Hemolysate-induced contraction in smooth muscle cells of the guinea pig basilar artery.

abstract：BACKGROUND AND PURPOSE:In animal models of cerebral ischemia, matrix metalloproteinase (MMP) expression was significantly increased and related to blood-brain barrier disruption, edema formation, and hemorrhagic transformation (HT). MMP inhibitors reduce HT after embolic ischemia in tissue-type plasminogen activator-tr...

journal_title：Stroke

authors： Montaner J,Alvarez-Sabín J,Molina CA,Anglés A,Abilleira S,Arenillas J,Monasterio J

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Quality of life (QoL) is important to stroke survivors yet is often recorded as a secondary measure in acute stroke randomized controlled trials. We examined whether commonly used stroke outcome measures captured aspects of QoL. METHODS:We examined primary outcomes by National Institutes of Heal...

journal_title：Stroke

authors： Ali M,Fulton R,Quinn T,Brady M,VISTA Collaboration.

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The inflammatory response within cerebral infarcts may have an influence on tissue damage. Since old animals with an impaired immune response have decreased inflammation after experimental cerebral infarction, we postulated that female animals with an increased immune response will have an increa...

journal_title：Stroke

authors： Li K,Futrell N,Tovar S,Wang LC,Wang DZ,Schultz LR

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral blood flow (CBF) is reduced after subarachnoid hemorrhage (SAH), and symptomatic vasospasm is a major cause of morbidity and mortality. Volume expansion has been reported to increase CBF after SAH, but CBF values in hypervolemic (HV) and normovolemic (NV) subjects have never been directl...

journal_title：Stroke

authors： Lennihan L,Mayer SA,Fink ME,Beckford A,Paik MC,Zhang H,Wu YC,Klebanoff LM,Raps EC,Solomon RA

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We sought to assess the reproducibility, interobserver variability, and application to clinical studies of a new method for the quantitative assessment of carotid plaque echogenicity. METHODS:Carotid plaques were scanned with the use of ultrasound, and their images were stored in a computer. The...

journal_title：Stroke

authors： Sabetai MM,Tegos TJ,Nicolaides AN,Dhanjil S,Pare GJ,Stevens JM

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hypothermia reduces neuronal damage in animal stroke models. Whether hypothermia is neuroprotective in patients with acute stroke remains to be clarified. In this case-control study, we evaluated the feasibility and safety of inducing modest hypothermia by a surface cooling method in awake patien...

journal_title：Stroke

authors： Kammersgaard LP,Rasmussen BH,Jørgensen HS,Reith J,Weber U,Olsen TS

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Autopsy series of patients with AIDS have found a 4% to 29% prevalence of cerebral infarction. Little is known of the prevalence of cerebral infarction when not associated with non-HIV central nervous system (CNS) infection, lymphoma, or cardioembolic sources. Clinical correlation has seldom been...

journal_title：Stroke

authors： Connor MD,Lammie GA,Bell JE,Warlow CP,Simmonds P,Brettle RD

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We sought to identify the most powerful binary measures of the treatment effect of tissue plasminogen activator (tPA) in the National Institute of Neurological Disorders and Stroke (NINDS) rTPA Stroke Trial. METHODS:Using the Classification and Regression Tree (CART) algorithm, we evaluated bina...

journal_title：Stroke

authors： Broderick JP,Lu M,Kothari R,Levine SR,Lyden PD,Haley EC,Brott TG,Grotta J,Tilley BC,Marler JR,Frankel M

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:MRI has become increasingly used in the acute setting to manage patients with stroke. There has been concern that MRI may not be sensitive in the detection of acute intracranial hemorrhage. We assessed whether strongly susceptibility-weighted MRI would be sensitive to intraparenchymal hemorrhage in the first...

journal_title：Stroke

authors： Patel MR,Edelman RR,Warach S

更新日期：1996-12-01 00:00:00

abstract：:We studied the effects of the calcium channel blocker nicardipine on regional tissue Ca2+, Na+, K+, and water shifts in the brains of seven Sprague-Dawley rats after permanent occlusions of the middle cerebral artery. We also assessed the entry of [14C]nicardipine into the brains of five rats; the highest concentratio...

