Intracerebral transplantation of porcine choroid plexus provides structural and functional neuroprotection in a rodent model of stroke.


BACKGROUND AND PURPOSE:Choroid plexus (CP) secretes a cocktail of neurotrophic factors. In the present study, CP from neonatal pigs was encapsulated within alginate microcapsules for in vitro and in vivo neuroprotective studies. METHODS:In vitro studies involved serum deprivation of rat embryonic cortical neurons and treatment with a range of concentrations of conditioned media from CP. For in vivo studies, rats received a 1-hour middle cerebral artery occlusion followed by intracranial transplantation of encapsulated or unencapsulated CP, empty capsules, or no transplant. Behavioral testing was conducted on days 1 to 3 after transplantation. Cerebral infarction was analyzed using 2,3,5-triphenyl-tetrazolium chloride staining at 3 days after transplantation. RESULTS:Conditioned media from CP produced a significant dose-dependent protection of serum-deprived cortical neurons. Enzyme-linked immunosorbent assay confirmed secretion of GDNF, BDNF, and NGF from CP. Parallel in vivo studies showed that CP transplants improved behavioral performance and decreased the volume of infarction. Both encapsulated and unencapsulated CP transplants were effective; however, more robust benefits accompanied encapsulated transplants. CONCLUSIONS:These data are the first to demonstrate the neuroprotective potential of transplanted CP and raise the intriguing possibility of using these cells as part of the treatment regimen for stroke and other neurological disorders.






Borlongan CV,Skinner SJ,Geaney M,Vasconcellos AV,Elliott RB,Emerich DF




Has Abstract


2004-09-01 00:00:00
















  • Impaired cerebral autoregulation is associated with vasospasm and delayed cerebral ischemia in subarachnoid hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Cerebral autoregulation may be impaired in the early days after subarachnoid hemorrhage (SAH). The purpose of this study was to examine the relationship between cerebral autoregulation and angiographic vasospasm (aVSP) and radiographic delayed cerebral ischemia (DCI) in patients with SAH. METHOD...


    pub_type: 杂志文章


    authors: Otite F,Mink S,Tan CO,Puri A,Zamani AA,Mehregan A,Chou S,Orzell S,Purkayastha S,Du R,Sorond FA

    更新日期:2014-03-01 00:00:00

  • Effects of some guanidino compounds on human cerebral arteries.

    abstract:BACKGROUND AND PURPOSE:Accumulation of endogenous guanidino-substituted analogues of L-arginine in chronic renal failure might contribute to some of the vascular and neurological disorders of this pathology. We tested the hypothesis that in human cerebral arteries, some guanidino compounds may increase vascular tone, t...


    pub_type: 临床试验,杂志文章


    authors: Segarra G,Medina P,Ballester RM,Lluch P,Aldasoro M,Vila JM,Lluch S,Pelligrino DA

    更新日期:1999-10-01 00:00:00

  • Cerebral vascular dysfunction during hypercholesterolemia.

    abstract:BACKGROUND AND PURPOSE:Studies of peripheral arteries in hypercholesterolemic animals suggest that increased generation of superoxide contributes to endothelial dysfunction, especially in the presence of atherosclerotic lesions. We tested the hypothesis that vasomotor function is impaired in cerebral arterioles during ...


    pub_type: 杂志文章


    authors: Kitayama J,Faraci FM,Lentz SR,Heistad DD

    更新日期:2007-07-01 00:00:00

  • Racial disparities in awareness and treatment of atrial fibrillation: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study.

    abstract:BACKGROUND AND PURPOSE:Warfarin reduces stroke risk by approximately 60% in patients with atrial fibrillation (AF). Differences in awareness and treatment of AF may contribute to racial and geographic disparities in stroke mortality. The objective was to examine predictors of awareness of the diagnosis of AF and treatm...


    pub_type: 杂志文章


    authors: Meschia JF,Merrill P,Soliman EZ,Howard VJ,Barrett KM,Zakai NA,Kleindorfer D,Safford M,Howard G

