Is white matter involved in patients entered into typical trials of neuroprotection?

abstract：BACKGROUND AND PURPOSE:We assessed whether the load of cerebral small vessel disease (cSVD) and its individual markers, including lacunes, white matter hyperintensities, microbleeds, and enlarged perivascular spaces (EPVS), are associated with arterial stiffness. METHODS:We evaluated cSVD markers in a cohort of 782 hy...

journal_title：Stroke

authors： Riba-Llena I,Jiménez-Balado J,Castañé X,Girona A,López-Rueda A,Mundet X,Jarca CI,Álvarez-Sabin J,Montaner J,Delgado P

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hemodynamic properties of brain arteriovenous malformations (AVMs) with risk factors for a future hemorrhage are essentially unknown. We hypothesized that AVMs with anatomic properties, which are associated with an increased rupture risk, exhibit different hemodynamic characteristics than those w...

journal_title：Stroke

authors： Illies T,Forkert ND,Saering D,Wenzel K,Ries T,Regelsberger J,Wegscheider K,Fiehler J

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although the cause of stroke among patients with patent foramen ovale (PFO) may be due to paradoxical cerebral embolism (PCE), this mechanism is often difficult to prove. The aim of our study was to evaluate the association between brain imaging findings suggestive of embolism and PFO among ische...

journal_title：Stroke

authors： Steiner MM,Di Tullio MR,Rundek T,Gan R,Chen X,Liguori C,Brainin M,Homma S,Sacco RL

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although the resting regional cerebral blood flow (rCBF) in aphasic patients has been thoroughly investigated with positron emission tomography (PET) and single-photon emission CT, and PET studies in normal subjects have elucidated the functional localization of language processing, little is kno...

journal_title：Stroke

authors： Ohyama M,Senda M,Kitamura S,Ishii K,Mishina M,Terashi A

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Attained height, an indicator of genetic potential and childhood growth environment, is inversely associated with stroke, but the mechanisms are poorly understood. We investigated whether childhood height and growth are associated with ischemic stroke (IS) and intracerebral hemorrhage (ICH). MET...

journal_title：Stroke

authors： Gjærde LK,Truelsen TC,Baker JL

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Cardiac involvement in Whipple's disease is not an uncommon phenomenon in autopsies, but its clinical occurrence is often overshadowed by gastrointestinal symptoms. We report a very atypical manifestation of this disorder. SUMMARY OF REPORT:An extraordinary presentation of an extremely long-lasting, culture...

journal_title：Stroke

authors： Naegeli B,Bannwart F,Bertel O

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral sinovenous thrombosis is a rare disease with severe neurological sequelae. The aim of this retrospective multicenter study was to investigate the clinical course, possible risk factors, and outcome of a cohort of neonatal patients with sinovenous thrombosis and, second, to estimate the i...

journal_title：Stroke

authors： Berfelo FJ,Kersbergen KJ,van Ommen CH,Govaert P,van Straaten HL,Poll-The BT,van Wezel-Meijler G,Vermeulen RJ,Groenendaal F,de Vries LS,de Haan TR

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Emergency medical services routing of patients with acute stroke to designated centers may increase the proportion of patients receiving care at facilities meeting national standards and augment recruitment for prehospital stroke research. METHODS:We analyzed consecutive patients enrolled within...

journal_title：Stroke

authors： Sanossian N,Liebeskind DS,Eckstein M,Starkman S,Stratton S,Pratt FD,Koenig W,Hamilton S,Kim-Tenser M,Conwit R,Saver JL,FAST-MAG Investigators and Coordinators.

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The pathophysiology of borderzone infarcts is not well understood. We investigated whether combined diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) could identify pathophysiologically meaningful categories of borderzone infarcts. METHODS:Seventeen patients with borderzone i...

journal_title：Stroke

authors： Chaves CJ,Silver B,Schlaug G,Dashe J,Caplan LR,Warach S

更新日期：2000-05-01 00:00:00

abstract：:We produced unilateral photochemical infarcts in the hindlimb sensorimotor neocortex of 186 rats by intravenous injection of the fluorescein derivative rose bengal and focal illumination of the intact skull surface. Infarcted rats showed specific, long-lasting deficits in tactile and proprioceptive placing reactions o...

