Reduced mortality and brain damage after locomotor activity in gerbil forebrain ischemia.

Abstract:

BACKGROUND AND PURPOSE:Preischemic spontaneous locomotor activity was distinguished in this laboratory as a factor influencing outcome after 15 and 20 minutes of forebrain ischemia in gerbils. Histological investigations were carried out to analyze potential relations between postischemic survival and a reduction of cerebral damage by spontaneous locomotor activity. METHODS:Male Mongolian gerbils were divided into two groups, one with access to running wheels ("runners") and one kept in conventional cages ("nonrunners") for 2 weeks preceding forebrain ischemia of 15 or 20 minutes. A total of 99 gerbils were divided in subgroups and were allowed to recover for 2 weeks for assessment of survival. Other subgroups (n = 7 to 9) were killed at day 4 for quantitative histology of selectively vulnerable areas such as hippocampus, cortex, striatum, and thalamus. RESULTS:Two weeks after 15-minute ischemia, 44% of non-runners had survived compared with 90% of runners (P < .01). With 20-minute ischemia all runners survived compared with 21% of nonrunners. Quantitative histology (15-minute ischemia) revealed selective nerve cell injury in various cerebral regions in both groups. In runners, however, with the exception of the CA1 sector, damage was attenuated in cortex, striatum, and hippocampus. Furthermore, the extent of thalamic infarction was reduced (P < .05). CONCLUSIONS:Locomotor activity before global cerebral ischemia is highly efficient in protecting the brain as demonstrated by enhanced survival and a reduction of tissue damage in Mongolian gerbils. The mechanisms underlying this protection are currently unclear. However, further understanding of this intriguing phenomenon should enhance the understanding of ischemia pathophysiology and lead to the development of new treatment strategies.

journal_name

Stroke

journal_title

Stroke

authors

Stummer W,Weber K,Tranmer B,Baethmann A,Kempski O

doi

10.1161/01.str.25.9.1862

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

1862-9

issue

9

eissn

0039-2499

issn

1524-4628

journal_volume

25

pub_type

杂志文章

相关文献

STROKE文献大全
  • Thalamic Diaschisis in Acute Ischemic Stroke: Occurrence, Perfusion Characteristics, and Impact on Outcome.

    abstract:BACKGROUND AND PURPOSE:Ipsilateral thalamic diaschisis (ITD) describes the reduction of thalamic function, metabolism, and perfusion resulting from a distant lesion of the ipsilateral hemisphere. Our aim was to evaluate the perfusion characteristics and clinical impact of ITD in acute middle cerebral artery stroke, whi...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.118.020698

    authors: Reidler P,Thierfelder KM,Fabritius MP,Sommer WH,Meinel FG,Dorn F,Wollenweber FA,Duering M,Kunz WG

    更新日期:2018-04-01 00:00:00

  • Prevalence of apolipoprotein E phenotypes in ischemic cerebrovascular disease. A case-control study.

    abstract:BACKGROUND AND PURPOSE:Apolipoprotein E polymorphism may influence the early development of coronary artery disease. We investigated the putative role of apolipoprotein E phenotypes in cerebral infarction. METHODS:The apolipoprotein E phenotypes of 69 patients (mean +/- SD age, 72 +/- 11 years) who had suffered comple...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.24.5.661

    authors: Couderc R,Mahieux F,Bailleul S,Fenelon G,Mary R,Fermanian J

    更新日期:1993-05-01 00:00:00

  • Barthel index for stroke trials: development, properties, and application.

    abstract:BACKGROUND AND PURPOSE:Robust measures of functional outcome are required to determine treatment effects in stroke trials. Of the various measures available, the Barthel index (BI) is one of the more prevalent. We aimed to describe validity, reliability, and responsiveness (clinimetric properties) of the BI in stroke t...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/STROKEAHA.110.598540

    authors: Quinn TJ,Langhorne P,Stott DJ

    更新日期:2011-04-01 00:00:00

  • Abnormal responses of the human cerebral microcirculation to papaverin during aneurysm surgery.

