosclerosis; S, small vessel disease; C, cardiac pathology; O, other causes; and D, dissection) assigns a degree of likelihood to every potential cause (1 for potentially causal, 2 for causality is uncertain, 3 for unlikely causal but disease is present, 0 for absence of...

journal_title：Stroke

authors： Sirimarco G,Lavallée PC,Labreuche J,Meseguer E,Cabrejo L,Guidoux C,Klein IF,Olivot JM,Abboud H,Adraï V,Kusmierek J,Ratani S,Touboul PJ,Mazighi M,Steg PG,Amarenco P

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although headache is the most common symptom in cerebral venous thrombosis, 5% to 30% of patients do not report headache at baseline. Characteristics of these patients have not been investigated. METHODS:In post hoc analysis of the International Study on Cerebral Vein and Dural Sinus Thrombosis ...

journal_title：Stroke

authors： Coutinho JM,Stam J,Canhão P,Barinagarrementeria F,Bousser MG,Ferro JM,ISCVT Investigators.

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The reproducibility of duplex scan measures of carotid atherosclerosis was evaluated as part of a study assessing the prevalence of carotid disease in elderly adults. METHODS:Doppler measures of blood flow velocity were used to evaluate disease severity, and extent of carotid plaque was scored f...

journal_title：Stroke

authors： Sutton-Tyrrell K,Wolfson SK Jr,Thompson T,Kelsey SF

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this study was to further analyze the temporal patterns of onset of intracerebral hemorrhage (ICH) and to determine whether or not subgroups with specific clinical characteristics exhibit different patterns of onset. METHODS:The daily, weekly, and yearly variations in occurrence o...

journal_title：Stroke

authors： Passero S,Reale F,Ciacci G,Zei E

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The role of athersclerosis in the difference between the pathogenesis of large-vessel disease (LVD) and small-vessel disease (SVD) is a matter of debate. Common carotid artery intima-media thickness (CCA IMT) is a marker of atherosclerosis. Our aim was to compare CCA IMT between SVD and LVD patie...

journal_title：Stroke

authors： Pruissen DM,Gerritsen SA,Prinsen TJ,Dijk JM,Kappelle LJ,Algra A,SMART Study Group.

更新日期：2007-04-01 00:00:00

abstract：:Endothelium dysfunction may result from increased production of reactive oxygen species and decreased availability of nitric oxide. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ie, statins) exert cholesterol-independent vasoprotective effects that are mediated, in part, through the inhibiti...

journal_title：Stroke

authors： Endres M,Laufs U

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) caused by ruptured intracranial aneurysm affects approximately 16 000 Americans annually, and almost 40% of affected patients die within 30 days despite the best current therapy. Prevention of SAH is therefore of paramount importance. We present a preliminary analysi...

journal_title：Stroke

authors： Kissela BM,Sauerbeck L,Woo D,Khoury J,Carrozzella J,Pancioli A,Jauch E,Moomaw CJ,Shukla R,Gebel J,Fontaine R,Broderick J

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hypothermia improves outcome in resuscitated patients and newborns with hypoxic brain injury. We studied the safety and feasibility of mild hypothermia in awake patients with stroke after intravenous thrombolysis. METHODS:Patients were randomized 1:1 to mild hypothermia (35°C) or to standard str...

journal_title：Stroke

authors： Piironen K,Tiainen M,Mustanoja S,Kaukonen KM,Meretoja A,Tatlisumak T,Kaste M

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The treatment of large brain arteriovenous malformations (BAVMs) is challenging, and embolization alone is seldom curative. The study goal is to enhance the efficacy of arteriovenous malformation embolization by adding a beta-emitting isotope to the embolic agent. METHODS:The pig rete mirabile w...

journal_title：Stroke

authors： Roy D,Soucy JP,Hartman NG,Janicki C,Weill A,Guilbert F,Papineau K,Raymond J

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aimed to investigate the feasibility and therapeutic effect of external counterpulsation (ECP) in ischemic stroke. METHODS:The trial was a randomized, crossover, assessment-blinded, proof-of-concept trial. ECP treatment consisted of 35 daily 1-hour sessions. Patients were randomized to either...

journal_title：Stroke

authors： Han JH,Leung TW,Lam WW,Soo YO,Alexandrov AW,Mok V,Leung YF,Lo R,Wong KS

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Arterial baroreflex is one of the most important mechanisms in the regulation of cardiovascular activities. Arterial baroreflex function can be expressed as baroreflex sensitivity (BRS). The present study was designed to test 2 hypotheses: (1) BRS is a new independent predictor for the incidence ...

