Abstract:
BACKGROUND AND PURPOSE:The etiology of subarachnoid hemorrhage (SAH) is poorly understood. Reduced lung function, expressed as low forced expiratory volume in 1 second (FEV(1)) and low forced vital capacity (FVC), is a predictor of cardiovascular disease, but whether reduced lung function is a risk factor for SAH is not known. The association between lung function and incidence of SAH was investigated in a prospective cohort study. METHODS:Between 1974 and 1992, 20 534 men and 7237 women (mean age, 44 years) were examined in a health screening program including spirometry. The incidence of SAH was studied during a mean follow-up of 26 years in relation to age- and height-standardized FEV(1), FVC, and FEV(1)/FVC. RESULTS:One hundred forty-five subjects had a SAH (18.3 per 100 000 person-years in men and 26.5 per 100 000 person-years in women). The hazard ratio for SAH in the lowest compared to the highest quartile of FEV(1) and FEV(1)/FVC was 2.24 (95% CI, 1.32-3.81; P for trend=0.014) and 1.92 (95% CI, 1.14-3.23; P for trend=0.003), respectively, after adjustment for several confounding factors including smoking and hypertension. The results persisted when analysis was restricted to nonsmokers. FVC showed no significant association with incidence of SAH. CONCLUSIONS:Baseline lung function, expressed as low FEV(1) or FEV(1)/FVC, is a risk factor for SAH, independently of smoking.
journal_name
Strokejournal_title
Strokeauthors
Söderholm M,Zia E,Hedblad B,Engström Gdoi
10.1161/STROKEAHA.112.658427subject
Has Abstractpub_date
2012-10-01 00:00:00pages
2598-603issue
10eissn
0039-2499issn
1524-4628pii
STROKEAHA.112.658427journal_volume
43pub_type
杂志文章相关文献
STROKE文献大全abstract::Background and Purpose- The simplified stroke-thrombolytic predictive instrument (s-Stroke-TPI) is useful for predicting the outcomes in thrombolysis-treated patients in Western populations. We aimed to validate its predictive value in Chinese patients. Methods- Data from thrombolysis implementation and monitor of acu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.022269
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The onset of spontaneous intracerebral hemorrhage (ICH) is often accompanied by transient blood pressure (BP) elevation. The prognostic value and the determinants of this BP reaction have not entirely been solved, and the present study was focused on these questions. METHODS:From 1985 to 1991 in...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.7.1396
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although chemokines have been implicated in cardiovascular diseases, few studies have addressed the role of these inflammatory mediators in ischemic stroke. This study tested the hypothesis that RANTES (CCL5; regulated on activation, normal T-cell expressed and secreted) mediates the cerebral mic...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.513150
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Carotid angioplasty may offer an effective treatment for carotid stenosis, but there has been concern about the incidence and clinical consequences of distal embolization. Transcranial Doppler monitoring in carotid endarterectomy has demonstrated embolic signals during this procedure. We used thi...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.25.12.2403
更新日期:1994-12-01 00:00:00
abstract::Little is known about outcome after cerebral infarction for different ethnic groups. Of 590 stroke patients hospitalized from 1983 to 1986 at the Neurological Institute, cerebral infarction over age 39 years occurred in 135 whites, 177 blacks, and 82 Hispanics. Outcome after cerebral infarction differed by ethnicity. ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.3.305
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Most improvement from poststroke aphasia occurs within the first 3 months, but there remains unexplained variability in recovery. Recently, we reported a strong correlation between initial impairment and change scores in motor recovery at 90 days. We wanted to determine whether aphasia recovery (...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.577338
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The lipid peroxidation inhibitor U-101033E was examined for effects on cerebral blood flow (CBF), cortical tissue hemoglobin oxygen saturation (HbSo2), and neuronal damage. METHODS:Fifteen minutes of global cerebral ischemia was induced by two-vessel occlusion and hypobaric hypotension. Wistar r...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.6.1240
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Approximately one fourth of stroke occur during sleep. Despite the clinical and radiological similarities between wake-up stroke (WUS) and non-WUS, the functional outcomes of WUS are largely unknown. METHODS:This retrospective analysis reviewed 2289 consecutive patients with acute ischemic strok...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.602243
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke is a major cause of death in the People's Republic of China (PRC), and the geographic distribution of stroke death varies substantially. We conducted an ecological analysis to investigate the relationship of prevalence of hypertension and other risk factors with stroke incidence and mortal...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Redundant internal carotid arteries have been considered a risk factor in tonsillectomy, adenoidectomy, and surgical treatment of peritonsillar abscess and also a potentially treatable cause of stroke. However, an association between internal carotid artery redundancy and spontaneous dissection h...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.6.1201
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of this study was to assess individual differences in the pharmacological effects of acetylsalicylic acid (ASA) on bleeding time as measured by in vitro platelet aggregation and to examine the consistency of responses over time. METHODS:We measured template IIR bleeding time and plat...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.3.591
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is unclear whether blood lipid profiles and statin use before intracerebral hemorrhage (ICH) are associated with its outcome. METHODS:The Helsinki ICH Study, a single-center observational registry of consecutive ICH patients, was used to study the associations between premorbid statin use, ba...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001829
更新日期:2013-08-01 00:00:00
abstract::Three leukotrienes (LTB4, C4, D4) were locally applied to cerebral arterioles in doses varying from 3 X 10(-8) to 4 X 10(-7) M and each produced a dose related constriction. LTC was tested in the presence and absence of FPL-55712, a relatively specific inhibitor of leukotriene receptors. A low dose (10(-8) M) of FPL-5...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.16.2.262
