Abstract:
:Eighteen patients with recent ischemic stroke were compared with an equal number of matched controls. Standardized suspensions of red cells as well as of red and white cells were filtered in a new filtration apparatus capable of discriminating between cell deformability and filter occlusion. Results show that red cell deformability, although slightly lower than in controls, is not significantly altered in stroke patients. Filter occlusion, however, was significantly higher in patients when red and white cell suspensions were filtered, but not when red cell suspensions were used, suggesting that white cell filterability is impaired after stroke, which could be due to decreased deformability and/or increased adhesiveness of leukocytes. Slowed white cell passage may also occur in the living microcirculation and may present an obstacle to nutritive flow in exchange vessels, possibly contributing to local ischemia and tissue necrosis after stroke.
journal_name
Strokejournal_title
Strokeauthors
Ernst E,Matrai A,Paulsen Fdoi
10.1161/01.str.18.1.59subject
Has Abstractpub_date
1987-01-01 00:00:00pages
59-62issue
1eissn
0039-2499issn
1524-4628journal_volume
18pub_type
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