journal_title：Stroke

authors： Hadani M,Young W,Flamm ES

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Brain iron overload plays a detrimental role in brain injury after intracerebral hemorrhage (ICH). A recent study found that minocycline acts as an iron chelator and reduces iron-induced neuronal death in vitro. The present study investigated if minocycline reduces iron overload after ICH and iro...

journal_title：Stroke

authors： Zhao F,Hua Y,He Y,Keep RF,Xi G

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The pressure-flow relation has been characterized in normal cerebrum, but it has not been studied in cerebrum dependent on collateral flow. The purpose of this investigation was to examine the relation between systemic pressure, regional cerebral blood flow, and middle cerebral artery branch pres...

journal_title：Stroke

authors： Muhonen MG,Sawin PD,Loftus CM,Heistad DD

更新日期：1992-07-01 00:00:00

abstract：:Various studies indicate that after a latent interval, a progressive focal deterioration of microvascular perfusion can develop in zones of acute damage to the central nervous system (CNS). In order to obtain reliable information concerning the possibility of platelet participation in this phenomenon, platelet deposit...

journal_title：Stroke

authors： Obrenovitch TP,Hallenbeck JM

更新日期：1985-03-01 00:00:00

abstract：:Three leukotrienes (LTB4, C4, D4) were locally applied to cerebral arterioles in doses varying from 3 X 10(-8) to 4 X 10(-7) M and each produced a dose related constriction. LTC was tested in the presence and absence of FPL-55712, a relatively specific inhibitor of leukotriene receptors. A low dose (10(-8) M) of FPL-5...

journal_title：Stroke

authors： Rosenblum WI

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The prevalence of constipation after stroke varies from 30% to 60%. The incidence of new-onset constipation during the early stage of stroke remains uncertain. The present study was designed to investigate the prevalence of new-onset constipation, its risk factors, and its impact on stroke outcom...

journal_title：Stroke

authors： Su Y,Zhang X,Zeng J,Pei Z,Cheung RT,Zhou QP,Ling L,Yu J,Tan J,Zhang Z

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Traditional vascular risk factors do not completely explain the asymmetry, racial, and sex differences in carotid artery disease. Carotid anatomy and geometry may play a role in the pathogenesis of internal carotid artery (ICA) stenosis, but their effects are unknown. We hypothesized that carotid...

journal_title：Stroke

authors： Phan TG,Beare RJ,Jolley D,Das G,Ren M,Wong K,Chong W,Sinnott MD,Hilton JE,Srikanth V

更新日期：2012-06-01 00:00:00

abstract：:Background and Purpose- The optimal antithrombotic strategy to balance thromboembolic and bleeding events, especially acute stroke, for patients with atrial fibrillation following coronary stenting remains a matter of debate. We conducted a network meta-analysis to identify the antithrombotic regimen associated with t...

journal_title：Stroke

authors： Knijnik L,Rivera M,Blumer V,Cardoso R,Fernandes A,Fernandes G,Ferreira T,Romano JG,Lambrakos LK,Cohen MG

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The *2 allele of the aldehyde dehydrogenase 2 gene (ALDH2) is the most common variant in Asian populations. The variant resulting in enzyme dysfunction was highly related to coronary artery disease. Recently, genome-wide association studies also discovered that the 12q24 locus near ALDH2 gene was...

journal_title：Stroke

authors： Sung YF,Lu CC,Lee JT,Hung YJ,Hu CJ,Jeng JS,Chiou HY,Peng GS

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Different distributions of cerebral microbleeds (CMBs) are associated with distinct pathological mechanisms. Lobar CMBs are thought to be related to cerebral amyloid angiopathy, whereas deep or infratentorial CMBs are related to hypertensive vasculopathy. The present study aimed to evaluate the e...

journal_title：Stroke

authors： Chung CP,Chou KH,Chen WT,Liu LK,Lee WJ,Chen LK,Lin CP,Wang PN

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Vorapaxar is an antiplatelet agent that antagonizes thrombin-mediated activation of the protease-activated receptor-1 on platelets. We tested the efficacy and safety of vorapaxar in a prespecified analysis in the stroke subcohort from a multinational, randomized, placebo-controlled trial. METHOD...

journal_title：Stroke

authors： Morrow DA,Alberts MJ,Mohr JP,Ameriso SF,Bonaca MP,Goto S,Hankey GJ,Murphy SA,Scirica BM,Braunwald E,Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events–TIMI 50 Steering Committee and Investigators

