Role of potassium channels in cerebral blood vessels.


BACKGROUND:Hyperpolarization of vascular muscle in response to activation of potassium channels is a major mechanism of vasodilatation. In cerebral blood vessels, four different potassium channels have been described: ATP-sensitive potassium channels, calcium-activated potassium channels, delayed rectifier potassium channels, and inward rectifier potassium channels. SUMMARY OF REVIEW:Activation of ATP-sensitive and calcium activated potassium channels appears to play a major role in relaxation of cerebral arteries and arterioles in response to diverse stimuli, including receptor-mediated agonists, intracellular second messengers, and hypoxia. Both calcium-activated and delayed rectifier potassium channels may contribute to a negative feedback system that regulates tone in large cerebral arteries. The influence of ATP-sensitive and calcium-activated potassium channels is altered in disease states such as hypertension, diabetes, and atherosclerosis. CONCLUSIONS:Activation of potassium channels is a major mechanism of cerebral vasodilatation. Alteration of activity of potassium channels and impairment of vasodilatation may contribute to the development or maintenance of cerebral ischemia or vasospasm.






Kitazono T,Faraci FM,Taguchi H,Heistad DD




Has Abstract


1995-09-01 00:00:00














  • Stroke Incidence and Outcomes in Northeastern Greece: The Evros Stroke Registry.

    abstract:BACKGROUND AND PURPOSE:Data are scarce on both stroke incidence rates and outcomes in Greece and in rural areas in particular. We performed a prospective population-based study evaluating the incidence of first-ever stroke in the Evros prefecture, a region of a total 147 947 residents located in North Eastern Greece. ...


    pub_type: 杂志文章


    authors: Tsivgoulis G,Patousi A,Pikilidou M,Birbilis T,Katsanos AH,Mantatzis M,Asimis A,Papanas N,Skendros P,Terzoudi A,Karamanli A,Kouroumichakis I,Zebekakis P,Maltezos E,Piperidou C,Vadikolias K,Heliopoulos I

    更新日期:2018-02-01 00:00:00

  • White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury.

    abstract:BACKGROUND AND PURPOSE:"Incidental" MRI white matter (WM) lesions, comprising periventricular lesions (PVLs) and deep subcortical lesions (DSCLs), are common in the aging brain. Direct evidence of ischemia associated with incidental WM lesions (WMLs) has been lacking, and their pathogenesis is unresolved. METHODS:A po...


    pub_type: 杂志文章


    authors: Fernando MS,Simpson JE,Matthews F,Brayne C,Lewis CE,Barber R,Kalaria RN,Forster G,Esteves F,Wharton SB,Shaw PJ,O'Brien JT,Ince PG,MRC Cognitive Function and Ageing Neuropathology Study Group.

    更新日期:2006-06-01 00:00:00

  • Are hypertension or cardiac embolism likely causes of lacunar infarction?

    abstract::We tested the hypothesis that hypertension is more common and cardiac embolism less common in patients with lacunar infarction than in patients with other types of cerebral infarction. We studied risk factor profiles in a series of 102 consecutive patients with a lacunar infarct and 202 consecutive patients with a car...


    pub_type: 杂志文章


    authors: Lodder J,Bamford JM,Sandercock PA,Jones LN,Warlow CP

    更新日期:1990-03-01 00:00:00

  • Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia.

    abstract:BACKGROUND AND PURPOSE:Leptin is the major adipose hormone that regulates body weight and energy expenditure by activating leptin receptors in the hypothalamus. Leptin receptors are also present in other cell types, and a potent antiapoptotic effect for leptin has recently been reported. We investigated whether leptin ...


    pub_type: 杂志文章


    authors: Zhang F,Wang S,Signore AP,Chen J

    更新日期:2007-08-01 00:00:00

  • High blood pressure, physical and cognitive function, and risk of stroke in the oldest old: the Leiden 85-plus Study.

    abstract:BACKGROUND AND PURPOSE:Epidemiological studies have shown mixed findings on the association between hypertension and stroke in the oldest old. Heterogeneity of the populations under study may underlie variation in outcomes. We examined whether the level of physical and cognitive function moderates the association betwe...


