Selective brain cooling during and after prolonged global ischemia reduces cortical damage in rats.

abstract：BACKGROUND AND PURPOSE:We sought to investigate the direct costs of acute hospitalization for patients with first-ever ischemic stroke in Taiwan. METHODS:Data were prospectively collected from 360 first-ever ischemic stroke patients. Hospital charges were used for analysis. Multiple linear regression analysis was used...

journal_title：Stroke

authors： Chang KC,Tseng MC

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Motor dysfunction after unilateral deafferentation in primates can be overcome by restraining the unaffected limb. We asked whether a constraint-induced movement (CIM) program could be implemented within 2 weeks after stroke and whether CIM is more effective than traditional upper-extremity (UE) ...

journal_title：Stroke

authors： Dromerick AW,Edwards DF,Hahn M

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Prevalence of cerebral microbleeds (CMB) in white and Asian populations range from 4% to 15%. However, there is no information from indigenous Latin American people. We aimed to assess prevalence and cerebrovascular correlates of CMB in stroke-free older adults living in rural Ecuador. METHODS:O...

journal_title：Stroke

authors： Del Brutto VJ,Zambrano M,Mera RM,Del Brutto OH

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Evidence suggests that the protease-activated receptor-1 (PAR-1), a thrombin receptor, mediates neuronal injury in experimental cerebral ischemia. The present study investigated whether PAR-1 plays a role in brain injury after global cerebral ischemia. METHODS:Adult male wild-type or PAR-1 knock...

journal_title：Stroke

authors： Wang J,Jin H,Hua Y,Keep RF,Xi G

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cannabidiol has been reported to be a neuroprotectant, but the neuroprotective mechanism of cannabidiol remains unclear. We studied the neuroprotective mechanism of cannabidiol in 4-hour middle cerebral artery (MCA) occlusion mice. METHODS:Male MCA occluded mice were treated with cannabidiol, ab...

journal_title：Stroke

authors： Mishima K,Hayakawa K,Abe K,Ikeda T,Egashira N,Iwasaki K,Fujiwara M

更新日期：2005-05-01 00:00:00

abstract：:Background and Purpose- The CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial) demonstrated equivalent composite outcomes between carotid endarterectomy (CEA) and carotid artery stenting (CAS) for treating carotid stenosis. We investigated nationwide trends in these procedures and associated peripr...

journal_title：Stroke

authors： Cole TS,Mezher AW,Catapano JS,Godzik J,Baranoski JF,Nakaji P,Albuquerque FC,Lawton MT,Little AS,Ducruet AF

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Aspirin resistance may be relatively common and associated with adverse outcome. Meta-analysis has clearly shown that 75 mg plain aspirin is the lowest effective dose; however, it is not known whether the recent increased use of enteric-coated aspirin could account for aspirin resistance. This st...

journal_title：Stroke

authors： Cox D,Maree AO,Dooley M,Conroy R,Byrne MF,Fitzgerald DJ

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Thrombolytic Therapy in Acute Ischemic Stroke Study, which started in August of 1991, was designed to assess the efficacy and safety of intravenous rtPA (alteplase) in patients with acute (0 to 6 hours) ischemic stroke. In October 1993 enrollment was halted because of Safety Committee (DMSB) ...

journal_title：Stroke

authors： Clark WM,Albers GW,Madden KP,Hamilton S

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Preclinical data suggest that cell-based therapies have the potential to improve stroke outcomes. METHODS:Eighteen patients with stable, chronic stroke were enrolled in a 2-year, open-label, single-arm study to evaluate the safety and clinical outcomes of surgical transplantation of modified bon...

journal_title：Stroke

authors： Steinberg GK,Kondziolka D,Wechsler LR,Lunsford LD,Coburn ML,Billigen JB,Kim AS,Johnson JN,Bates D,King B,Case C,McGrogan M,Yankee EW,Schwartz NE

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The sensitivity of the brain to brief periods of profound ischemia or prolonged periods of modest ischemia mandates an aggressive approach to acute stroke care. Past studies have shown that many stroke patients do not receive acute care in an urgent and timely fashion. The formation of acute stro...

journal_title：Stroke

authors： Alberts MJ,Chaturvedi S,Graham G,Hughes RL,Jamieson DG,Krakowski F,Raps E,Scott P

