The versican gene and the risk of intracranial aneurysms.

Abstract:

BACKGROUND AND PURPOSE:The proteoglycan versican is an excellent candidate gene for intracranial aneurysms (IAs) because it plays an important role in extracellular matrix assembly and is localized in a previously implicated locus for IAs on chromosome 5q. METHODS:We analyzed all the common variations using 16-tag single nucleotide polymorphisms (SNPs) and haplotypes in the versican gene using a 2-stage genotyping approach. For stage 1, 16 SNPs were genotyped in 307 cases and 639 controls. For stage 2, the two SNPs yielding the most significant associations (P<0.01) were genotyped in a second independent cohort of 310 cases for confirmation of the associations. RESULTS:In stage 1, we found several SNPs in strong linkage disequilibrium and haplotypes constituting these SNPs associated with IAs in the Dutch population (strongest SNP association for rs173686 with odds ratio=1.34, 95% CI=1.09 to 1.65, P=0.004). In stage 2, we confirmed association for the 2 SNPs with the most significant associations (strongest SNP association for rs173686 with odds ratio=1.36, 95% CI=1.11 to 1.67, P=0.003). CONCLUSIONS:SNPs in strong linkage disequilibrium and haplotypes constituting these SNPs in the versican gene are associated with IAs suggesting that variation in or near the versican gene plays a role in susceptibility to IAs.

journal_name

Stroke

journal_title

Stroke

authors

Ruigrok YM,Rinkel GJ,Wijmenga C

doi

10.1161/01.STR.0000236499.55301.09

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

2372-4

issue

9

eissn

0039-2499

issn

1524-4628

pii

01.STR.0000236499.55301.09

journal_volume

37

pub_type

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