    pub_type: 杂志文章


    authors: Sabayan B,van Vliet P,de Ruijter W,Gussekloo J,de Craen AJ,Westendorp RG

    更新日期:2013-01-01 00:00:00

  • Feeding artery pressure and venous drainage pattern are primary determinants of hemorrhage from cerebral arteriovenous malformations.

    abstract:PURPOSE:The purpose of this study was to define the influence of feeding mean arterial pressure (FMAP) in conjunction with other morphological or clinical risk factors in determining the probability of hemorrhagic presentation in patients with cerebral arteriovenous malformations (AVMs). METHODS:Clinical and angiograp...


    pub_type: 杂志文章


    authors: Duong DH,Young WL,Vang MC,Sciacca RR,Mast H,Koennecke HC,Hartmann A,Joshi S,Mohr JP,Pile-Spellman J

    更新日期:1998-06-01 00:00:00

  • Overexpression of CuZn-SOD prevents lipopolysaccharide-induced endothelial dysfunction.

    abstract:BACKGROUND AND PURPOSE:Inflammation is thought to be a major contributor to carotid artery disease. Lipopolysaccharide (LPS) activates inflammatory mechanisms thought to contribute to endothelial dysfunction by mechanisms that are not well defined. The goal of this study was to determine whether overexpression of CuZn-...


    pub_type: 杂志文章


    authors: Didion SP,Kinzenbaw DA,Fegan PE,Didion LA,Faraci FM

    更新日期:2004-08-01 00:00:00

  • B vitamin plasma levels and the risk of ischemic stroke and transient ischemic attack in a German cohort.

    abstract:BACKGROUND AND PURPOSE:Data from prospective studies on the associations between B vitamin plasma levels and the risk of stroke are limited. We investigated the individual and combined effects of plasma folate, vitamin B12, and pyridoxal 5-phosphate (PLP) levels on the risk of ischemic stroke and transient ischemic att...


    pub_type: 杂志文章


    authors: Weikert C,Dierkes J,Hoffmann K,Berger K,Drogan D,Klipstein-Grobusch K,Spranger J,Möhlig M,Luley C,Boeing H

    更新日期:2007-11-01 00:00:00

  • Health-related quality of life among long-term survivors of stroke : results from the Auckland Stroke Study, 1991-1992.

    abstract:BACKGROUND AND PURPOSE:The consequences of stroke are a major health concern. This study was conducted to compare the health-related quality of life among long-term survivors of stroke with that of the general population. METHODS:Our data are taken from a population-based case-control study of all 6-year survivors of ...


    pub_type: 杂志文章


    authors: Hackett ML,Duncan JR,Anderson CS,Broad JB,Bonita R

    更新日期:2000-02-01 00:00:00

  • Stroke thrombolysis: having more time translates into delayed therapy: data from the Austrian Stroke Unit Registry.

    abstract:BACKGROUND AND PURPOSE:Efficacy of intravenous thrombolysis in acute ischemic stroke declines with increasing time to treatment initiation. Previous small-scale studies suggested that the earlier patients arrive, the longer it takes to administer recombinant tissue plasminogen activator. METHODS:Of 32 529 patients wit...


    pub_type: 杂志文章


    authors: Ferrari J,Knoflach M,Kiechl S,Willeit J,Matosevic B,Seyfang L,Lang W,Austrian Stroke Unit Registry Collaborators.

