Abstract:
BACKGROUND AND PURPOSE:Most previous studies addressed the cognitive impact of lacunar infarcts using radiologic correlations that are known to correlate poorly with neuropathological data. Moreover, absence of systematic bilateral assessment of vascular lesions and masking effects of Alzheimer disease pathology and macrovascular lesions may explain discrepancies among previous reports. To define the relative contribution of silent lacunes to cognitive decline, we performed a detailed analysis of lacunar and microvascular pathology in both cortical and subcortical areas of 72 elderly individuals without significant neurofibrillary tangle pathology or macrovascular lesions. METHODS:Cognitive status was assessed prospectively using the Clinical Dementia Rating (CDR) scale; neuropathological evaluation included Abeta-protein deposition staging and bilateral assessment of microvascular ischemic pathology and lacunes; statistical analysis included multivariate models controlling for age, amyloid deposits, and microvascular pathology. RESULTS:Thalamic and basal ganglia lacunes were negatively associated with CDR scores; cortical microinfarcts, periventricular and diffuse white matter demyelination also significantly affected cognition. In a multivariate model, cortical microinfarcts and thalamic and basal ganglia lacunes explained 22% of CDR variability; amyloid deposits and microvascular pathology explained 12%, and the assessment of thalamic and basal ganglia lacunes added an extra 17%. Deep white matter lacunes were not related to cognitive status in univariate and multivariate models. CONCLUSIONS:In agreement with the recently proposed concept of subcortical ischemic vascular dementia, our autopsy series provides important evidence that gray matter lacunes are independent predictors of cognitive decline in elderly individuals without concomitant dementing processes such as Alzheimer disease.
journal_name
Strokejournal_title
Strokeauthors
Gold G,Kövari E,Herrmann FR,Canuto A,Hof PR,Michel JP,Bouras C,Giannakopoulos Pdoi
10.1161/01.STR.0000166052.89772.b5subject
Has Abstractpub_date
2005-06-01 00:00:00pages
1184-8issue
6eissn
0039-2499issn
1524-4628pii
01.STR.0000166052.89772.b5journal_volume
36pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Patients with atrial fibrillation have a high risk of stroke and other vascular events even if anticoagulated. The primary objective here is to determine whether routine blood pressure-lowering provides additional protection for this high-risk patient group. METHODS:This study was a subsidiary a...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/01.STR.0000181115.59173.42
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Milk fat globule-EGF factor-8 (MFGE8) has been reported to be neuroprotective in ischemic stroke. However, the effects of MFGE8 in early brain injury after subarachnoid hemorrhage (SAH) have not been investigated. We investigated the role of MFGE8 in early brain injury and the potential mechanism...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.006635
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We have previously reported that extracellular ATP activates P(2u) receptors and increases intracellular free Ca(2+) ([Ca(2+)](i)) by G protein/phospholipase C/inositol 1,4,5-triphosphate pathways in cerebral artery smooth muscle cells. However, the possible contribution of other signaling pathwa...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.6.1377
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Accumulation of iron after intracerebral hemorrhage causes free radical formation and oxidative damage resulting in liquefaction. The aim of this study was the investigation of molecular mechanisms underlying estrogen-mediated neuroprotective effect against iron-induced brain injury in vivo. MET...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.562850
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Results from large multicenter studies have shown that carotid endarterectomy, performed with low perioperative morbidity and mortality, is beneficial for patients with symptomatic carotid stenosis > or = 70% as calculated according to strict angiographic criteria. To apply these results in clini...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.8.1325
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Severe atherosclerosis in the aortic arch is associated with a high risk of recurrent vascular events, but the optimal antithrombotic strategy is unclear. METHODS:This prospective randomized controlled, open-labeled trial, with blinded end point evaluation (PROBE design) tested superiority of as...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.113.004251
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:The ability to quickly and efficiently identify the ischemic penumbra in the acute stroke clinical setting is an important goal for stroke researchers and clinicians. Early and accurate identification of potentially salvageable versus irreversibly infarcted brain tissue may enable selection of the most appro...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.STR.0000097608.38779.CC
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Antiplatelet therapy is currently one of the methods for preventing transient ischemic attacks and cerebral thrombosis. Because antiplatelet agents are generally administered on a long-term basis, patient compliance is an important factor. The purpose of this study was to determine the compliance...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.25.12.2337
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The objective is to compare the effects of high-intensity interval training (HIIT) with long versus short intervals on endurance and motor performance. Their influence on neuroplasticity markers is assessed in the ipsilesional and contralesional cortex and hippocampus since their remodeling could...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.031873
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral ischemia and stroke are leading causes of morbidity and mortality. An approach to protecting the brain during ischemia is to try to increase the delivery of oxygen via the residual blood flow through and around ischemic tissue. To test this hypothesis, we used a novel oxygen delivery age...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.8.1624
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The perfusion territories of the brain-feeding arteries are difficult to assess in vivo and therefore standard cerebral perfusion territory templates are often used to determine the relation between cerebral infarcts and the feeding vasculature. In the present study, we compared this infarct clas...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.539866
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Carotid endarterectomy (CE) has been shown to be beneficial in patients with symptomatic high-grade (70% to 99%) internal carotid artery stenosis. To achieve this benefit, complications must be kept to a minimum. Complications not associated with the procedure itself, but related to medical condi...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.30.9.1759
