Positron imaging of cerebral blood flow during continuous inhalation of C15O2.

Abstract:

:This investigation tests the hypothesis that the normal cerebral image obtained non-invasively during continuous inhalation of C15O2 is related to cerebral blood flow. Trace amounts of CO2 labeled with the positron-emitting radionuclide 15O were administered to 4 normal subjects at normo- and hypocapnia and to 2 of these subjects at hypercapnia. Hypocapnia typically caused a marked decrease in cerebral 15O activity, and hypercapnia a small increase in activity. The relative difference in the change in count rate in response to hypo- and hypercapnia is what one would expect if the activity represented bloow flow, according to a mathematical model which assumes the 15O label enters the brain as water of perfusion. The findings in this study suggest that the normal cerebral image obtained during continuous inhalation of C15O2 is related to cerebral blood flow, but in a non-linear fashion, and that the technique would be more sensitive to ischemic events than to hyperemic phenomena.

journal_name

Stroke

journal_title

Stroke

authors

Ackerman RH,Subramanyam R,Correia JA,Alpert NM,Taveras JM

doi

10.1161/01.str.11.1.45

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

45-9

issue

1

eissn

0039-2499

issn

1524-4628

journal_volume

11

pub_type

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