更新日期:1985-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Determinants of long-term outcome are not well defined in minor stroke patients. This study aims to evaluate which factors are independent long-term predictors of death and major stroke recurrence in a cohort of minor ischemic strokes. METHODS:A cohort of 322 patients with first-ever minor ische...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.1.126
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although both general and abdominal adiposity are well-established risk factors for coronary heart disease, their associations with stroke are less well characterized, particularly in generally lean Asian populations. METHODS:We evaluated associations of body mass index (BMI), waist-hip ratio (W...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.539692
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Tetrahydrobiopterin (THBP) is an essential cofactor for nitric oxide synthase (NOS), which is responsible for the synthesis of the endothelium-derived relaxing factor (EDRF) responsible for mediating the vasorelaxation produced by acetylcholine (ACh). Previous publications suggest that EDRFACh is...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.1.186
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Sonic hedgehog (Shh) protein is required for the maintenance of neural progenitor cells (NPCs) in the embryonic and adult hippocampus. Brain ischemia causes increased proliferation of hippocampal NPCs. We therefore examined whether Shh regulates the increase in proliferation of NPCs after ischemi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.561951
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:lipoprotein(a) [Lp(a)] level is an established risk factor for coronary artery disease and has been implicated in carotid artery disease (CAAD). The relationship between genetic variation in the LPA gene region and CAAD risk remains unknown. METHODS:we genotyped single nucleotide polymorphisms (...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.110.591230
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Chinese patients largely experience acute ischemic stroke (AIS) because of large artery atherosclerosis rather than cardioembolism, and whether tirofiban is safe and effective in these patients treated with endovascular thrombectomy (ET) is unknown. This study evaluated the safety and efficacy of...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.019193
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral autoregulation may be impaired in the early days after subarachnoid hemorrhage (SAH). The purpose of this study was to examine the relationship between cerebral autoregulation and angiographic vasospasm (aVSP) and radiographic delayed cerebral ischemia (DCI) in patients with SAH. METHOD...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.002630
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hyperglycemia on admission is common after ischemic stroke. It is associated with unfavorable outcome after treatment with intravenous thrombolysis and after intra-arterial treatment. Whether hyperglycemia influences the effect of reperfusion treatment is unknown. We assessed whether increased ad...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.116.016071
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Some clinical models, like California ABCD and unified ABCD2 scores, are now available to predict the early risk of stroke after a TIA. Despite the transitivity of symptoms, DWI identified an area of acute brain ischemia in almost half of patients. It would be interesting to know how the presence...
journal_title:Stroke
pub_type: 信件
doi:10.1161/STROKEAHA.108.537969
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Many patients with acute basilar artery occlusion may require endotracheal intubation and mechanical ventilation. The circumstances and predictive value for outcome in these patients are not well documented. METHODS:We reviewed the medical records of 25 patients admitted into the intensive care ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.8.1301
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Atherosclerosis is a complex subclinical cardiovascular disorder with a substantial genetic component. This study sought to identify genetic loci influencing carotid plaque in 2 independent samples. METHODS:B-mode ultrasound was performed to determine the presence and area of carotid plaque. Var...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.596981
更新日期:2010-12-01 00:00:00
abstract::In children with Moyamoya disease, transient ischemic attacks often occur during hyperventilation, and the frequency of attacks usually decreases with advancing age. To elucidate the mechanism of the attacks, the regional cerebral blood flow was measured during rest and/or hyperventilation in children aged 3-16 with M...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.5.906
更新日期:1987-09-01 00:00:00
abstract::A 55-year-old woman with an aortic arch syndrome of acute onset and dysphasia, resulting from the excessive administration of ergotamine tartrate suppositories, is described. Complete resolution of symptoms and return of upper limb and carotid artery pulses to normal occurred within four days of cessation of the ergot...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.14.5.811
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Limited data exist on the performance of the revised Framingham Stroke Risk Score (R-FSRS) and the R-FSRS in conjunction with nontraditional risk markers. We compared the R-FSRS, original FSRS, and the Pooled Cohort Equation for stroke prediction and assessed the improvement in discrimination by ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.018928
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Evidence suggests that an alteration in cerebral hemodynamics plays a relevant role in the occurrence of stroke in patients with carotid occlusion. The purpose of the present study was to evaluate the relationships among baseline characteristics, type and number of collateral pathways, cerebral v...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.32.7.1552
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Aging is associated with a reduction in cerebral perfusion. Impaired vasodilatation in large brain arteries could be implicated. This study sought age-related changes in vasodilator responses to norepinephrine in rat basilar artery and investigated which aspects of norepinephrine's action are res...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.9.1812
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with carotid occlusive disease and stage 2 cerebral hemodynamic failure, characterized by an increased oxygen extraction fraction (OEF) as measured by positron emission tomography (PET) and otherwise known as misery perfusion, have a high risk of cerebral ischemia and subsequent stroke. ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.0000027638.19392.7e
更新日期:2002-09-01 00:00:00