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Risk-factor modeling has been proposed to identify patients with carotid stenosis who will most benefit from surgery. Validation by independent institutions performing carotid endarterectomy is necessary to determine the applicability of such models to the individual patient. METHODS:A series of...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.0000051729.79990.fb
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:One hundred twelve patients undergoing elective carotid endarterectomy for symptomatic and asymptomatic carotid artery stenosis were enrolled in a prospective study to evaluate the incidence of change in postoperative cerebral function. METHODS:Patients were evaluated preoperatively and postoper...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.6.1110
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Loss of movement coordination is the main postacute symptom after cerebellar infarction. Although the course of motor recovery has been described previously, detailed kinematic descriptions of acute stage ataxia are rare and no attempt has been made to link improvements in motor function to measu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.583641
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to investigate the direct costs of acute hospitalization for patients with first-ever ischemic stroke in Taiwan. METHODS:Data were prospectively collected from 360 first-ever ischemic stroke patients. Hospital charges were used for analysis. Multiple linear regression analysis was used...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000095565.12945.18
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is an inverse association between dairy food consumption and the incidence of stroke in observational studies. However, it is unknown whether the relationship is causal or, if so, what components in milk are responsible for reducing the incidence of stroke. METHODS:Stroke-prone spontaneous...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.618496
更新日期:2012-02-01 00:00:00
abstract::Background and Purpose- Carotid web (CW) is a rare form of focal fibromuscular dysplasia defined as an abnormal shelf-like projection of intimal fibrous tissue into the carotid bulb. It is theorized that CW leads to ischemic stroke secondary to blood flow stasis and subsequent embolization. The natural history and opt...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.021907
更新日期:2018-12-01 00:00:00
abstract::Regional cerebral blood flow, blood volume, fractional oxygen extraction, and oxygen consumption were measured by positron emission tomography in 4 stroke patients prior to and 6 months following omental transposition surgery. Preoperatively, 3 patients showed the typical picture of established infarction with a match...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.1.46
更新日期:1987-01-01 00:00:00
abstract::The external diameters of rat and rabbit basilar arteries were determined before and after formaldehyde fixation in relaxed and drug constricted vessels. Fixation usually resulted in an immediate vessel constriction followed by partial relaxation after several hours. However, the results were inconstant from vessel to...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.11.1.99
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Early carotid surgery or stenting after thrombolytic treatment for stroke has become more common during recent years. It is unclear whether this carries an increased risk of postoperative complications and death. The aim of this nationwide population-based study was, therefore, to investigate the...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.003763
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To study the longitudinal relationship of functional change in walking ability and change in time-dependent covariates and to develop a multivariate regression model to predict longitudinal change of walking ability. METHODS:A total of 101 acute stroke patients with first-ever ischemic middle ce...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/01.STR.0000190839.29234.50
更新日期:2005-12-01 00:00:00
abstract::We evaluated the effects of aging and hypertension on endothelium-dependent relaxation of rat common carotid arteries using 14-week-old (young) and 11-month-old (old) Wistar-Kyoto rats (WKY) and age-matched spontaneously hypertensive rats (SHR). Isometric tension of common carotid artery ring segments was measured. Wi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.7.892
更新日期:1988-07-01 00:00:00
abstract::Using the dexamethasone suppression test, we studied the activity of the hypothalamic-pituitary-adrenal axis within the first week after onset in 62 patients with acute ischemic stroke. Compared with two control groups (one comprising 25 elderly patients with various acute medical disorders and the other comprising 33...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.12.1685
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We compared among young patients with ischemic stroke the distribution of vascular risk factors among sex, age groups, and 3 distinct geographic regions in Europe. METHODS:We included patients with first-ever ischemic stroke aged 15 to 49 years from existing hospital- or population-based prospec...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.112.662866
更新日期:2012-10-01 00:00:00
abstract::Life table analysis is a powerful statistical tool that has become the preferred technique for studying both the natural history of and the effect of treatment on disease outcome. We have found only one report using life table analysis to study rehabilitation outcome after stroke. We assessed the recovery of both inde...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.11.1354
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Little is known about the clinical outcomes associated with posthemorrhage anticoagulation resumption for atrial fibrillation. This study had 2 objectives: first, to evaluate anticoagulation use after a first major bleed on warfarin or dabigatran and, second, to compare effectiveness and safety o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.015150
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Alberta Stroke program early CT score (ASPECTS) is a semiquantative scale for estimating extent and distribution of early ischemic changes within the MCA territory in the acute stroke setting. Good interobserver agreement of total ASPECTS is demonstrated for noncontrast CT (NCCT) and other im...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.665208
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Virtual reality (VR) is a new promising computer-assisted technology to promote motor recovery in stroke patients. VR-induced neuroplasticity supporting locomotor recovery is not known. We investigated the effects of VR intervention on cortical reorganization and associated locomotor recovery in ...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/01.STR.0000162715.43417.91
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It has been suggested that the interleukin-1A (IL-1A) allele 2 is a risk factor for Alzheimer's disease (AD). Because cerebral amyloid angiopathy-related hemorrhage (CAAH) often coexists with AD, we examined the IL-1A polymorphism in CAAH. METHODS:In a case-control study, patients with pathologi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000089294.85447.1E
更新日期:2003-10-01 00:00:00