Danish very-low-dose aspirin after carotid endarterectomy trial.


:The effect of very-low-dose aspirin as an antithrombotic agent was evaluated blindly in 301 patients who had recently undergone carotid endarterectomy. After randomization, 150 patients received aspirin and 151 received placebo. The two groups were comparable with regard to age, sex, blood pressure, previous cerebrovascular events, and smoking habits. The effect of the study medication on platelet aggregation was measured twice in each patient during the first 2 months and at each follow-up visit; the dose was individually adjusted. In 76% of the patients receiving aspirin, 50 mg/day gave satisfactory platelet inhibition, 13% needed 60 mg/day, 8% needed 70 mg/day, and 3% needed 100 mg/day. Platelet aggregation was found to be inhibited in only 1.2% of the measurements in the patients receiving placebo. Observation during treatment averaged 21 months; total intention-to-treat follow-up averaged 25 months. For the combined outcome events of transient ischemic attack, stroke, acute myocardial infarction, and vascular death, aspirin reduced risk by 11% (95% confidence limits: -38% to 48%, p greater than 0.1). Thus, there was no significant effect of very-low-dose aspirin in our trial.






Boysen G,Sørensen PS,Juhler M,Andersen AR,Boas J,Olsen JS,Joensen P




Has Abstract


1988-10-01 00:00:00














  • Role of the contralateral inferior frontal gyrus in recovery of language function in poststroke aphasia: a combined repetitive transcranial magnetic stimulation and positron emission tomography study.

    abstract:BACKGROUND AND PURPOSE:Functional neuroimaging studies have demonstrated right inferior frontal gyrus (IFG) activation in poststroke aphasia. It remains unclear whether this activation is essential for language performance. We tested this hypothesis in a positron emission tomography (PET) activation study during a sema...


    pub_type: 杂志文章


    authors: Winhuisen L,Thiel A,Schumacher B,Kessler J,Rudolf J,Haupt WF,Heiss WD

    更新日期:2005-08-01 00:00:00

  • Does Contralesional Hand Function After Neonatal Stroke Only Depend on Lesion Characteristics?

    abstract:BACKGROUND AND PURPOSE:In children having suffered from neonatal arterial ischemic stroke, the relationship between contralesional hand performance and structural changes in brain areas remote from the infarct site was examined. METHODS:Using voxel-based morphometry, we correlated contralesional gross manual dexterity...


    pub_type: 杂志文章


    authors: Dinomais M,Hertz-Pannier L,Groeschel S,Delion M,Husson B,Kossorotoff M,Renaud C,Chabrier S,The Tich SN,AVCnn Study Group.

    更新日期:2016-06-01 00:00:00

  • Hypertensive putaminal hemorrhage: treatment and results. Is surgical treatment superior to conservative one?

    abstract::Seventy-four patients with hypertensive putaminal hemorrhage (HPH) were followed at least 6 months after treatment and estimated by ADL. They were graded according to the state of consciousness on admission. The grading consists of 6 grades: Grade 1, fully conscious; Grade 2, somnolent; Grade 3, stuporous; Grade 4, se...


    pub_type: 杂志文章


    authors: Waga S,Yamamoto Y

    更新日期:1983-07-01 00:00:00

  • Beyond conventional stroke guidelines: setting priorities.

    abstract:BACKGROUND AND PURPOSE:Priorities in the care of stroke patients are often intuitive. An open and translucent priority-setting procedure would benefit patients, professionals, and decision-makers. Prioritization is an innovative part of the new Swedish national stroke guidelines. METHODS:Working groups identified diag...


    pub_type: 杂志文章


    authors: Norrving B,Wester P,Sunnerhagen KS,Terént A,Sohlberg A,Berggren F,Wester PO,Asplund K,Stroke Guidelines Working Group, National Board of Health and Welfare, Stockholm, Sweden.

    更新日期:2007-07-01 00:00:00

  • Anterior choroidal artery territory infarcts. Study of presumed mechanisms.

    abstract:BACKGROUND AND PURPOSE:A previous study suggested that occlusive diseases of small penetrating arteries account for most anterior choroidal artery (AChA) territory infarcts, but half of the patients did not have an echocardiogram. Cases of AChA territory infarcts associated with internal carotid artery stenosis or atri...


    pub_type: 杂志文章


    authors: Leys D,Mounier-Vehier F,Lavenu I,Rondepierre P,Pruvo JP

    更新日期:1994-04-01 00:00:00

  • Prophylactic but not delayed administration of simvastatin protects against long-lasting cognitive and morphological consequences of neonatal hypoxic-ischemic brain injury, reduces interleukin-1beta and tumor necrosis factor-alpha mRNA induction, and does

    abstract:BACKGROUND AND PURPOSE:Prophylactic administration of simvastatin has been shown to protect against brain damage and its long-lasting behavioral consequences in neonatal rats. To establish the drug treatment window, we evaluated the effectiveness of simvastatin administered at different intervals before and after strok...