    更新日期:2010-04-01 00:00:00

  • Late stroke: comparison of percutaneous coronary intervention versus coronary artery bypass grafting in patients with multivessel disease and unprotected left main disease: a meta-analysis and review of literature.

    abstract:BACKGROUND AND PURPOSE:Studies have suggested that the early excess risk of stroke in coronary artery bypass grafting (CABG) may be compensated for by a slow but progressive catch-up phenomenon in patients undergoing percutaneous coronary intervention (PCI). We therefore undertook this analysis to compare the temporal ...


    pub_type: 杂志文章,meta分析,评审


    authors: Athappan G,Chacko P,Patvardhan E,Gajulapalli RD,Tuzcu EM,Kapadia SR

    更新日期:2014-01-01 00:00:00

  • Effect of internal carotid artery occlusion on intracranial hemodynamics. Transcranial Doppler evaluation and clinical correlation.

    abstract::Neurologic deficits that occur simultaneously with or subsequent to internal carotid artery occlusion may be influenced by the adequacy of the intracerebral collateral circulation. Transcranial Doppler ultrasonography was used to evaluate mean middle cerebral artery blood velocity and blood flow in major collateral ar...


    pub_type: 杂志文章


    authors: Schneider PA,Rossman ME,Bernstein EF,Torem S,Ringelstein EB,Otis SM

    更新日期:1988-05-01 00:00:00

  • Risk of stroke from new carotid artery occlusion in the Asymptomatic Carotid Surgery Trial-1.

    abstract:BACKGROUND AND PURPOSE:In the Asymptomatic Carotid Surgery Trial-1 (ACST-1), 3120 patients with tight asymptomatic carotid stenosis were randomly assigned to medical treatment alone or to carotid endarterectomy and appropriate medication. Successful carotid endarterectomy significantly reduced 10-year stroke risk in yo...


    pub_type: 杂志文章,随机对照试验


    authors: den Hartog AG,Halliday AW,Hayter E,Pan H,Kong X,Moll FL,de Borst GJ,Asymptomatic Carotid Surgery Trial Collaborators.

    更新日期:2013-06-01 00:00:00

  • Lacunar infarcts and white matter attenuation. Ophthalmologic and microcirculatory aspects of the pathophysiology.

    abstract:BACKGROUND AND PURPOSE:By means of neurological and ophthalmologic examinations we considered whether there is a microcirculatory disorder not related to hypertension and diabetes in patients with lacunar infarcts and whether there are microcirculatory differences in patients with lacunar infarcts compared with those w...


    pub_type: 杂志文章


    authors: Schneider R,Rademacher M,Wolf S

    更新日期:1993-12-01 00:00:00

  • Costs of stroke using patient-level data: a critical review of the literature.

    abstract:BACKGROUND AND PURPOSE:With decision-analytic models becoming more popular to assess the cost-effectiveness of health care interventions, the need for robust estimates on the costs of cerebrovascular disease is paramount. This study reports the results from a literature review of the costs of cerebrovascular diseases, ...


    pub_type: 杂志文章,meta分析,评审


    authors: Luengo-Fernandez R,Gray AM,Rothwell PM

    更新日期:2009-02-01 00:00:00

  • Plaque ulceration and lumen thrombus are the main sources of cerebral microemboli in high-grade internal carotid artery stenosis.

    abstract:BACKGROUND AND PURPOSE:Previous work has shown that rates of cerebral microemboli downstream of high-grade internal carotid artery stenosis are higher in recently symptomatic compared with asymptomatic patients. In addition, microembolic rates decline after carotid endarterectomy. We conducted a prospective investigati...


    pub_type: 杂志文章


    authors: Sitzer M,Müller W,Siebler M,Hort W,Kniemeyer HW,Jäncke L,Steinmetz H

    更新日期:1995-07-01 00:00:00

  • A comparison of the costs and survival of hospital-admitted stroke patients across Europe.