journal_title：Stroke

authors： Liu AJ,Ma XJ,Shen FM,Liu JG,Chen H,Su DF

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We compared two-dimensional time-of-flight magnetic resonance angiography (MRA) and duplex ultrasonography with arteriography for the detection of 70% to 99% stenoses at the carotid artery bifurcation (ie, surgical disease according to findings of the North American Carotid Endarterectomy Trial)....

journal_title：Stroke

authors： Mittl RL Jr,Broderick M,Carpenter JP,Goldberg HI,Listerud J,Mishkin MM,Berkowitz HD,Atlas SW

更新日期：1994-01-01 00:00:00

abstract：:We looked at FiO2, choice of anesthetic, nutritional status, and body temperature in a gerbil model of forebrain ischemia to determine their effect on data interpretation, ischemic outcome, and extent of pharmacologic protection. We subjected 484 gerbils to 5 minutes of forebrain ischemia under different experimental ...

journal_title：Stroke

authors： Clifton GL,Taft WC,Blair RE,Choi SC,DeLorenzo RJ

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Watershed ischemia is a significant cause of stroke in severe carotid disease, but its pathophysiology is unsettled. Although hemodynamic compromise has long been regarded as the main mechanism-particularly with deep watershed infarction-there is some contradictory evidence from clinical and path...

journal_title：Stroke

authors： Moustafa RR,Izquierdo-Garcia D,Jones PS,Graves MJ,Fryer TD,Gillard JH,Warburton EA,Baron JC

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Aging is associated with a reduction in cerebral perfusion. Impaired vasodilatation in large brain arteries could be implicated. This study sought age-related changes in vasodilator responses to norepinephrine in rat basilar artery and investigated which aspects of norepinephrine's action are res...

journal_title：Stroke

authors： Arribas SM,Vila E,McGrath JC

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A J-shaped relationship has been demonstrated between alcohol and both clinical cardiovascular events and carotid atherosclerosis. A similar J-shaped relationship has been found between alcohol intake and inflammatory markers. If inflammation were on the intermediate causal pathway between alcoho...

journal_title：Stroke

authors： Jerrard-Dunne P,Sitzer M,Risley P,Steckel DA,Buehler A,von Kegler S,Markus HS,Carotid Atherosclerosis Progression Study.

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In the Asymptomatic Carotid Surgery Trial-1 (ACST-1), 3120 patients with tight asymptomatic carotid stenosis were randomly assigned to medical treatment alone or to carotid endarterectomy and appropriate medication. Successful carotid endarterectomy significantly reduced 10-year stroke risk in yo...

journal_title：Stroke

authors： den Hartog AG,Halliday AW,Hayter E,Pan H,Kong X,Moll FL,de Borst GJ,Asymptomatic Carotid Surgery Trial Collaborators.

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carotid artery stenting (CAS) is an alternative to carotid endarterectomy (CEA) for stroke prevention. The value of this therapy relative to CEA remains uncertain. METHODS:In 10 958 Medicare patients aged 66 years or older between 2004 and 2006, we analyzed in-hospital, 1-year stroke, myocardial...

journal_title：Stroke

authors： Wang FW,Esterbrooks D,Kuo YF,Mooss A,Mohiuddin SM,Uretsky BF

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cilostazol, a phosphodiesterase 3' inhibitor, is used in Asia-Pacific countries for stroke prevention, but rarely used elsewhere. In addition to weak antiplatelet effects, it stabilizes endothelium, aids myelin repair and astrocyte-neuron energy transfer in laboratory models, effects that may be ...

journal_title：Stroke

authors： McHutchison C,Blair GW,Appleton JP,Chappell FM,Doubal F,Bath PM,Wardlaw JM

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Computed tomography is now routinely used in many hospitals to investigate cerebrovascular disease. The purpose of our prospective study was to determine whether cranial computed tomography in connection with neurological assessment was useful in prognostic evaluation of survival after acute stro...

journal_title：Stroke

authors： Rasmussen D,Køhler O,Worm-Petersen S,Blegvad N,Jacobsen HL,Bergmann I,Egeblad M,Friis M,Nielsen NT

更新日期：1992-04-01 00:00:00