    abstract:BACKGROUND AND PURPOSE:The role of the cerebral microcirculation in delayed ischemia after subarachnoid hemorrhage remains obscure. To test the hypothesis that cerebral arterioles have a reduced capacity to dilate after subarachnoid hemorrhage, we studied the microvascular responses to papaverine (PPV) in patients unde...

    journal_title:Stroke

    pub_type: 信件

    doi:10.1161/STROKEAHA.108.522375

    authors: Pennings FA,Albrecht KW,Muizelaar JP,Schuurman PR,Bouma GJ

    更新日期:2009-01-01 00:00:00

  • Lacunar syndrome due to intracerebral hemorrhage.

    abstract::It has been recognized that small intracerebral hemorrhage not uncommonly produced lacunar syndromes. In this study, we examined cases of intracerebral hemorrhage presenting as lacunar syndromes. Of 174 cases with recent intracerebral hemorrhage, 19 presented with a lacunar syndrome: 4 presented with pure motor hemipa...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.16.3.454

    authors: Mori E,Tabuchi M,Yamadori A

    更新日期:1985-05-01 00:00:00

  • Anticoagulant-related hemorrhage in acute cerebral embolism.

    abstract::Five patients with nonseptic cerebral embolism of cardiac origin are reported in whom early anticoagulant therapy resulted in clinical deterioration or death from frank hemorrhage into the acute infarct. In each patient an initial CT scan excluded the presence of intracerebral hemorrhage and a second CT scan, after cl...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.15.3.426

    authors: Shields RW Jr,Laureno R,Lachman T,Victor M

    更新日期:1984-05-01 00:00:00

  • Real-time validation of transcranial Doppler criteria in assessing recanalization during intra-arterial procedures for acute ischemic stroke: an international, multicenter study.

    abstract:BACKGROUND AND PURPOSE:We sought to evaluate the diagnostic accuracy of ultrasound criteria for recanalization during real-time transcranial Doppler monitoring of intra-arterial reperfusion procedures in acute ischemic stroke patients in an international, multicenter study. METHODS:Consecutive acute ischemic stroke pa...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.112.675074

    authors: Tsivgoulis G,Ribo M,Rubiera M,Vasdekis SN,Barlinn K,Athanasiadis D,Bavarsad Shahripour R,Giannopoulos S,Stamboulis E,Harrigan MR,Molina CA,Alexandrov AV

    更新日期:2013-02-01 00:00:00

  • Detection of intracranial atherosclerosis: which imaging techniques are available in European hospitals?

    abstract:BACKGROUND AND PURPOSE:The diagnosis of intracranial atherosclerosis requires availability of appropriate imaging techniques. The objective was to evaluate the proportion of European hospitals where imaging techniques necessary to detect intracranial atherosclerosis are available. Method- We randomly selected 886 hospi...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.526434

    authors: Balucani C,Leys D,Ringelstein EB,Kaste M,Hacke W,Executive Committee of the European Stroke Initiative.

    更新日期:2009-03-01 00:00:00

  • Decreased nighttime heart rate variability is associated with increased stroke risk.

    abstract:BACKGROUND AND PURPOSE:Prediction of stroke in healthy individuals is challenging and there is a diurnal variation of stroke onset. We hypothesized that heart rate variability with a focus on nighttime heart rate variability will predict the risk of stroke in apparently healthy middle-age and elderly subjects. METHODS...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.607697

    authors: Binici Z,Mouridsen MR,Køber L,Sajadieh A

    更新日期:2011-11-01 00:00:00

  • Dichotomous effects of chronic intermittent hypoxia on focal cerebral ischemic injury.

    abstract:BACKGROUND AND PURPOSE:Obstructive sleep apnea, a condition associated with chronic intermittent hypoxia (CIH), carries an increased risk of stroke. However, CIH has been reported to either increase or decrease brain injury in models of focal cerebral ischemia. The factors determining the differential effects of CIH on...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.004816

    authors: Jackman KA,Zhou P,Faraco G,Peixoto PM,Coleman C,Voss HU,Pickel V,Manfredi G,Iadecola C

    更新日期:2014-05-01 00:00:00

  • Internal carotid artery redundancy is significantly associated with dissection.