    abstract:BACKGROUND AND PURPOSE:Policy makers require evidence on the costs and outcomes of different ways of organizing stroke care. This study compared the costs and survival of different ways of providing stroke care. METHODS:Hospitalized stroke patients from 13 European centers were included, with demographic, case-mix, an...


    pub_type: 杂志文章,多中心研究


    authors: Grieve R,Hutton J,Bhalla A,Rastenytë D,Ryglewicz D,Sarti C,Lamassa M,Giroud M,Dundas R,Wolfe CD

    更新日期:2001-07-01 00:00:00

  • Stroke awareness and knowledge retention in children: The Brain Child Project.

    abstract:BACKGROUND AND PURPOSE:Efforts at public education to improve adults' response to stroke symptoms continue to be disappointing, and very little has been developed to improve the knowledge base of children regarding brain attacks. Children may be able to exert a positive influence on adult behavior and to learn positive...


    pub_type: 杂志文章


    authors: Dressman LA,Hunter J

    更新日期:2002-02-01 00:00:00

  • Are distal protection devices 'protective' during carotid angioplasty and stenting?

    abstract:BACKGROUND AND PURPOSE:To evaluate the periprocedural outcome after carotid artery stenting with embolic brain protection (EBP+) versus without embolic brain protection (EBP-). METHODS:We retrospectively reviewed data from a prospective nonrandomized database of 357 patients who underwent carotid artery stenting in th...


    pub_type: 杂志文章


    authors: Tallarita T,Rabinstein AA,Cloft H,Kallmes D,Oderich GS,Brown RD,Lanzino G

    更新日期:2011-07-01 00:00:00

  • Sarcoidosis presenting with stroke.

    abstract::A 25-year-old black man with sarcoidosis presented with transient ischemic attacks followed by sudden, persistent right hemiparesis. He gave a history of recent, recurrent lower motor neuron facial palsy. Computed tomography demonstrated an infarct in the left internal capsule. Chest x-ray film showed bilateral hilar ...


    pub_type: 杂志文章


    authors: Brown MM,Thompson AJ,Wedzicha JA,Swash M

    更新日期:1989-03-01 00:00:00

  • Human serum albumin and its N-terminal tetrapeptide (DAHK) block oxidant-induced neuronal death.

    abstract:BACKGROUND AND PURPOSE:Studies using animal models of stroke have shown that human serum albumin (HSA) significantly ameliorates cerebral ischemic injury after both transient and permanent ischemia, even when administered after the onset of ischemia or reperfusion. The mechanism of this effect remains uncertain, and pr...


    pub_type: 杂志文章


    authors: Gum ET,Swanson RA,Alano C,Liu J,Hong S,Weinstein PR,Panter SS

    更新日期:2004-02-01 00:00:00

  • Hypertensive putaminal hemorrhage: treatment and results. Is surgical treatment superior to conservative one?

    abstract::Seventy-four patients with hypertensive putaminal hemorrhage (HPH) were followed at least 6 months after treatment and estimated by ADL. They were graded according to the state of consciousness on admission. The grading consists of 6 grades: Grade 1, fully conscious; Grade 2, somnolent; Grade 3, stuporous; Grade 4, se...


    pub_type: 杂志文章


    authors: Waga S,Yamamoto Y

    更新日期:1983-07-01 00:00:00

  • The effect of a thromboxane synthetase inhibitor, OKY-046, on urinary excretion of immunoreactive thromboxane B2 and 6-keto-prostaglandin F1 alpha in patients with ischemic cerebrovascular disease.

    abstract::Thromboxane synthetase activity is selectively inhibited by (E)-3-[4-(1-imidazolylmethyl)phenyl]-2-propenoic acid hydrochloride monohydrate (OKY-046). A single dose of 100 mg OKY-046 was orally administered to patients with ischemic cerebrovascular disease and healthy volunteers. Platelet aggregation and thromboxane B...


