Role of protease-activated receptor-1 in brain injury after experimental global cerebral ischemia.

abstract：BACKGROUND AND PURPOSE:In acute stroke care, rapid but careful evaluation of patients is mandatory but requires an experienced stroke neurologist. Telemedicine offers the possibility of bringing such expertise quickly to more patients. This study tested for the first time whether remote video examination is feasible an...

journal_title：Stroke

authors： Handschu R,Littmann R,Reulbach U,Gaul C,Heckmann JG,Neundörfer B,Scibor M

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The overall burden of prior infections may contribute to atherosclerosis and stroke risk. We hypothesized that serological evidence of common infections would be associated with carotid plaque thickness in a multiethnic cohort. METHODS:Antibody titers to 5 common infectious microorganisms (ie, C...

journal_title：Stroke

authors： Elkind MS,Luna JM,Moon YP,Boden-Albala B,Liu KM,Spitalnik S,Rundek T,Sacco RL,Paik MC

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Studies of the cerebroprotective effects of selective brain cooling have failed to show amelioration of ischemic injury in the cerebral cortex. This study was designed to test the hypothesis that mild-to-moderate selective brain cooling initiated after the onset of global brain ischemia in rats p...

journal_title：Stroke

authors： Kuluz JW,Gregory GA,Yu AC,Chang Y

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is currently no consensus on (1) the percentage of patients who develop spasticity after ischemic stroke, (2) the relation between spasticity and initial clinical findings after acute stroke, and (3) the impact of spasticity on activities of daily living and health-related quality of life. ...

journal_title：Stroke

authors： Urban PP,Wolf T,Uebele M,Marx JJ,Vogt T,Stoeter P,Bauermann T,Weibrich C,Vucurevic GD,Schneider A,Wissel J

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral small vessel disease (SVD) is associated with cognitive impairment. This may be because of decreased microstructural integrity and microvascular perfusion, but data on these relationships are scarce. We determined the relationship between cognition and microvascular perfusion and microst...

journal_title：Stroke

authors： Zhang CE,Wong SM,Uiterwijk R,Staals J,Backes WH,Hoff EI,Schreuder T,Jeukens CR,Jansen JF,van Oostenbrugge RJ

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Analysis of quality of care for in-hospital stroke has not been previously performed at the national level. This study compares patient characteristics, process measures of quality, and outcomes for in-hospital strokes with those for community-onset strokes in a national cohort. METHODS:We perfo...

journal_title：Stroke

authors： Cumbler E,Wald H,Bhatt DL,Cox M,Xian Y,Reeves M,Smith EE,Schwamm L,Fonarow GC

更新日期：2014-01-01 00:00:00

abstract：:Five patients with nonseptic cerebral embolism of cardiac origin are reported in whom early anticoagulant therapy resulted in clinical deterioration or death from frank hemorrhage into the acute infarct. In each patient an initial CT scan excluded the presence of intracerebral hemorrhage and a second CT scan, after cl...

journal_title：Stroke

authors： Shields RW Jr,Laureno R,Lachman T,Victor M

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Extracorporeal rheopheresis is a safe method to optimize hemorheology. Our aim was to determine whether treatment with extracorporeal rheopheresis in patients with acute ischemic hemispheric stroke improves cerebral perfusion as assessed with serial 99mTc-ethyl-cysteinate-dimer single-photon emis...

journal_title：Stroke

authors： Berrouschot J,Barthel H,Köster J,Hesse S,Rössler A,Knapp WH,Schneider D

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Data from recent multicenter carotid endarterectomy trials have questioned the validity and reliability of Doppler ultrasound in the assessment of carotid stenosis. METHODS:We prospectively analyzed 45 patients undergoing carotid angiography to compare the North American Symptomatic Carotid Enda...

journal_title：Stroke

authors： Alexandrov AV,Bladin CF,Maggisano R,Norris JW

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Epidemiological and laboratory studies suggest that increasing concentrations of plasma homocysteine (total homocysteine [tHcy]) accelerate cardiovascular disease by promoting vascular inflammation, endothelial dysfunction, and hypercoagulability. METHODS:We conducted a randomized controlled tri...

journal_title：Stroke

authors： Dusitanond P,Eikelboom JW,Hankey GJ,Thom J,Gilmore G,Loh K,Yi Q,Klijn CJ,Langton P,van Bockxmeer FM,Baker R,Jamrozik K