    pub_type: 杂志文章


    authors: Balduini W,Mazzoni E,Carloni S,De Simoni MG,Perego C,Sironi L,Cimino M

    更新日期:2003-08-01 00:00:00

  • Assessing the laryngeal cough reflex and the risk of developing pneumonia after stroke: an interhospital comparison.

    abstract:BACKGROUND AND PURPOSE:We sought to evaluate the efficacy of testing the laryngeal cough reflex in identifying pneumonia risk in acute stroke patients. METHODS:We performed a prospective study of 400 consecutive acute stroke patients examined using the reflex cough test (RCT) compared with 204 consecutive acute stroke...


    pub_type: 杂志文章


    authors: Addington WR,Stephens RE,Gilliland KA

    更新日期:1999-06-01 00:00:00

  • Effects of stroke localization on cardiac autonomic balance and sudden death.

    abstract:BACKGROUND AND PURPOSE:Stroke has been shown to alter autonomic function. The purpose of this study was to show the differential effects of stroke localization on autonomic function parameters assessed by heart rate variability (HRV). METHODS:To determine the differential effect of ischemic stroke localization on auto...


    pub_type: 杂志文章


    authors: Tokgözoglu SL,Batur MK,Topçuoglu MA,Saribas O,Kes S,Oto A

    更新日期:1999-07-01 00:00:00

  • Stroke unit care and outcome: results from the 2001 National Sentinel Audit of Stroke (England, Wales, and Northern Ireland).

    abstract:BACKGROUND AND PURPOSE:Stroke unit care is one of the most powerful interventions available to help stroke patients. There are limited data available to assess the impact of stroke units in routine clinical practice outside randomized clinical trials. This article uses data from the 2001 to 2002 National Stroke Audit t...


    pub_type: 杂志文章


    authors: Rudd AG,Hoffman A,Irwin P,Lowe D,Pearson MG

    更新日期:2005-01-01 00:00:00

  • Delayed cerebral ischemia following arteriography.

    abstract::Cerebral ischemic events associated with arteriography are usually attributed to catheter-induced emboli. We present three patients with cerebral ischemia occurring 6 to 48 hours post-arteriography. We suspected that alternate pathogenic mechanisms were in effect. To evaluate the possibility that sustained platelet ac...


    pub_type: 杂志文章


    authors: Fisher M,Sandler R,Weiner JM

    更新日期:1985-05-01 00:00:00

  • Potential consequences for recruitment, power, and external validity of requirements for additional risk factors for eligibility in randomized controlled trials in secondary prevention of stroke.

    abstract:BACKGROUND AND PURPOSE:Eligibility criteria determine the external validity (generalizability) of the results of randomized controlled trials. To increase the number of outcome events, and hence statistical power, some recent stroke prevention trials have required additional vascular risk factors for eligibility. METH...


    pub_type: 杂志文章,随机对照试验


    authors: Howard SC,Algra A,Warlow CP,Rothwell PM

    更新日期:2006-01-01 00:00:00

  • Effects of isovolemic hemodilution on hemodynamics, cerebral perfusion, and cerebral vascular reactivity.

    abstract:BACKGROUND AND PURPOSE:To verify the hemorheological effects of isovolemic hemodilution on hemodynamics and cerebral perfusion of normal humans, we tested the efficacy of isovolemic hemodilution in systemic hemodynamics and cerebral bood flow augmentation and its influences in vascular reserve. METHODS:Isovolemic hemo...


    pub_type: 杂志文章


    authors: Tu YK,Liu HM

    更新日期:1996-03-01 00:00:00

  • Transcranial Doppler sonography monitoring of local intra-arterial thrombolysis in acute occlusion of the middle cerebral artery.

    abstract:BACKGROUND AND PURPOSE:The aim of this study is to report on the use of transcranial Doppler ultrasonography as a noninvasive diagnostic monitoring tool during local intra-arterial thrombolysis in a patient with acute embolic occlusion of the middle cerebral artery. CASE DESCRIPTION:We describe a 41-year-old woman wit...


    pub_type: 杂志文章


    authors: Karnik R,Stelzer P,Slany J

    更新日期:1992-02-01 00:00:00

  • Effects of surgical revascularization on cerebral oxygen metabolism in patients with Moyamoya disease: an 15O-gas positron emission tomographic study.

    abstract:BACKGROUND AND PURPOSE:This prospective study was aimed to evaluate the effects of surgical revascularization on cerebral oxygen metabolism in moyamoya disease. METHODS:This study included totally 69 hemispheres of 42 patients who underwent superficial temporal artery to middle cerebral artery anastomosis and indirect...


