Trial of secondary prevention with atenolol after transient ischemic attack or nondisabling ischemic stroke. The Dutch TIA Trial Study Group.

Abstract:

BACKGROUND AND PURPOSE:beta-Blockers prevent vascular events in patients after myocardial infarction and lower blood pressure, the main risk factor for stroke. Hence, we assessed the effects of atenolol on the occurrence of death from vascular causes, stroke, or myocardial infarction and on blood pressure in patients after a transient ischemic attack or nondisabling ischemic stroke. METHODS:In a double-blind, placebo-controlled randomized clinical trial we studied the occurrence of the outcome event death from vascular causes, nonfatal stroke, or nonfatal myocardial infarction and the outcome event fatal or nonfatal stroke as well as blood pressure on follow-up. A total of 1,473 aspirin-treated patients with transient ischemic attack or nondisabling ischemic stroke were randomized to 50 mg atenolol daily or placebo. The mean follow-up was 2.6 years. RESULTS:Patients on atenolol had a risk of 97/732 (13.3%) for the combined outcome event versus a risk of 95/741 (12.8%) for those on placebo (adjusted hazard ratio, 1.00; 95% confidence interval, 0.76-1.33). The adjusted hazard ratio for fatal or nonfatal stroke was 0.82 (95% confidence interval, 0.57-1.19). More patients on beta-blocker (153) reported adverse effects than on placebo (103). At the first follow-up visit after randomization (median at 4 months) systolic blood pressure in the atenolol group had dropped by 8.0 mm Hg compared with 2.2 mm Hg in the placebo group (difference, 5.8 mm Hg; 95% confidence interval, 2.9-8.6 mm Hg). For diastolic blood pressure this difference was 2.9 mm Hg (95% confidence interval, 1.5-4.4 mm Hg). CONCLUSIONS:Our data neither confirm nor rule out that atenolol prevents important vascular events in patients after transient ischemic attack or nondisabling ischemic stroke, given the modest effect on blood pressure, the restrictions in patient selection, and the limited number of patient-years.

journal_name

Stroke

journal_title

Stroke

authors

doi

10.1161/01.str.24.4.543

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

543-8

issue

4

eissn

0039-2499

issn

1524-4628

journal_volume

24

pub_type

临床试验,杂志文章,随机对照试验

相关文献

STROKE文献大全
  • Symptomatic intracranial hemorrhage after stroke thrombolysis: comparison of prediction scores.

    abstract:BACKGROUND AND PURPOSE:Several prognostic scores have been developed to predict the risk of symptomatic intracranial hemorrhage (sICH) after ischemic stroke thrombolysis. We compared the performance of these scores in a multicenter cohort. METHODS:We merged prospectively collected data of patients with consecutive isc...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.113.003806

    authors: Strbian D,Michel P,Seiffge DJ,Saver JL,Numminen H,Meretoja A,Murao K,Weder B,Forss N,Parkkila AK,Eskandari A,Cordonnier C,Davis SM,Engelter ST,Tatlisumak T

    更新日期:2014-03-01 00:00:00

  • Incidence of aneurysmal subarachnoid hemorrhage in Shimokita, Japan, from 1989 to 1998.

    abstract:BACKGROUND AND PURPOSE:The incidence of subarachnoid hemorrhage (SAH) has been investigated in many studies. A recent study in Izumo, Japan, indicates that the incidence of SAH is as high as that in Finland. The purpose of this study was to confirm the high incidence of SAH in Japan. METHODS:The incidence rate of SAH ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/hs0102.101891

    authors: Ohkuma H,Fujita S,Suzuki S

    更新日期:2002-01-01 00:00:00

  • Predictors of Outcome in Aneurysmal Subarachnoid Hemorrhage Patients: Observations From a Multicenter Data Set.

    abstract:BACKGROUND AND PURPOSE:The mortality and morbidity after aneurysmal subarachnoid hemorrhage has improved because of better diagnosis, early treatment to secure the aneurysm, and better management of disease-specific complications. With these improvements in care, it is not clear if the previously identified independent...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.117.017777

    authors: Galea JP,Dulhanty L,Patel HC,UK and Ireland Subarachnoid Hemorrhage Database Collaborators.