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Iron is an essential element for the human body. It has, however, been suggested that excessive iron stores may increase the risk of vascular disease. So far, epidemiologic studies on stroke are sparse. METHODS:We studied the association between iron status and stroke risk in a population-based ...

journal_title：Stroke

authors： van der A DL,Grobbee DE,Roest M,Marx JJ,Voorbij HA,van der Schouw YT

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Zinc protoporphyrin (ZnPP) has multiple actions. It is an interleukin-1 antagonist as well as a hemeoxygenase inhibitor. Interleukin-1 is produced in ischemic brain and probably contributes to ischemic injury, although the role of heme oxygenase during ischemia is unknown. Whether ZnPP treatment ...

journal_title：Stroke

authors： Kadoya C,Domino EF,Yang GY,Stern JD,Betz AL

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke patients without evidence of arterial occlusion may not be suitable candidates for thrombolytic therapy. In our study, we investigated the outcomes of patients with negative CT angiography results for arterial occlusion. METHODS:The study included patients treated within 3 hours after sym...

journal_title：Stroke

authors： Mikulik R,Goldemund D,Reif M,Aulicky P,Krupa P

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There are uncertainties surrounding the optimal management of patients with brain swelling after an ischemic stroke. Guidelines are needed on how to manage this major complication, how to provide the best comprehensive neurological and medical care, and how to best inform families facing complex ...

journal_title：Stroke

authors： Wijdicks EF,Sheth KN,Carter BS,Greer DM,Kasner SE,Kimberly WT,Schwab S,Smith EE,Tamargo RJ,Wintermark M,American Heart Association Stroke Council.

更新日期：2014-04-01 00:00:00

abstract：:True, three-dimensional proton nuclear magnetic resonance imaging at 0.147 tesla was performed postmortem on 2 patients embodying various stroke syndromes, including chronic (4 and 15 years) infarction, subacute (within 1 week) bland infarction, acute (2 days) hemorrhagic infarction, and hematoma secondary to ruptured...

journal_title：Stroke

authors： DeWitt LD,Kistler JP,Miller DC,Richardson EP Jr,Buonanno FS

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purposes of this study were to assess the relationships between anatomic and technical factors and the 30-day risk of stroke or death after carotid angioplasty and stenting in the Endarterectomy versus Stenting in Patients with Symptomatic Severe Carotid Stenosis (EVA-3S) trial and to perform...

journal_title：Stroke

authors： Naggara O,Touzé E,Beyssen B,Trinquart L,Chatellier G,Meder JF,Mas JL,EVA-3S Investigators.

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The independent contribution of insulin resistance to atherosclerosis is still under debate. We compared associations of 2 different indices of insulin resistance, the Homeostasis Model Assessment (HOMA) index and kITT from a short insulin tolerance test with carotid atherosclerosis. METHODS:A t...

journal_title：Stroke

authors： Sourij H,Schmoelzer I,Dittrich P,Paulweber B,Iglseder B,Wascher TC

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The current report details our initial periprocedural experience with Wingspan (Boston Scientific/Target), the first self-expanding stent system designed for the treatment of intracranial atheromatous disease. METHODS:All patients undergoing angioplasty and stenting with the Gateway balloon-Wing...

journal_title：Stroke

authors： Fiorella D,Levy EI,Turk AS,Albuquerque FC,Niemann DB,Aagaard-Kienitz B,Hanel RA,Woo H,Rasmussen PA,Hopkins LN,Masaryk TJ,McDougall CG

更新日期：2007-03-01 00:00:00

abstract：:Background and Purpose- To test the hypothesis that covert brain infarcts (CBIs) are more likely to be located in noneloquent brain areas compared with clinical strokes and that CBI etiological subtypes carry a differential risk of vascular events compared with people without CBI. Methods- We used brain magnetic reson...

journal_title：Stroke

authors： Gutierrez J,Gil-Guevara A,Ramaswamy S,DeRosa J,Di Tullio MR,Cheung K,Rundek T,Sacco RL,Wright CB,Elkind MSV

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Increased mean platelet volume (MPV), indicating higher platelet reactivity, is associated with an increased risk of myocardial infarction. Higher levels of MPV have been found in patients with acute ischemic stroke than in control subjects. Data from smaller studies regarding an association betw...

journal_title：Stroke

authors： Greisenegger S,Endler G,Hsieh K,Tentschert S,Mannhalter C,Lalouschek W

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this study was to investigate the periprocedural morbidity, mortality, and long-term clinical and angiographic follow-up using stent-assisted coiling and stenting alone for treatment of cranial fusiform dissecting and atherosclerotic aneurysms. METHODS:The Institutional Review Boa...

