Improvement in aphasia scores after stroke is well predicted by initial severity.

Abstract:

BACKGROUND AND PURPOSE:Most improvement from poststroke aphasia occurs within the first 3 months, but there remains unexplained variability in recovery. Recently, we reported a strong correlation between initial impairment and change scores in motor recovery at 90 days. We wanted to determine whether aphasia recovery (defined as a change from baseline to 90 days) shows a comparably strong correlation and whether the relation was similar to that in motor recovery. METHODS:Twenty-one stroke patients had aphasia scores on the Western Aphasia Battery (WAB) obtained on stroke admission (WAB(initial)) and at 90 days (WAB(3 mo)). The relation between actual change (Delta) scores (defined as WAB(3 mo)- WAB(initial)) and WAB(initial) was calculated in multiple-regression analysis. RESULTS:Regression analysis demonstrated that WAB(initial) was highly correlated with DeltaWAB (R(2)=0.81, P<0.001) and that, in addition, the relation between WAB(initial) and DeltaWAB was proportional, such that patients recovered 0.73 of maximal potential recovery (WAB(maximum)-WAB(initial)). CONCLUSIONS:We show that, like motor recovery, there is a highly predictable relation between aphasia recovery and initial impairment, which is also proportional in nature. The comparability of recovery from motor and language impairment suggests that common mechanisms may govern reduction of poststroke neurologic impairment across different functional domains and that they could be the focus of therapeutic intervention.

journal_name

Stroke

journal_title

Stroke

authors

Lazar RM,Minzer B,Antoniello D,Festa JR,Krakauer JW,Marshall RS

doi

10.1161/STROKEAHA.109.577338

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

1485-8

issue

7

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.109.577338

journal_volume

41

pub_type

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