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Familial aggregation of intracranial aneurysms (IAs) indicates a genetic role in the pathogenesis of this disease. Despite a number of reported susceptibility loci, no disease-causing gene variants have been identified. In this study, we used a parametric genomewide linkage approach to search for...

journal_title：Stroke

authors： Santiago-Sim T,Depalma SR,Ju KL,McDonough B,Seidman CE,Seidman JG,Kim DH

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients. METHODS:Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers w...

journal_title：Stroke

authors： Heo JH,Kim SH,Lee KY,Kim EH,Chu CK,Nam JM

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Based on thrombus location and nature and anatomic features of aorta and cerebral arteries, we hypothesized that cardiogenic embolisms (CE) and aortogenic embolisms (AE) might have different right-left propensity and lesion patterns. METHODS:We retrospectively reviewed patients with acute ischem...

journal_title：Stroke

authors： Kim HJ,Song JM,Kwon SU,Kim BJ,Kang DH,Song JK,Kim JS,Kang DW

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Evidence now exists for a pathogenic role for neutrophils in acute cerebral ischemia. We have studied the patterns and temporal profile of cerebral neutrophil recruitment to areas of acute ischemic stroke (IS) and have attempted to correlate this with neurological status and outcome. METHODS:Pat...

journal_title：Stroke

authors： Price CJ,Menon DK,Peters AM,Ballinger JR,Barber RW,Balan KK,Lynch A,Xuereb JH,Fryer T,Guadagno JV,Warburton EA

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Magnetic resonance perfusion (MRP) and computed tomographic perfusion (CTP) are being increasingly applied in acute stroke trials and clinical practice, yet the comparability of their perfusion values is not well validated. The aim of this study was to validate the comparability of CTP and MRP me...

journal_title：Stroke

authors： Lin L,Bivard A,Levi CR,Parsons MW

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We found age-related vulnerability to cerebral ischemia in the hippocampus and striatum in spontaneously hypertensive rats. Further study revealed that ischemia-induced release of hippocampal taurine, an inhibitory amino acid, was reduced by 40% in aged rats compared with adult rats, which sugges...

journal_title：Stroke

authors： Yao H,Ooboshi H,Ibayashi S,Uchimura H,Fujishima M

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Diffusion-weighted imaging sometimes fails to detect early computed tomography (CT) ischemic lesions in acute ischemic stroke patients, which is termed reversed discrepancy (RD), but its clinical significance remains unclear. The incidence and factors associated with RD in acute ischemic stroke p...

journal_title：Stroke

authors： Kawano H,Hirano T,Nakajima M,Inatomi Y,Yonehara T

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In ischemic stroke, diffusion-weighted (DW) and perfusion-weighted (PW) magnet resonance imaging (MRI) is used to define the mismatch as the therapeutic target. With positron emission tomography (PET), we characterized the metabolic patterns of tissue compartments identified by MRI and compared t...

journal_title：Stroke

authors： Sobesky J,Zaro Weber O,Lehnhardt FG,Hesselmann V,Neveling M,Jacobs A,Heiss WD

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Previous studies reported that Tat-NR2B9c, a peptide disrupting the N-methyl-d-aspartate receptor-postsynaptic density protein-95 interaction, reduced ischemic damage in the acute phase after stroke. However, its effect in the subacute phase is unknown. The aim of this study is to determine wheth...

journal_title：Stroke

authors： Zhou HH,Tang Y,Zhang XY,Luo CX,Gao LY,Wu HY,Chang L,Zhu DY

更新日期：2015-05-01 00:00:00

abstract：:A 55-year-old woman with an aortic arch syndrome of acute onset and dysphasia, resulting from the excessive administration of ergotamine tartrate suppositories, is described. Complete resolution of symptoms and return of upper limb and carotid artery pulses to normal occurred within four days of cessation of the ergot...

journal_title：Stroke

authors： Feneley MP,Morgan JJ,McGrath MA,Egan JD

更新日期：1983-09-01 00:00:00

abstract：:Experimental subarachnoid hemorrhage was induced in 52 adult male Wistar rats by microsurgical transclival basilar artery puncture. Telencephalic blood flow measured in 24 rats with subarachnoid hemorrhage was compared with that in 23 sham-operated rats and 10 unoperated control rats using the [14C]butanol indicator f...