    更新日期:2017-11-01 00:00:00

  • Prediction of hemorrhagic transformation after thrombolytic therapy of clot embolism: an MRI investigation in rat brain.

    abstract:BACKGROUND AND PURPOSE:Thrombolytic treatment of stroke carries the risk of hemorrhagic transformation. Therefore, the potential of MRI for prediction of recombinant tissue plasminogen activator (rtPA)-induced bleeding is explored to identify patients in whom rtPA treatment may provoke such complications. METHODS:Spon...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.0000014619.59851.65

    authors: Neumann-Haefelin C,Brinker G,Uhlenküken U,Pillekamp F,Hossmann KA,Hoehn M

    更新日期:2002-05-01 00:00:00

  • The angiopathy of subarachnoid hemorrhage: angiographic and morphologic correlates.

    abstract::In patients with subarachnoid hemorrhage, particularly hemorrhage due to aneurysmal rupture, there was a positive significant relation between angiographic vessel constriction and vessel pathology (angiopathy). Furthermore, there was a positive relationship between post-hemorrhage survival time and the severity of ang...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.14.2.240

    authors: Smith RR,Clower BR,Peeler DF Jr,Yoshioka J

    更新日期:1983-03-01 00:00:00

  • Ultrasonic evaluation of early carotid atherosclerosis.

    abstract::We investigated the prevalence of carotid atherosclerosis, including mild early lesions, and its association with cervical bruits and various risk factors (age, male sex, hypertension, hyperlipidemia, diabetes mellitus, obesity, and cigarette smoking) in 232 consecutive Japanese patients. High-resolution real-time B-m...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.21.11.1567

    authors: Handa N,Matsumoto M,Maeda H,Hougaku H,Ogawa S,Fukunaga R,Yoneda S,Kimura K,Kamada T

    更新日期:1990-11-01 00:00:00

  • Changes in cost and outcome among US patients with stroke hospitalized in 1990 to 1991 and those hospitalized in 2000 to 2001.

    abstract:BACKGROUND AND PURPOSE:The purpose of this study was to evaluate the impact of new treatments by examining the changes between 1990 to 1991 and 2000 to 2001 in in-hospital mortality rates and hospital charges in adult patients with stroke. METHODS:From the Nationwide Inpatient Survey, the largest all-payer inpatient c...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.106.467506

    authors: Qureshi AI,Suri MF,Nasar A,Kirmani JF,Ezzeddine MA,Divani AA,Giles WH

    更新日期:2007-07-01 00:00:00

  • Problems of carotid Doppler scanning which can be overcome by using frequency analysis.

    abstract::The value of the concomittant use of a real time frequency analyzer along with a continuous wave carotid Doppler scanner is demonstrated in this study of 118 cases. With a colour-coded Doppler scanner alone, internal carotid stenoses greater than 35% were diagnosed with a sensitivity of 95% and a specificity of 82%. W...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.13.5.660

    authors: Johnston KW,Brown PM,Kassam M

    更新日期:1982-09-01 00:00:00

  • Changes in locomotor activity and passive avoidance task performance induced by cerebral ischemia in Mongolian gerbils.

    abstract:BACKGROUND AND PURPOSE:We investigated changes in locomotor activity, passive avoidance task performance, and hippocampal CA1 neurons induced by cerebral ischemia in Mongolian gerbils to examine the relation between these behavioral changes and CA1 neuronal damage. METHODS:Spontaneous locomotor activity was measured u...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.3.645

    authors: Karasawa Y,Araki H,Otomo S

    更新日期:1994-03-01 00:00:00

  • Muscle sympathetic nerve activity during cold pressor test in patients with cerebrovascular accidents.

    abstract:BACKGROUND AND PURPOSE:Autonomic dysfunction is frequently present in patients with cerebrovascular accidents (CVA). However, the pathophysiological mechanisms of these disorders are not clear. The purpose of the study was to assess the effects of CVA on the autonomic nervous system. METHODS:In eight male patients wit...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.29.3.607

    authors: Mizushima T,Tajima F,Nakamura T,Yamamoto M,Lee KH,Ogata H

    更新日期:1998-03-01 00:00:00

  • Predictors of major vascular events in patients with a transient ischemic attack or minor ischemic stroke and with nonrheumatic atrial fibrillation. European Atrial Fibrillation Trial (EAFT) Study Group.