    pub_type: 杂志文章


    authors: Uyama O,Nagatsuka K,Nakabayashi S,Isaka Y,Yoneda S,Kimura K,Abe H

    更新日期:1985-03-01 00:00:00

  • Stroke, statins, and cholesterol. A meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors.

    abstract:BACKGROUND AND PURPOSE:To estimate the effect of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors ("statins") on stroke ris, we combined the data of the randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors published so far. METHODS:The studies were identified using ...


    pub_type: 杂志文章,meta分析


    authors: Blauw GJ,Lagaay AM,Smelt AH,Westendorp RG

    更新日期:1997-05-01 00:00:00

  • Prospective follow-up study between 3 and 15 months after stroke: improvements and decline in cognitive function among dementia-free stroke survivors >75 years of age.

    abstract:BACKGROUND AND PURPOSE:Poststroke cognitive impairment is frequent. There are, however, few longitudinal studies examining delayed changes in poststroke cognition. METHODS:As part of a longitudinal study of incident dementia after stroke, 115 older stroke survivors (>75 years of age) without dementia were evaluated at...


    pub_type: 杂志文章


    authors: Ballard C,Rowan E,Stephens S,Kalaria R,Kenny RA

    更新日期:2003-10-01 00:00:00

  • Early intensive versus minimally invasive approach to postoperative hemodynamic management after subarachnoid hemorrhage.

    abstract:BACKGROUND AND PURPOSE:The results of previous studies suggest that early goal-directed fluid therapy (EGDT) reduces delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage, but the effects of EGDT on clinical outcomes are still unclear. This study aimed to determine whether EGDT improves outcomes comp...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Mutoh T,Kazumata K,Terasaka S,Taki Y,Suzuki A,Ishikawa T

    更新日期:2014-05-01 00:00:00

  • Cerebral artery mass in the rabbit is reduced by chronic sympathetic denervation.

    abstract::Weights of matching right and left middle or posterior cerebral arteries and their main branches from the same animal were compared 8-10 weeks after unilateral denervation by superior cervical ganglionectomy. When compared in pairs, the denervated arterial systems weighed significantly less (mean 85%) than their inner...


    pub_type: 杂志文章


    authors: Bevan RD,Tsuru H,Bevan JA

    更新日期:1983-05-01 00:00:00

  • Assessing the laryngeal cough reflex and the risk of developing pneumonia after stroke: an interhospital comparison.

    abstract:BACKGROUND AND PURPOSE:We sought to evaluate the efficacy of testing the laryngeal cough reflex in identifying pneumonia risk in acute stroke patients. METHODS:We performed a prospective study of 400 consecutive acute stroke patients examined using the reflex cough test (RCT) compared with 204 consecutive acute stroke...


    pub_type: 杂志文章


    authors: Addington WR,Stephens RE,Gilliland KA

    更新日期:1999-06-01 00:00:00

  • Dichotomous effects of chronic intermittent hypoxia on focal cerebral ischemic injury.

    abstract:BACKGROUND AND PURPOSE:Obstructive sleep apnea, a condition associated with chronic intermittent hypoxia (CIH), carries an increased risk of stroke. However, CIH has been reported to either increase or decrease brain injury in models of focal cerebral ischemia. The factors determining the differential effects of CIH on...


    pub_type: 杂志文章


    authors: Jackman KA,Zhou P,Faraco G,Peixoto PM,Coleman C,Voss HU,Pickel V,Manfredi G,Iadecola C

    更新日期:2014-05-01 00:00:00

  • Finding the most powerful measures of the effectiveness of tissue plasminogen activator in the NINDS tPA stroke trial.

    abstract:BACKGROUND AND PURPOSE:We sought to identify the most powerful binary measures of the treatment effect of tissue plasminogen activator (tPA) in the National Institute of Neurological Disorders and Stroke (NINDS) rTPA Stroke Trial. METHODS:Using the Classification and Regression Tree (CART) algorithm, we evaluated bina...


