Role of platelet function in symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage.

abstract：:Brain injury, including ischemia, changes normal astrocytes into reactive species that hypertrophy and begin to proliferate. Understanding the mechanisms that underlie these changes could lead to new abilities to promote regeneration and retard neural degeneration after ischemia. Because ionic changes occur after nonn...

journal_title：Stroke

authors： Kraig RP,Jaeger CB

更新日期：1990-11-01 00:00:00

abstract：:Cerebral blood flow was studied in rabbits immediately following complete circulatory stasis of varying duration. Systemic arterial pressure was measured continuously. The postischemic circulation was examined both by an infusion of carbon black and, in separate experiments, by injection of 14C-antipyrine into the blo...

journal_title：Stroke

authors： Fischer EG,Ames A 3rd,Lorenzo AV

更新日期：1979-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The efficacy of neuroprotective approaches in stroke may be influenced by existing comorbidities. Here, we compared the effects of normobaric hyperoxia (NBO) in normotensive versus hypertensive rats subjected to transient focal cerebral ischemia. METHODS:Male Sprague-Dawley and spontaneously hyp...

journal_title：Stroke

authors： Lan J,Esposito E,Ayata C,Singhal AB,Lo EH,Ji X

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:MRI characterization of carotid plaque has been studied recently as a potential tool to predict stroke caused by carotid atherosclerosis. We performed a systematic review and meta-analysis to summarize the association of MRI-determined intraplaque hemorrhage, lipid-rich necrotic core, and thinnin...

journal_title：Stroke

authors： Gupta A,Baradaran H,Schweitzer AD,Kamel H,Pandya A,Delgado D,Dunning A,Mushlin AI,Sanelli PC

更新日期：2013-11-01 00:00:00

abstract：:Background and Purpose- The diagnosis of transient ischemic attack is challenging. Evidence of acute ischemia on MRI diffusion-weighted imaging is highly variable and confirmed in only about one-third of patients. This study investigated the significance of blood-brain barrier dysfunction (BBBD) mapping in patients wi...

journal_title：Stroke

authors： Serlin Y,Ofer J,Ben-Arie G,Veksler R,Ifergane G,Shelef I,Minuk J,Horev A,Friedman A

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In acute ischemic stroke, fast and complete recanalization of the occluded vessel is associated with improved outcomes. We describe a novel measure for newer generation devices: the first pass effect (FPE). FPE is defined as achieving a complete recanalization with a single thrombectomy device pa...

journal_title：Stroke

authors： Zaidat OO,Castonguay AC,Linfante I,Gupta R,Martin CO,Holloway WE,Mueller-Kronast N,English JD,Dabus G,Malisch TW,Marden FA,Bozorgchami H,Xavier A,Rai AT,Froehler MT,Badruddin A,Nguyen TN,Taqi MA,Abraham MG,Yoo AJ,

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cannabidiol has been reported to be a neuroprotectant, but the neuroprotective mechanism of cannabidiol remains unclear. We studied the neuroprotective mechanism of cannabidiol in 4-hour middle cerebral artery (MCA) occlusion mice. METHODS:Male MCA occluded mice were treated with cannabidiol, ab...

journal_title：Stroke

authors： Mishima K,Hayakawa K,Abe K,Ikeda T,Egashira N,Iwasaki K,Fujiwara M

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We performed the present study to determine whether the site of occlusion in the vertebrobasilar circulation could be identified by the measurement of blood flow velocity in the bilateral vertebral arteries. METHODS:Using color-coded duplex carotid ultrasonography, we measured the time-averaged ...

journal_title：Stroke

authors： Kimura K,Yasaka M,Moriyasu H,Tsuchiya T,Yamaguchi T

更新日期：1994-05-01 00:00:00

abstract：:The frequency of clinically significant coronary artery disease (CAD) among stroke patients and the impact of CAD on stroke rehabilitation were studied in 132 patients with first thrombotic or embolic stroke who participated in comprehensive rehabilitation. Sixty-one patients (46%) had a history of CAD, and 16 of the ...

journal_title：Stroke

authors： Roth EJ,Mueller K,Green D

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Our objective was to study age-specific prevalence, computed tomographic (CT) characteristics, risk factors, and the prognostic influence on stroke outcome of silent infarction in acute stroke patients. METHODS:The study was prospective and community-based and included 801 acute stroke patients,...

