Why human color vision cannot reliably detect cerebrospinal fluid xanthochromia.

Abstract:

BACKGROUND:Visual assessment of cerebrospinal fluid (CSF) for xanthochromia (yellow color) is practiced by the majority of laboratories worldwide as a means of diagnosing intracranical bleeds. METHODS:Colorimetric and spectrophotometric analysis of CSF samples for recognizing the presence of bilirubin either in low concentrations or in the presence of hemolysed blood. RESULTS:The experiments provide the physiological and colorimetric basis for abandoning visual assessment of CSF for xanthochromia. CONCLUSIONS:We strongly recommend relying on spectrophotometry as the analytical method of choice.

journal_name

Stroke

journal_title

Stroke

authors

Petzold A,Keir G,Sharpe TL

doi

10.1161/01.STR.0000166344.75440.b9

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

1295-7

issue

6

eissn

0039-2499

issn

1524-4628

pii

01.STR.0000166344.75440.b9

journal_volume

36

pub_type

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