    pub_type: 杂志文章


    authors: Kuroda S,Kashiwazaki D,Hirata K,Shiga T,Houkin K,Tamaki N

    更新日期:2014-09-01 00:00:00

  • Hyperhomocysteinemia and hypofibrinolysis in young adults with ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:Data from epidemiological and case-control studies suggest that increased total homocysteine (tHcy) levels are associated with increased risk for thromboembolic disease. The mechanisms by which hyperhomocysteinemia contributes to thrombogenesis are incompletely understood. The main objectives of ...


    pub_type: 杂志文章


    authors: Kristensen B,Malm J,Nilsson TK,Hultdin J,Carlberg B,Dahlén G,Olsson T

    更新日期:1999-05-01 00:00:00

  • Brain microvascular hemodynamic responses to induced seizures.

    abstract::Arteriolar diameters and venular erythrocyte velocities in the small pial vessels on the surface of the cat brain were measured by TV methods during induced epileptic seizures through a cranial window. Grand mal seizures maximally dilated arterioles and increased venular erythrocyte velocity up to 400%. High positive ...


    pub_type: 杂志文章


    authors: Myers RR,Intaglietta M

    更新日期:1976-01-01 00:00:00

  • Treatment of constipation and fecal incontinence in stroke patients: randomized controlled trial.

    abstract:BACKGROUND AND PURPOSE:Despite its high prevalence in stroke survivors, there is little clinical research on bowel dysfunction in this population. This is the first randomized controlled trial to evaluate treatment of constipation and fecal incontinence in stroke survivors. METHODS:Stroke patients with constipation or...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Harari D,Norton C,Lockwood L,Swift C

    更新日期:2004-11-01 00:00:00

  • Validation of Wall Enhancement as a New Imaging Biomarker of Unruptured Cerebral Aneurysm.

    abstract::Background and Purpose- High-resolution vessel wall magnetic resonance imaging is a promising technique for assessing wall structures of unruptured intracranial aneurysms (UIAs). However, the relationship between aneurysmal high-resolution vessel wall magnetic resonance imaging features and their histopathologic mecha...


    pub_type: 杂志文章


    authors: Quan K,Song J,Yang Z,Wang D,An Q,Huang L,Liu P,Li P,Tian Y,Zhou L,Zhu W

    更新日期:2019-06-01 00:00:00

  • Stroke, statins, and cholesterol. A meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors.

    abstract:BACKGROUND AND PURPOSE:To estimate the effect of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors ("statins") on stroke ris, we combined the data of the randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors published so far. METHODS:The studies were identified using ...


    pub_type: 杂志文章,meta分析


    authors: Blauw GJ,Lagaay AM,Smelt AH,Westendorp RG

    更新日期:1997-05-01 00:00:00

  • Effect of phorbol myristate acetate on cerebral blood flow in normal and neutrophil-depleted rats.

    abstract:BACKGROUND AND PURPOSE:Recent evidence suggests a possible role for leukocytes in ischemic brain injury. This study examined the effect of activation of endogenous circulating leukocytes on cerebral blood flow in normal and neutrophil-depleted rats. METHODS:Leukocytes were activated by rapid injection of either 50 mic...


    pub_type: 杂志文章


    authors: Uhl MW,Kochanek PM,Schiding JK,Nemoto EM

    更新日期:1993-12-01 00:00:00

  • Dysregulated RANK ligand/RANK axis in hyperhomocysteinemic subjects: effect of treatment with B-vitamins.

    abstract:BACKGROUND AND PURPOSE:Homocysteine has been linked to increased risk of ischemic stroke and other cardiovascular events. Matrix degradation and inflammation play an important role in these disorders, and we have demonstrated increased levels of matrix-degrading enzymes and inflammatory cytokines in hyperhomocysteinemi...


    pub_type: 杂志文章,随机对照试验


    authors: Nenseter MS,Ueland T,Retterstøl K,Strøm E,Mørkrid L,Landaas S,Ose L,Aukrust P,Holven KB

    更新日期:2009-01-01 00:00:00

  • MRI-based separation of congenital and acquired vertebrobasilar artery anomalies in ischemic stroke of the posterior circulation.

    abstract:BACKGROUND AND PURPOSE:Stroke MRI protocols provide useful information about underlying vessel pathologies in the anterior circulation by means of intracranial time-of-flight angiography. However, these protocols mostly fail in the posterior circulation to differentiate between congenital variants and secondary thrombo...


    pub_type: 信件


    authors: Freund W,Kassubek J,Aschoff AJ,Huber R

    更新日期:2008-08-01 00:00:00

  • Strictly Lobar Cerebral Microbleeds Are Associated With Cognitive Impairment.

