Abstract:
:We measured cerebrovascular reactivity to carbon dioxide in the cerebral cortex and the subcortical white matter of 12 healthy adult volunteers (four young subjects aged 21-24, four middle-aged subjects aged 34-40, and four elderly subjects aged 62-85 years). Blood flow was computed from the concentration history of xenon-133 in the volume of interest measured with an ultrapure germanium detector array. End-tidal PaCO2 ranged from 35.4 to 42.6 mm Hg. The mean +/- SD baseline blood flows in the cerebral cortex were 60 +/- 7, 51 +/- 9, and 33 +/- 4 ml/100 cm3/min in the young, the middle-aged, and the elderly subjects, respectively; the corresponding subcortical white matter baseline blood flows were 21 +/- 1, 22 +/- 3, and 16 +/- 5 ml/100 cm3/min. Mean +/- SD cerebrovascular reactivities to carbon dioxide in the cerebral cortex were 2.03 +/- 0.58, 1.36 +/- 0.41, and 0.72 +/- 0.19 ml/100 cm3/min/mm Hg PaCO2 for the young, the middle-aged, and the elderly subjects, respectively; the corresponding reactivities in the subcortical white matter were 0.69 +/- 0.11, 0.59 +/- 0.17, and 0.36 +/- 0.41 ml/100 cm3/min/mm Hg PaCO2. Blood flow and cerebrovascular reactivity in the cerebral cortex of the young subjects were significantly higher than those for white matter and significantly higher than those in the elderly subjects (p less than 0.001). Age vs. blood flow (for the cortex) and age vs. cerebrovascular reactivity (for both cortical gray and subcortical white matter) also showed significant linear correlation (p less than 0.05). However, the age-related changes in white matter blood flow and cerebrovascular reactivity were slow, and the differences among the age groups were not statistically significant.
journal_name
Strokejournal_title
Strokeauthors
Reich T,Rusinek Hdoi
10.1161/01.str.20.4.453subject
Has Abstractpub_date
1989-04-01 00:00:00pages
453-7issue
4eissn
0039-2499issn
1524-4628journal_volume
20pub_type
杂志文章,评审相关文献
STROKE文献大全abstract::Continuous-wave (CW) Doppler ultrasound imaging for prediction of arteriogrphic abnormality at the carotid bifurcation was carried out in 195 arteries of 105 patients. The Doppler method had no predictive value when compared to angiographic findings in arteries classified as 0-50% stenosis by Doppler. In 50-75% stenos...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.11.4.402
更新日期:1980-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Transcatheter closure of patent foramen ovale (PFO) has been reported to improve migraine in patients with cerebrovascular disorders in noncontrolled studies. The aim of the study was to compare the course of migraine assessed prospectively over a 12-month period in symptomatic (for cerebrovascul...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000199082.07317.43
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recovery from hemiparesis due to corticospinal tract infarction is well documented, but the mechanism of recovery is unknown. Functional MRI (fMRI) provides a means of identifying focal brain activity related to movement of a paretic hand. Although prior studies have suggested that supplementary ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.3.656
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Improvements in cardiac surgery mortality and morbidity have focused interest on the neurological injury such as stroke and cognitive decline that may accompany an otherwise successful operation. We aimed to investigate (1) the rate of stroke, new ischemic change on MRI, and cognitive impairment ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.107.502989
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In prehension tasks with objects placed within arm's reach, patients with hemiparesis caused by stroke use excessive trunk movement to compensate for arm motor impairments. Compensatory trunk movements may improve motor function in the short term but may limit arm recovery in the long term. Previ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.STR.0000132569.33572.75
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although the physical and, to a lesser extent, emotional outcome of stroke survivors has been well documented, there are far fewer data relating to the outcomes of those who care for them. We aimed to describe the outcome of those caring for stroke patients and to identify both patient and caregi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.9.1867
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The reliability of the National Institutes of Health Stroke Scale (NIHSS) has been established through testing its use in live and videotaped patients. This reliability testing has primarily focused on the use of the scale by neurologists. We sought to determine the reliability of the NIHSS as us...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.2.307
更新日期:1997-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with acute ischemic stroke and intracranial arterial obstructions have a poor prognosis and a high probability of deteriorating at 24 hours. We aimed to evaluate the diagnostic accuracy of power motion mode Doppler (PMD-TCD) compared with CT angiography as standard in diagnosing intracra...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.542704
更新日期:2009-06-01 00:00:00
abstract::We examined the 21-aminosteroid U74006F, a potent inhibitor of lipid peroxidation, for potential neuroprotective effects in a canine model of complete cerebral ischemia. Two 1.5-mg/kg boluses were administered to six dogs, the first bolus 15 minutes prior to a 12-minute episode of complete cerebral ischemia and the se...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.7.902
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of the present study is to determine the effect of mild hypothermia on the synthesis of ubiquitin, an important protein for maintenance of cell viability, in the hippocampal neurons following transient cerebral ischemia. METHODS:Transient ischemia was induced by occluding both common...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.12.1574
更新日期:1991-12-01 00:00:00
abstract::Background and Purpose- Although older age is one of the most important risk factor for stroke in atrial fibrillation (AF), the appropriate age threshold (eg, CHA2DS2-VASc score [congestive heart failure, hypertension, age ≥75 years (doubled), diabetes mellitus, prior stroke or transient ischemic attack (doubled), vas...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.021047
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:White matter hyperintensities (WMH) are frequently seen on neuroimaging of elderly and are associated with cognitive decline and the development of dementia. Yet, the temporal dynamics of conversion of normal-appearing white matter (NAWM) into WMH remains unknown. We examined whether and when pro...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.020980
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Evidence suggests that the protease-activated receptor-1 (PAR-1), a thrombin receptor, mediates neuronal injury in experimental cerebral ischemia. The present study investigated whether PAR-1 plays a role in brain injury after global cerebral ischemia. METHODS:Adult male wild-type or PAR-1 knock...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.661819