journal_title：Stroke

authors： De Ryck M,Van Reempts J,Borgers M,Wauquier A,Janssen PA

更新日期：1989-10-01 00:00:00

abstract：:Background and Purpose- Timely access to endovascular thrombectomy (EVT) centers is vital for best acute ischemic stroke outcomes. Methods- US stroke-treating centers were mapped utilizing geo-mapping and stratified into non-EVT or EVT if they reported ≥1 acute ischemic stroke thrombectomy code in 2017 to Center for M...

journal_title：Stroke

authors： Sarraj A,Savitz S,Pujara D,Kamal H,Carroll K,Shaker F,Reddy S,Parsha K,Fournier LE,Jones EM,Sharrief A,Martin-Schild S,Grotta J

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A transient ischemic attack (TIA) in the brain is classically considered a syndrome lasting <24 hours. Having previously shown that an experimental challenge with the GABAA agonist midazolam in recovered stroke patients can reinduce the acute clinical state, we determined whether TIA patients wou...

journal_title：Stroke

authors： Lazar RM,Fitzsimmons BF,Marshall RS,Mohr JP,Berman MF

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aimed to determine clinical and hemodynamic predictors of early reocclusion (RO) in stroke patients treated with intravenous tissue plasminogen activator (tPA). METHODS:We studied 142 consecutive stroke patients with a documented middle cerebral artery (MCA) occlusion treated with intravenous...

journal_title：Stroke

authors： Rubiera M,Alvarez-Sabín J,Ribo M,Montaner J,Santamarina E,Arenillas JF,Huertas R,Delgado P,Purroy F,Molina CA

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transcranial Doppler ultrasonography (TCD) is the standard technique for monitoring emboli in the cerebral circulation. Embolic signals have been detected with the use of this technique in most patients undergoing coronary artery bypass surgery. We previously reported that the majority of emboli ...

journal_title：Stroke

authors： Barbut D,Yao FS,Hager DN,Kavanaugh P,Trifiletti RR,Gold JP

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients with cerebral amyloid angiopathy (CAA) are at high risk for intracerebral hemorrhage (ICH), but no effective prevention strategies have been established. The objective is to determine whether lowering of blood pressure (BP) provides protection for this high-risk patient group. METHODS:T...

journal_title：Stroke

authors： Arima H,Tzourio C,Anderson C,Woodward M,Bousser MG,MacMahon S,Neal B,Chalmers J,PROGRESS Collaborative Group.

更新日期：2010-02-01 00:00:00

abstract：:Background and Purpose- Hyperacute assessment and management of patients with stroke, termed code stroke, is a time-sensitive and high-stakes clinical scenario. In the context of the current coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 virus, the ability to deliver timely and efficacious care ...

journal_title：Stroke

authors： Khosravani H,Rajendram P,Notario L,Chapman MG,Menon BK

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cannabidiol has been reported to be a neuroprotectant, but the neuroprotective mechanism of cannabidiol remains unclear. We studied the neuroprotective mechanism of cannabidiol in 4-hour middle cerebral artery (MCA) occlusion mice. METHODS:Male MCA occluded mice were treated with cannabidiol, ab...

journal_title：Stroke

authors： Mishima K,Hayakawa K,Abe K,Ikeda T,Egashira N,Iwasaki K,Fujiwara M

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Limited systemic fibrinolysis and reduced dosage are features of intra-arterial thrombolyis (IAT) that may be advantageous in the treatment of postoperative strokes. However, IAT may increase the risk of surgical bleeding. We sought to determine the safety of postoperative IAT. METHODS:This was ...

journal_title：Stroke

authors： Chalela JA,Katzan I,Liebeskind DS,Rasmussen P,Zaidat O,Suarez JI,Chiu D,Klucznick RP,Jauch E,Cucchiara BL,Saver J,Kasner SE

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ischemic brain injury secondary to an arterial occlusion is characterized by acute local inflammation. Blood polymorphonuclear leukocytes (PMNL), primarily neutrophils, adhere to endothelial cells and rapidly invade the injured brain after the arterial occlusion. This neutrophilic invasion might ...

journal_title：Stroke

authors： Kostulas N,Kivisäkk P,Huang Y,Matusevicius D,Kostulas V,Link H

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of this experiment was to study the serial changes in brain intracellular pH, cerebral blood flow, and the oxidation/reduction level of intramitochondrial nicotinamide adenine dinucleotide fluorescence across the cortical surface during severe incomplete global ischemia. METHODS:Reduced ...