    abstract:BACKGROUND AND PURPOSE:Redundant internal carotid arteries have been considered a risk factor in tonsillectomy, adenoidectomy, and surgical treatment of peritonsillar abscess and also a potentially treatable cause of stroke. However, an association between internal carotid artery redundancy and spontaneous dissection h...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.6.1201

    authors: Barbour PJ,Castaldo JE,Rae-Grant AD,Gee W,Reed JF 3rd,Jenny D,Longennecker J

    更新日期:1994-06-01 00:00:00

  • Gene therapy for cerebral vascular disease.

    abstract:BACKGROUND:Gene transfer to peripheral arteries has been accomplished with catheter-based approaches. Recently, gene transfer to the carotid artery and intracranial vessels has been achieved both in vitro and in vivo. Although gene therapy for cerebral vascular disease may not be accomplished for years, currently avail...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/01.str.27.9.1688

    authors: Heistad DD,Faraci FM

    更新日期:1996-09-01 00:00:00

  • Bexarotene Enhances Macrophage Erythrophagocytosis and Hematoma Clearance in Experimental Intracerebral Hemorrhage.

    abstract::Background and Purpose- Enhancement of erythrophagocytosis by macrophages in a timely manner can limit the toxic effects of erythrocyte metabolites and promote brain recovery after intracerebral hemorrhage (ICH). In the current study, we investigated the therapeutic effect of retinoid X receptor agonist, bexarotene, i...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.119.027037

    authors: Chang CF,Massey J,Osherov A,Angenendt da Costa LH,Sansing LH

    更新日期:2020-02-01 00:00:00

  • Transient ischemic attack and incident depression.

    abstract:BACKGROUND AND PURPOSE:Depression after stroke is common. Like stroke, transient ischemic attack (TIA) is a manifestation of long-term atherosclerotic damage to the brain. However, the risk of depression developing after a TIA is uncertain. We studied whether TIA increases the risk of incident late-life depression. ME...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.604405

    authors: Luijendijk HJ,Stricker BH,Wieberdink RG,Koudstaal PJ,Hofman A,Breteler MM,Tiemeier H

    更新日期:2011-07-01 00:00:00

  • Microglial Calcium Waves During the Hyperacute Phase of Ischemic Stroke.

    abstract:BACKGROUND AND PURPOSE:Ischemic injury triggers multiple pathological responses in the brain tissue, including spreading depolarizations across the cerebral cortex (cortical spreading depolarizations [CSD]). Microglia have been recently shown to play a significant role in the propagation of CSD. However, the intracellu...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.120.032766

    authors: Liu L,Kearns KN,Eli I,Sharifi KA,Soldozy S,Carlson EW,Scott KW,Sluzewski MF,Acton ST,Stauderman KA,Kalani MYS,Park M,Tvrdik P

    更新日期:2021-01-01 00:00:00

  • Safety of thrombolysis in stroke mimics: results from a multicenter cohort study.

    abstract:BACKGROUND AND PURPOSE:Intravenous thrombolysis for acute ischemic stroke is beneficial within 4.5 hours of symptom onset, but the effect rapidly decreases over time, necessitating quick diagnostic in-hospital work-up. Initial time strain occasionally results in treatment of patients with an alternate diagnosis (stroke...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.111.000126

    authors: Zinkstok SM,Engelter ST,Gensicke H,Lyrer PA,Ringleb PA,Artto V,Putaala J,Haapaniemi E,Tatlisumak T,Chen Y,Leys D,Sarikaya H,Michel P,Odier C,Berrouschot J,Arnold M,Heldner MR,Zini A,Fioravanti V,Padjen V,Beslac-Bu

    更新日期:2013-04-01 00:00:00

  • Photochemical stroke model: flunarizine prevents sensorimotor deficits after neocortical infarcts in rats.

    abstract::We produced unilateral photochemical infarcts in the hindlimb sensorimotor neocortex of 186 rats by intravenous injection of the fluorescein derivative rose bengal and focal illumination of the intact skull surface. Infarcted rats showed specific, long-lasting deficits in tactile and proprioceptive placing reactions o...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.20.10.1383

    authors: De Ryck M,Van Reempts J,Borgers M,Wauquier A,Janssen PA

    更新日期:1989-10-01 00:00:00

  • Retreatment of ruptured cerebral aneurysms in patients randomized by coiling or clipping in the International Subarachnoid Aneurysm Trial (ISAT).

