Abstract:
:Brain injury, including ischemia, changes normal astrocytes into reactive species that hypertrophy and begin to proliferate. Understanding the mechanisms that underlie these changes could lead to new abilities to promote regeneration and retard neural degeneration after ischemia. Because ionic changes occur after nonneural cells are exposed to mitogens, we have begun to examine the ionic changes that may trigger reactive gliosis. We showed that two changes thought to be important for mitogenesis, elevation of interstitial potassium or intracellular pH, are correlated with reactive gliosis as indicated by increased immunohistochemical staining for glial fibrillary acidic protein. This relation was seen after activation of cerebral cortex by recurrent spreading depression but not by physiologic stimulation. Deoxyribonucleic acid synthesis occurs in fibroblasts only when intracellular potassium exceeds 90 mM, a level seen in astrocytes only during spreading depression. Thus, our results support the contention that a threshold level of potassium (and pH) must be exceeded in eukaryotic cells before proliferation or anabolism will proceed.
journal_name
Strokejournal_title
Strokeauthors
Kraig RP,Jaeger CBsubject
Has Abstractpub_date
1990-11-01 00:00:00pages
III184-7issue
11 Suppleissn
0039-2499issn
1524-4628journal_volume
21pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND:Gene transfer to peripheral arteries has been accomplished with catheter-based approaches. Recently, gene transfer to the carotid artery and intracranial vessels has been achieved both in vitro and in vivo. Although gene therapy for cerebral vascular disease may not be accomplished for years, currently avail...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.27.9.1688
更新日期:1996-09-01 00:00:00
abstract::Using clinical presentation, angiography, computed tomography, and nuclear magnetic resonance imaging, 7 patients were identified who had strictly unilateral hemispheric infarction and unilateral cerebrovascular disease. In 6, cerebral blood flow measured by fluorine-18-fluoromethane inhalation and positron emission t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.5.882
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We tested the hypothesis that sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, promotes functional recovery and neurogenesis after stroke. METHODS:Male Wistar rats were subjected to embolic middle cerebral artery occlusion. Sildenafil (Viagra) was administered orally for 7 consecutive da...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000034399.95249.59
更新日期:2002-11-01 00:00:00
abstract::To elucidate the connection between blood flow and the localized genesis and development of atherosclerosis and thrombosis at the human carotid artery bifurcation, detailed studies of the flow patterns and distributions of fluid velocity and wall shear rate in this region were carried out using a transparent segment o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.15.1.50
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In a previous study, we occasionally found that the rat given naloxone in the preoptic region develops behavioral seizures. In view of knowledge that the forebrain including the medial septal nucleus provides cholinergic projections to the hippocampal formation, the present study examined the eff...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.9.1325
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Spontaneous dissection of the cervical internal carotid artery (sICAD) is mainly assessed with MRI and magnetic resonance angiography (MRA), which are not always at hand. In contrast, color duplex sonography (CDS) is readily available. We undertook this prospective study to examine the accuracy o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000198811.65068.16
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several studies have reported poor outcomes in patients too good to treat with intravenous thrombolysis because of mild or rapidly improving symptoms. We sought to determine baseline clinical and imaging predictors of poor outcome in these patients. METHODS:Among 3950 consecutive stroke admissio...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.014871
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is currently no consensus on (1) the percentage of patients who develop spasticity after ischemic stroke, (2) the relation between spasticity and initial clinical findings after acute stroke, and (3) the impact of spasticity on activities of daily living and health-related quality of life. ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.581991
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke symptoms can be very stressful for family caregivers, but most knowledge about the prevalence and stressfulness of stroke-related patient problems is derived from convenience samples. In addition, little is known about perceived benefits of the stroke caregiving experience. The purpose of ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.545269
更新日期:2009-06-01 00:00:00
abstract::Background and Purpose- The purpose of this study was to assess recent trends in the admission and mortality rates for subarachnoid hemorrhage in Canada. Methods- This retrospective cross-sectional study was based on data retrieved from the Canadian Institute for Health Information for all patients diagnosed with suba...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.022332
更新日期:2018-11-21 00:00:00
abstract:BACKGROUND AND PURPOSE:The outcomes of carotid endarterectomy (CEA) are, in addition to patient baseline characteristics, highly dependent on the safety of the surgical procedure. During the successive stages of the operation, transcranial Doppler (TCD) monitoring of the middle cerebral artery (MCA) was used to assess ...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.str.31.8.1817
更新日期:2000-08-01 00:00:00
abstract::Background and Purpose- In this era of endovascular therapy (EVT) with early, complete recanalization and reperfusion, we have observed an even more rapid apparent diffusion coefficient (ADC) normalization within the acute ischemic lesion compared with the natural history or IV-tPA-treated patient. In this study, we a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.025784
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Elevated soluble CD40 ligand (sCD40L) was shown to be related to cardiovascular events, but the role of sCD40L in predicting recurrent stroke remains unclear. METHODS:Baseline sCD40L levels were measured in 3044 consecutive patients with acute minor stroke and transient ischemic attack, who had ...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.115.008685
更新日期:2015-07-01 00:00:00
