Use of Statins and Outcomes in Intracerebral Hemorrhage Patients.

Abstract:

BACKGROUND AND PURPOSE:Statin use may be associated with improved outcome in intracerebral hemorrhage patients. However, the topic remains controversial. Our analysis examined the effect of prior, continued, or new statin use on intracerebral hemorrhage outcomes using the ERICH (Ethnic/Racial Variations of Intracerebral Hemorrhage) data set. METHODS:We analyzed ERICH (a multicenter study designed to examine ethnic variations in the risk, presentation, and outcomes of intracerebral hemorrhage) to explore the association of statin use and hematoma growth, mortality, and 3-month disability. We computed subset analyses with respect to 3 statin categories (prior, continued, or new use). RESULTS:Two thousand four hundred and fifty-seven enrolled cases (mean age, 62 years; 42% females) had complete data on mortality and 3-month disability (modified Rankin Scale). Among those, 1093 cases were on statins (prior, n=268; continued, n=423; new, n=402). Overall, statin use was associated with reduced mortality and disability without any effect on hematoma growth. This association was primarily driven by continued/new statin use. A multivariate analysis adjusted for age and major predictors for poor outcome showed that continued/new statins users had good outcomes compared with prior users. However, statins may have been continued/started more frequently among less severe patients. When a propensity score was developed based on factors that could influence a physician's decision in prescribing statins and used as a covariate, continued/new statin use was no longer a significant predictor of good outcome. CONCLUSIONS:Although statin use, especially continued/new use, was associated with improved intracerebral hemorrhage outcomes, this effect may merely reflect the physician's view of a patient's prognosis rather than a predictor of survival.

journal_name

Stroke

journal_title

Stroke

authors

Siddiqui FM,Langefeld CD,Moomaw CJ,Comeau ME,Sekar P,Rosand J,Kidwell CS,Martini S,Osborne JL,Stutzman S,Hall C,Woo D

doi

10.1161/STROKEAHA.117.017358

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

2098-2104

issue

8

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.117.017358

journal_volume

48

pub_type

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