    abstract:BACKGROUND AND PURPOSE:Because the long-term security of endovascular treatments remains uncertain, a follow-up study of the patients treated in the International Subarachnoid Aneurysm Trial was performed to compare the frequency, timing, and consequences of aneurysm recurrence. METHODS:Patient data were reclassified ...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.106.466987

    authors: Campi A,Ramzi N,Molyneux AJ,Summers PE,Kerr RS,Sneade M,Yarnold JA,Rischmiller J,Byrne JV

    更新日期:2007-05-01 00:00:00

  • Extracorporeal rheopheresis in the treatment of acute ischemic stroke: A randomized pilot study.

    abstract:BACKGROUND AND PURPOSE:Extracorporeal rheopheresis is a safe method to optimize hemorheology. Our aim was to determine whether treatment with extracorporeal rheopheresis in patients with acute ischemic hemispheric stroke improves cerebral perfusion as assessed with serial 99mTc-ethyl-cysteinate-dimer single-photon emis...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.str.30.4.787

    authors: Berrouschot J,Barthel H,Köster J,Hesse S,Rössler A,Knapp WH,Schneider D

    更新日期:1999-04-01 00:00:00

  • Alteration in abundance and compartmentalization of inflammation-related miRNAs in plasma after intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:We tested the hypothesis that circulating microRNAs (miRNAs) present in plasma might display a specific signature in patients with intracerebral hemorrhage. METHODS:Global miRNA profiles were determined with the Agilent Human miRNA Microarray platform, and validated by quantitative polymerase ch...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.000835

    authors: Guo D,Liu J,Wang W,Hao F,Sun X,Wu X,Bu P,Zhang Y,Liu Y,Liu F,Zhang Q,Jiang F

    更新日期:2013-06-01 00:00:00

  • Preischemic but not postischemic zinc protoporphyrin treatment reduces infarct size and edema accumulation after temporary focal cerebral ischemia in rats.

    abstract:BACKGROUND AND PURPOSE:Zinc protoporphyrin (ZnPP) has multiple actions. It is an interleukin-1 antagonist as well as a hemeoxygenase inhibitor. Interleukin-1 is produced in ischemic brain and probably contributes to ischemic injury, although the role of heme oxygenase during ischemia is unknown. Whether ZnPP treatment ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.26.6.1035

    authors: Kadoya C,Domino EF,Yang GY,Stern JD,Betz AL

    更新日期:1995-06-01 00:00:00

  • Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke.

    abstract:BACKGROUND AND PURPOSE:Neutrophil Extracellular Traps (NETs) are DNA extracellular networks decorated with histones and granular proteins produced by activated neutrophils. NETs have been identified as major triggers and structural factors of thrombosis. A recent study designated extracellular DNA threads from NETs as ...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/STROKEAHA.117.019896

    authors: Ducroux C,Di Meglio L,Loyau S,Delbosc S,Boisseau W,Deschildre C,Ben Maacha M,Blanc R,Redjem H,Ciccio G,Smajda S,Fahed R,Michel JB,Piotin M,Salomon L,Mazighi M,Ho-Tin-Noe B,Desilles JP

    更新日期:2018-03-01 00:00:00

  • Trends in 10-year survival of patients with stroke hospitalized between 1980 and 2000: the Minnesota stroke survey.

    abstract:BACKGROUND AND PURPOSE:We report on trends in poststroke survival, both in the early period after stroke and over the long term. We examine these trends by stroke subtype. METHODS:The Minnesota Stroke Survey is a study of all hospitalized patients with acute stroke aged 30 to 74 years in the Minneapolis-St Paul metrop...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.005512

    authors: Lakshminarayan K,Berger AK,Fuller CC,Jacobs DR Jr,Anderson DC,Steffen LM,Sillah A,Luepker RV