    pub_type: 杂志文章


    authors: Broderick JP,Lu M,Kothari R,Levine SR,Lyden PD,Haley EC,Brott TG,Grotta J,Tilley BC,Marler JR,Frankel M

    更新日期:2000-10-01 00:00:00

  • Incremental predictive value of carotid inflammation in acute ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:Microwave Radiometry (MWR) allows in vivo noninvasive assessment of internal temperature of tissues. The aim of the present study was to evaluate in patients with ischemic stroke and bilateral carotid plaques (1) whether ipsilateral carotid arteries exhibit higher temperature differences (ΔT), as...


    pub_type: 杂志文章


    authors: Toutouzas K,Benetos G,Drakopoulou M,Deligianni C,Spengos K,Stefanadis C,Siores E,Tousoulis D

    更新日期:2015-01-01 00:00:00

  • Role of extracellular Ca2+ in subarachnoid hemorrhage-induced spasm of the rabbit basilar artery.

    abstract:BACKGROUND AND PURPOSE:The role of extracellular Ca2+ in the maintenance of chronic vasospasm after subarachnoid hemorrhage (SAH) is largely unknown. Indeed, studies thus far have been limited to demonstrations that L-type Ca(2+)-channel antagonists were unable to reverse the spasm. This study tested whether SAH-induce...


    pub_type: 杂志文章


    authors: Zuccarello M,Boccaletti R,Tosun M,Rapoport RM

    更新日期:1996-10-01 00:00:00

  • A randomized trial of aspirin or heparin in hospitalized patients with recent transient ischemic attacks. A pilot study.

    abstract::In a randomized pilot study we compared the efficacy of temporary anticoagulation with intravenous heparin sodium to the efficacy of aspirin in preventing cerebral infarction in hospitalized patients with recent (less than 7 days) transient ischemic attacks (TIAs). Fifty-five patients (33 men, 22 women) aged 36-81 (me...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Biller J,Bruno A,Adams HP Jr,Godersky JC,Loftus CM,Mitchell VL,Banwart KJ,Jones MP

    更新日期:1989-04-01 00:00:00

  • Stroke Etiology and Thrombus Computed Tomography Characteristics in Patients With Acute Ischemic Stroke: A MR CLEAN Registry Substudy.

    abstract::Background and Purpose- If a relationship between stroke etiology and thrombus computed tomography characteristics exists, assessing these characteristics in clinical practice could serve as a useful additional diagnostic tool for the identification of stroke subtype. Our purpose was to study the association of stroke...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Boodt N,Compagne KCJ,Dutra BG,Samuels N,Tolhuisen ML,Alves HCBR,Kappelhof M,Lycklama À Nijeholt GJ,Marquering HA,Majoie CBLM,Lingsma HF,Dippel DWJ,van der Lugt A,Coinvestigators MR CLEAN Registry.

    更新日期:2020-06-01 00:00:00

  • Pressure-flow relations in canine collateral-dependent cerebrum.

    abstract:BACKGROUND AND PURPOSE:The pressure-flow relation has been characterized in normal cerebrum, but it has not been studied in cerebrum dependent on collateral flow. The purpose of this investigation was to examine the relation between systemic pressure, regional cerebral blood flow, and middle cerebral artery branch pres...


    pub_type: 杂志文章


    authors: Muhonen MG,Sawin PD,Loftus CM,Heistad DD

    更新日期:1992-07-01 00:00:00

  • Cerebral autoregulation: an in vitro study.

    abstract::Cerebral autoregulation can be duplicated in vitro using the large middle cerebral arteries from a calf. The limits of autoregulation were between 50 and 150 mm Hg. Excessively high pressures may lead to the appearance of the "sausage- or bead-string" response followed by forced dilation. These results suggest the exi...


    pub_type: 杂志文章


    authors: Vinall PE,Simeone FA

    更新日期:1981-09-01 00:00:00