Danish very-low-dose aspirin after carotid endarterectomy trial.

Abstract:

:The effect of very-low-dose aspirin as an antithrombotic agent was evaluated blindly in 301 patients who had recently undergone carotid endarterectomy. After randomization, 150 patients received aspirin and 151 received placebo. The two groups were comparable with regard to age, sex, blood pressure, previous cerebrovascular events, and smoking habits. The effect of the study medication on platelet aggregation was measured twice in each patient during the first 2 months and at each follow-up visit; the dose was individually adjusted. In 76% of the patients receiving aspirin, 50 mg/day gave satisfactory platelet inhibition, 13% needed 60 mg/day, 8% needed 70 mg/day, and 3% needed 100 mg/day. Platelet aggregation was found to be inhibited in only 1.2% of the measurements in the patients receiving placebo. Observation during treatment averaged 21 months; total intention-to-treat follow-up averaged 25 months. For the combined outcome events of transient ischemic attack, stroke, acute myocardial infarction, and vascular death, aspirin reduced risk by 11% (95% confidence limits: -38% to 48%, p greater than 0.1). Thus, there was no significant effect of very-low-dose aspirin in our trial.

journal_name

Stroke

journal_title

Stroke

authors

Boysen G,Sørensen PS,Juhler M,Andersen AR,Boas J,Olsen JS,Joensen P

doi

10.1161/01.str.19.10.1211

subject

Has Abstract

pub_date

1988-10-01 00:00:00

pages

1211-5

issue

10

eissn

0039-2499

issn

1524-4628

journal_volume

19

pub_type

临床试验,杂志文章,随机对照试验

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