    abstract:BACKGROUND AND PURPOSE:The risk of major vascular events after an initial episode of cerebral ischemia in patients with nonrheumatic atrial fibrillation (NRAF) varies from 2% to 15% in the first year and is approximately 5% yearly thereafter. Few studies have reported on risk factors that can be used to identify high-r...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/01.str.26.5.801

    authors: van Latum JC,Koudstaal PJ,Venables GS,van Gijn J,Kappelle LJ,Algra A

    更新日期:1995-05-01 00:00:00

  • Predicting long-term independency in activities of daily living after middle cerebral artery stroke: does information from MRI have added predictive value compared with clinical information?

    abstract:BACKGROUND AND PURPOSE:To investigate whether neuroimaging information has added predictive value compared with clinical information for independency in activities of daily living (ADL) 1 year after stroke. METHODS:Seventy-five first-ever middle cerebral artery stroke survivors were evaluated in logistic regression an...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000206462.09410.6f

    authors: Schiemanck SK,Kwakkel G,Post MW,Kappelle LJ,Prevo AJ

    更新日期:2006-04-01 00:00:00

  • Altered Fibrin Clot Properties in Patients With Cerebral Venous Sinus Thrombosis: Association With the Risk of Recurrence.

    abstract:BACKGROUND AND PURPOSE:Venous thromboembolism and ischemic stroke are associated with unfavorable fibrin clot structure and function. We hypothesized that denser fibrin networks displaying impaired lysability characterize patients with cerebral venous sinus thrombosis (CVST). METHODS:We assessed plasma fibrin clot pro...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.115.009528

    authors: Siudut J,Świat M,Undas A

    更新日期:2015-09-01 00:00:00

  • Long-term risk of recurrent stroke after a first-ever stroke. The Oxfordshire Community Stroke Project.

    abstract:BACKGROUND AND PURPOSE:There have been few community-based studies of long-term prognosis after acute stroke. This study aims to provide precise estimates of the absolute and relative risks of stroke recurrence in an unselected cohort of patients with a first-ever stroke. METHODS:Six hundred seventy-five patients were...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.2.333

    authors: Burn J,Dennis M,Bamford J,Sandercock P,Wade D,Warlow C

    更新日期:1994-02-01 00:00:00

  • Telemedicine in emergency evaluation of acute stroke: interrater agreement in remote video examination with a novel multimedia system.

    abstract:BACKGROUND AND PURPOSE:In acute stroke care, rapid but careful evaluation of patients is mandatory but requires an experienced stroke neurologist. Telemedicine offers the possibility of bringing such expertise quickly to more patients. This study tested for the first time whether remote video examination is feasible an...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.STR.0000102043.70312.E9

    authors: Handschu R,Littmann R,Reulbach U,Gaul C,Heckmann JG,Neundörfer B,Scibor M

    更新日期:2003-12-01 00:00:00

  • Prospective study of depressive symptoms and risk of stroke among japanese.

    abstract:BACKGROUND AND PURPOSE:We sought to examine the relationship between depressive symptoms and the incidence of stroke among Japanese men and women. METHODS:A 10.3-year prospective study on the relationship between depressive symptoms and the incidence of stroke was conducted with 901 men and women aged 40 to 78 years i...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.32.4.903

    authors: Ohira T,Iso H,Satoh S,Sankai T,Tanigawa T,Ogawa Y,Imano H,Sato S,Kitamura A,Shimamoto T

    更新日期:2001-04-01 00:00:00

  • Infectious burden and carotid plaque thickness: the northern Manhattan study.

    abstract:BACKGROUND AND PURPOSE:The overall burden of prior infections may contribute to atherosclerosis and stroke risk. We hypothesized that serological evidence of common infections would be associated with carotid plaque thickness in a multiethnic cohort. METHODS:Antibody titers to 5 common infectious microorganisms (ie, C...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.109.571299

    authors: Elkind MS,Luna JM,Moon YP,Boden-Albala B,Liu KM,Spitalnik S,Rundek T,Sacco RL,Paik MC