journal_title：Stroke

authors： Jørgensen HS,Nakayama H,Raaschou HO,Gam J,Olsen TS

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The role of decompressive hemicraniectomy (DC) in malignant cerebral infarction (MCI) has clearly been established, but little is known about the course of intracranial pressure (ICP) in patients undergoing this surgical measure. In this study, we investigated the role of invasive ICP monitoring ...

journal_title：Stroke

authors： Hernández-Durán S,Meinen L,Rohde V,von der Brelie C

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Mild stroke (MS) and rapidly improving stroke (RIS) symptoms are common stroke presentations. Our objective is to describe the short-term outcomes in this population. METHODS:A retrospective analysis of patients with ischemic stroke in the Get With The Guidelines-Stroke registry who arrived ≤4.5...

journal_title：Stroke

authors： Romano JG,Smith EE,Liang L,Gardener H,Campo-Bustillo I,Khatri P,Bhatt DL,Fonarow GC,Sacco RL,Schwamm LH

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Brain iron overload plays a detrimental role in brain injury after intracerebral hemorrhage (ICH). A recent study found that minocycline acts as an iron chelator and reduces iron-induced neuronal death in vitro. The present study investigated if minocycline reduces iron overload after ICH and iro...

journal_title：Stroke

authors： Zhao F,Hua Y,He Y,Keep RF,Xi G

更新日期：2011-12-01 00:00:00

abstract：:Little is known about outcome after cerebral infarction for different ethnic groups. Of 590 stroke patients hospitalized from 1983 to 1986 at the Neurological Institute, cerebral infarction over age 39 years occurred in 135 whites, 177 blacks, and 82 Hispanics. Outcome after cerebral infarction differed by ethnicity. ...

journal_title：Stroke

authors： Sacco RL,Hauser WA,Mohr JP,Foulkes MA

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The role of early and delayed recanalization after thrombolysis in the development of hemorrhagic transformation (HT) subtypes remains uncertain. We sought to explore the association between the timing of recanalization and HT risk in patients with proximal middle cerebral artery (MCA) occlusion ...

journal_title：Stroke

authors： Molina CA,Alvarez-Sabín J,Montaner J,Abilleira S,Arenillas JF,Coscojuela P,Romero F,Codina A

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Plasminogen activator inhibitor type 1 (PAI-1) is the main inhibitor of fibrinolysis, and high levels may increase the risk of cardiovascular disease. The 4G/5G polymorphism affects PAI-1 gene transcription with lower levels of plasma PAI-1 in the presence of the 5G allele. We investigated whethe...

journal_title：Stroke

authors： Hoekstra T,Geleijnse JM,Kluft C,Giltay EJ,Kok FJ,Schouten EG

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The INTEnsive blood pressure Reduction in Acute Cerebral hemorrhage Trial (INTERACT) pilot study showed that early intensive blood pressure-lowering can attenuate hematoma growth in acute intracerebral hemorrhage. The present analysis aimed to determine the treatment effects on hematoma growth by...

journal_title：Stroke

authors： Arima H,Huang Y,Wang JG,Heeley E,Delcourt C,Parsons M,Li Q,Neal B,Chalmers J,Anderson C,INTERACT1 Investigators.

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The relationship between diabetic retinopathy and ischemic stroke is uncertain and examined in this study. METHODS:A population-based, prospective cohort study of 1617 middle-aged persons with diabetes. Diabetic retinopathy signs were ascertained from retinal photographs, and incident ischemic s...

journal_title：Stroke

authors： Cheung N,Rogers S,Couper DJ,Klein R,Sharrett AR,Wong TY

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of the present study is to determine the effect of mild hypothermia on the synthesis of ubiquitin, an important protein for maintenance of cell viability, in the hippocampal neurons following transient cerebral ischemia. METHODS:Transient ischemia was induced by occluding both common...

journal_title：Stroke

authors： Yamashita K,Eguchi Y,Kajiwara K,Ito H

更新日期：1991-12-01 00:00:00

abstract：:Recent data strongly suggest that repetitive ischemic episodes have an adverse cumulative effect on development of edema and tissue damage. We wanted to assess further whether special risks such as exacerbation of extracellular acidification reflecting progressive exhaustion of the capacity to buffer H+ in the extrace...

journal_title：Stroke

authors： Matsumoto T,Obrenovitch TP,Parkinson NA,Symon L

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The watershed cortical areas are the first to be deprived of sufficient blood flow in the event of cerebral hypoperfusion and will be the sites of watershed microinfarcts. Cerebral hypoperfusion is associated with Alzheimer disease (AD), but information regarding the occurrence of watershed corti...

