Rapid decline of cerebral microemboli of arterial origin after intravenous acetylsalicylic acid.

Abstract:

BACKGROUND AND PURPOSE:The present study investigated the influence of the antiplatelet agent acetylsalicylic acid (ASA) on cerebral microembolism as detected by transcranial Doppler sonography (TCD). METHODS:Nine patients with recent transient ischemic attack or minor stroke of arterial origin were investigated. Eight had not received an antiplatelet or anticoagulant medication before TCD, and in 1 patient a preexisting ASA medication (100 mg/d) had not been changed since the onset of stroke symptoms. An initial 1-hour TCD monitoring was extended for an additional 2.5 hours after an intravenous bolus injection of 500 mg ASA and was repeated for 1 hour on the following day. RESULTS:Microembolic signals (MES) were detected in all patients only on the symptomatic side. After the ASA bolus injection, a significant drop of the MES rate was found in 7 patients, all without previous medication, starting 30 minutes after the application (mean per hour=25.1 [range, 6 to 66] versus mean per hour=6.4 [range, 0 to 14]). In 3 of these patients, platelet aggregation tests were performed that demonstrated normal aggregation before bolus injection and inhibited aggregability as early as 30 minutes after bolus injection. The rate of MES remained unchanged in 1 patient without antiplatelet medication. The ninth patient, who had suffered an ischemic event on ASA, showed only a transient decrease of MES frequency. CONCLUSIONS:In patients with recent stroke of arterial origin, intravenous ASA can rapidly reduce cerebral microemboli as detected by TCD. Microemboli might be a useful parameter to monitor early effects of antiplatelet therapy.

journal_name

Stroke

journal_title

Stroke

authors

Goertler M,Baeumer M,Kross R,Blaser T,Lutze G,Jost S,Wallesch CW

doi

10.1161/01.str.30.1.66

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

66-9

issue

1

eissn

0039-2499

issn

1524-4628

journal_volume

30

pub_type

临床试验,杂志文章

相关文献

STROKE文献大全
  • Characterization of critical hemodynamics contributing to aneurysmal remodeling at the basilar terminus in a rabbit model.

    abstract:BACKGROUND AND PURPOSE:Hemodynamic insult by bilateral common carotid artery ligation has been shown to induce aneurysmal remodeling at the basilar terminus in a rabbit model. To characterize critical hemodynamics that initiate this remodeling, we applied a novel hemodynamics-histology comapping technique. METHODS:Eig...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.585992

    authors: Metaxa E,Tremmel M,Natarajan SK,Xiang J,Paluch RA,Mandelbaum M,Siddiqui AH,Kolega J,Mocco J,Meng H

    更新日期:2010-08-01 00:00:00

  • Cerebral blood flow in single and multiple lacunar infarctions.

    abstract:BACKGROUND AND PURPOSE:Single and multiple lacunar infarctions may have some difference in underlying diseases and cerebral blood flows. To determine the difference, we investigated underlying diseases and cerebral blood flows in single and multiple lacunar infarctions. METHODS:Fifteen cases of lacunar infarction, 10 ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.7.1458

    authors: Mochizuki Y,Oishi M,Takasu T

    更新日期:1997-07-01 00:00:00

  • Stroke treatment economic model (STEM): predicting long-term costs from functional status.

    abstract:BACKGROUND AND PURPOSE:Stroke is a debilitating disease with long-term social and economic consequences. As new therapies for acute ischemic stroke are forthcoming, there is an increasing need to understand their long-term economic implications. To address this need, a stroke economic model was created. METHODS:The mo...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.30.12.2574

    authors: Caro JJ,Huybrechts KF

    更新日期:1999-12-01 00:00:00

  • Chronic valproate treatment enhances postischemic angiogenesis and promotes functional recovery in a rat model of ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:Enhanced angiogenesis facilitates neurovascular remodeling processes and promotes brain functional recovery after stroke. Previous studies from our laboratory demonstrated that valproate (VPA), a histone deacetylase inhibitor, protects against experimental brain ischemia. The present study invest...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.112.652545

    authors: Wang Z,Tsai LK,Munasinghe J,Leng Y,Fessler EB,Chibane F,Leeds P,Chuang DM