    更新日期:2010-09-01 00:00:00

  • Characterization of critical hemodynamics contributing to aneurysmal remodeling at the basilar terminus in a rabbit model.

    abstract:BACKGROUND AND PURPOSE:Hemodynamic insult by bilateral common carotid artery ligation has been shown to induce aneurysmal remodeling at the basilar terminus in a rabbit model. To characterize critical hemodynamics that initiate this remodeling, we applied a novel hemodynamics-histology comapping technique. METHODS:Eig...


    pub_type: 杂志文章


    authors: Metaxa E,Tremmel M,Natarajan SK,Xiang J,Paluch RA,Mandelbaum M,Siddiqui AH,Kolega J,Mocco J,Meng H

    更新日期:2010-08-01 00:00:00

  • Immunohistochemical characterization of the amyloid deposits and quantitation of pertinent cerebrospinal fluid proteins in hereditary cerebral hemorrhage with amyloidosis.

    abstract::Cystatin C, a protein inhibitor of lysosomal cysteine proteinases, was demonstrated by immunohistochemical techniques to be present in the birefringent amyloid deposits of the small arteries in the cerebrum, cerebellum, and leptomeninges of 10 Icelandic individuals with hereditary cerebral hemorrhage with amyloidosis....


    pub_type: 杂志文章


    authors: Löfberg H,Grubb AO,Nilsson EK,Jensson O,Gudmundsson G,Blöndal H,Arnason A,Thorsteinsson L

    更新日期:1987-03-01 00:00:00

  • Nocturnal blood pressure dip in stroke survivors. A pilot study.

    abstract:BACKGROUND AND PURPOSE:The influence of a nocturnal blood pressure dip on stroke recurrence has not yet been clarified. In this pilot study, we attempted to establish a correlation of the nocturnal blood pressure dip with stroke recurrence and development of new silent ischemic lesions in patients with chronic ischemic...


    pub_type: 杂志文章


    authors: Nakamura K,Oita J,Yamaguchi T

    更新日期:1995-08-01 00:00:00

  • Effectiveness and Safety of Oral Anticoagulants Among Nonvalvular Atrial Fibrillation Patients.

    abstract::Background and Purpose- This ARISTOPHANES study (Anticoagulants for Reduction in Stroke: Observational Pooled Analysis on Health Outcomes and Experience of Patients) used multiple data sources to compare stroke/systemic embolism (SE) and major bleeding (MB) among a large number of nonvalvular atrial fibrillation patie...


    pub_type: 杂志文章


    authors: Lip GYH,Keshishian A,Li X,Hamilton M,Masseria C,Gupta K,Luo X,Mardekian J,Friend K,Nadkarni A,Pan X,Baser O,Deitelzweig S

    更新日期:2018-12-01 00:00:00

  • Marked Regional Variation in Acute Stroke Treatment Among Medicare Beneficiaries.

    abstract:BACKGROUND AND PURPOSE:Little is known about how regions vary in their use of thrombolysis (intravenous tissue-type plasminogen activator and intra-arterial treatment) for acute stroke. We sought to determine regional variation in thrombolysis treatment and investigate the extent to which regional variation is accounte...


    pub_type: 杂志文章


    authors: Skolarus LE,Meurer WJ,Shanmugasundaram K,Adelman EE,Scott PA,Burke JF

    更新日期:2015-07-01 00:00:00

  • Diabetes mellitus: a risk factor for ischemic stroke in a large biracial population.

    abstract:BACKGROUND AND PURPOSE:We previously reported increased incidence of ischemic stroke among both blacks and whites with diabetes mellitus, especially in those aged <55 years. With rising prevalence of diabetes mellitus in the past decade, we revisit the impact of diabetes mellitus on stroke incidence in the same populat...


    pub_type: 杂志文章,多中心研究


    authors: Khoury JC,Kleindorfer D,Alwell K,Moomaw CJ,Woo D,Adeoye O,Flaherty ML,Khatri P,Ferioli S,Broderick JP,Kissela BM

    更新日期:2013-06-01 00:00:00

  • Inosine reduces ischemic brain injury in rats.

    abstract:BACKGROUND AND PURPOSE:Purinergic nucleoside inosine elicits protection and regeneration during various injuries. The purpose of this study was to examine the protective effects of inosine against cerebral ischemia. METHODS:Adult Sprague-Dawley rats were anesthetized. Inosine, hypoxathine, or vehicle was administered ...


