Abstract:
BACKGROUND AND PURPOSE:The first goal of this study was to determine the effect of glutamate on permeability and reactivity of the cerebral microcirculation. The second goal of this study was to determine a possible role for nitric oxide in the effects of glutamate on the cerebral microcirculation. METHODS:We examined the pial microcirculation in rats with intravital microscopy. Permeability of the blood-brain barrier was quantified by the clearance of fluorescent-labeled dextran (molecular weight, 10 000 D; FITC-dextran-10K) before and during application of glutamate (0.1 and 1.0 mmol/L). In addition, we examined the permeability of the blood-brain barrier during application of a nitric oxide donor, S-nitroso-acetyl-penicillamine (SNAP; 10 mumol/L). Diameter of pial arterioles was measured before and during application of glutamate or SNAP. To determine a potential role for nitric oxide in glutamate-induced effects on the cerebral microcirculation, we examined the effects of NG-monomethyl-L-arginine (10 mumol/L). RESULTS:In control rats, clearance of FITC-dextran-10K from pial vessels was minimal, and the diameter of pial arterioles remained constant during the experimental period. Topical application of glutamate (0.1 and 1.0 mmol/L) and SNAP (10 mumol/L) produced an increase in clearance of FITC-dextran-10K and in diameter of pial arterioles. In addition, NG-monomethyl-L-arginine (10 mumol) attenuated glutamate-induced increases in permeability of the blood brain barrier and glutamate-induced dilatation of cerebral arterioles. CONCLUSIONS:The findings of the present study suggest that glutamate, a major neurotransmitter in the brain, increases permeability of the blood-brain barrier to low-molecular-weight molecules and dilates cerebral arterioles via a nitric oxide-dependent mechanism.
journal_name
Strokejournal_title
Strokeauthors
Mayhan WG,Didion SPdoi
10.1161/01.str.27.5.965subject
Has Abstractpub_date
1996-05-01 00:00:00pages
965-9; discussion 970issue
5eissn
0039-2499issn
1524-4628journal_volume
27pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:To assess the role of the endothelial nitric oxide synthase (eNOS) gene variants as risk factors for early atherosclerosis, we sought to investigate whether two polymorphisms located in the exon 7 (Glu298-->Asp) and in the promoter region (T-786-->C) of the eNOS gene were associated with function...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000126482.86708.37
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Early carotid surgery or stenting after thrombolytic treatment for stroke has become more common during recent years. It is unclear whether this carries an increased risk of postoperative complications and death. The aim of this nationwide population-based study was, therefore, to investigate the...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.003763
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To investigate the efficacy of bone marrow mononuclear cell (BMMNC) treatment against ischemic white matter (WM) damage in a hypoperfused brain. METHODS:Mice were administered intravenous treatment of vehicle, spleen-derived marrow mononuclear cells (MNCs), or BMMNCs (5 × 10⁶ cells) obtained fro...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.596379
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Coffee and tea consumption could potentially reduce the risk of stroke because these beverages have antioxidant properties, and coffee may improve insulin sensitivity. We examined the associations of coffee and tea consumption with risk of stroke subtypes. METHODS:We used prospective data from t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.504183
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In acute stroke care, rapid but careful evaluation of patients is mandatory but requires an experienced stroke neurologist. Telemedicine offers the possibility of bringing such expertise quickly to more patients. This study tested for the first time whether remote video examination is feasible an...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.STR.0000102043.70312.E9
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Chronic kidney disease may increase the risk for ischemic stroke or systemic embolism in patients with nonvalular atrial fibrillation (AF). We conducted a meta-analysis to summarize all published studies to investigate the link between chronic kidney disease and risk of thromboembolic events in A...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.114.006881
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In a previous study, we occasionally found that the rat given naloxone in the preoptic region develops behavioral seizures. In view of knowledge that the forebrain including the medial septal nucleus provides cholinergic projections to the hippocampal formation, the present study examined the eff...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.9.1325
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Screening for dysphagia is essential to the implementation of preventive therapies for patients with stroke. A systematic review was undertaken to determine the evidence-based validity of dysphagia screening items using instrumental evaluation as the reference standard. METHODS:Four databases fr...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/STROKEAHA.111.640946
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Our aim was to estimate the cost-effectiveness of transferring patients with intracerebral hemorrhage from centers without specialized neurological intensive care units (neuro-ICUs) to centers with neuro-ICUs. METHODS:Decision analytic models were developed for the lifetime horizons. Model input...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.006653
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Within different brain regions, we determine the comparative value of multiphase computed tomographic angiography (mCTA) and computed tomographic perfusion (CTP) in predicting follow-up infarction. METHODS:Patients with M1-middle cerebral artery occlusions were prospectively included in this mul...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.116.015969
更新日期:2017-04-01 00:00:00
abstract::Background and Purpose- The simplified stroke-thrombolytic predictive instrument (s-Stroke-TPI) is useful for predicting the outcomes in thrombolysis-treated patients in Western populations. We aimed to validate its predictive value in Chinese patients. Methods- Data from thrombolysis implementation and monitor of acu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.022269
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The physiological function of cellular prion protein (PrPc) is not yet understood. Recent findings suggest that PrPc may have neuroprotective properties, and its absence increases susceptibility to neuronal injury. The purpose of this study was to elucidate the role of PrPc in ischemic brain inju...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000217262.03192.d4
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The administration of glucose has been shown to worsen brain injury in adult animals but has no effect on the severity of injury in newborn rats. We wished to see whether the results in newborn rats could be extended to another newborn animal. METHODS:In 44 0- to 3-day-old piglets, hypoxic-ische...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.7.1055
更新日期:1993-07-01 00:00:00
abstract::To evaluate the role of platelet function in the pathogenesis of cerebral vasospasm, we compared sequential changes of platelet aggregability and beta-thromboglobulin and thromboxane B2 concentrations in blood samples from the internal jugular and peripheral vein of 13 patients with aneurysmal subarachnoid hemorrhage....