    更新日期:2012-09-01 00:00:00

  • The FAST-ED App: A Smartphone Platform for the Field Triage of Patients With Stroke.

    abstract:BACKGROUND AND PURPOSE:The Emergency Medical Services field triage to stroke centers has gained considerable complexity with the recent demonstration of clinical benefit of endovascular treatment for acute ischemic stroke. We sought to describe a new smartphone freeware application designed to assist Emergency Medical ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.016026

    authors: Nogueira RG,Silva GS,Lima FO,Yeh YC,Fleming C,Branco D,Yancey AH,Ratcliff JJ,Wages RK,Doss E,Bouslama M,Grossberg JA,Haussen DC,Sakano T,Frankel MR

    更新日期:2017-05-01 00:00:00

  • Prevention of Stroke in Atrial Fibrillation After Coronary Stenting.

    abstract::Background and Purpose- The optimal antithrombotic strategy to balance thromboembolic and bleeding events, especially acute stroke, for patients with atrial fibrillation following coronary stenting remains a matter of debate. We conducted a network meta-analysis to identify the antithrombotic regimen associated with t...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析

    doi:10.1161/STROKEAHA.119.026078

    authors: Knijnik L,Rivera M,Blumer V,Cardoso R,Fernandes A,Fernandes G,Ferreira T,Romano JG,Lambrakos LK,Cohen MG

    更新日期:2019-08-01 00:00:00

  • Muscle sympathetic nerve activity during cold pressor test in patients with cerebrovascular accidents.

    abstract:BACKGROUND AND PURPOSE:Autonomic dysfunction is frequently present in patients with cerebrovascular accidents (CVA). However, the pathophysiological mechanisms of these disorders are not clear. The purpose of the study was to assess the effects of CVA on the autonomic nervous system. METHODS:In eight male patients wit...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.29.3.607

    authors: Mizushima T,Tajima F,Nakamura T,Yamamoto M,Lee KH,Ogata H

    更新日期:1998-03-01 00:00:00

  • Methionine sulfoximine reduces cortical infarct size in rats after middle cerebral artery occlusion.

    abstract::The methionine analogue methionine sulfoximine was administered to 10 rats 24 hours before occlusion of the proximal left middle cerebral artery. Three days later the rats were decapitated and the brain infarct volumes were compared with those in 10 control rats that received saline before middle cerebral artery occlu...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.21.2.322

    authors: Swanson RA,Shiraishi K,Morton MT,Sharp FR

    更新日期:1990-02-01 00:00:00

  • Ischemic Core and Hypoperfusion Volumes Correlate With Infarct Size 24 Hours After Randomization in DEFUSE 3.

    abstract::Background and Purpose- Accurate prediction of the subsequent infarct volume early after stroke onset helps determine appropriate interventions and prognosis. In the DEFUSE 3 trial (Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke), we evaluated the accuracy of baseline ischemic core and hypoperfu...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.118.023177

    authors: Rao V,Christensen S,Yennu A,Mlynash M,Zaharchuk G,Heit J,Marks MP,Lansberg MG,Albers GW

    更新日期:2019-03-01 00:00:00

  • Thrombolysis-related hemorrhagic infarction: a marker of early reperfusion, reduced infarct size, and improved outcome in patients with proximal middle cerebral artery occlusion.

    abstract:BACKGROUND AND PURPOSE:The role of early and delayed recanalization after thrombolysis in the development of hemorrhagic transformation (HT) subtypes remains uncertain. We sought to explore the association between the timing of recanalization and HT risk in patients with proximal middle cerebral artery (MCA) occlusion ...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.0000016323.13456.e5

    authors: Molina CA,Alvarez-Sabín J,Montaner J,Abilleira S,Arenillas JF,Coscojuela P,Romero F,Codina A

