Abstract:
BACKGROUND AND PURPOSE:Current guidelines recommend against routine auscultation of carotid arteries, believing that carotid bruits are poor predictors of either underlying carotid stenosis or stroke risk in asymptomatic patients. We investigated whether the presence of a carotid bruit is associated with increased risk for transient ischemic attack, stroke, or death by stroke (stroke death). METHODS:We searched Medline (1966 to December 2009) and EMBASE (1974 to December 2009) with the terms "carotid" and "bruit." Bibliographies of all retrieved articles were also searched. Articles were included if they prospectively reported the incidence of transient ischemic attack, stroke, or stroke death in asymptomatic adults. Two authors independently reviewed and extracted data. RESULTS:We included 28 prospective cohort articles that followed a total of 17 913 patients for 67 708 patient-years. Among studies that directly compared patients with and without bruits, the rate ratio for transient ischemic attack was 4.00 (95% CI, 1.8 to 9.0, P<0.0005, n=5 studies), stroke was 2.5 (95% CI, 1.8 to 3.5, P<0.0005, n=6 studies), and stroke death was 2.7 (95% CI, 1.33 to 5.53, P=0.002, n=3 studies). Among the larger pool of studies that provided data on rates, transient ischemic attack rates were 2.6 per 100 patient-years (95% CI, 2.0 to 3.2, P<0.0005, n=24 studies) for those with bruits compared with 0.9 per 100 patient-years (95% CI, 0.2 to 1.6, P=0.02, n=5 studies) for those without carotid bruits. Stroke rates were 1.6 per 100 patient-years (95% CI, 1.3 to 1.9, P<0.0005, n=26 studies) for those with bruits compared with 1.3 per 100 patient-years (95% CI, 0.8 to 1.7, P<0.0005, n=6) without carotid bruits, and death rates were 0.32 (95% CI, 0.20 to 0.44, P<0.005, n=13 studies) for those with bruits compared with 0.35 (95% CI, 0.00 to 0.81, P=0.17, n=3 studies) for those without carotid bruits. CONCLUSIONS:The presence of a carotid bruit may increase the risk of cerebrovascular disease.
journal_name
Strokejournal_title
Strokeauthors
Pickett CA,Jackson JL,Hemann BA,Atwood JEdoi
10.1161/STROKEAHA.110.585554subject
Has Abstractpub_date
2010-10-01 00:00:00pages
2295-302issue
10eissn
0039-2499issn
1524-4628pii
STROKEAHA.110.585554journal_volume
41pub_type
杂志文章,meta分析相关文献
STROKE文献大全abstract::We investigated the prevalence of carotid atherosclerosis, including mild early lesions, and its association with cervical bruits and various risk factors (age, male sex, hypertension, hyperlipidemia, diabetes mellitus, obesity, and cigarette smoking) in 232 consecutive Japanese patients. High-resolution real-time B-m...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.11.1567
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Higher proportions of hemorrhagic stroke and lacunar infarction were reported in rural Japan compared with those in Western countries. We examined the relative proportions of stroke subtypes in an urban Japanese city where westernized lifestyles are more common than in rural areas. METHODS:Strok...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000221714.96986.5f
更新日期:2006-06-01 00:00:00
abstract::Using the dexamethasone suppression test, we studied the activity of the hypothalamic-pituitary-adrenal axis within the first week after onset in 62 patients with acute ischemic stroke. Compared with two control groups (one comprising 25 elderly patients with various acute medical disorders and the other comprising 33...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.12.1685
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The incidence, causes, and prognosis of nonhemorrhagic strokes and intraparenchymal hemorrhages occurring in association with pregnancy or puerperium are poorly understood. METHODS:We carried out a retrospective (1989 through 1991) and prospective (1992) study in 63 public maternities (348,295 d...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.6.930
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Different distributions of cerebral microbleeds (CMBs) are associated with distinct pathological mechanisms. Lobar CMBs are thought to be related to cerebral amyloid angiopathy, whereas deep or infratentorial CMBs are related to hypertensive vasculopathy. The present study aimed to evaluate the e...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.014166
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Ischemic injury triggers multiple pathological responses in the brain tissue, including spreading depolarizations across the cerebral cortex (cortical spreading depolarizations [CSD]). Microglia have been recently shown to play a significant role in the propagation of CSD. However, the intracellu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.032766
