Abstract:
BACKGROUND AND PURPOSE:The lipophilic calcium channel antagonist flunarizine has been demonstrated to be neuroprotective in several models of cerebral ischemia. Ischemic spinal cord injury may have a similar pathophysiology and hence may respond in a similar fashion. This study was designed to investigate the effects of pretreatment with flunarizine on systemic hemodynamics, spinal cord blood flow, and neurological recovery in a rabbit model of ischemic spinal cord injury. METHODS:New Zealand White rabbits were anesthetized with ketamine and xylazine and instrumented for systemic blood pressure monitoring and spinal cord blood flow measurements using the microsphere method. After pretreatment with flunarizine or vehicle, ischemic spinal cord injury was created selectively in the caudal regions of the spinal cord by cross-clamping the abdominal aorta for a period of 25 minutes. Spinal cord blood flow was measured before, during, and 15 minutes after cross-clamp removal. Animals were allowed to recover and were graded neurologically at 18 and 24 hours after ischemia. RESULTS:Flunarizine injection was associated with hypotension that was both transient and dose related. Animals pretreated with flunarizine 0.4 mg/kg had significantly improved neurological recovery scores at 18 hours after ischemia (P = .017) compared with vehicle controls. At 24 hours this effect was lessened (P = .095); however, 60% of flunarizine-treated animals retained their ability to hop, whereas all of the vehicle-treated animals were nonambulatory. CONCLUSIONS:Flunarizine has a protective effect on neurological recovery after experimental ischemic spinal cord injury. The therapeutic window is narrow, and dosing is limited by untoward hypotension. The mechanism of protection likely involves inhibition of pathological cytosolic calcium accumulation rather than a direct effect on vascular smooth muscle.
journal_name
Strokejournal_title
Strokeauthors
Johnson SH,Kraimer JM,Graeber GMdoi
10.1161/01.str.24.10.1547subject
Has Abstractpub_date
1993-10-01 00:00:00pages
1547-53issue
10eissn
0039-2499issn
1524-4628journal_volume
24pub_type
杂志文章相关文献
STROKE文献大全abstract::The effect of prostaglandin E1 on regional cerebral blood flow (rCBF) was studied with the intra-arterial 133Xe method in ten awake patients under local anesthesia. Measurements were taken from 16 areas of a hemisphere in seven patients, from 35 areas of a hemisphere in two patients and from 256 areas of a hemisphere ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.7.6.566
更新日期:1976-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Pathogenetic classification of intracerebral hemorrhage (ICH), using systems such as SMASH-U (structural vascular lesions, medication, cerebral amyloid angiopathy [CAA], systemic disease, hypertension, or undetermined), is important in predicting functional outcomes and mortality in patients with...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.005598
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:White matter hyperintensities (WMH) are frequently seen on neuroimaging of elderly and are associated with cognitive decline and the development of dementia. Yet, the temporal dynamics of conversion of normal-appearing white matter (NAWM) into WMH remains unknown. We examined whether and when pro...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.020980
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Symptomatic intracranial hemorrhage (SICH) is the most feared complication after tissue plasminogen activator (tPA) stroke treatment. Endogenous fibrinolysis inhibitors play an essential role in the coagulation/fibrinolysis balance and may be involved in the bleeding process. We aim to determine ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000137608.73660.4c
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We evaluated the neuroprotective effect of UK-279,276 (also referred to as recombinant neutrophil inhibitory factor), a selective CD11b/CD18 antagonist, in combination with thrombolytic therapy on focal cerebral ischemia. METHODS:Male Wistar rats (n=88) were subjected to embolic middle cerebral ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000077016.55891.2E
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The effect of statins on progression of carotid intima-media complex thickness (IMT) has been shown exclusively in nonstroke Western patients. This study aimed to determine the effect of low-dose pravastatin on carotid IMT in Japanese patients with noncardioembolic ischemic stroke. METHODS:This ...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.117.018387
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Delayed cerebral ischemia and infarction due to reduced CBF remains the leading cause of poor outcome after aneurysmal subarachnoid hemorrhage. Hypertonic saline (HS) is associated with an increase in CBF. This study explores whether CBF enhancement with HS in patients with poor-grade subarachnoi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.560698
更新日期:2010-01-01 00:00:00
abstract::The etiology of cerebrovascular disease (CDV) in young patients is difficult to establish if the common causes of a focal neurological deficit are excluded by appropriate investigations. Since in some observations prolapse of the mitral-valve (MVP), alterations of platelet function, or both have been linked with cereb...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.13.4.454
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Few cohort studies have examined the association of carotid intima-media thickness (IMT) and plaque characteristics with the risk of stroke in apparently healthy persons. We examined the relationship of carotid IMT and the surface, morphology, and calcification of carotid plaques with the inciden...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000147723.52033.9e
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Thrombolytic treatment of stroke carries the risk of hemorrhagic transformation. Therefore, the potential of MRI for prediction of recombinant tissue plasminogen activator (rtPA)-induced bleeding is explored to identify patients in whom rtPA treatment may provoke such complications. METHODS:Spon...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000014619.59851.65
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Familial aggregation of intracranial aneurysms (IAs) indicates a genetic role in the pathogenesis of this disease. Despite a number of reported susceptibility loci, no disease-causing gene variants have been identified. In this study, we used a parametric genomewide linkage approach to search for...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.534396
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hypoxic-ischemic (HI) brain injury in newborn infants represents a major cause of cerebral palsy, development delay, and epilepsy. Stem cell-based therapy has the potential to rescue and replace the ischemic tissue caused by HI and to restore function. However, the mechanisms by which stem cell t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.573691
