Abstract:
BACKGROUND AND PURPOSE:Intracranial aneurysms and aneurysmal subarachnoid hemorrhage may occur more frequently in sickle-cell disease (SCD), and this could be related to the sickle genotype and moyamoya syndrome seen in SCD. METHODS:Records from a total of 1002 patients with SCD attending 2 specialized adult hematologic services were retrospectively reviewed. We analyzed data of a cohort of 767 patients attending 1 SCD clinic between 2002 and 2013 and of 235 patients from the other clinic who have had neurovascular imaging between 2007 and 2014. RESULTS:We identified 4 patients in the cohort who had an aneurysmal subarachnoid hemorrhage during 9063 patient-years. The highest incidence rate was seen among women in the age group 30 to 39 years with the hemoglobin SS (HbSS) genotype (440 per 100 000 patient-years). Unruptured intracranial aneurysms were found in 20 of the 324 patients, who had imaging data; the prevalence was significantly higher in patients with HbSS genotype compared with other sickle genotypes with the highest prevalence (15%) observed in women in the age group 30 to 39 years. Fifty-one HbSS patients had a moyamoya vasculopathy, but only 3 of these had concomitant intracranial aneurysms. CONCLUSIONS:Intracranial aneurysms are common in HbSS SCD. There was also a trend toward more common occurrence of aneurysmal subarachnoid hemorrhage in HbSS; women in the age group 30 to 39 years were most at risk. There was no correlation between the occurrence of intracranial aneurysms and moyamoya syndrome.
journal_name
Strokejournal_title
Strokeauthors
Birkeland P,Gardner K,Kesse-Adu R,Davies J,Lauritsen J,Rom Poulsen F,Tolias CM,Thein SLdoi
10.1161/STROKEAHA.116.012664subject
Has Abstractpub_date
2016-07-01 00:00:00pages
1710-3issue
7eissn
0039-2499issn
1524-4628pii
STROKEAHA.116.012664journal_volume
47pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND:Urinary incontinence in the acute stage of stroke is seen as a predictor of death, severe disability, and an important factor on hospital discharge destination. Therefore, it is an important measure of stroke severity that not only affects the lives of stroke survivors but also those of caregivers. SUMMARY ...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.29.2.524
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Intravenous Nimodipine West European Stroke Trial (INWEST) found a correlation between nimodipine-induced reduction in blood pressure (BP) and an unfavorable outcome in acute stroke. We sought to confirm this correlation with and without adjustment for prognostic variables and to investigate ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.31.6.1250
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Tacrolimus, an immunosuppressant agent, has been shown to reduce tissue injury and leukocyte accumulation after transient ischemia. This study was designed to evaluate quantitatively the inhibitory effects of tacrolimus on leukocyte rolling and on subsequent leukocyte accumulation in vivo after t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.7.1431
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Middle cerebral artery (MCA) stenosis is a relatively rare occlusive disease with an annual stroke risk of approximately 7% to 8%. However, the frequent coincidence of cardiac or ipsilateral carotid artery disease may lead to difficulties in identifying the relevant embolizing source in symptomat...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.8.1347
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Loss of movement coordination is the main postacute symptom after cerebellar infarction. Although the course of motor recovery has been described previously, detailed kinematic descriptions of acute stage ataxia are rare and no attempt has been made to link improvements in motor function to measu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.583641
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Endothelium-derived hyperpolarizing factor (EDHF)-mediated dilations are potentiated after several pathologies, including ischemia/reperfusion (I/R). However, no study to date has addressed the mechanism by which this potentiation occurs. This study tested the hypothesis that potentiated EDHF-med...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000027439.61501.39
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Central autonomic dysfunction increases stroke morbidity and mortality. We aimed to investigate whether poststroke autonomic dysfunction graded by Ewing battery can predict clinical outcome. METHODS:In this prospective observational study, we assessed autonomic function of ischemic stroke patien...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.117.019312
更新日期:2018-01-01 00:00:00
abstract::Background and Purpose- In this era of endovascular therapy (EVT) with early, complete recanalization and reperfusion, we have observed an even more rapid apparent diffusion coefficient (ADC) normalization within the acute ischemic lesion compared with the natural history or IV-tPA-treated patient. In this study, we a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.025784
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Endogenous norepinephrine release induced by cerebral ischemia may lead to small areas of necrosis in normal hearts. Conversely, norepinephrine may be one of the mediators that limit myocardial infarct size by ischemic preconditioning. Because brief ischemia in kidneys or skeletal muscle limits i...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.32.3.767
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within minutes of onset, and perfusion MRI can evaluate the brain's microcirculation. N-Methyl-D-aspartate (NMDA) antagonists and reperfusion can reduce lesion size in stroke models. We used diffusion and p...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.12.2074
更新日期:1993-12-01 00:00:00
abstract::Background and Purpose- The aim of the present study was to evaluate the relationship between normal-appearing white matter (NAWM) integrity and postischemic stroke recovery in 4 main domains including cognition, mood, gait, and dependency. Methods- A prospective study was conducted, including patients diagnosed for a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.026886
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Development of translational functional imaging modalities for atherosclerosis risk stratification is sought for stroke prediction. Our group has developed late-phase contrast-enhanced ultrasound (LP-CEUS) to quantify microbubble contrast retention within carotid atherosclerosis and shown it to s...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.631200
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several studies have reported a better functional outcome in lobar intracerebral hemorrhage (ICH) compared with deep location. However, among lobar ICH, a correlation of hemorrhage site-involving the specific lobes-with functional outcome has not been established. METHODS:Conservatively treated ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.015890