journal_title：Stroke

authors： Tomlinson FH,Anderson RE,Meyer FB

更新日期：1993-03-01 00:00:00

abstract：:We measured cerebral blood flow and somatosensory evoked potentials during transient focal cerebral ischemia in cats to compare the effects of four commonly used anesthetic regimens: ketamine/fentanyl/N2O (fentanyl), pentobarbital, ketamine/alpha-chloralose (alpha-chloralose), and ketamine/halothane/N2O (halothane). S...

journal_title：Stroke

authors： Helfaer MA,Kirsch JR,Traystman RJ

更新日期：1990-05-01 00:00:00

abstract：:The hemolysate (10(-5)-10(-2) times dilution; original hemoglobin concentration was 0.83 +/- 0.10 X 10(-3)M) evoked the contraction in a dose dependent manner, and this contraction was composed of low and high sensitive responses as estimated from the Eadie-Hofstee's plot. Indomethacin (10(-7)-10(-5)M) inhibited the l...

journal_title：Stroke

authors： Fujiwara S,Kuriyama H

更新日期：1984-05-01 00:00:00

abstract：:Experimental subarachnoid hemorrhage (SAH) was induced in baboons by repeated injections of autologous blood into cisterna chiasmatis and cisterna magna, a total of 14-33 ml being injected over 3-4 days. Cerebral blood flow (CBF; 133xenon clearance) and cerebral metabolic rate of oxygen (CMRO2) were measured before, a...

journal_title：Stroke

authors： Sahlin C,Delgado T,Owman C,Svendgaard NA

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The mechanisms underlying frontal lobe dysfunction in moyamoya disease (MMD) are unknown. We aimed to determine whether chronic ischemia induces subtle microstructural brain changes in adult MMD and evaluated the association of changes with neuropsychological performance. METHODS:MRI, including ...

journal_title：Stroke

authors： Kazumata K,Tha KK,Narita H,Kusumi I,Shichinohe H,Ito M,Nakayama N,Houkin K

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Limited data are available on management of outpatients with stroke or transient ischemic attack (TIA) and on clinicians' reasons for withholding procedures recommended by guidelines. We assessed to what extent guidelines are appropriately applied after ischemic stroke or TIA, in admitted patient...

journal_title：Stroke

authors： Scholte op Reimer WJ,Dippel DW,Franke CL,van Oostenbrugge RJ,de Jong G,Hoeks S,Simoons ML

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A high rate of postprocedure complications in the Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis (SAMMPRIS) trial has raised concerns whether such results are representative of intracranial stent placement in actual routine practice. METHODS:Using the Nationwide In...

journal_title：Stroke

authors： Siddiq F,Adil MM,Norby K,Qureshi AI

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We have shown that acute treatment with candesartan in an experimental model of stroke resulted in vascular protection and improved outcomes at 24 hours poststroke, but the mechanisms are unknown. We now examine effects of candesartan on proangiogenic factors and 7-day outcomes using the same tre...

journal_title：Stroke

authors： Kozak A,Ergul A,El-Remessy AB,Johnson MH,Machado LS,Elewa HF,Abdelsaid M,Wiley DC,Fagan SC

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Few pediatric reports of thrombolysis exist. We sought to determine national rates of thrombolysis among pediatric ischemic stroke patients using a national database. METHODS:Patients between the ages of 1 and 17 years, entered in the Nationwide Inpatient Sample between 2000 and 2003, with Inter...

journal_title：Stroke

authors： Janjua N,Nasar A,Lynch JK,Qureshi AI

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Because best medical treatment is improving, the risk of stroke in asymptomatic carotid artery stenosis (ACAS) may decline. We evaluated the risk of ischemic stroke and stratified it according to stroke subtype in patients with ACAS during long-term follow-up. METHODS:In total, 4319 consecutive ...

journal_title：Stroke

authors： den Hartog AG,Achterberg S,Moll FL,Kappelle LJ,Visseren FL,van der Graaf Y,Algra A,de Borst GJ,SMART Study Group.

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Based on thrombus location and nature and anatomic features of aorta and cerebral arteries, we hypothesized that cardiogenic embolisms (CE) and aortogenic embolisms (AE) might have different right-left propensity and lesion patterns. METHODS:We retrospectively reviewed patients with acute ischem...

journal_title：Stroke

authors： Kim HJ,Song JM,Kwon SU,Kim BJ,Kang DH,Song JK,Kim JS,Kang DW

更新日期：2011-08-01 00:00:00