Abstract:
BACKGROUND AND PURPOSE:The proteoglycan versican is an excellent candidate gene for intracranial aneurysms (IAs) because it plays an important role in extracellular matrix assembly and is localized in a previously implicated locus for IAs on chromosome 5q. METHODS:We analyzed all the common variations using 16-tag single nucleotide polymorphisms (SNPs) and haplotypes in the versican gene using a 2-stage genotyping approach. For stage 1, 16 SNPs were genotyped in 307 cases and 639 controls. For stage 2, the two SNPs yielding the most significant associations (P<0.01) were genotyped in a second independent cohort of 310 cases for confirmation of the associations. RESULTS:In stage 1, we found several SNPs in strong linkage disequilibrium and haplotypes constituting these SNPs associated with IAs in the Dutch population (strongest SNP association for rs173686 with odds ratio=1.34, 95% CI=1.09 to 1.65, P=0.004). In stage 2, we confirmed association for the 2 SNPs with the most significant associations (strongest SNP association for rs173686 with odds ratio=1.36, 95% CI=1.11 to 1.67, P=0.003). CONCLUSIONS:SNPs in strong linkage disequilibrium and haplotypes constituting these SNPs in the versican gene are associated with IAs suggesting that variation in or near the versican gene plays a role in susceptibility to IAs.
journal_name
Strokejournal_title
Strokeauthors
Ruigrok YM,Rinkel GJ,Wijmenga Cdoi
10.1161/01.STR.0000236499.55301.09subject
Has Abstractpub_date
2006-09-01 00:00:00pages
2372-4issue
9eissn
0039-2499issn
1524-4628pii
01.STR.0000236499.55301.09journal_volume
37pub_type
杂志文章相关文献
STROKE文献大全abstract::There is a strong link between antiphospholipid antibodies and stroke. Retrospective studies indicate that these patients are generally young, often have had prior thrombotic events including stroke, frequently complain of headaches, and often experience amaurosis fugax. Cardiac valvular lesions, particularly involvin...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:
更新日期:1992-02-01 00:00:00
abstract::Previous studies suggest that rheological changes associated with ischemia may produce postischemic hypoperfusion. We tested whether intracarotid or intravenous infusions of saline improve neurological outcome from incomplete cerebral ischemia in rats. Rats were anesthetized with 1.4% isoflurane in air, and ischemia w...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.6.797
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Improvements in cardiac surgery mortality and morbidity have focused interest on the neurological injury such as stroke and cognitive decline that may accompany an otherwise successful operation. We aimed to investigate (1) the rate of stroke, new ischemic change on MRI, and cognitive impairment ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.107.502989
更新日期:2008-05-01 00:00:00
abstract::A xenon-133 method was used to measure cerebral blood flow (CBF) before and after cerebrospinal fluid (CSF) removal in patients with normal pressure hydrocephalus (NPH). Preliminary results suggested that shunting should be performed on patients whose CBF increased after CSF removal. There was a significant increase i...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.6.1074
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The majority of pharmacological agents for stroke were developed based on the assumption that neurological deficits will be reduced upon the successful interruption of biochemical mechanisms leading to neuronal death. Despite significant evidence of preclinical efficacy, none of these agents succ...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.109.559914
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Type 2 diabetes is associated with a high cardiovascular morbidity and mortality. Recent advances of intervention studies in type 2 diabetes with use of carotid intima-media thickness (CIMT) measurement as a surrogate end point may allow for better understanding of the undetermined process of ath...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.STR.0000236632.58323.cd
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The impact of anesthesia technique on the outcomes of mechanical thrombectomy for acute ischemic stroke remains an issue of debate. We investigated the association of general anesthesia with outcomes in patients undergoing mechanical thrombectomy for ischemic stroke. METHODS:We performed a cohor...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.015343
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In 2006, the American Heart Association recommended that carotid revascularization generally occurs within 2 weeks of stroke based on data from 2 trials of carotid endarterectomy (CEA). We aimed to determine whether the time between stroke and CEA or carotid artery stenting (CAS) has decreased an...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.015766
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:One of the reasons for the failure of trials of neuroprotection in stroke may be the lack of white matter (WM) protection. However, whether patients entered into typical neuroprotection trials have WM involved in the ischemic process is unknown. We studied patients who were enrolled in neuroprote...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000189748.52500.a7
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke is the leading cause of adult disability worldwide. Currently, there is no effective treatment for stroke survivors. Stem cell factor (SCF) and granulocyte-colony stimulating factor (G-CSF) are the growth factors regulating hematopoiesis. We have previously observed that SCF and G-CSF have...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.486217
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Repetitive transcranial magnetic stimulation of the primary motor cortex (M1) may improve outcomes after stroke. The aim of this study was to determine the effects of M1 theta burst stimulation (TBS) and standardized motor training on upper-limb function of patients with chronic stroke. METHODS:...
