Sex-specific role of thioredoxin in neuroprotection against iron-induced brain injury conferred by estradiol.

abstract：BACKGROUND AND PURPOSE:It has been suggested that the interleukin-1A (IL-1A) allele 2 is a risk factor for Alzheimer's disease (AD). Because cerebral amyloid angiopathy-related hemorrhage (CAAH) often coexists with AD, we examined the IL-1A polymorphism in CAAH. METHODS:In a case-control study, patients with pathologi...

journal_title：Stroke

authors： McCarron MO,Stewart J,McCarron P,Love S,Vinters HV,Ironside JW,Mann DM,Graham DI,Nicoll JA

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pial arterioles transiently dilate during cortical spreading depression (CSD), although the mechanisms are unclear. We tested the hypothesis that increased production of nitric oxide (NO) promotes arteriolar dilation. METHODS:Urethane-anesthetized rabbits were equipped with cranial windows, and ...

journal_title：Stroke

authors： Colonna DM,Meng W,Deal DD,Busija DW

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To test the safety and recanalization efficacy of intra-arterial local delivery of plasminogen activators in acute ischemic stroke, a randomized trial of recombinant pro-urokinase (rpro-UK) versus placebo was undertaken in patients with angiographically documented proximal middle cerebral artery ...

journal_title：Stroke

authors： del Zoppo GJ,Higashida RT,Furlan AJ,Pessin MS,Rowley HA,Gent M

更新日期：1998-01-01 00:00:00

abstract：:Occlusion of the anterior cerebral artery is a rare condition. A review of CT scans from 413 patients with ischemic infarction confirmed this low relative incidence: only 3% of CT scans evidencing infarction involved the territory of the anterior cerebral artery. Four major mechanisms of anterior cerebral artery occlu...

journal_title：Stroke

authors： Gacs G,Fox AJ,Barnett HJ,Vinuela F

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Changes in stroke incidence are likely to occur as a consequence of aging of the population, but evidence for this hypothesis is lacking. METHODS:A prospective community-based registry of first-ever strokes (1994 to 1998) classified according to the International Classification of Diseases, 9th ...

journal_title：Stroke

authors： Carolei A,Marini C,Di Napoli M,Di Gianfilippo G,Santalucia P,Baldassarre M,De Matteis G,di Orio F

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We assessed the influence of different visual stimuli and the reproducibility and habituation of evoked flow responses using simultaneous two-channel transcranial Doppler monitoring and flow velocity averaging. METHODS:We measured stimulus-related percentage changes in posterior cerebral, basila...

journal_title：Stroke

authors： Sturzenegger M,Newell DW,Aaslid R

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Large falls in blood pressure after meals have been demonstrated in fit and frail elderly subjects; these changes may be associated with an increased incidence of stroke. Postprandial falls in BP may be particularly deleterious after acute stroke, when normal baroreflex mechanisms and cerebral au...

journal_title：Stroke

authors： Robinson TG,Potter JF

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Our aim was to explore whether the mismatch in lesion visibility between b1000 and b0 images is an alternative to mismatch between diffusion-weighted imaging and fluid-attenuated inversion recovery imaging as a surrogate marker of stroke age. METHODS:We analyzed patients from the European multic...

journal_title：Stroke

authors： Geraldo AF,Berner LP,Haesebaert J,Chabrol A,Cho TH,Derex L,Hermier M,Louis-Tisserand G,Chamard L,Klaerke Mikkelsen I,Ribe L,Østergaard L,Hjort N,Pedraza S,Thomalla G,Baron JC,Nighoghossian N,Berthèzene Y

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Disruption of the endothelial layer is the first step in the atherogenic process. Experimental studies have shown that endothelial progenitor cells (EPCs) are involved in endothelial homeostasis and repair. Conversely, EPC depletion has been demonstrated in the setting of established atherosclero...

journal_title：Stroke

authors： Fadini GP,Coracina A,Baesso I,Agostini C,Tiengo A,Avogaro A,de Kreutzenberg SV

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Atrial fibrillation (AF) is a major risk factor for ischemic stroke and its prevalence increases steeply with age. Population-based data on its influence on stroke outcome are scarce. METHODS:We evaluated the prevalence of AF and its influence on prognosis in patients with a first-ever ischemic ...