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Many studies have reported frequent cognitive deficits associated with subarachnoid hemorrhage (SAH) and aneurysm repair. One study found more severe cognitive deficits after clipping than coiling of aneurysms, raising the possibility that deficits are due to surgery instead of SAH itself. This p...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.STR.0000087787.38080.B8
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The association between minor ST-T abnormalities and stroke incidence has not been well elucidated. We sought to examine the relationship between nonspecific minor or major ST-T abnormalities and the incidence of stroke among Japanese men and women. METHODS:A 15.4-year prospective study was cond...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000103742.83117.FB
更新日期:2003-12-01 00:00:00
abstract::To determine the efficacy of calcium channel blockers in preserving neurologic function after central nervous system ischemia, we studied three such agents in two animal models. We treated rabbits after inducing ischemia in the brain with intra-arterial microspheres and in the spinal cord using a removable aortic occl...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.8.1020
更新日期:1988-08-01 00:00:00
abstract::Longitudinal stretch of the rabbit basilar artery produces local injury followed by prolonged circular constriction. After stretching and rapid release in vitro localized constrictions promptly occurred. This could be prevented by prior treatment with cyanide or calcium-free solution. Once produced, constrictions pers...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.7.2.174
更新日期:1976-03-01 00:00:00
abstract::Using clinical presentation, angiography, computed tomography, and nuclear magnetic resonance imaging, 7 patients were identified who had strictly unilateral hemispheric infarction and unilateral cerebrovascular disease. In 6, cerebral blood flow measured by fluorine-18-fluoromethane inhalation and positron emission t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.5.882
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hypothermia reduces neuronal damage in animal stroke models. Whether hypothermia is neuroprotective in patients with acute stroke remains to be clarified. In this case-control study, we evaluated the feasibility and safety of inducing modest hypothermia by a surface cooling method in awake patien...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.31.9.2251
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In prehension tasks with objects placed within arm's reach, patients with hemiparesis caused by stroke use excessive trunk movement to compensate for arm motor impairments. Compensatory trunk movements may improve motor function in the short term but may limit arm recovery in the long term. Previ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.STR.0000132569.33572.75
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Vorapaxar is an antiplatelet agent that antagonizes thrombin-mediated activation of the protease-activated receptor-1 on platelets. We tested the efficacy and safety of vorapaxar in a prespecified analysis in the stroke subcohort from a multinational, randomized, placebo-controlled trial. METHOD...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.111.000433
更新日期:2013-03-01 00:00:00
abstract::The effects of hypoxic hypoxia on cerebral hemodynamics and somatosensory evoked potential (SEP) were studied in 10 pentobarbital anestheteized dogs. Cerebral blood flow (CBF) was measured using the venous outflow technique and cerebral oxygen consumption (CMRO2) was calculated from the arterio-cerebro-venous oxygen d...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.1.30
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dipyridamole increases the concentration of circulating adenosine, which is a potent vasodilator, by inhibition of uptake of adenosine into the erythrocytes, and hence produces coronary vasodilation. However, the effects of dipyridamole on cerebral circulation is not pronounced. This study invest...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.8.1616
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:CADASIL is a newly recognized cause of subcortical ischemic strokes that progressively leads to dementia associated with pseudobulbar palsy and severe motor disability. This deleterious progression and the severity of clinical presentation are widely variable among affected subjects. The exact ro...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.12.2637
更新日期:1999-12-01 00:00:00
abstract::We evaluated the effects of aging and hypertension on endothelium-dependent relaxation of rat common carotid arteries using 14-week-old (young) and 11-month-old (old) Wistar-Kyoto rats (WKY) and age-matched spontaneously hypertensive rats (SHR). Isometric tension of common carotid artery ring segments was measured. Wi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.7.892
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The mortality and morbidity after aneurysmal subarachnoid hemorrhage has improved because of better diagnosis, early treatment to secure the aneurysm, and better management of disease-specific complications. With these improvements in care, it is not clear if the previously identified independent...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.117.017777
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke and systemic embolic events are known to occur as complications of hypertrophic cardiomyopathy (HCM), and these complications are more common in patients with accompanying atrial fibrillation (AF). The diagnosis of AF is sometimes difficult, however, and it is possible that subclinical asy...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.012130
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Delayed paraplegia remains a devastating complication after ischemic spinal cord injury associated with aortic surgery and trauma. Although apoptosis has been implicated in the pathogenesis of delayed neurodegeneration, mechanisms responsible for the delayed paraplegia remain incompletely underst...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.600429
更新日期:2011-08-01 00:00:00
abstract::With the use of a new ultrasonic volume flow meter (VFM), over 8000 measurements of common carotid blood flow were made in 120 normal control subjects and 550 patients with various neurological disease. The accuracy of the flow meter in measuring blood flow on an experimental model ranged from 93 to 97%. In normal sub...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.14.2.256
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:CT remains the most commonly used imaging technique in acute stroke but is often delayed after minor stroke. Interobserver reliability in distinguishing hemorrhagic transformation of infarction from intracerebral hemorrhage may depend on delays to CT but has not been reported previously despite t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.553933
更新日期:2009-12-01 00:00:00