    pub_type: 杂志文章


    authors: Shen H,Chen GJ,Harvey BK,Bickford PC,Wang Y

    更新日期:2005-03-01 00:00:00

  • Cortical activity, ionic homeostasis, and acidosis during rat brain repetitive ischemia.

    abstract::Recent data strongly suggest that repetitive ischemic episodes have an adverse cumulative effect on development of edema and tissue damage. We wanted to assess further whether special risks such as exacerbation of extracellular acidification reflecting progressive exhaustion of the capacity to buffer H+ in the extrace...


    pub_type: 杂志文章


    authors: Matsumoto T,Obrenovitch TP,Parkinson NA,Symon L

    更新日期:1990-08-01 00:00:00

  • Response of day-to-day home blood pressure variability by antihypertensive drug class after transient ischemic attack or nondisabling stroke.

    abstract:BACKGROUND AND PURPOSE:Visit-to-visit variability in systolic blood pressure (SBP) is associated with an increased risk of stroke and was reduced in randomized trials by calcium channel blockers and diuretics but not by renin-angiotensin system inhibitors. However, time of day effects could not be determined. Day-to-da...


    pub_type: 杂志文章


    authors: Webb AJ,Wilson M,Lovett N,Paul N,Fischer U,Rothwell PM

    更新日期:2014-10-01 00:00:00

  • Mesenchymal stem cells primed with valproate and lithium robustly migrate to infarcted regions and facilitate recovery in a stroke model.

    abstract:BACKGROUND AND PURPOSE:The migratory efficiency of mesenchymal stem cells (MSC) toward cerebral infarct after transplantation is limited. Valproate (VPA) and lithium enhance in vitro migration of MSC by upregulating CXC chemokine receptor 4 and matrix metalloproteinase-9, respectively. Ability of VPA and lithium to pro...


    pub_type: 杂志文章


    authors: Tsai LK,Wang Z,Munasinghe J,Leng Y,Leeds P,Chuang DM

    更新日期:2011-10-01 00:00:00

  • Treatment of intracranial aneurysms by embolization with coils: a systematic review.

    abstract:BACKGROUND:Embolization with coils is increasingly used for the treatment of intracranial aneurysms. To assess the percentage of complications, the percentage of aneurysm occlusion, and the short-term outcome, we performed a systematic review of studies on embolization with controlled detachable or pushable coils. SUM...


    pub_type: 杂志文章,评审


    authors: Brilstra EH,Rinkel GJ,van der Graaf Y,van Rooij WJ,Algra A

    更新日期:1999-02-01 00:00:00

  • Behavioral risk factor prevalence and lifestyle change after stroke: a prospective study.

    abstract:BACKGROUND AND PURPOSE:Stroke patients have a 15-fold increased risk of recurrent stroke, and those with > or =1 risk factor have a further increased risk of recurrence. Previous work found management of physiological risk factors after stroke to be unsatisfactory, but there is little information on behavioral risks wi...


    pub_type: 杂志文章


    authors: Redfern J,McKevitt C,Dundas R,Rudd AG,Wolfe CD

    更新日期:2000-08-01 00:00:00

  • Breathing 100% oxygen after global brain ischemia in Mongolian Gerbils results in increased lipid peroxidation and increased mortality.

    abstract::Exposure of Mongolian gerbils to a 100% oxygen atmosphere after 15 minutes of global brain ischemia resulted in a marked increase in the production of pentane, an in vivo product of lipid peroxidation. Much less pentane production occurred in animals subjected to global brain ischemia then exposed to an air atmosphere...


    pub_type: 杂志文章


    authors: Mickel HS,Vaishnav YN,Kempski O,von Lubitz D,Weiss JF,Feuerstein G

    更新日期:1987-03-01 00:00:00

  • Effects of flunarizine on neurological recovery and spinal cord blood flow in experimental spinal cord ischemia in rabbits.

    abstract:BACKGROUND AND PURPOSE:The lipophilic calcium channel antagonist flunarizine has been demonstrated to be neuroprotective in several models of cerebral ischemia. Ischemic spinal cord injury may have a similar pathophysiology and hence may respond in a similar fashion. This study was designed to investigate the effects o...