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Carotid artery stenosis causes up to 10% of all ischemic strokes. Carotid endarterectomy (CEA) was introduced as a treatment to prevent stroke in the early 1950s. Carotid stenting (CAS) was introduced as a treatment to prevent stroke in 1994. METHODS:The Carotid Revascularization Endarterectomy ...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.110.595330
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to measure the overall rate of usage of tissue-type plasminogen activator (tPA) for ischemic stroke at academic medical centers, and to determine whether ethnicity was associated with usage. METHODS:Between June and December 1999, 42 academic medical centers in the United States each i...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.str.32.5.1061
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We tested the hypothesis that fibrin structure/function is unfavorably altered in patients with cryptogenic ischemic stroke. METHODS:Ex vivo plasma fibrin clot permeability, turbidimetry, and efficiency of fibrinolysis were determined in 89 patients with patent foramen ovale (PFO) and a history ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.532812
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A number of studies have shown that reduced intrauterine growth and low birth weight are associated with raised rates of fatal and nonfatal stroke in adult life. Whether this increased risk of stroke is modified by growth in childhood or by socioeconomic status in adult life is not known. METHOD...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.4.869
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hypoxic-ischemic (HI) brain injury in newborn infants represents a major cause of cerebral palsy, development delay, and epilepsy. Stem cell-based therapy has the potential to rescue and replace the ischemic tissue caused by HI and to restore function. However, the mechanisms by which stem cell t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.573691
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The role of extracellular Ca2+ in the maintenance of chronic vasospasm after subarachnoid hemorrhage (SAH) is largely unknown. Indeed, studies thus far have been limited to demonstrations that L-type Ca(2+)-channel antagonists were unable to reverse the spasm. This study tested whether SAH-induce...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.10.1896
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Pathogenetic classification of intracerebral hemorrhage (ICH), using systems such as SMASH-U (structural vascular lesions, medication, cerebral amyloid angiopathy [CAA], systemic disease, hypertension, or undetermined), is important in predicting functional outcomes and mortality in patients with...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.005598
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The first goal of this study was to determine the effect of glutamate on permeability and reactivity of the cerebral microcirculation. The second goal of this study was to determine a possible role for nitric oxide in the effects of glutamate on the cerebral microcirculation. METHODS:We examined...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.5.965
更新日期:1996-05-01 00:00:00
abstract::The gerbil model was used to assess the therapeutic effects of the calcium antagonist nimodipine on cerebral ischemia. Transient cerebral ischemia was produced in each gerbil by bilateral common carotid occlusion of 10-, 15- or 20-min duration. Nimodipine (0.01 or 0.1 mg/kg) was administered intraperitoneally just bef...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.4.748
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Anticoagulation is a highly effective secondary prevention in patients with cardioembolic stroke and atrial fibrillation/flutter (AF). However, the condition remains underdiagnosed, because paroxysmal AF may be missed by diagnostic tests in the acute phase. In this study, the sensitivity of AF de...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.111.642199
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The risk of stroke and death in patients with atrial fibrillation is strongly associated with age and concomitant comorbidities. The aim of this study was to examine the age dependence of risk factors for stroke and mortality in young patients with atrial fibrillation. METHODS:This study is a po...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.004903
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Multipotent mesenchymal stromal cell (MSC) harvested exosomes are hypothesized as the major paracrine effectors of MSCs. In vitro, the miR-17-92 cluster promotes oligodendrogenesis, neurogenesis, and axonal outgrowth. We, therefore, investigated whether the miR-17-92 cluster-enriched exosomes har...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.015204
更新日期:2017-03-01 00:00:00