journal_title：Stroke

authors： Wakhloo AK,Mandell J,Gounis MJ,Brooks C,Linfante I,Winer J,Weaver JP

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Differences exist between European countries in the proportion of patients who die or become dependent after stroke. The aim of the present study was to identify differences in the use of time by stroke patients in 4 rehabilitation centers in 4 European countries. METHODS:In each of the 4 center...

journal_title：Stroke

authors： De Wit L,Putman K,Dejaeger E,Baert I,Berman P,Bogaerts K,Brinkmann N,Connell L,Feys H,Jenni W,Kaske C,Lesaffre E,Leys M,Lincoln N,Louckx F,Schuback B,Schupp W,Smith B,De Weerdt W

更新日期：2005-09-01 00:00:00

abstract：:Changes of regional cerebral blood flow from rest to mental activation by a visually presented spatial reasoning test were measured during normo- and hypercapnia in 10 healthy subjects. Hypercapnia, elicited by inhalation of 6% CO2, resulted in similar flow increases in all 32 cortical regions measured. Increases of f...

journal_title：Stroke

authors： Maximilian VA,Prohovnik I,Risberg J

更新日期：1980-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sonothrombolysis is a new treatment approach in acute ischemic stroke. The results of a monocenter, randomized clinical study are presented. METHODS:Subjects with acute middle cerebral artery main stem occlusion were randomized into a target group receiving 1-hour transcranial continuous insonat...

journal_title：Stroke

authors： Eggers J,König IR,Koch B,Händler G,Seidel G

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) caused by ruptured intracranial aneurysm affects approximately 16 000 Americans annually, and almost 40% of affected patients die within 30 days despite the best current therapy. Prevention of SAH is therefore of paramount importance. We present a preliminary analysi...

journal_title：Stroke

authors： Kissela BM,Sauerbeck L,Woo D,Khoury J,Carrozzella J,Pancioli A,Jauch E,Moomaw CJ,Shukla R,Gebel J,Fontaine R,Broderick J

更新日期：2002-05-01 00:00:00

abstract：:This investigation tests the hypothesis that the normal cerebral image obtained non-invasively during continuous inhalation of C15O2 is related to cerebral blood flow. Trace amounts of CO2 labeled with the positron-emitting radionuclide 15O were administered to 4 normal subjects at normo- and hypocapnia and to 2 of th...

journal_title：Stroke

authors： Ackerman RH,Subramanyam R,Correia JA,Alpert NM,Taveras JM

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Delayed cerebral ischemia and infarction due to reduced CBF remains the leading cause of poor outcome after aneurysmal subarachnoid hemorrhage. Hypertonic saline (HS) is associated with an increase in CBF. This study explores whether CBF enhancement with HS in patients with poor-grade subarachnoi...

journal_title：Stroke

authors： Al-Rawi PG,Tseng MY,Richards HK,Nortje J,Timofeev I,Matta BF,Hutchinson PJ,Kirkpatrick PJ

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A precise definition of genetic factors responsible for common forms of stroke is still lacking. The purpose of the present study was to investigate the contributory role of the genes encoding atrial natriuretic peptide (ANP) and type A natriuretic peptide receptor (NPRA) in humans' susceptibilit...

journal_title：Stroke

authors： Rubattu S,Stanzione R,Di Angelantonio E,Zanda B,Evangelista A,Tarasi D,Gigante B,Pirisi A,Brunetti E,Volpe M

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carotid angioplasty and stenting (CAS) is associated with higher risk of periprocedural stroke and death when compared with carotid endarterectomy (CEA). By contrast, the risk of myocardial infarction (MI) was higher after CEA than after CAS in randomized trials. However, numbers were small, and ...

journal_title：Stroke

authors： Boulanger M,Camelière L,Felgueiras R,Berger L,Rerkasem K,Rothwell PM,Touzé E

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The ABC/2 method for calculating intracerebral hemorrhage (ICH) volume has been well validated. However, the formula, derived from the volume of an ellipse, assumes the shape of ICH is elliptical. We sought to compare the agreement of the ABC/2 formula with other methods through retrospective ana...

journal_title：Stroke

authors： Haley MD,Gregson BA,Mould WA,Hanley DF,Mendelow AD

更新日期：2018-02-01 00:00:00