    更新日期:2010-03-01 00:00:00

  • Long-term prognosis after a minor stroke: 10-year mortality and major stroke recurrence rates in a hospital-based cohort.

    abstract:BACKGROUND AND PURPOSE:Determinants of long-term outcome are not well defined in minor stroke patients. This study aims to evaluate which factors are independent long-term predictors of death and major stroke recurrence in a cohort of minor ischemic strokes. METHODS:A cohort of 322 patients with first-ever minor ische...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.29.1.126

    authors: Prencipe M,Culasso F,Rasura M,Anzini A,Beccia M,Cao M,Giubilei F,Fieschi C

    更新日期:1998-01-01 00:00:00

  • Low-dose recombinant tissue-type plasminogen activator enhances clot resolution in brain hemorrhage: the intraventricular hemorrhage thrombolysis trial.

    abstract:BACKGROUND AND PURPOSE:Patients with intracerebral hemorrhage and intraventricular hemorrhage have a reported mortality of 50% to 80%. We evaluated a clot lytic treatment strategy for these patients in terms of mortality, ventricular infection, and bleeding safety events, and for its effect on the rate of intraventricu...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/STROKEAHA.110.610949

    authors: Naff N,Williams MA,Keyl PM,Tuhrim S,Bullock MR,Mayer SA,Coplin W,Narayan R,Haines S,Cruz-Flores S,Zuccarello M,Brock D,Awad I,Ziai WC,Marmarou A,Rhoney D,McBee N,Lane K,Hanley DF Jr

    更新日期:2011-11-01 00:00:00

  • Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke.

    abstract:BACKGROUND AND PURPOSE:In animal models of cerebral ischemia, matrix metalloproteinase (MMP) expression was significantly increased and related to blood-brain barrier disruption, edema formation, and hemorrhagic transformation (HT). MMP inhibitors reduce HT after embolic ischemia in tissue-type plasminogen activator-tr...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/hs1201.99512

    authors: Montaner J,Alvarez-Sabín J,Molina CA,Anglés A,Abilleira S,Arenillas J,Monasterio J

    更新日期:2001-12-01 00:00:00

  • Risk of stroke from new carotid artery occlusion in the Asymptomatic Carotid Surgery Trial-1.

    abstract:BACKGROUND AND PURPOSE:In the Asymptomatic Carotid Surgery Trial-1 (ACST-1), 3120 patients with tight asymptomatic carotid stenosis were randomly assigned to medical treatment alone or to carotid endarterectomy and appropriate medication. Successful carotid endarterectomy significantly reduced 10-year stroke risk in yo...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.111.000348

    authors: den Hartog AG,Halliday AW,Hayter E,Pan H,Kong X,Moll FL,de Borst GJ,Asymptomatic Carotid Surgery Trial Collaborators.

    更新日期:2013-06-01 00:00:00

  • Response of the cerebral circulation to profound hypocarbia in neonatal lambs.

    abstract::Hyperventilation to extremely low arterial carbon dioxide tension (PaCO2) has been used in the management of persistent pulmonary hypertension in newborn infants. With progressive hypocarbia, cerebral vasoconstriction occurs, raising the concern that extreme hypocarbia may result in cerebral oxygen deprivation. Theref...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.19.11.1365

    authors: Rosenberg AA

    更新日期:1988-11-01 00:00:00

  • Pathogenic ischemic stroke phenotypes in the NINDS-stroke genetics network.

    abstract:BACKGROUND AND PURPOSE:NINDS (National Institute of Neurological Disorders and Stroke)-SiGN (Stroke Genetics Network) is an international consortium of ischemic stroke studies that aims to generate high-quality phenotype data to identify the genetic basis of pathogenic stroke subtypes. This analysis characterizes the e...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.007362

    authors: Ay H,Arsava EM,Andsberg G,Benner T,Brown RD Jr,Chapman SN,Cole JW,Delavaran H,Dichgans M,Engström G,Giralt-Steinhauer E,Grewal RP,Gwinn K,Jern C,Jimenez-Conde J,Jood K,Katsnelson M,Kissela B,Kittner SJ,Kleindorfer D