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The decision to proceed with surgery in cerebellar infarct with mass effect (CIMASS) in deteriorating patients is based on clinical features. The potential role of neuroimaging in predicting deterioration has not been systematically studied. In this study we determine the role of neuroimaging in ...

journal_title：Stroke

authors： Koh MG,Phan TG,Atkinson JL,Wijdicks EF

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Close relations between leukoaraiosis detected by computed tomography or magnetic resonance imaging and stroke, particularly lacunar infarction, have been reported. We studied whether leukoaraiosis is related to long-term prognosis for patients with lacunar infarction. METHODS:We examined monthl...

journal_title：Stroke

authors： Miyao S,Takano A,Teramoto J,Takahashi A

更新日期：1992-10-01 00:00:00

abstract：:Background and Purpose- Emergency medical services (EMSs) are critical for early treatment of patients with ischemic stroke, yet data on EMS utilization and its association with timely treatment in China are still limited. Methods- We examined data from the Chinese Stroke Center Alliance for patients with ischemic str...

journal_title：Stroke

authors： Gu HQ,Rao ZZ,Yang X,Wang CJ,Zhao XQ,Wang YL,Liu LP,Wang CY,Liu C,Li H,Li ZX,Xiao RP,Wang YJ,Chinese Stroke Center Alliance Investigators.

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Timing of carotid endarterectomy after stroke in a patient with a fixed neurological deficit remains an important but unresolved question. Early surgery has been associated with cerebral hemorrhage and infarct extension. Delayed endarterectomy exposes the patient to recurrent stroke and carotid occlusion. Th...

journal_title：Stroke

authors： Pritz MB

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries. SUMMARY OF REVIEW:We tested whether there is any evidence from unconfounded randomized clinical trials that treatment with mannitol reduces short- and long-term case fatality a...

journal_title：Stroke

authors： Bereczki D,Liu M,Prado GF,Fekete I

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Fruits and vegetables are known for their beneficial effects on chronic diseases. The purpose of the present study was to investigate the protective effect of a diet rich in fruits and vegetables on total stroke mortality and its 2 main subtypes in men and women separately. METHODS:A prospective...

journal_title：Stroke

authors： Sauvaget C,Nagano J,Allen N,Kodama K

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Leptin is the major adipose hormone that regulates body weight and energy expenditure by activating leptin receptors in the hypothalamus. Leptin receptors are also present in other cell types, and a potent antiapoptotic effect for leptin has recently been reported. We investigated whether leptin ...

journal_title：Stroke

authors： Zhang F,Wang S,Signore AP,Chen J

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Limited systemic fibrinolysis and reduced dosage are features of intra-arterial thrombolyis (IAT) that may be advantageous in the treatment of postoperative strokes. However, IAT may increase the risk of surgical bleeding. We sought to determine the safety of postoperative IAT. METHODS:This was ...

journal_title：Stroke

authors： Chalela JA,Katzan I,Liebeskind DS,Rasmussen P,Zaidat O,Suarez JI,Chiu D,Klucznick RP,Jauch E,Cucchiara BL,Saver J,Kasner SE

更新日期：2001-06-01 00:00:00

abstract：:Background and Purpose- Disturbance of endoplasmic reticulum (ER) Ca2+ homeostasis causes neuronal cell injury in stroke. By contrast, ischemic preconditioning (IPC)-a brief sublethal ischemic episode affording tolerance to a subsequent ischemic insult-restores ER Ca2+ homeostasis. Under physiological conditions, ER c...

journal_title：Stroke

authors： Secondo A,Petrozziello T,Tedeschi V,Boscia F,Vinciguerra A,Ciccone R,Pannaccione A,Molinaro P,Pignataro G,Annunziato L

更新日期：2019-05-01 00:00:00

abstract：:Thromboxane synthetase activity is selectively inhibited by (E)-3-[4-(1-imidazolylmethyl)phenyl]-2-propenoic acid hydrochloride monohydrate (OKY-046). A single dose of 100 mg OKY-046 was orally administered to patients with ischemic cerebrovascular disease and healthy volunteers. Platelet aggregation and thromboxane B...

journal_title：Stroke

authors： Uyama O,Nagatsuka K,Nakabayashi S,Isaka Y,Yoneda S,Kimura K,Abe H

更新日期：1985-03-01 00:00:00