journal_title:Stroke
pub_type: 信件
doi:10.1161/STROKEAHA.110.583278
更新日期:2010-07-01 00:00:00
abstract::Background and Purpose- To test the hypothesis that covert brain infarcts (CBIs) are more likely to be located in noneloquent brain areas compared with clinical strokes and that CBI etiological subtypes carry a differential risk of vascular events compared with people without CBI. Methods- We used brain magnetic reson...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.026068
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Evidence of a relationship of fish intake to stroke incidence or mortality is weak. This report examines the association of fish consumption with stroke. METHODS:A cohort of 2107 men aged 40 to 55 years from the Chicago Western Electric Study who were free of coronary heart disease and stroke th...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.2.204
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stent-assisted coiling has expanded the treatment of intracranial aneurysms, but the rates of procedure-related neurological complications and the incidence of angiographic aneurysm recurrence of this novel treatment are not yet well known. We present our experience with stent-assisted coiling wi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.558114
更新日期:2010-01-01 00:00:00
abstract::As indicated by Barnett, Plum and Walton, a definitive clinical trial to resolve the issue of the effectiveness of carotid endarterectomy is clearly needed. A proposal to foster such a trial, through a moratorium on third-party reimbursement other than for randomized patients, has herein been presented. ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.6.1335
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Because no population-based estimates are available for asymptomatic retinal emboli, we aimed to assess prevalence and associations of this sign in a defined older Australian urban population. METHODS:A total of 3654 persons aged 49 years or older, representing 82% of residents in an urban area ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.1.63
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:In 15% to 20% of patients with a spontaneous subarachnoid hemorrhage, no aneurysm is found on the first angiogram. This review emphasizes that this group of patients is in fact heterogeneous and describes the clinical features, pattern of hemorrhage on early computed tomographic (CT) scan, prognosis, and pro...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.24.9.1403
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Whether and how the arterial pathology underlying lacunar ischemic stroke differs from the atherothrombotic processes causing most other ischemic strokes is still debated. Different risks of recurrent stroke and MI after lacunar versus nonlacunar ischemic stroke may support a distinct lacunar art...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.558221
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Spontaneous dissection of the cervical internal carotid artery (sICAD) is mainly assessed with MRI and magnetic resonance angiography (MRA), which are not always at hand. In contrast, color duplex sonography (CDS) is readily available. We undertook this prospective study to examine the accuracy o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000198811.65068.16
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Arterial baroreflex is one of the most important mechanisms in the regulation of cardiovascular activities. Arterial baroreflex function can be expressed as baroreflex sensitivity (BRS). The present study was designed to test 2 hypotheses: (1) BRS is a new independent predictor for the incidence ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.106.480061
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Because the blood circulation system of retina and brain are closely related to each other, we examined whether stroke is associated with localized retinal nerve fiber layer defects (RNFLDs). METHODS:Patients with acute ischemic stroke as part of a hospital-based study group were compared with t...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.113.004629
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The perfusion territories of the brain-feeding arteries are difficult to assess in vivo and therefore standard cerebral perfusion territory templates are often used to determine the relation between cerebral infarcts and the feeding vasculature. In the present study, we compared this infarct clas...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.539866
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this study was to test whether arterial spin labeling (ASL) can detect significant differences in relative cerebral blood flow (rCBF) in the core, mismatch, and reverse-mismatch regions, and whether rCBF values measured by ASL in those areas differ from values obtained using dynamic su...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.635979
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Choroid plexus (CP) secretes a cocktail of neurotrophic factors. In the present study, CP from neonatal pigs was encapsulated within alginate microcapsules for in vitro and in vivo neuroprotective studies. METHODS:In vitro studies involved serum deprivation of rat embryonic cortical neurons and ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000138954.25825.0b
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The objective of this study was to determine the prevalence of intracranial plaques and stenoses and their causal role in patients with fatal stroke. Intracranial atherosclerosis is considered to be a rare condition with a severe prognosis. However, disease prevalence may be underestimated due to...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.496513
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Alberta Stroke program early CT score (ASPECTS) is a semiquantative scale for estimating extent and distribution of early ischemic changes within the MCA territory in the acute stroke setting. Good interobserver agreement of total ASPECTS is demonstrated for noncontrast CT (NCCT) and other im...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.665208
更新日期:2013-01-01 00:00:00
abstract::Leukoaraiosis is a common finding in stroke patients and has been strongly associated with risk of incident stroke and dementia. Leukoaraiosis may also be an independent predictor of stroke outcomes. There is increasing evidence from neuroimaging to support the concept that some leukoaraiosis is caused by white matter...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.110.596056
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) is the only type of stroke with female predominance, suggesting that reproductive factors may play a role in the etiology. We conducted a population-based study to examine the influence of parity on the risk of SAH in women. METHODS:We linked data from 3 national Sw...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000105933.16654.B4
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of this study was to assess the prevalence and characteristics of silent cerebral infarction in a population-based consecutive autopsy series of residents of Hisayama, Kyushu, Japan. METHODS:Autopsy records, cerebral pathological findings, and clinical charts of 966 Hisayama resident...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.3.380
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Milk fat globule-EGF factor-8 (MFGE8) has been reported to be neuroprotective in ischemic stroke. However, the effects of MFGE8 in early brain injury after subarachnoid hemorrhage (SAH) have not been investigated. We investigated the role of MFGE8 in early brain injury and the potential mechanism...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.006635
更新日期:2014-12-01 00:00:00