    更新日期:2014-12-01 00:00:00

  • The versican gene and the risk of intracranial aneurysms.

    abstract:BACKGROUND AND PURPOSE:The proteoglycan versican is an excellent candidate gene for intracranial aneurysms (IAs) because it plays an important role in extracellular matrix assembly and is localized in a previously implicated locus for IAs on chromosome 5q. METHODS:We analyzed all the common variations using 16-tag sin...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000236499.55301.09

    authors: Ruigrok YM,Rinkel GJ,Wijmenga C

    更新日期:2006-09-01 00:00:00

  • Effects of flunarizine on neurological recovery and spinal cord blood flow in experimental spinal cord ischemia in rabbits.

    abstract:BACKGROUND AND PURPOSE:The lipophilic calcium channel antagonist flunarizine has been demonstrated to be neuroprotective in several models of cerebral ischemia. Ischemic spinal cord injury may have a similar pathophysiology and hence may respond in a similar fashion. This study was designed to investigate the effects o...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.24.10.1547

    authors: Johnson SH,Kraimer JM,Graeber GM

    更新日期:1993-10-01 00:00:00

  • An epidemiological survey of stroke in Lhasa, Tibet, China.

    abstract:BACKGROUND AND PURPOSE:There have not been any new epidemiological studies related to stroke in Tibet for 20 years. This study aimed to collect stroke data from The City Staff Medical Insurance Registry in Lhasa, Tibet, to describe the incidence, clinical subtypes, and associated risk factors of stroke. METHODS:We use...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.586669

    authors: Zhao Y,Yao Z,D'Souza W,Zhu C,Chun H,Zhuoga C,Zhang Q,Hu X,Zhou D

    更新日期:2010-12-01 00:00:00

  • Pentoxifylline increases cerebral blood flow in patients with cerebrovascular disease.

    abstract::We determined the immediate effects of pentoxifylline on cerebral blood flow in 10 patients with cerebrovascular disease; four received 400 mg and six received 800 mg pentoxifylline orally. Regional cerebral blood flow was measured before (baseline) and 2, 4, and 6 hours after pentoxifylline administration using the x...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.20.12.1662

    authors: Bowton DL,Stump DA,Prough DS,Toole JF,Lefkowitz DS,Coker L

    更新日期:1989-12-01 00:00:00

  • Thrombolysis in brain ischemia (TIBI) transcranial Doppler flow grades predict clinical severity, early recovery, and mortality in patients treated with intravenous tissue plasminogen activator.

    abstract:BACKGROUND AND PURPOSE:TIMI angiographic classification measures coronary residual flow and recanalization. We developed a Thrombolysis in Brain Ischemia (TIBI) classification by using transcranial Doppler (TCD) to noninvasively monitor intracranial vessel residual flow signals. We examined whether the emergent TCD TIB...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/01.str.32.1.89

    authors: Demchuk AM,Burgin WS,Christou I,Felberg RA,Barber PA,Hill MD,Alexandrov AV

    更新日期:2001-01-01 00:00:00

  • Prophylactic but not delayed administration of simvastatin protects against long-lasting cognitive and morphological consequences of neonatal hypoxic-ischemic brain injury, reduces interleukin-1beta and tumor necrosis factor-alpha mRNA induction, and does

    abstract:BACKGROUND AND PURPOSE:Prophylactic administration of simvastatin has been shown to protect against brain damage and its long-lasting behavioral consequences in neonatal rats. To establish the drug treatment window, we evaluated the effectiveness of simvastatin administered at different intervals before and after strok...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000080677.24419.88

    authors: Balduini W,Mazzoni E,Carloni S,De Simoni MG,Perego C,Sironi L,Cimino M

    更新日期:2003-08-01 00:00:00

  • Coffee consumption and risk of stroke in women.

    abstract:BACKGROUND AND PURPOSE:Coffee consumption has been inconsistently associated with stroke incidence and mortality in previous studies. We investigated the association between coffee consumption and stroke incidence in the Swedish Mammography Cohort. METHODS:We prospectively followed of 34,670 women without a history of...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.603787

    authors: Larsson SC,Virtamo J,Wolk A

    更新日期:2011-04-01 00:00:00