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Transcranial direct current stimulation is emerging as a promising tool for the treatment of several neurological conditions, including cerebral ischemia. The therapeutic role of this noninvasive treatment is, however, limited to chronic phases of stroke. We thus ought to investigate whether diff...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001687
更新日期:2013-11-01 00:00:00
abstract::Background and Purpose- The purpose of this study was to conduct a meta-analysis of CVOTs (cardiovascular outcome trials) to evaluate the effect of glucagon-like peptide-1 receptor agonists therapy in reducing the risk of stroke in patients with type 2 diabetes mellitus. Methods- PubMed and other electronic sources we...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.119.027557
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Data from epidemiological and case-control studies suggest that increased total homocysteine (tHcy) levels are associated with increased risk for thromboembolic disease. The mechanisms by which hyperhomocysteinemia contributes to thrombogenesis are incompletely understood. The main objectives of ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.5.974
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Little is known about the clinical outcomes associated with posthemorrhage anticoagulation resumption for atrial fibrillation. This study had 2 objectives: first, to evaluate anticoagulation use after a first major bleed on warfarin or dabigatran and, second, to compare effectiveness and safety o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.015150
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although chemokines have been implicated in cardiovascular diseases, few studies have addressed the role of these inflammatory mediators in ischemic stroke. This study tested the hypothesis that RANTES (CCL5; regulated on activation, normal T-cell expressed and secreted) mediates the cerebral mic...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.513150
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Attained height, an indicator of genetic potential and childhood growth environment, is inversely associated with stroke, but the mechanisms are poorly understood. We investigated whether childhood height and growth are associated with ischemic stroke (IS) and intracerebral hemorrhage (ICH). MET...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.019880
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The use of lithium as a neuroprotective agent has been demonstrated using various models in which improvements in infarct size, DNA damage, and neurological function were reported. We further investigated neurohemodynamic aspects of the treatment-associated recovery by assessing the therapeutic e...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.492215
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There are uncertainties surrounding the optimal management of patients with brain swelling after an ischemic stroke. Guidelines are needed on how to manage this major complication, how to provide the best comprehensive neurological and medical care, and how to best inform families facing complex ...
journal_title:Stroke
pub_type: 杂志文章,实务指引
doi:10.1161/01.str.0000441965.15164.d6
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke is a major cause of death in the People's Republic of China (PRC), and the geographic distribution of stroke death varies substantially. We conducted an ecological analysis to investigate the relationship of prevalence of hypertension and other risk factors with stroke incidence and mortal...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract::The purpose of this study was to develop an animal model that could be used to test the ability of Doppler ultrasound to detect arterial emboli composed of materials that are often involved in cerebral emboli. Emboli introduced into the rabbit aorta via the left renal artery consisted of clotted whole blood, platelets...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.2.253
更新日期:1991-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although cerebral penetrating arterioles are main regulators of the brain microcirculation, little is known about the effect of endothelium-derived relaxation factor on these vessels. This study examined the effects of nitric oxide synthase inhibitors on the spontaneous tone of isolated rat cereb...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.11.2227
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In addition to low-density lipoprotein (LDL) cholesterol, small, dense LDL particles and oxidative modification of LDL have been linked to the pathogenesis of atherosclerosis. The present study was aimed at investigating the association between carotid artery intima-media thickness (IMT) and LDL ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000014924.29238.e1
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Chlamydia pneumoniae infection has recently become noteworthy in relation to atherosclerosis. We investigated by immunohistochemistry the distribution of C pneumoniae infection in the atherosclerotic carotid artery. METHODS:Twenty carotid atherosclerotic lesions that were resected during carotid...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.29.4.773
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this investigation was to compare the respective efficacy of transcranial Doppler sonography (TCD) and magnetic resonance angiography (MRA) for the assessment of intracranial hemodynamics in patients with extracranial occlusion or severe stenosis of the internal carotid artery (ICA). ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.2.214
更新日期:1995-02-01 00:00:00
abstract::We determined the immediate effects of pentoxifylline on cerebral blood flow in 10 patients with cerebrovascular disease; four received 400 mg and six received 800 mg pentoxifylline orally. Regional cerebral blood flow was measured before (baseline) and 2, 4, and 6 hours after pentoxifylline administration using the x...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.12.1662
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Transcranial color-coded sonography is a new development in noninvasive cerebral vascular imaging. Reference data using this technique are described. METHODS:Blood velocities and pulsatility and resistance indices were determined in the anterior cerebral, middle cerebral, posterior cerebral, ver...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.2.390
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dysphagia is a common stroke symptom and leads to serious complications such as aspiration and pneumonia. Early dysphagia screening can reduce these complications. In many hospitals, dysphagia screening is performed by speech-language therapists who are often not available on weekends/holidays, w...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.018157
更新日期:2017-09-01 00:00:00