Minocycline-induced attenuation of iron overload and brain injury after experimental intracerebral hemorrhage.

abstract：BACKGROUND AND PURPOSE:High-dose human albumin (ALB) is robustly neuroprotective in rodent stroke models. A phase I dose-escalation study was conducted to assess the safety of ALB therapy in ischemic stroke. We analyzed the data for preliminary evidence of treatment efficacy. METHODS:Eighty-two subjects with acute isc...

journal_title：Stroke

authors： Palesch YY,Hill MD,Ryckborst KJ,Tamariz D,Ginsberg MD

更新日期：2006-08-01 00:00:00

abstract：:The authors report an autopsy case with repeated transient ischemic attacks and subsequent strokes demonstrating evidence of artery-to-artery embolism from thrombi generated in the stenotic middle cerebral artery to the distal cortical branches. This case substantiates the existence of intracranial artery-to-artery em...

journal_title：Stroke

authors： Masuda J,Ogata J,Yutani C,Miyashita T,Yamaguchi T

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Fibrinogen is an independent risk factor for coronary events in population-based studies and in patients with coronary heart disease, but there is uncertainty about prediction of stroke, particularly in secondary prevention. METHODS:We studied unpublished data from 3 prospective studies of patie...

journal_title：Stroke

authors： Rothwell PM,Howard SC,Power DA,Gutnikov SA,Algra A,van Gijn J,Clark TG,Murphy MF,Warlow CP

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It remains uncertain whether lower dose intravenous tissue-type plasminogen activator (tPA) for stroke is as effective and safe as the standard dose. METHODS:We analyzed data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China). Patients who were treate...

journal_title：Stroke

authors： Liao X,Wang Y,Pan Y,Wang C,Zhao X,Wang DZ,Wang C,Liu L,Wang Y,Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China Investigators.

更新日期：2014-08-01 00:00:00

abstract：:Background and Purpose- Several vascular risk factors are known to be associated with the occurrence of intracranial aneurysms (IAs). Coronary artery calcium (CAC), which reflects the atherosclerotic burden of the coronary arteries, is a known predictor of cardiovascular events and stroke. We investigated the relation...

journal_title：Stroke

authors： Cho BH,Kim JH,Suh SH,Baik SJ,Lee HS,Kim J,Lee KY

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke is associated with increased risk of dementia. There has been a decline in mortality from stroke among persons 65 and over in recent decades in the US. It is not clear, however, how this process has affected incidence of various dementias. METHODS:We evaluated over time changes in stroke ...

journal_title：Stroke

authors： Ukraintseva S,Sloan F,Arbeev K,Yashin A

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ischemic injury triggers multiple pathological responses in the brain tissue, including spreading depolarizations across the cerebral cortex (cortical spreading depolarizations [CSD]). Microglia have been recently shown to play a significant role in the propagation of CSD. However, the intracellu...

journal_title：Stroke

authors： Liu L,Kearns KN,Eli I,Sharifi KA,Soldozy S,Carlson EW,Scott KW,Sluzewski MF,Acton ST,Stauderman KA,Kalani MYS,Park M,Tvrdik P

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In intracerebral hemorrhage (ICH), preexisting cognitive impairment has been identified as a risk factor for increased mortality and morbidity. However, previous studies examined predominantly White populations; therefore, the prevalence and effect of preICH cognitive impairment has not been stud...

journal_title：Stroke

authors： Sawyer RP,Yim E,Coleman E,Demel SL,Sekar P,Woo D

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aimed to investigate the feasibility and therapeutic effect of external counterpulsation (ECP) in ischemic stroke. METHODS:The trial was a randomized, crossover, assessment-blinded, proof-of-concept trial. ECP treatment consisted of 35 daily 1-hour sessions. Patients were randomized to either...

journal_title：Stroke

authors： Han JH,Leung TW,Lam WW,Soo YO,Alexandrov AW,Mok V,Leung YF,Lo R,Wong KS

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The INTEnsive blood pressure Reduction in Acute Cerebral hemorrhage Trial (INTERACT) pilot study showed that early intensive blood pressure-lowering can attenuate hematoma growth in acute intracerebral hemorrhage. The present analysis aimed to determine the treatment effects on hematoma growth by...

journal_title：Stroke

authors： Arima H,Huang Y,Wang JG,Heeley E,Delcourt C,Parsons M,Li Q,Neal B,Chalmers J,Anderson C,INTERACT1 Investigators.