journal_title：Stroke

authors： Suter OC,Sunthorn T,Kraftsik R,Straubel J,Darekar P,Khalili K,Miklossy J

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We sought to investigate whether the combination of blood flow measurements in the major cerebral arteries and measurements of cerebral metabolism can provide new insight into the hemodynamic effect of carotid lesions in patients with severe stenosis (> 70% reduction in diameter) of the internal ...

journal_title：Stroke

authors： van der Grond J,Eikelboom BC,Mali WP

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:MRI has become increasingly used in the acute setting to manage patients with stroke. There has been concern that MRI may not be sensitive in the detection of acute intracranial hemorrhage. We assessed whether strongly susceptibility-weighted MRI would be sensitive to intraparenchymal hemorrhage in the first...

journal_title：Stroke

authors： Patel MR,Edelman RR,Warach S

更新日期：1996-12-01 00:00:00

abstract：:It is generally stated that ulceration of the carotid bifurcation plaque may give rise to embolization and symptoms of cerebral ischemia. It has been suggested that prophylactic carotid endarterectomy is indicated in asymptomatic patients if the angiogram is interpreted as showing ulceration. We therefore determined t...

journal_title：Stroke

authors： Eikelboom BC,Riles TR,Mintzer R,Baumann FG,DeFillip G,Lin J,Imparato AM

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ischemic injury triggers multiple pathological responses in the brain tissue, including spreading depolarizations across the cerebral cortex (cortical spreading depolarizations [CSD]). Microglia have been recently shown to play a significant role in the propagation of CSD. However, the intracellu...

journal_title：Stroke

authors： Liu L,Kearns KN,Eli I,Sharifi KA,Soldozy S,Carlson EW,Scott KW,Sluzewski MF,Acton ST,Stauderman KA,Kalani MYS,Park M,Tvrdik P

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Thromboxane prostaglandin receptors have been implicated to be involved in the atherosclerotic process. We assessed whether Terutroban, a thromboxane prostaglandin receptor antagonist, affects the progression of atherosclerosis, as measured by common carotid intima-media thickness and carotid pla...

journal_title：Stroke

authors： Bots ML,Ford I,Lloyd SM,Laurent S,Touboul PJ,Hennerici MG,Prevention of Cerebrovascular and Cardiovascular Events of Ischemic Origin With Terutroban in Patients With a History of Ischemic Stroke or Transient Ischemic Attack Vascular Ultrasou

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Emboli and proinflammatory mediators are suspected of generating cerebral edema after coronary surgery. In contrast to cardiopulmonary bypass (CPB), off-pump coronary artery bypass surgery (OPCAB) reduces microemboli count and proinflammatory mediator release but carries the risk of hemodynamic i...

journal_title：Stroke

authors： Bierbach B,Meier M,Kasper-König W,Heimann A,Alessandri B,Horstick G,Oelert H,Kempski O

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The lipid peroxidation inhibitor U-101033E was examined for effects on cerebral blood flow (CBF), cortical tissue hemoglobin oxygen saturation (HbSo2), and neuronal damage. METHODS:Fifteen minutes of global cerebral ischemia was induced by two-vessel occlusion and hypobaric hypotension. Wistar r...

journal_title：Stroke

authors： Soehle M,Heimann A,Kempski O

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Combined Lysis of Thrombus in Brain Ischemia With Transcranial Ultrasound and Systemic T-PA-Hands-Free (CLOTBUST-HF) study is a first-in-human, National Institutes of Health-sponsored, multicenter, open-label, pilot safety trial of tissue-type plasminogen activator (tPA) plus a novel operator...

journal_title：Stroke

authors： Barreto AD,Alexandrov AV,Shen L,Sisson A,Bursaw AW,Sahota P,Peng H,Ardjomand-Hessabi M,Pandurengan R,Rahbar MH,Barlinn K,Indupuru H,Gonzales NR,Savitz SI,Grotta JC

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The present study investigated the influence of the antiplatelet agent acetylsalicylic acid (ASA) on cerebral microembolism as detected by transcranial Doppler sonography (TCD). METHODS:Nine patients with recent transient ischemic attack or minor stroke of arterial origin were investigated. Eigh...

journal_title：Stroke

authors： Goertler M,Baeumer M,Kross R,Blaser T,Lutze G,Jost S,Wallesch CW

更新日期：1999-01-01 00:00:00