Abstract:
:This investigation tests the hypothesis that the normal cerebral image obtained non-invasively during continuous inhalation of C15O2 is related to cerebral blood flow. Trace amounts of CO2 labeled with the positron-emitting radionuclide 15O were administered to 4 normal subjects at normo- and hypocapnia and to 2 of these subjects at hypercapnia. Hypocapnia typically caused a marked decrease in cerebral 15O activity, and hypercapnia a small increase in activity. The relative difference in the change in count rate in response to hypo- and hypercapnia is what one would expect if the activity represented bloow flow, according to a mathematical model which assumes the 15O label enters the brain as water of perfusion. The findings in this study suggest that the normal cerebral image obtained during continuous inhalation of C15O2 is related to cerebral blood flow, but in a non-linear fashion, and that the technique would be more sensitive to ischemic events than to hyperemic phenomena.
journal_name
Strokejournal_title
Strokeauthors
Ackerman RH,Subramanyam R,Correia JA,Alpert NM,Taveras JMdoi
10.1161/01.str.11.1.45subject
Has Abstractpub_date
1980-01-01 00:00:00pages
45-9issue
1eissn
0039-2499issn
1524-4628journal_volume
11pub_type
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