Leukocyte rheology in recent stroke.

Abstract:

:Eighteen patients with recent ischemic stroke were compared with an equal number of matched controls. Standardized suspensions of red cells as well as of red and white cells were filtered in a new filtration apparatus capable of discriminating between cell deformability and filter occlusion. Results show that red cell deformability, although slightly lower than in controls, is not significantly altered in stroke patients. Filter occlusion, however, was significantly higher in patients when red and white cell suspensions were filtered, but not when red cell suspensions were used, suggesting that white cell filterability is impaired after stroke, which could be due to decreased deformability and/or increased adhesiveness of leukocytes. Slowed white cell passage may also occur in the living microcirculation and may present an obstacle to nutritive flow in exchange vessels, possibly contributing to local ischemia and tissue necrosis after stroke.

journal_name

Stroke

journal_title

Stroke

authors

Ernst E,Matrai A,Paulsen F

doi

10.1161/01.str.18.1.59

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

59-62

issue

1

eissn

0039-2499

issn

1524-4628

journal_volume

18

pub_type

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