journal_title：Stroke

authors： Marini C,De Santis F,Sacco S,Russo T,Olivieri L,Totaro R,Carolei A

更新日期：2005-06-01 00:00:00

abstract：:The postischemic production of PGE2, PGD2, 6-keto-PGF1 alpha, and TXB2 in brain tissue was studied in Mongolian gerbils using tissue extraction as well as a new ex vivo method. This new method permits the study of prostaglandin synthesis in slices from discrete areas of the brain (cortex, hippocampus, striatum, hypoth...

journal_title：Stroke

authors： Kempski O,Shohami E,von Lubitz D,Hallenbeck JM,Feuerstein G

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients with atrial fibrillation have a high risk of stroke and other vascular events even if anticoagulated. The primary objective here is to determine whether routine blood pressure-lowering provides additional protection for this high-risk patient group. METHODS:This study was a subsidiary a...

journal_title：Stroke

authors： Arima H,Hart RG,Colman S,Chalmers J,Anderson C,Rodgers A,Woodward M,MacMahon S,Neal B,PROGRESS Collaborative Group.

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To establish a less invasive and reproducible focal ischemia model in the rat, we adopted a 2-laser system (ie, photothrombosis and YAG laser-induced reperfusion). METHODS:The distal middle cerebral artery (MCA) of spontaneously hypertensive rats was occluded by 568-nm krypton laser and intraven...

journal_title：Stroke

authors： Yao H,Sugimori H,Fukuda K,Takada J,Ooboshi H,Kitazono T,Ibayashi S,Iida M

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Single and multiple lacunar infarctions may have some difference in underlying diseases and cerebral blood flows. To determine the difference, we investigated underlying diseases and cerebral blood flows in single and multiple lacunar infarctions. METHODS:Fifteen cases of lacunar infarction, 10 ...

journal_title：Stroke

authors： Mochizuki Y,Oishi M,Takasu T

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Nonaneurysmal perimesencephalic hemorrhage, a distinct form of subarachnoid hemorrhage, is a recently described variant of intracranial hemorrhage. We describe two patients who presented with unusual features of this type of subarachnoid hemorrhage and also two patients who had a perimesencephalic pattern of...

journal_title：Stroke

authors： Schievink WI,Wijdicks EF,Piepgras DG,Nichols DA,Ebersold MJ

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The genetic basis of white matter hyperintensities (WMH) is still unknown. This study examines the heritability of WMH in both sexes and in different brain regions, and the influence of age. METHODS:Participants from the Older Australian Twins Study were recruited (n=320; 92 monozygotic and 68 d...

journal_title：Stroke

authors： Sachdev PS,Thalamuthu A,Mather KA,Ames D,Wright MJ,Wen W,OATS Collaborative Research Team.

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients with carotid occlusive disease and stage 2 cerebral hemodynamic failure, characterized by an increased oxygen extraction fraction (OEF) as measured by positron emission tomography (PET) and otherwise known as misery perfusion, have a high risk of cerebral ischemia and subsequent stroke. ...

journal_title：Stroke

authors： Imaizumi M,Kitagawa K,Hashikawa K,Oku N,Teratani T,Takasawa M,Yoshikawa T,Rishu P,Ohtsuki T,Hori M,Matsumoto M,Nishimura T

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Silent brain infarction (SBI) is often found with white matter hyperintensity. A recent genetic study on elderly twins indicated that the susceptibility to white matter hyperintensity was largely determined by genetic factors, implying the existence of genetic susceptibility for SBI as well. We t...

journal_title：Stroke

authors： Notsu Y,Nabika T,Park HY,Masuda J,Kobayashi S

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The integrin-linked kinase (ILK) signaling pathway contributes to regulation of cellular adhesion, migration, and differentiation, and to apoptotic cell death after a variety of cell death stimuli. We have reported that overexpression of copper/zinc superoxide dismutase (SOD1) reduces apoptotic c...

journal_title：Stroke

authors： Saito A,Hayashi T,Okuno S,Nishi T,Chan PH

更新日期：2004-11-01 00:00:00

abstract：:Background and Purpose- Mobile Stroke Units (MSUs) provide innovative prehospital stroke care but their 24/7 operation has not been studied. Our study investigates 24/7 MSU diurnal variations related to transport frequency, patient characteristics, and stroke treatments. Methods- We compared transportation frequency, ...

journal_title：Stroke

authors： Zaidat OO,Changal KH,Sultan-Qurraie A,de Havenon A,Calderon VJ,Goins-Whitmore J,Patterson MS,Lin E

