Constricting effect of leukotrienes on cerebral arterioles of mice.

abstract：BACKGROUND AND PURPOSE:Stroke MRI protocols provide useful information about underlying vessel pathologies in the anterior circulation by means of intracranial time-of-flight angiography. However, these protocols mostly fail in the posterior circulation to differentiate between congenital variants and secondary thrombo...

journal_title：Stroke

authors： Freund W,Kassubek J,Aschoff AJ,Huber R

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The relation between symptomatic lacunar infarction, silent stroke, and arterial hypertension is controversial. METHODS:From 500 patients with ischemic or hemorrhagic stroke admitted to the Downtown Barcelona Stroke Registry between July 1992 and December 1994, we evaluated prospectively the pre...

journal_title：Stroke

authors： Chamorro A,Saiz A,Vila N,Ascaso C,Blanc R,Alday M,Pujol J

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Mild stroke (MS) and rapidly improving stroke (RIS) symptoms are common stroke presentations. Our objective is to describe the short-term outcomes in this population. METHODS:A retrospective analysis of patients with ischemic stroke in the Get With The Guidelines-Stroke registry who arrived ≤4.5...

journal_title：Stroke

authors： Romano JG,Smith EE,Liang L,Gardener H,Campo-Bustillo I,Khatri P,Bhatt DL,Fonarow GC,Sacco RL,Schwamm LH

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The consequences of stroke are a major health concern. This study was conducted to compare the health-related quality of life among long-term survivors of stroke with that of the general population. METHODS:Our data are taken from a population-based case-control study of all 6-year survivors of ...

journal_title：Stroke

authors： Hackett ML,Duncan JR,Anderson CS,Broad JB,Bonita R

更新日期：2000-02-01 00:00:00

abstract：:Background and Purpose- Knowledge of the use of secondary preventive medication in young adults is limited. We studied the use of statins and its association with subsequent vascular events in young adults with ischemic stroke-a patient group with a known low burden of atherosclerosis. Methods- The study population in...

journal_title：Stroke

authors： van Dongen MME,Aarnio K,Martinez-Majander N,Pirinen J,Sinisalo J,Lehto M,Kaste M,Tatlisumak T,de Leeuw FE,Putaala J

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Administration of histamine receptor antagonists has been reported to produce contradictory results, either reducing or increasing neural damage induced by ischemia. In this study, we investigated the neuroprotective effects of histamine H2-receptor antagonists in an "in vitro" model of ischemia....

journal_title：Stroke

authors： Malagelada C,Xifró X,Badiola N,Sabrià J,Rodríguez-Alvarez J

更新日期：2004-10-01 00:00:00

abstract：:Spontaneously hypertensive rats (SHR) have been shown to have an increased capacity for superior cervical sympathetic nerve activity which may protect against stroke (Mueller et al: Stroke 13: 115, 1982). Sympathetic nerve activity has never been examined in the stroke-prone substrain of SHR (SP). In this study we mea...

journal_title：Stroke

authors： Mueller SM,Black WL Jr

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Postischemic cerebral inflammation may contribute to ischemic cell damage. Intercellular adhesion molecule-1 (ICAM-1) is a glycoprotein expressed on endothelial cells that facilitates leukocyte adhesion. We investigated the effect of administration of an anti-ICAM-1 antibody (1A29) on ischemic ce...

journal_title：Stroke

authors： Zhang RL,Chopp M,Jiang N,Tang WX,Prostak J,Manning AM,Anderson DC

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Within different brain regions, we determine the comparative value of multiphase computed tomographic angiography (mCTA) and computed tomographic perfusion (CTP) in predicting follow-up infarction. METHODS:Patients with M1-middle cerebral artery occlusions were prospectively included in this mul...

journal_title：Stroke

authors： d'Esterre CD,Trivedi A,Pordeli P,Boesen M,Patil S,Hwan Ahn S,Najm M,Fainardi E,Shankar JJ,Rubiera M,Almekhlafi MA,Mandzia J,Khaw AV,Barber P,Coutts S,Hill MD,Demchuk AM,Sajobi T,Forkert ND,Goyal M,Lee TY,Menon B

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pending the results of randomized controlled trials, the benefit and safety of bridging therapy (combined intravenous and intra-arterial thrombolysis) remain to be determined. The aim of this analysis was to give reliable estimates of efficacy and safety outcomes of bridging therapy. METHODS:We ...