journal_title：Stroke

authors： Kader A,Krauss WE,Onesti ST,Elliott JP,Solomon RA

更新日期：1990-04-01 00:00:00

abstract：:Background and Purpose- Acetylsalicylic acid and clopidogrel are the 2 main antithrombotic drugs for secondary prevention in patients with ischemic stroke (IS) without indication for anticoagulation. Because of their limited efficacy and potential side effects, novel antiplatelet agents are urgently needed. Cilostazol...

journal_title：Stroke

authors： Bieber M,Schuhmann MK,Volz J,Kumar GJ,Vaidya JR,Nieswandt B,Pham M,Stoll G,Kleinschnitz C,Kraft P

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this study was to assess individual differences in the pharmacological effects of acetylsalicylic acid (ASA) on bleeding time as measured by in vitro platelet aggregation and to examine the consistency of responses over time. METHODS:We measured template IIR bleeding time and plat...

journal_title：Stroke

authors： Kawasaki T,Ozeki Y,Igawa T,Kambayashi J

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carotid angioplasty may offer an effective treatment for carotid stenosis, but there has been concern about the incidence and clinical consequences of distal embolization. Transcranial Doppler monitoring in carotid endarterectomy has demonstrated embolic signals during this procedure. We used thi...

journal_title：Stroke

authors： Markus HS,Clifton A,Buckenham T,Brown MM

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Lacunar syndromes correlate with a lacunar stroke on imaging in 50% to 60% of cases. Computed tomography perfusion (CTP) is becoming the preferred imaging modality for acute stroke triage. We aimed to estimate the sensitivity, specificity, and predictive values for noncontrast computed tomography...

journal_title：Stroke

authors： Garcia-Esperon C,Visser M,Churilov L,Miteff F,Bivard A,Lillicrap T,Levi CR,Spratt NJ,Parsons MW

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hypothermia reduces neuronal damage in animal stroke models. Whether hypothermia is neuroprotective in patients with acute stroke remains to be clarified. In this case-control study, we evaluated the feasibility and safety of inducing modest hypothermia by a surface cooling method in awake patien...

journal_title：Stroke

authors： Kammersgaard LP,Rasmussen BH,Jørgensen HS,Reith J,Weber U,Olsen TS

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Studies on cardiovascular disease have preferentially involved men because of the lower frequency of the disease in preelderly women. The aim of this analysis was to examine, with the use of a standardized ultrasound protocol, a cohort of women to differentiate early atherosclerotic lesions in di...

journal_title：Stroke

authors： Rubba P,Panico S,Bond MG,Covetti G,Celentano E,Iannuzzi A,Galasso R,Belisario MA,Pastinese A,Sacchetti L,Mancini M,Salvatore F

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The remaining limitations of ultrasonographic imaging in accurately quantifying internal carotid stenosis or diagnosing internal carotid occlusion may be overcome by enhancing the echogenicity of flowing arterial blood with contrast agents. This study assessed the usefulness of the intravenous (t...

journal_title：Stroke

authors： Sitzer M,Fürst G,Siebler M,Steinmetz H

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Multipotent mesenchymal stromal cell (MSC) harvested exosomes are hypothesized as the major paracrine effectors of MSCs. In vitro, the miR-17-92 cluster promotes oligodendrogenesis, neurogenesis, and axonal outgrowth. We, therefore, investigated whether the miR-17-92 cluster-enriched exosomes har...

journal_title：Stroke

authors： Xin H,Katakowski M,Wang F,Qian JY,Liu XS,Ali MM,Buller B,Zhang ZG,Chopp M

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ischemic stroke accounts for 70% to 80% of all strokes, but intracerebral and subarachnoid hemorrhagic strokes have greater fatality. Age-standardized death rates from overall stroke are higher among men than women, but little is known about sex differences in stroke subtype mortality by race/eth...

journal_title：Stroke

authors： Ayala C,Croft JB,Greenlund KJ,Keenan NL,Donehoo RS,Malarcher AM,Mensah GA

更新日期：2002-05-01 00:00:00