    更新日期:2014-09-01 00:00:00

  • Risk Profile of Symptomatic Lacunar Stroke Versus Nonlobar Intracerebral Hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Although lacunar stroke (LS) and deep intracerebral hemorrhage (dICH) represent acute manifestations of the same pathological process involving cerebral small vessels (small vessel disease), it remains unclear what factors predispose to one phenotype rather than the other at individual level. ME...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.013722

    authors: Morotti A,Paciaroni M,Zini A,Silvestrelli G,Del Zotto E,Caso V,Dell'Acqua ML,Simone AM,Lanari A,Costa P,Poli L,De Giuli V,Gamba M,Ciccone A,Ritelli M,Di Castelnuovo A,Iacoviello L,Colombi M,Agnelli G,Grassi M,de G

    更新日期:2016-08-01 00:00:00

  • Left atrial enlargement and stroke recurrence: the Northern Manhattan Stroke Study.

    abstract:BACKGROUND AND PURPOSE:Although left atrial enlargement (LAE) increases incident stroke risk, the association with recurrent stroke is less clear. Our aim was to determine the association of LAE with recurrent stroke most likely related to embolism (cryptogenic and cardioembolic) and all ischemic stroke recurrences. M...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/STROKEAHA.115.008711

    authors: Yaghi S,Moon YP,Mora-McLaughlin C,Willey JZ,Cheung K,Di Tullio MR,Homma S,Kamel H,Sacco RL,Elkind MS

    更新日期:2015-06-01 00:00:00

  • Venous sinus thrombosis associated with androgens in a healthy young man.

    abstract:BACKGROUND:Cerebral venous sinus thrombosis is rare and can be promoted by various conditions. We report the case of cerebral venous thrombosis in a patient using androgens. CASE DESCRIPTION:A 31-year-old man using androgens for bodybuilding was admitted for headache and vomiting. He had cerebral venous sinus thrombos...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.1.212

    authors: Jaillard AS,Hommel M,Mallaret M

    更新日期:1994-01-01 00:00:00

  • Distribution of Chlamydia pneumoniae infection in the athersclerotic carotid artery.

    abstract:BACKGROUND AND PURPOSE:Chlamydia pneumoniae infection has recently become noteworthy in relation to atherosclerosis. We investigated by immunohistochemistry the distribution of C pneumoniae infection in the atherosclerotic carotid artery. METHODS:Twenty carotid atherosclerotic lesions that were resected during carotid...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.29.4.773

    authors: Yamashita K,Ouchi K,Shirai M,Gondo T,Nakazawa T,Ito H

    更新日期:1998-04-01 00:00:00

  • Multicenter validation study of real-time ultrasonography, arteriography, and pathology: pathologic evaluation of carotid endarterectomy specimens.

    abstract::The morphologic description and measurements of endarterectomy specimens are usually believed to be accurate and are used as the gold standard against which the findings of diagnostic procedures are judged. Pathology data on 289 endarterectomy specimens from five participating centers and the corresponding angiography...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.19.3.289

    authors: Schenk EA,Bond MG,Aretz TH,Angelo JN,Choi HY,Rynalski T,Gustafson NF,Berson AS,Ricotta JJ,Goodison MW

    更新日期:1988-03-01 00:00:00

  • Leukoaraiosis in relation to prognosis for patients with lacunar infarction.

    abstract:BACKGROUND AND PURPOSE:Close relations between leukoaraiosis detected by computed tomography or magnetic resonance imaging and stroke, particularly lacunar infarction, have been reported. We studied whether leukoaraiosis is related to long-term prognosis for patients with lacunar infarction. METHODS:We examined monthl...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.23.10.1434

    authors: Miyao S,Takano A,Teramoto J,Takahashi A

    更新日期:1992-10-01 00:00:00

  • Virtual reality-induced cortical reorganization and associated locomotor recovery in chronic stroke: an experimenter-blind randomized study.

    abstract:BACKGROUND AND PURPOSE:Virtual reality (VR) is a new promising computer-assisted technology to promote motor recovery in stroke patients. VR-induced neuroplasticity supporting locomotor recovery is not known. We investigated the effects of VR intervention on cortical reorganization and associated locomotor recovery in ...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/01.STR.0000162715.43417.91

    authors: You SH,Jang SH,Kim YH,Hallett M,Ahn SH,Kwon YH,Kim JH,Lee MY

    更新日期:2005-06-01 00:00:00