journal_title：Stroke

authors： Mazighi M,Meseguer E,Labreuche J,Amarenco P

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Abnormalities of dermal connective tissue have been detected in patients with spontaneous cervical artery dissections (sCAD), suggesting an underlying structural defect of the arterial wall. Alpha1-antitrypsin (A1-AT) is a circulating serine proteinase inhibitor of proteolytic enzymes that helps ...

journal_title：Stroke

authors： Vila N,Millán M,Ferrer X,Riutort N,Escudero D

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Visual assessment of cerebrospinal fluid (CSF) for xanthochromia (yellow color) is practiced by the majority of laboratories worldwide as a means of diagnosing intracranical bleeds. METHODS:Colorimetric and spectrophotometric analysis of CSF samples for recognizing the presence of bilirubin either in low co...

journal_title：Stroke

authors： Petzold A,Keir G,Sharpe TL

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The spontaneously hypertensive stroke-prone rat (SHRSP) is an animal model for a complex form of cerebrovascular pathology. MRI provides an efficient and noninvasive tool for studying the time course of brain damage. The aim of this study was to gain new insights into the pathological phenomena r...

journal_title：Stroke

authors： Guerrini U,Sironi L,Tremoli E,Cimino M,Pollo B,Calvio AM,Paoletti R,Asdente M

更新日期：2002-03-01 00:00:00

abstract：:Background and Purpose- Recanalization with tPA (tissue-type plasminogen activator) is the only pharmacological therapy available for patients with ischemic stroke. However, the percentage of patients who may receive this therapy is limited by the risk of hemorrhagic transformation (HT)-the main complication of ischem...

journal_title：Stroke

authors： García-Yébenes I,García-Culebras A,Peña-Martínez C,Fernández-López D,Díaz-Guzmán J,Negredo P,Avendaño C,Castellanos M,Gasull T,Dávalos A,Moro MA,Lizasoain I

更新日期：2018-09-01 00:00:00

abstract：:Although the blood flow tracer hexamethylpropyleneamine oxime is now widely used for cerebral blood flow mapping using single-photon emission computed tomography, its uptake into acutely ischemic brain has not been well studied. We performed a double-label autoradiographic study in which 99mTc-hexamethylpropyleneamine...

journal_title：Stroke

authors： Bullock R,Patterson J,Park C

更新日期：1991-10-01 00:00:00

abstract：:Background and Purpose- Intracranial thrombi can be characterized according to their permeability as measured by contrast agent penetration. Thrombus composition and its associated pathogenesis are important factors affecting treatment and secondary prevention. We aimed to explore the histopathologic factors explainin...

journal_title：Stroke

authors： Berndt M,Friedrich B,Maegerlein C,Moench S,Hedderich D,Lehm M,Zimmer C,Straeter A,Poppert H,Wunderlich S,Schirmer L,Oberdieck P,Kaesmacher J,Boeckh-Behrens T

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Systemic administration of Toll-like receptor (TLR) 4 and TLR9 agonists before cerebral ischemia have been shown to reduce ischemic injury by reprogramming the response of the brain to stroke. Our goal was to explore the mechanism of TLR-induced neuroprotection by determining whether a TLR7 agoni...

journal_title：Stroke

authors： Leung PY,Stevens SL,Packard AE,Lessov NS,Yang T,Conrad VK,van den Dungen NN,Simon RP,Stenzel-Poore MP

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In acute ischemic stroke, fast and complete recanalization of the occluded vessel is associated with improved outcomes. We describe a novel measure for newer generation devices: the first pass effect (FPE). FPE is defined as achieving a complete recanalization with a single thrombectomy device pa...

journal_title：Stroke

authors： Zaidat OO,Castonguay AC,Linfante I,Gupta R,Martin CO,Holloway WE,Mueller-Kronast N,English JD,Dabus G,Malisch TW,Marden FA,Bozorgchami H,Xavier A,Rai AT,Froehler MT,Badruddin A,Nguyen TN,Taqi MA,Abraham MG,Yoo AJ,

更新日期：2018-03-01 00:00:00

abstract：:Brain energy state and glycolytic metabolites were measured in young (6 month) and aged (28 month) male rats under normoxic (70% nitrous oxide, 30% oxygen) or hypoxic (PaO2 = 25 mm Hg) test conditions. Hypoxic ischemia was induced in one cerebral hemisphere by ligation of one carotid artery. Under normoxic test condit...