    更新日期:2002-06-01 00:00:00

  • High stroke incidence in the prospective community-based L'Aquila registry (1994-1998). First year's results.

    abstract:BACKGROUND AND PURPOSE:Changes in stroke incidence are likely to occur as a consequence of aging of the population, but evidence for this hypothesis is lacking. METHODS:A prospective community-based registry of first-ever strokes (1994 to 1998) classified according to the International Classification of Diseases, 9th ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.12.2500

    authors: Carolei A,Marini C,Di Napoli M,Di Gianfilippo G,Santalucia P,Baldassarre M,De Matteis G,di Orio F

    更新日期:1997-12-01 00:00:00

  • Reduced vasomotor reactivity in cerebral microangiopathy : a study with near-infrared spectroscopy and transcranial Doppler sonography.

    abstract:BACKGROUND AND PURPOSE:Reduction of cerebral blood flow and vasomotor reactivity (VMR) are thought to play an important role in the pathogenesis of cerebral microangiopathy. The aim of our study was to determine whether near-infrared spectroscopy (NIRS) can detect a reduced VMR in patients with microangiopathy, whether...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.31.4.924

    authors: Terborg C,Gora F,Weiller C,Röther J

    更新日期:2000-04-01 00:00:00

  • Relation of coronary atherosclerosis and apolipoprotein E genotypes in Alzheimer patients.

    abstract:BACKGROUND AND PURPOSE:Apolipoprotein E (apoE) epsilon 4 allele has been associated with a high risk for coronary heart disease. Increased frequency of the epsilon 4 allele has also been reported in patients with late-onset familial and sporadic Alzheimer's disease (AD). The aim of this study was to investigate the deg...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.26.5.743

    authors: Kosunen O,Talasniemi S,Lehtovirta M,Heinonen O,Helisalmi S,Mannermaa A,Paljärvi L,Ryynänen M,Riekkinen PJ Sr,Soininen H

    更新日期:1995-05-01 00:00:00

  • Stent placement in acute cerebral artery occlusion: use of a self-expandable intracranial stent for acute stroke treatment.

    abstract:BACKGROUND AND PURPOSE:Stent placement has been applied in small case series as a rescue therapy in combination with different thrombolytic agents, percutaneous balloon angioplasty (PTA), and mechanical thromboembolectomy (MT) in acute stroke treatment. These studies report a considerable mortality and a high rate of i...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.533810

    authors: Brekenfeld C,Schroth G,Mattle HP,Do DD,Remonda L,Mordasini P,Arnold M,Nedeltchev K,Meier N,Gralla J

    更新日期:2009-03-01 00:00:00

  • Therapeutic hypothermia for brain ischemia: where have we come and where do we go?

    abstract::Mild hypothermia is an established neuroprotectant in the laboratory, showing remarkable and consistent effects across multiple laboratories and models of brain injury. At the clinical level, mild hypothermia has shown benefits in patients who have experienced cardiac arrest and in some pediatric populations experienc...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/STROKEAHA.110.595371

    authors: Yenari MA,Hemmen TM

    更新日期:2010-10-01 00:00:00

  • Trends in 10-year survival of patients with stroke hospitalized between 1980 and 2000: the Minnesota stroke survey.

    abstract:BACKGROUND AND PURPOSE:We report on trends in poststroke survival, both in the early period after stroke and over the long term. We examine these trends by stroke subtype. METHODS:The Minnesota Stroke Survey is a study of all hospitalized patients with acute stroke aged 30 to 74 years in the Minneapolis-St Paul metrop...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.005512

    authors: Lakshminarayan K,Berger AK,Fuller CC,Jacobs DR Jr,Anderson DC,Steffen LM,Sillah A,Luepker RV

    更新日期:2014-09-01 00:00:00

  • Role of carotid endarterectomy in asymptomatic carotid stenosis. A Veterans Administration Cooperative Study.

