Abstract:
BACKGROUND AND PURPOSE:The relationship between diabetic retinopathy and ischemic stroke is uncertain and examined in this study. METHODS:A population-based, prospective cohort study of 1617 middle-aged persons with diabetes. Diabetic retinopathy signs were ascertained from retinal photographs, and incident ischemic stroke events were prospectively identified and validated. RESULTS:Over an average follow-up of 7.8 years, there were 75 ischemic stroke events. After adjustment for age, gender, race, center, 6-year mean arterial blood pressure, anti-hypertensive treatment use, fasting glucose, insulin treatment, duration of diabetes, high-density lipoprotein and low-density lipoprotein cholesterol levels and cigarette smoking status, diabetic retinopathy was associated with an increased risk of ischemic stroke (hazard rate ratio, 2.34; 95% CI, 1.13 to 4.86). CONCLUSIONS:Diabetic retinopathy predicts incident ischemic stroke in people with diabetes, independent of other risk factors.
journal_name
Strokejournal_title
Strokeauthors
Cheung N,Rogers S,Couper DJ,Klein R,Sharrett AR,Wong TYdoi
10.1161/01.STR.0000254547.91276.50subject
Has Abstractpub_date
2007-02-01 00:00:00pages
398-401issue
2eissn
0039-2499issn
1524-4628pii
01.STR.0000254547.91276.50journal_volume
38pub_type
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