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.7.854
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recanalization status after intravenous thrombolysis (IVT) in patients with ischemic stroke is a reference point to proceed with a rescue reperfusion intervention, although early neurological improvement (NI) may preclude endovascular procedures. We aimed to evaluate the importance of restoration...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.000048
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Wall shear stress (WSS) is one of the main pathogenic factors in the development of saccular cerebral aneurysms. The magnitude and distribution of the WSS in and around human middle cerebral artery (MCA) aneurysms were analyzed using the method of computed fluid dynamics (CFD). METHODS:Twenty ma...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000144648.89172.0f
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Leptin is the major adipose hormone that regulates body weight and energy expenditure by activating leptin receptors in the hypothalamus. Leptin receptors are also present in other cell types, and a potent antiapoptotic effect for leptin has recently been reported. We investigated whether leptin ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.482786
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is still unclear that impaired cerebrovascular reactivity (CVR) to acetazolamide is comparable to elevated oxygen extraction fraction (OEF) on positron emission tomography (PET) in patients with occlusive carotid diseases. Therefore, in this study, the authors aimed to clarify whether OEF is e...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000198878.66000.4e
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Homocysteine has been linked to increased risk of ischemic stroke and other cardiovascular events. Matrix degradation and inflammation play an important role in these disorders, and we have demonstrated increased levels of matrix-degrading enzymes and inflammatory cytokines in hyperhomocysteinemi...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.108.522995
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The role of extracellular Ca2+ in the maintenance of chronic vasospasm after subarachnoid hemorrhage (SAH) is largely unknown. Indeed, studies thus far have been limited to demonstrations that L-type Ca(2+)-channel antagonists were unable to reverse the spasm. This study tested whether SAH-induce...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.10.1896
更新日期:1996-10-01 00:00:00
abstract::Coarctation of the aorta is an uncommon cause of cerebral hemorrhage in the full- or near-term infant. The clinical, radiologic, and neurologic findings of four infants with aortic coarctation and cerebral hemorrhage are presented. In all four infants, cerebral hemorrhage was associated with only moderate elevation of...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.13.4.491
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this study is to report on the use of transcranial Doppler ultrasonography as a noninvasive diagnostic monitoring tool during local intra-arterial thrombolysis in a patient with acute embolic occlusion of the middle cerebral artery. CASE DESCRIPTION:We describe a 41-year-old woman wit...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.2.284
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Decompressive surgery (hemicraniectomy) for life-threatening massive cerebral infarction represents a controversial issue in neurocritical care medicine. We report here the 30-day mortality and 6- and 12-month functional outcomes from the DESTINY trial. METHODS:DESTINY (ISRCTN01258591) is a pros...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.107.485649
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:NINDS (National Institute of Neurological Disorders and Stroke)-SiGN (Stroke Genetics Network) is an international consortium of ischemic stroke studies that aims to generate high-quality phenotype data to identify the genetic basis of pathogenic stroke subtypes. This analysis characterizes the e...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.007362
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Carotid plaque composition is a major determinant of cerebrovascular events. In the present analysis, we evaluated the relationship between intraplaque hemorrhage (IPH) and a thin/ruptured fibrous cap (TRFC) in moderately stenosed carotid arteries and cerebral infarcts on MRI in the ipsilateral h...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.008121
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We aimed to describe the frequency and characteristics of acute ischemic stroke and transient ischemic attacks presenting predominantly with amnesia (ischemic amnesia) and to identify clinical clues for differentiating them from transient global amnesia (TGA). METHODS:We retrospectively analyzed...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.017420
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The etiology of moyamoya disease (MMD) remains obscure. This study was undertaken to identify specific proteins associated with the pathogenesis of MMD. METHODS:We studied cerebrospinal fluid (CSF) from 20 patients with angiographically confirmed MMD (4 boys and 16 girls; age range, 3 to 13 year...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000100159.43123.D7
更新日期:2003-12-01 00:00:00
abstract::We studied the effects of the calcium channel blocker nicardipine on regional tissue Ca2+, Na+, K+, and water shifts in the brains of seven Sprague-Dawley rats after permanent occlusions of the middle cerebral artery. We also assessed the entry of [14C]nicardipine into the brains of five rats; the highest concentratio...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.9.1125
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Few studies currently assess the health-related quality of life of individuals following a stroke. One of the major challenges of assessing quality of life is the high likelihood that after a stroke a patient will not be able to complete such an assessment. One practical solution is to have a fam...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.10.1888
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Little information is available regarding black-white differences in stroke incidence in young adults. METHODS:Cerebral infarction and intracerebral hemorrhage rates among adults 15 to 44 years of age were studied in Baltimore City and Baltimore County for 1988. Diagnoses were based on neurologi...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00