    abstract::A multi-centered cooperative study is being undertaken to determine the role of carotid endarterectomy in the treatment of asymptomatic carotid stenosis. The primary objective is to compare the incidence of transient ischemic attacks, stroke, and death in previously asymptomatic patients with arteriographically confir...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.str.17.3.534

    authors:

    更新日期:1986-05-01 00:00:00

  • Dietary cysteine and other amino acids and stroke incidence in women.

    abstract:BACKGROUND AND PURPOSE:Cysteine could potentially lower the risk of stroke through antihypertensive and antioxidant effects. Our aim was to evaluate the hypothesis that cysteine intake is inversely associated with stroke incidence. METHODS:We used data from the Swedish Mammography Cohort, a population-based prospectiv...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/STROKEAHA.114.008022

    authors: Larsson SC,Håkansson N,Wolk A

    更新日期:2015-04-01 00:00:00

  • Is diabetic retinopathy an independent risk factor for ischemic stroke?

    abstract:BACKGROUND AND PURPOSE:The relationship between diabetic retinopathy and ischemic stroke is uncertain and examined in this study. METHODS:A population-based, prospective cohort study of 1617 middle-aged persons with diabetes. Diabetic retinopathy signs were ascertained from retinal photographs, and incident ischemic s...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000254547.91276.50

    authors: Cheung N,Rogers S,Couper DJ,Klein R,Sharrett AR,Wong TY

    更新日期:2007-02-01 00:00:00

  • Lack of evolution of the cerebral blood flow during clinical recovery of a stroke.

    abstract::Cerebral blood flow and clinical parameters were studied in 30 stroke patients at 15th, 30th, 60th, 90th days after the cerebral insult (Xenon 133 inhalation method). The clinical improvement was not accompanied by a progressive normalization of the CBF at rest. No relationship was found between the clinical data and ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.14.1.77

    authors: Demeurisse G,Verhas M,Capon A,Paternot J

    更新日期:1983-01-01 00:00:00

  • Nationwide Analysis of Cost Variation for Treatment of Aneurysmal Subarachnoid Hemorrhage.

    abstract::Background and Purpose- Aneurysmal subarachnoid hemorrhage (aSAH) has a high healthcare cost burden. Methods- We performed a cross-sectional analysis of the costs of clipping and coiling of aSAH using the National Inpatient Sample and Vizient databases. We conducted multiple regression analyses to estimate national co...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.118.023079

    authors: Yoon S,Yoon JC,Winkler E,Liu C,Lawton MT

    更新日期:2018-12-03 00:00:00

  • Comparison of hypertension management after stroke and myocardial infarction: results from ECLAT1--a French nationwide study.

    abstract:BACKGROUND AND PURPOSE:Hypertension control is a cornerstone of preventive treatment in patients at risk for cerebral attack. The aim of this study was to analyze hypertension management in secondary prevention of stroke as compared with patients in secondary prevention of myocardial infarction (MI). METHODS:The ECLAT...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000131547.71502.81

    authors: Amar J,Cambou JP,Touzé E,Bongard V,Jullien G,Vahanian A,Coppé G,Mas JL,ECLAT1 Study Investigators.

    更新日期:2004-07-01 00:00:00

  • Sulcal effacement with preserved gray-white junction: a sign of reversible ischemia.

    abstract:BACKGROUND AND PURPOSE:Sulcal effacement with preserved underlying gray-white matter junction (isolated sulcal effacement [ISE]) in acute ischemic stroke may not represent irreversible parenchymal injury. We aimed to evaluate the frequency and significance of ISE in patients with large vessel occlusion acute ischemic s...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/STROKEAHA.115.009304

    authors: Haussen DC,Lima A,Frankel M,Anderson A,Belagaje S,Nahab F,Rangaraju S,Nogueira RG

    更新日期:2015-06-01 00:00:00

  • Lipoprotein-associated phospholipase A2 and C-reactive protein for risk-stratification of patients with TIA.