    pub_type: 杂志文章


    authors: Johnson SH,Kraimer JM,Graeber GM

    更新日期:1993-10-01 00:00:00

  • Intracerebral hemorrhage in the very old: future demographic trends of an aging population.

    abstract:BACKGROUND AND PURPOSE:In most European societies and in the United States, the percentage of patients ≥80 years has been rising over the past century. The present study was conducted to observe this demographic change and its impact on patients with intracerebral hemorrhage (ICH). METHODS:We reviewed patients' data w...


    pub_type: 杂志文章


    authors: Stein M,Misselwitz B,Hamann GF,Scharbrodt W,Schummer DI,Oertel MF

    更新日期:2012-04-01 00:00:00

  • There's no place like home : an evaluation of early supported discharge for stroke.

    abstract:BACKGROUND AND PURPOSE:Because stroke management is aimed at facilitating community reintegration, it would be logical that the sooner the patient can be discharged home, the sooner reintegration can commence. The purpose of this study was to determine the effectiveness of prompt discharge combined with home rehabilita...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mayo NE,Wood-Dauphinee S,Côté R,Gayton D,Carlton J,Buttery J,Tamblyn R

    更新日期:2000-05-01 00:00:00

  • Endothelin B receptor antagonists attenuate subarachnoid hemorrhage-induced cerebral vasospasm.

    abstract:BACKGROUND AND PURPOSE:While it has been widely reported that the vasospasm following subarachnoid hemorrhage (SAH) is prevented/reversed by endothelin (ET) receptor antagonists selective for the ET(A) receptor and by nonselective ET receptor antagonists, ie, antagonists of both the ET(A) and ET(B) receptors, there are...


    pub_type: 杂志文章


    authors: Zuccarello M,Boccaletti R,Romano A,Rapoport RM

    更新日期:1998-09-01 00:00:00

  • Etiologic Workup in Cases of Cryptogenic Stroke: A Systematic Review of International Clinical Practice Guidelines.

    abstract::Background and Purpose- Identifying the etiology of acute ischemic stroke is essential for effective secondary prevention. However, in at least one third of ischemic strokes, existing investigative protocols fail to determine the underlying cause. Establishing etiology is complicated by variation in clinical practice,...


    pub_type: 杂志文章


    authors: McMahon NE,Bangee M,Benedetto V,Bray EP,Georgiou RF,Gibson JME,Lane DA,Al-Khalidi AH,Chatterjee K,Chauhan U,Clegg AJ,Lightbody CE,Lip GYH,Sekhar A,Watkins CL

    更新日期:2020-05-01 00:00:00

  • DNA Content in Ischemic Stroke Thrombi Can Help Identify Cardioembolic Strokes Among Strokes of Undetermined Cause.

    abstract:BACKGROUND AND PURPOSE:Identification of acute ischemic stroke (AIS) cause is crucial for guidance of secondary prevention. Previous studies have yielded inconsistent results regarding possible correlations between AIS cause and thrombus composition, as assessed by semiquantitative histological analysis. Here, we perfo...


    pub_type: 杂志文章


    authors: Di Meglio L,Desilles JP,Solonomenjanahary M,Labreuche J,Ollivier V,Dupont S,Deschildre C,Maacha MB,Consoli A,Lapergue B,Piotin M,Blanc R,Ho-Tin-Noe B,Mazighi M,compoCLOT study group†.

    更新日期:2020-09-01 00:00:00

  • Stroke unit care and outcome: results from the 2001 National Sentinel Audit of Stroke (England, Wales, and Northern Ireland).

    abstract:BACKGROUND AND PURPOSE:Stroke unit care is one of the most powerful interventions available to help stroke patients. There are limited data available to assess the impact of stroke units in routine clinical practice outside randomized clinical trials. This article uses data from the 2001 to 2002 National Stroke Audit t...


    pub_type: 杂志文章


    authors: Rudd AG,Hoffman A,Irwin P,Lowe D,Pearson MG

    更新日期:2005-01-01 00:00:00