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The pressure-flow relation has been characterized in normal cerebrum, but it has not been studied in cerebrum dependent on collateral flow. The purpose of this investigation was to examine the relation between systemic pressure, regional cerebral blood flow, and middle cerebral artery branch pres...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.7.988
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Abnormalities of dermal connective tissue have been detected in patients with spontaneous cervical artery dissections (sCAD), suggesting an underlying structural defect of the arterial wall. Alpha1-antitrypsin (A1-AT) is a circulating serine proteinase inhibitor of proteolytic enzymes that helps ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000085085.20390.A3
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) causes acute vasoconstriction that contributes to ischemic brain injury shortly after the initial bleed. It has been theorized that decreased availability of nitric oxide (NO) may contribute to acute vasoconstriction. Therefore we examined the effect of the NO donor ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.9.1955
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small-artery disease that clinically involves only the brain. Particularly early in the disease, patients can show substantial or complete recovery after individual strokes. Cortic...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/hs0202.103337
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We demonstrated previously that treatment with selective kappa-opioid receptor (KOR) agonist BRL 52537 hydrochloride [(+/-)-1-(3,4-dichlorophenyl) acetyl-2-(1-pyrrolidinyl) methylpiperidine] (1) has a long therapeutic window for providing ischemic neuroprotection, and (2) attenuates ischemia-evok...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000169928.76321.3d
更新日期:2005-07-01 00:00:00
abstract::Endothelium dysfunction may result from increased production of reactive oxygen species and decreased availability of nitric oxide. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ie, statins) exert cholesterol-independent vasoprotective effects that are mediated, in part, through the inhibiti...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.STR.0000143319.73503.38
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Angiotensin II produces oxidative stress and endothelial dysfunction in cerebral arteries, and angiotensin II type I receptors may play a role in longevity and vascular aging. Angiotensin-converting enzyme type 2 (ACE2) converts angiotensin II to angiotensin (1-7) and thus, may protect against ef...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.667063
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Spontaneous dissection of the cervical internal carotid artery (sICAD) is mainly assessed with MRI and magnetic resonance angiography (MRA), which are not always at hand. In contrast, color duplex sonography (CDS) is readily available. We undertook this prospective study to examine the accuracy o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000198811.65068.16
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Atrial fibrillation (AF) is a major risk factor for ischemic stroke and its prevalence increases steeply with age. Population-based data on its influence on stroke outcome are scarce. METHODS:We evaluated the prevalence of AF and its influence on prognosis in patients with a first-ever ischemic ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000166053.83476.4a
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Arachidonic acid that is released following cerebral ischemia can be metabolized to 20-hydroxyeicosatetraenoic acid (20-HETE). 20-HETE is a potent vasoconstrictor that may contribute to ischemic injury. This study examined the effects of blockading the synthesis of 20-HETE with TS-011 on infarct ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000217398.37075.07
更新日期:2006-05-01 00:00:00
abstract::TCD recording of flow velocities in intracranial vessels was first described by Aaslid in 1982. The utility of this instrument becomes more apparent as it is used in different clinical settings and compared with angiographic findings (Figures 1 and 2). Its importance in early detection of vasospasm in subarachnoid hem...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.7.915
更新日期:1988-07-01 00:00:00
abstract::Background and Purpose- Despite evidence to support the prescription of antihypertensive medications before hospital discharge to promote medication adherence and prevent recurrent events, many patients with stroke miss out on these medications at discharge. We aimed to examine patient, clinical, and system-level diff...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.026823
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The reliability of the EuroQol and SF-36 questionnaires after stroke is not known. We therefore aimed to assess and compare the test-retest reliability of both instruments in a group of stroke patients. METHODS:A total of 2253 patients with stroke entered by United Kingdom hospitals in the Inter...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.29.1.63
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Combined Lysis of Thrombus in Brain Ischemia With Transcranial Ultrasound and Systemic T-PA-Hands-Free (CLOTBUST-HF) study is a first-in-human, National Institutes of Health-sponsored, multicenter, open-label, pilot safety trial of tissue-type plasminogen activator (tPA) plus a novel operator...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.002713
更新日期:2013-12-01 00:00:00
abstract::A previously healthy young woman presented with sudden onset of quadriplegia, anesthesia below the C3 dermatome, respiratory paralysis, vertical nystagmus, ocular bobbing and cortical blindness. After partial resolution of the latter deficits, she remained quadriplegic, with a C3 level of anesthesia, and in respirator...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.14.3.413
更新日期:1983-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Delayed cerebral ischemia (DCI) is the most important cause for a poor clinical outcome after a subarachnoid hemorrhage. The aim of this study was to assess whether goal-directed hemodynamic therapy (GDHT), as compared to standard clinical care, reduces the rate of DCI after subarachnoid hemorrha...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.120.029279
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The newly-described computed tomography angiography (CTA) Spot Sign is present in about one third of patients with acute primary intracerebral hemorrhage (PICH) and predicts hematoma expansion. This sign has not been systematically evaluated in patients with secondary causes of ICH, and mimics ha...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.499442
更新日期:2008-04-01 00:00:00
abstract::The relationship between normal aging and regional cerebral blood flow (rCBF) computed as initial slope index (ISI) by Fourier method was investigated in 105 right-handed healthy volunteers (132 measurements) by Xe-133 inhalation method, and age-matched normal values were calculated. Mean brain ISI values showed signi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.15.2.336
更新日期:1984-03-01 00:00:00