更新日期：2019-07-01 00:00:00

abstract：:Little is known about outcome after cerebral infarction for different ethnic groups. Of 590 stroke patients hospitalized from 1983 to 1986 at the Neurological Institute, cerebral infarction over age 39 years occurred in 135 whites, 177 blacks, and 82 Hispanics. Outcome after cerebral infarction differed by ethnicity. ...

journal_title：Stroke

authors： Sacco RL,Hauser WA,Mohr JP,Foulkes MA

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carotid artery intima-media thickness (IMT) is a marker of cardiovascular disease associated with incident stroke. We studied whether IMT rate of change is associated with stroke. METHODS:We studied 5028 participants of the Multi-Ethnic Study of Atherosclerosis (MESA) comprising white, Chinese, ...

journal_title：Stroke

authors： Polak JF,Pencina MJ,O'Leary DH,D'Agostino RB

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The epsilon4 allele of the apolipoprotein E (apoE) has been related to the occurrence of myocardial infarction, but its association with ischemic stroke is controversial. We have evaluated the relation between apoE alleles and the occurrence of cerebrovascular ischemia. METHODS:The apoE epsilon ...

journal_title：Stroke

authors： Margaglione M,Seripa D,Gravina C,Grandone E,Vecchione G,Cappucci G,Merla G,Papa S,Postiglione A,Di Minno G,Fazio VM

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is an inverse association between dairy food consumption and the incidence of stroke in observational studies. However, it is unknown whether the relationship is causal or, if so, what components in milk are responsible for reducing the incidence of stroke. METHODS:Stroke-prone spontaneous...

journal_title：Stroke

authors： Chiba T,Itoh T,Tabuchi M,Ooshima K,Satou T,Ezaki O

更新日期：2012-02-01 00:00:00

abstract：:Though unilateral blood distribution of the vertebral artery has not been studied in humans, it is significant when considering the ischemic events especially embolic occlusion in vertebrobasilar system. To clarify the blood distribution, Krypton-81m was continuously infused into the vertebral arteries of 10 patients....

journal_title：Stroke

authors： Taki W,Handa H,Higa T,Tanada S,Fukuyama H,Fujita T,Yonekawa Y,Kameyama M,Torizuka K

更新日期：1984-05-01 00:00:00

abstract：:Background and Purpose- In acute stroke patients with large vessel occlusion, the goal of intravenous thrombolysis (IVT) is to achieve early recanalization (ER). Apart from occlusion site and thrombus length, predictors of early post-IVT recanalization are poorly known. Better collaterals might also facilitate ER, for...

journal_title：Stroke

authors： Seners P,Roca P,Legrand L,Turc G,Cottier JP,Cho TH,Arquizan C,Bracard S,Ozsancak C,Ben Hassen W,Naggara O,Lion S,Debiais S,Berthezene Y,Costalat V,Richard S,Magni C,Mas JL,Baron JC,Oppenheim C

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients with arteriovenous malformations are younger individuals who are at risk of a stroke or have experienced one. Our objective was to determine these patients' perceptions of quality of life with a stroke by eliciting utility values. METHODS:Utility values were obtained with the standard g...

journal_title：Stroke

authors： Shin AY,Porter PJ,Wallace MC,Naglie G

更新日期：1997-12-01 00:00:00

abstract：:Eighteen patients with recent ischemic stroke were compared with an equal number of matched controls. Standardized suspensions of red cells as well as of red and white cells were filtered in a new filtration apparatus capable of discriminating between cell deformability and filter occlusion. Results show that red cell...

journal_title：Stroke

authors： Ernst E,Matrai A,Paulsen F

更新日期：1987-01-01 00:00:00

abstract：:The initial Stroke Therapy Academic Industry Roundtable (STAIR) recommendations published in 1999 were intended to improve the quality of preclinical studies of purported acute stroke therapies. Although recognized as reasonable, they have not been closely followed nor rigorously validated. Substantial advances have o...

journal_title：Stroke

authors： Fisher M,Feuerstein G,Howells DW,Hurn PD,Kent TA,Savitz SI,Lo EH,STAIR Group.

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ischemic postconditioning, a brief episode of ischemia after a prolonged ischemic insult, has been found to reduce the delayed neuronal loss after stroke. However, the mechanisms underlying such endogenous neuroprotective strategy remain obscure. In this study, we try to explore the excitatory po...

journal_title：Stroke

authors： Liu J,Xu Q,Wang H,Wang R,Hou XY

更新日期：2013-07-01 00:00:00