abstract::HDL-cholesterol levels were determined by a heparin-Ca precipitation method in 89 survivors of cerebral infarction (CI) (75 males, 14 females) and 14 patients with transient ischemic attacks (TIA) (8 males, 6 females). The mean values of HDL-cholesterol concentration and HDL:LDL-cholesterol ratio for both sexes of CI ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.12.2.167
更新日期:1981-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Data from epidemiological and case-control studies suggest that increased total homocysteine (tHcy) levels are associated with increased risk for thromboembolic disease. The mechanisms by which hyperhomocysteinemia contributes to thrombogenesis are incompletely understood. The main objectives of ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.5.974
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To verify the hemorheological effects of isovolemic hemodilution on hemodynamics and cerebral perfusion of normal humans, we tested the efficacy of isovolemic hemodilution in systemic hemodynamics and cerebral bood flow augmentation and its influences in vascular reserve. METHODS:Isovolemic hemo...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.3.441
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is increasing interest in defining stroke lesion volume thresholds to predict poststroke outcome. However, there is a paucity of data on factors that impact the association between critical infarct thresholds volume and outcome. We sought to determine whether lesion thresholds best predicti...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.013982
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of our study was to compare lesion location between moyamoya disease-related intracerebral hemorrhage (MMD-ICH) and primary intracerebral hemorrhage (P-ICH). METHODS:Ninety-three patients each with MMD-ICH and P-ICH were compared. In patients with MMD-ICH, angiographic findings were ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.654004
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This study reviews the perioperative use of red blood cell transfusion in cerebrovascular neurosurgery. The current algorithm for preoperative ordering of red cells is historical and dated. More blood is ordered than is actually transfused, and considerable variability exists between different in...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/hs0402.105296
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Acute cocaine use has been temporally associated with aneurysmal subarachnoid hemorrhage (aSAH). This study analyzes the impact of cocaine use on patient presentation, complications, and outcomes. METHODS:Data of patients admitted with aSAH between 1991 and 2009 were reviewed to determine impact...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.000749
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We examined whether hemodynamic and metabolic abnormalities in the cerebral white matter, basal ganglia, and thalamus are associated with asymptomatic white matter lesions (WML) depicted on MR images. METHODS:A positron emission tomographic study with H2(15)O, C15O, and 15O2 was performed in eig...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.10.1944
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke in young adults has a dramatic effect on life; therefore, we investigated the long-term functional outcome after transient ischemic attack, ischemic stroke, or intracerebral hemorrhage in adults aged 18 to 50 years. METHODS:We studied 722 young patients with first-ever stroke admitted bet...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.004411
更新日期:2014-04-01 00:00:00
abstract::Platelet activating factor, a potent inducer of in vivo platelet activation and thrombosis, has been shown to be excessively active in acute ischemic stroke patients. Therefore, we studied the effect of aspirin/dipyridamole therapy in inhibiting platelet activating factor-induced platelet activation in acute ischemic ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.5.609
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The present study determines associations between early blood pressure (BP) variability and stroke outcomes after intravenous thrombolysis. METHODS:In 527 stroke patients receiving intravenous alteplase (0.6 mg/kg), BP was measured 8 times within the first 25 hours. BP variability was determined...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.681007
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In malignant cerebral venous thrombosis (CVT) patients, emergency decompressive surgery has been suggested as a life-saving procedure. We report 12 patients with malignant CVT, among whom 8 underwent operation. METHODS:Retrospective study of 12 patients from 3 stroke units who had a malignant CV...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.572909
更新日期:2010-04-01 00:00:00
abstract::Leukoaraiosis is a common finding in stroke patients and has been strongly associated with risk of incident stroke and dementia. Leukoaraiosis may also be an independent predictor of stroke outcomes. There is increasing evidence from neuroimaging to support the concept that some leukoaraiosis is caused by white matter...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.110.596056
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Malignant cerebellar edema (MCE) is a life-threatening complication of acute ischemic stroke that requires timely diagnosis and management. Aim of this study was to identify imaging predictors in initial multiparametric computed tomography (CT), including whole-brain CT perfusion (WB-CTP). METHO...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.018237
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to assess the reproducibility, interobserver variability, and application to clinical studies of a new method for the quantitative assessment of carotid plaque echogenicity. METHODS:Carotid plaques were scanned with the use of ultrasound, and their images were stored in a computer. The...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.9.2189
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Combined effects of socioeconomic position and well-established risk factors on stroke incidence have not been formally investigated. METHODS:In a pooled cohort study of 68 643 men and women aged 30 to 70 years in Denmark, we examined the combined effect and interaction between socioeconomic pos...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.005252
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Endothelial progenitor cells (EPCs) migrate from bone marrow to systemic circulation in response to tissue ischemia where they differentiate into mature endothelial cells for angiogenesis in situ. This study tested the hypothesis that the level of circulating EPCs is substantially increased and p...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.489401
更新日期:2008-01-01 00:00:00