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aim to investigate whether histopathologic examination of thrombi retrieved from acute ischemic stroke patients undergoing endovascular treatment could distinguish cancer-related stroke from other etiologies. METHODS:Thrombi from patients undergoing endovascular treatment were analyzed. The e...

journal_title：Stroke

authors： Fu CH,Chen CH,Lin YH,Lee CW,Tsai LK,Tang SC,Shun CT,Jeng JS

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Noncontrast computed tomographic (CT) hypodensities have been shown to be associated with hematoma expansion in intracerebral hemorrhage (ICH), but their impact on functional outcome is yet to be determined. We evaluated whether baseline noncontrast CT hypodensities are associated with poor clini...

journal_title：Stroke

authors： Boulouis G,Morotti A,Brouwers HB,Charidimou A,Jessel MJ,Auriel E,Pontes-Neto O,Ayres A,Vashkevich A,Schwab KM,Rosand J,Viswanathan A,Gurol ME,Greenberg SM,Goldstein JN

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Brain injury caused by stroke is a frequent cause of perinatal morbidity and mortality with limited therapeutic options. Mesenchymal stem cells (MSC) have been shown to improve outcome after neonatal hypoxic-ischemic brain injury mainly by secretion of growth factors stimulating repair processes....

journal_title：Stroke

authors： van Velthoven CT,Sheldon RA,Kavelaars A,Derugin N,Vexler ZS,Willemen HL,Maas M,Heijnen CJ,Ferriero DM

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:A number of clinical syndromes describing the presentation of deep brain infarcts are called lacunar syndromes resulting from small vessel occlusion (SVO). To verify the reliability of the clinical diagnosis "lacunar syndrome," the value was investigated with diffusion-weighted MRI (DWI). METHODS AND RESULT...

journal_title：Stroke

authors： Wessels T,Röttger C,Jauss M,Kaps M,Traupe H,Stolz E

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Perihematomal edema formation and consequent cell death contribute to the delayed brain injury evoked by intracerebral hemorrhage (ICH). We aimed to evaluate the effect of α7 nicotinic acetylcholine receptor (α7nAChR) stimulation on behavior, brain edema, and neuronal apoptosis. Furthermore, we a...

journal_title：Stroke

authors： Krafft PR,Altay O,Rolland WB,Duris K,Lekic T,Tang J,Zhang JH

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebrovascular disease can complicate head and neck radiotherapy and result in transient ischemic attack and ischemic stroke. Although the incidence of radiation vasculopathy is predicted to rise with improvements in median cancer survival, the pathogenesis, natural history, and management of th...

journal_title：Stroke

authors： Plummer C,Henderson RD,O'Sullivan JD,Read SJ

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Combined effects of socioeconomic position and well-established risk factors on stroke incidence have not been formally investigated. METHODS:In a pooled cohort study of 68 643 men and women aged 30 to 70 years in Denmark, we examined the combined effect and interaction between socioeconomic pos...

journal_title：Stroke

authors： Nordahl H,Osler M,Frederiksen BL,Andersen I,Prescott E,Overvad K,Diderichsen F,Rod NH

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Most randomized controlled trials of venous thromboembolism prophylaxis have focused on reduction of deep vein thrombosis, predominantly asymptomatic deep vein thrombosis, detected on imaging. We aimed to estimate the effects of graduated compression stockings on venous thromboembolism events, su...

journal_title：Stroke

authors： CLOTS Trials Collaboration.,Dennis M,Sandercock P,Reid J,Graham C,Murray G,Venables G,Rudd A,Bowler G

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carotid endarterectomy (CE) has been shown to be beneficial in patients with symptomatic high-grade (70% to 99%) internal carotid artery stenosis. To achieve this benefit, complications must be kept to a minimum. Complications not associated with the procedure itself, but related to medical condi...

journal_title：Stroke

authors： Paciaroni M,Eliasziw M,Kappelle LJ,Finan JW,Ferguson GG,Barnett HJ

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Perfusion-weighted magnetic resonance imaging (PWI) is a reliable and semiquantitative method for estimating cerebral hemodynamics. We sought to evaluate the potential of PWI for assessing cerebral blood flow (CBF) and metabolism compared with positron emission tomography (PET) in patients with c...