abstract::At the same time as the world recognizes the rapid economic development in China, Chinese healthcare system has also had significant improvement. However, this nation of 1.4 billion faces tough challenges in treating stroke, the leading cause of death in China. The recently completed Chinese National Stroke Registry h...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.111.635755
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Animal data suggest the use of beta-human chorionic gonadotropin followed by erythropoietin to promote brain repair after stroke. The current study directly translated these results by evaluating safety of this sequential growth factor therapy through a 3-center, single-dose, open-label, noncontr...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.109.574343
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Stroke PROTECT (Preventing Recurrence Of Thromboembolic Events through Coordinated Treatment) program systematically implements, at the time of acute transient ischemic attack (TIA) or ischemic stroke admission, 8 medication/behavioral secondary prevention measures known to improve outcome in...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000147967.49567.d6
更新日期:2004-12-01 00:00:00
abstract::The frequency of clinically significant coronary artery disease (CAD) among stroke patients and the impact of CAD on stroke rehabilitation were studied in 132 patients with first thrombotic or embolic stroke who participated in comprehensive rehabilitation. Sixty-one patients (46%) had a history of CAD, and 16 of the ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.1.42
更新日期:1988-01-01 00:00:00
abstract::Background and Purpose- Although obesity is an established risk factor for cardiovascular disease and stroke, studies have shown evidence of an obesity paradox-a protective effect of obesity in patients who already have these disease states. Data on the obesity paradox in intracerebral hemorrhage is limited. Methods- ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.024638
更新日期:2019-04-01 00:00:00
abstract::In 100 consecutive patients with acute cerebrovascular accident, due to cerebral thrombosis in 72, cerebral hemorrhage in 12, embolus in 6, and subarachnoid hemorrhage in 10, there were 90 who had electrocardiographic abnormalities during the first three days after admission, compared to 50% in a control group. The pa...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.8.4.448
更新日期:1977-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Elevated soluble CD40 ligand (sCD40L) was shown to be related to cardiovascular events, but the role of sCD40L in predicting recurrent stroke remains unclear. METHODS:Baseline sCD40L levels were measured in 3044 consecutive patients with acute minor stroke and transient ischemic attack, who had ...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.115.008685
更新日期:2015-07-01 00:00:00
abstract::It remains uncertain whether platelet activation in ischemic stroke is contributory or secondary to brain ischemia. The efficacy of aspirin (ASA) in stroke prevention suggests that platelet activation contributes to the occurrence of stroke. On the other hand, platelet activation may be simply a generalized consequenc...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.16.4.643
更新日期:1985-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To clarify hemodynamic risk factors for hemorrhage in arteriovenous malformations (AVMs), the mean transit time (MTT) of feeding arteries and draining veins in AVMs with and without hemorrhage was measured and analyzed. METHODS:Morphological features such as the number and diameter of draining a...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.STR.0000089924.43363.E3
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Little is known about the clinical outcomes associated with posthemorrhage anticoagulation resumption for atrial fibrillation. This study had 2 objectives: first, to evaluate anticoagulation use after a first major bleed on warfarin or dabigatran and, second, to compare effectiveness and safety o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.015150
更新日期:2017-01-01 00:00:00
abstract::In the rat an intracisternal injection of blood induces an angiographically demonstrable biphasic cerebral arterial vasospasm. Chemical destruction of the central serotoninergic and dopaminergic pathways prior to the cisternal blood injection does not affect the spasm pattern after the subarachnoid haemorrhage. It is ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.1.86
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke is a major cause of death in the People's Republic of China (PRC), and the geographic distribution of stroke death varies substantially. We conducted an ecological analysis to investigate the relationship of prevalence of hypertension and other risk factors with stroke incidence and mortal...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00