    abstract:BACKGROUND AND PURPOSE:Different distributions of cerebral microbleeds (CMBs) are associated with distinct pathological mechanisms. Lobar CMBs are thought to be related to cerebral amyloid angiopathy, whereas deep or infratentorial CMBs are related to hypertensive vasculopathy. The present study aimed to evaluate the e...


    pub_type: 杂志文章


    authors: Chung CP,Chou KH,Chen WT,Liu LK,Lee WJ,Chen LK,Lin CP,Wang PN

    更新日期:2016-10-01 00:00:00

  • Clomethiazole Acute Stroke Study in ischemic stroke (CLASS-I): final results.

    abstract:BACKGROUND AND PURPOSE:A previous trial (the Clomethiazole Acute Stroke Study) generated the hypothesis that clomethiazole is effective in patients with a major ischemic stroke (total anterior circulation syndrome), and this was tested in the present study. METHODS:A total of 1198 patients with major ischemic stroke a...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Lyden P,Shuaib A,Ng K,Levin K,Atkinson RP,Rajput A,Wechsler L,Ashwood T,Claesson L,Odergren T,Salazar-Grueso E,CLASS-I\/H\/T Investigators.

    更新日期:2002-01-01 00:00:00

  • Effects of fosinopril and pravastatin on carotid intima-media thickness in subjects with increased albuminuria.

    abstract:BACKGROUND AND PURPOSE:Elevated urinary albumin excretion (UAE) is associated with an increased carotid intima-media thickness (IMT). Because angiotensin-converting enzyme inhibitors as well as statins have been shown to lower UAE and the progression of IMT, we assessed the effects of fosinopril and pravastatin on caro...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Asselbergs FW,van Roon AM,Hillege HL,de Jong PE,Gans RO,Smit AJ,van Gilst WH,PREVEND IT Investigators.

    更新日期:2005-03-01 00:00:00

  • Candesartan augments ischemia-induced proangiogenic state and results in sustained improvement after stroke.

    abstract:BACKGROUND AND PURPOSE:We have shown that acute treatment with candesartan in an experimental model of stroke resulted in vascular protection and improved outcomes at 24 hours poststroke, but the mechanisms are unknown. We now examine effects of candesartan on proangiogenic factors and 7-day outcomes using the same tre...


    pub_type: 杂志文章


    authors: Kozak A,Ergul A,El-Remessy AB,Johnson MH,Machado LS,Elewa HF,Abdelsaid M,Wiley DC,Fagan SC

    更新日期:2009-05-01 00:00:00

  • High blood pressure, physical and cognitive function, and risk of stroke in the oldest old: the Leiden 85-plus Study.

    abstract:BACKGROUND AND PURPOSE:Epidemiological studies have shown mixed findings on the association between hypertension and stroke in the oldest old. Heterogeneity of the populations under study may underlie variation in outcomes. We examined whether the level of physical and cognitive function moderates the association betwe...


    pub_type: 杂志文章


    authors: Sabayan B,van Vliet P,de Ruijter W,Gussekloo J,de Craen AJ,Westendorp RG

    更新日期:2013-01-01 00:00:00

  • Ultrasonic demonstration of external and internal carotid patency with common carotid occlusion: a preliminary report.

    abstract::Non-invasive ultrasonic imaging of the carotid bifurcation by duplex scanning and ultrasonic arteriography combined with pulsed Doppler spectrum analysis demonstrated patency of the external and internal carotid arteries distal to a common carotid occlusion in 3 patients. Common carotid occlusion is not invariably ass...


    pub_type: 杂志文章


    authors: Blackshear WM Jr,Phillips DJ,Bodily KC,Strandness DE Jr

    更新日期:1980-05-01 00:00:00

  • Effect of triamcinolone acetonide injections on hemiplegic shoulder pain : A randomized clinical trial.

    abstract:UNLABELLED:Background and Purpose-Hemiplegic shoulder pain is not uncommon after stroke. Its origin is still unknown, and although many different methods of treatment are applied, none have yet been proved to be effective. We sought to study the efficacy of 3 injections of intra-articular triamcinolone acetonide on pai...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Snels IA,Beckerman H,Twisk JW,Dekker JH,Peter De Koning,Koppe PA,Lankhorst GJ,Bouter LM

    更新日期:2000-10-01 00:00:00

  • Perforating branches of the middle cerebral artery. Microanatomy and clinical significance of their intracerebral segments.

    abstract::Perforating branches of the middle cerebral arteries (MCA) were examined on the forebrain hemispheres of fourteen human brains. It was noticed that their intracerebral segments arose from the MCA main trunk, and its terminal and collateral (cortical) branches. They terminated in certain parts of the basal ganglia and ...


    pub_type: 杂志文章


    authors: Marinkovic SV,Milisavljevic MM,Kovacevic MS,Stevic ZD

    更新日期:1985-11-01 00:00:00