journal_title：Stroke

authors： Hoffman WE,Pelligrino D,Miletich DJ,Albrecht RF

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Global cerebral blood flow (CBF) is an important yet largely unknown quantity in the treatment of neurological intensive care patients. Color duplex sonography of the extracranial cerebral arteries can be used to measure global CBF volume directly at the bedside. To establish reference data on gl...

journal_title：Stroke

authors： Scheel P,Ruge C,Petruch UR,Schöning M

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The goal of this study was to characterize cortical reorganization after stroke and its relation with the site of the stroke-induced lesion and degree of motor recovery using functional MRI (fMRI). METHODS:Fourteen stroke patients with an affected upper limb were studied longitudinally. Three fM...

journal_title：Stroke

authors： Feydy A,Carlier R,Roby-Brami A,Bussel B,Cazalis F,Pierot L,Burnod Y,Maier MA

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We sought to determine the effects of aging on regional cerebral blood flow and ischemic brain damage in transient cerebral ischemia in rats. METHODS:Five adult (5-6 months) and five aged (18-22 months) female spontaneously hypertensive rats were subjected to 20 minutes of bilateral carotid occl...

journal_title：Stroke

authors： Yao H,Sadoshima S,Ooboshi H,Sato Y,Uchimura H,Fujishima M

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The PIWI-interacting RNA (piRNA) is the most predominant RNA species in eukaryotes. The piRNA are a class of noncoding RNAs that bind and degrade the RNA formed by the transposons to control the transposon-induced gene mutations. The role of piRNA after focal ischemia is not yet evaluated. METHO...

journal_title：Stroke

authors： Dharap A,Nakka VP,Vemuganti R

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The trends in stroke incidence reported so far have not been entirely consistent, although declining trends in mortality from stroke have been reported from a number of studies around the world. This study aims to evaluate the 10-year trends (from 1983 through 1992) in incidence, attack rate, and...

journal_title：Stroke

authors： Tuomilehto J,Rastenyte D,Sivenius J,Sarti C,Immonen-Räihä P,Kaarsalo E,Kuulasmaa K,Narva EV,Salomaa V,Salmi K,Torppa J

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Exogenous delivery of vascular endothelial growth factor gene (VEGF) may provide a useful approach to the treatment of brain ischemia. We investigated the use of a hypoxia-responsive element to control VEGF expression given for neuroprotection. METHODS:Three groups (n=36) of mice received AAVH9-...

journal_title：Stroke

authors： Shen F,Su H,Fan Y,Chen Y,Zhu Y,Liu W,Young WL,Yang GY

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hetereothermic mammals tolerate hypoxia during euthermy and torpor, and evidence suggests this tolerance may extend beyond hypoxia to cerebral ischemia. During hibernation, CA1 hippocampal neurons endure extreme fluctuations in cerebral blood flow during transitions into and out of torpor as well...

journal_title：Stroke

authors： Dave KR,Prado R,Raval AP,Drew KL,Perez-Pinzon MA

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Many studies associate fever with poor outcome in patients with neurological injury, but this relationship is blurred by divergence in populations and outcome measures. We sought to incorporate all recent scholarship addressing fever in brain-injured patients into a comprehensive meta-analysis to...

journal_title：Stroke

authors： Greer DM,Funk SE,Reaven NL,Ouzounelli M,Uman GC

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion evolution. N-Methyl-D-aspartate (NMDA) antagonists inhibit SDs and reduce infarct size. The glycine site on the NMDA receptor complex offers a therapeutic target for acute focal ischemia, potentially devoid ...

journal_title：Stroke

authors： Tatlisumak T,Takano K,Meiler MR,Fisher M

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Our aims were to identify predictors of early neurological improvement in acute ischemic stroke patients, to evaluate its impact on clinical outcome, and to investigate possible mechanisms. METHODS:A consecutive series of 152 first-ever ischemic hemispheric stroke patients hospitalized within 5 ...

journal_title：Stroke

authors： Toni D,Fiorelli M,Bastianello S,Falcou A,Sette G,Ceschin V,Sacchetti ML,Argentino C

更新日期：1997-01-01 00:00:00

abstract：:Background and Purpose- Intracerebral hemorrhage (ICH) has a poorer prognosis than acute ischemic stroke (AIS). However, clinician perception of prognosis may influence treatment decisions and adversely affect outcome. On acute CT, the conspicuity of ICH compared with AIS may lead clinicians to overestimate severity a...

journal_title：Stroke

authors： Tilling EJ,El Tawil S,Muir KW

更新日期：2019-02-01 00:00:00