journal_title：Stroke

authors： Kajimoto K,Moriwaki H,Yamada N,Hayashida K,Kobayashi J,Miyashita K,Naritomi H

更新日期：2003-07-01 00:00:00

abstract：:Spontaneous dissections of the extracranial internal carotid artery are diagnosed more frequently as their clinical and angiographic features are more widely recognized. Familial occurrence of spontaneous dissection of the internal carotid artery has not been previously reported. We describe the occurrence of this ent...

journal_title：Stroke

authors： Mokri B,Piepgras DG,Wiebers DO,Houser OW

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke and systemic embolic events are known to occur as complications of hypertrophic cardiomyopathy (HCM), and these complications are more common in patients with accompanying atrial fibrillation (AF). The diagnosis of AF is sometimes difficult, however, and it is possible that subclinical asy...

journal_title：Stroke

authors： Haruki S,Minami Y,Hagiwara N

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intracranial aneurysms and aneurysmal subarachnoid hemorrhage may occur more frequently in sickle-cell disease (SCD), and this could be related to the sickle genotype and moyamoya syndrome seen in SCD. METHODS:Records from a total of 1002 patients with SCD attending 2 specialized adult hematolog...

journal_title：Stroke

authors： Birkeland P,Gardner K,Kesse-Adu R,Davies J,Lauritsen J,Rom Poulsen F,Tolias CM,Thein SL

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The effect of tissue-type plasminogen activator on functional outcome decreases progressively over time. However, given the differential pattern of arterial occlusion, stroke severity, and speed of ischemic lesion growth among candidates for reperfusion, the time window should be adjusted accordi...

journal_title：Stroke

authors： Muchada M,Rubiera M,Rodriguez-Luna D,Pagola J,Flores A,Kallas J,Sanjuan E,Meler P,Alvarez-Sabin J,Ribo M,Molina CA

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intracranial cerebral atherosclerosis causes ischemic stroke in a significant number of patients. Technological advances over the past 10 years have enabled endovascular treatment of intracranial atherosclerotic stenosis. The number of patients treated with angioplasty or stent-assisted angioplas...

journal_title：Stroke

authors： Schumacher HC,Meyers PM,Higashida RT,Derdeyn CP,Lavine SD,Nesbit GM,Sacks D,Rasmussen P,Wechsler LR

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Desmoteplase is a novel and highly fibrin-specific thrombolytic agent. Evidence of safety and efficacy was obtained in 2 phase II trials (Desmoteplase In Acute Ischemic Stroke [DIAS] and Desmoteplase for Acute Ischemic Stroke [DEDAS]). The DIAS-2 phase III trial did not replicate the positive pha...

journal_title：Stroke

authors： Fiebach JB,Al-Rawi Y,Wintermark M,Furlan AJ,Rowley HA,Lindstén A,Smyej J,Eng P,Warach S,Pedraza S

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Silent cerebrovascular disease (CVD) has been proposed as a predisposing condition for clinically overt stroke and vascular dementia. Recently, we found increased thrombin generation in silent CVD patients. Here, we report the effect of thrombin inhibition using a potent selective thrombin inhibi...

journal_title：Stroke

authors： Kario K,Matsuo T,Hoshide S,Umeda Y,Shimada K

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Dysphagia can lead to pneumonia and subsequent death after acute stroke. However, no prospective study has demonstrated reduced pneumonia prevalence after implementation of a dysphagia screen. METHODS:We performed a single-center prospective interrupted time series trial of a quality initiative ...

journal_title：Stroke

authors： Titsworth WL,Abram J,Fullerton A,Hester J,Guin P,Waters MF,Mocco J

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:This study was designed to investigate the correlation between reflex sympathetic dystrophy syndrome (RSDS) in hemiplegic patients and spontaneous electromyographic (EMG) activity, as well as to determine the predictive value of spontaneous EMG activity in early diagnosis of RSDS. METHODS:An EMG...

journal_title：Stroke

authors： Cheng PT,Hong CZ

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Intravenous Nimodipine West European Stroke Trial (INWEST) found a correlation between nimodipine-induced reduction in blood pressure (BP) and an unfavorable outcome in acute stroke. We sought to confirm this correlation with and without adjustment for prognostic variables and to investigate ...

journal_title：Stroke

authors： Ahmed N,Näsman P,Wahlgren NG

更新日期：2000-06-01 00:00:00