    abstract:BACKGROUND AND PURPOSE:Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a marker of unstable atherosclerotic plaque, and is predictive of both primary and secondary stroke in population-based studies. METHODS:We conducted a prospective study of patients with acute TIA who presented to the ED. Clinical risk sco...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.109.553545

    authors: Cucchiara BL,Messe SR,Sansing L,MacKenzie L,Taylor RA,Pacelli J,Shah Q,Kasner SE

    更新日期:2009-07-01 00:00:00

  • Characterization of fluoromisonidazole binding in stroke.

    abstract:BACKGROUND AND PURPOSE:[18F]fluoromisonidazole (FMISO) positron emission tomography has been used to image hypoxia early after human stroke. To further study the role of hypoxia in stroke and the binding characteristics of FMISO, we aimed to develop [3H]FMISO autoradiography in an animal stroke model. We hypothesized t...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000226908.93295.9d

    authors: Spratt NJ,Ackerman U,Tochon-Danguy HJ,Donnan GA,Howells DW

    更新日期:2006-07-01 00:00:00

  • General and abdominal adiposity and risk of stroke in Chinese women.

    abstract:BACKGROUND AND PURPOSE:Although both general and abdominal adiposity are well-established risk factors for coronary heart disease, their associations with stroke are less well characterized, particularly in generally lean Asian populations. METHODS:We evaluated associations of body mass index (BMI), waist-hip ratio (W...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.539692

    authors: Zhang X,Shu XO,Gao YT,Yang G,Li H,Zheng W

    更新日期:2009-04-01 00:00:00

  • Mice expressing a bovine basic fibroblast growth factor transgene in the brain show increased resistance to hypoxemic-ischemic cerebral damage.

    abstract:BACKGROUND AND PURPOSE:Cerebral intraventricular infusion of acidic or basic fibroblast growth factor has been shown to attenuate ischemic damage to hippocampal CA1 neurons in the gerbil. The purpose of the present study was to determine if the basic fibroblast growth factor transgenic mouse has an enhanced ability to ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.24.11.1735

    authors: MacMillan V,Judge D,Wiseman A,Settles D,Swain J,Davis J

    更新日期:1993-11-01 00:00:00

  • Vascular occlusion enables selecting acute ischemic stroke patients for treatment with desmoteplase.

    abstract:BACKGROUND AND PURPOSE:Desmoteplase is a novel and highly fibrin-specific thrombolytic agent. Evidence of safety and efficacy was obtained in 2 phase II trials (Desmoteplase In Acute Ischemic Stroke [DIAS] and Desmoteplase for Acute Ischemic Stroke [DEDAS]). The DIAS-2 phase III trial did not replicate the positive pha...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.642322

    authors: Fiebach JB,Al-Rawi Y,Wintermark M,Furlan AJ,Rowley HA,Lindstén A,Smyej J,Eng P,Warach S,Pedraza S

    更新日期:2012-06-01 00:00:00

  • Targeted Infarction of the Internal Capsule in the Rat Using Microstimulation Guidance.

    abstract::Background and Purpose- Lacunar strokes are subcortical infarcts with small size and high disability rates, largely due to injury of the corticospinal tract in the internal capsule (IC). Current rodent models of lacunar infarcts are created based on stereotactic coordinates. We tested the hypothesis that better unders...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.119.025646

    authors: Wen TC,Sindhurakar A,Ramirez VC,Park H,Gupta D,Carmel JB

    更新日期:2019-09-01 00:00:00

  • Autonomic ganglionic blockade does not prevent reduction in cerebral blood flow velocity during orthostasis in humans.

    abstract:BACKGROUND AND PURPOSE:The underlying mechanisms for reductions in cerebral blood flow (CBF) during orthostasis are not completely understood. This study tested the hypothesis that sympathetic activation causes cerebral vasoconstriction leading to reductions in CBF during lower body negative pressure (LBNP). METHODS:C...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.STR.0000260095.94175.d0

    authors: Zhang R,Levine BD

    更新日期:2007-04-01 00:00:00