Abstract:
:Internal carotid blood flow, taken as an index of cerebral blood flow (CBF); arterial pressure; and respiratory O2 and CO2 concentrations, were measured in halothane (1%)-anesthetized, paralyzed and mechanically ventilated rabbits. CBF was determined at end-tidal CO2 of 4% (normocapnia) and 8%, as inspired O2 [O2]I) was varied stepwise over the range of 6.5 to 92%. Normocapnic CBF was constant over the range of 15 to 92% [O2]I, but it increased significantly to 240% and 380% of control when [O2]I was at 10% and 6.5%, respectively. Cerebrovascular response to CO2 was constant over the range of [O2]I tested, except for a significant elevation to 180% of control at [O2]I of 10%.
journal_name
Strokejournal_title
Strokeauthors
Quint SR,Scremin OU,Sonnenschein RR,Rubinstein EHdoi
10.1161/01.str.11.3.286subject
Has Abstractpub_date
1980-05-01 00:00:00pages
286-9issue
3eissn
0039-2499issn
1524-4628journal_volume
11pub_type
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