Tacrolimus (FK506) attenuates leukocyte accumulation after transient retinal ischemia.


BACKGROUND AND PURPOSE:Tacrolimus, an immunosuppressant agent, has been shown to reduce tissue injury and leukocyte accumulation after transient ischemia. This study was designed to evaluate quantitatively the inhibitory effects of tacrolimus on leukocyte rolling and on subsequent leukocyte accumulation in vivo after transient retinal ischemia and the protective effects of tacrolimus on ischemia-induced neural damage. METHODS:Retinal ischemia was induced for 60 minutes in anesthetized pigmented rats by temporary ligation of the optic sheath. Tacrolimus was administered at 10 minutes after ischemic induction. At 4, 12, 24, and 48 hours after reperfusion, leukocyte behavior in the retinal microcirculation was evaluated in vivo with acridine orange digital fluorography. After 7 days of reperfusion, ischemia-induced retinal damage was evaluated histologically. RESULTS:Treatment with tacrolimus suppressed leukocyte rolling; the maximum number of rolling leukocytes was reduced by 60.1% at 12 hours after reperfusion (P<0.05). In tacrolimus-treated rats, the velocity of rolling leukocytes was significantly faster than in vehicle-treated rats (P<0.01). The subsequent leukocyte accumulation was reduced by 61.6% at 24 hours after reperfusion (P<0.01). Histological examination demonstrated the protective effect of tacrolimus on ischemia-induced retinal damage, which was more substantial in the inner retina (P<0.01). CONCLUSIONS:The present study demonstrated the inhibitory effect of tacrolimus on leukocyte rolling and on subsequent leukocyte accumulation and the therapeutic potency to neural injury after transient retinal ischemia.






Tsujikawa A,Ogura Y,Hiroshiba N,Miyamoto K,Kiryu J,Honda Y




Has Abstract


1998-07-01 00:00:00


1431-7; discussion 1437-8












  • White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury.

    abstract:BACKGROUND AND PURPOSE:"Incidental" MRI white matter (WM) lesions, comprising periventricular lesions (PVLs) and deep subcortical lesions (DSCLs), are common in the aging brain. Direct evidence of ischemia associated with incidental WM lesions (WMLs) has been lacking, and their pathogenesis is unresolved. METHODS:A po...


    pub_type: 杂志文章


    authors: Fernando MS,Simpson JE,Matthews F,Brayne C,Lewis CE,Barber R,Kalaria RN,Forster G,Esteves F,Wharton SB,Shaw PJ,O'Brien JT,Ince PG,MRC Cognitive Function and Ageing Neuropathology Study Group.

    更新日期:2006-06-01 00:00:00

  • Evaluation of genetic risk factors for silent brain infarction.

    abstract:BACKGROUND AND PURPOSE:Silent brain infarction (SBI) is often found with white matter hyperintensity. A recent genetic study on elderly twins indicated that the susceptibility to white matter hyperintensity was largely determined by genetic factors, implying the existence of genetic susceptibility for SBI as well. We t...


    pub_type: 杂志文章


    authors: Notsu Y,Nabika T,Park HY,Masuda J,Kobayashi S

    更新日期:1999-09-01 00:00:00

  • Reduced risk of intracerebral hemorrhage with dynamic recreational exercise but not with heavy work activity.

    abstract:BACKGROUND AND PURPOSE:It is unclear whether intracerebral hemorrhage (ICH) is associated with dynamic or static exercise. Our aim was to assess whether such an association exists. METHODS:A case-control study was undertaken involving 331 consecutive cases of primary ICH and 331 age- and sex-matched community-based ne...


    pub_type: 杂志文章


    authors: Thrift AG,Donnan GA,McNeil JJ

    更新日期:2002-02-01 00:00:00

  • Damage to the Left Precentral Gyrus Is Associated With Apraxia of Speech in Acute Stroke.

    abstract:BACKGROUND AND PURPOSE:Apraxia of speech (AOS) is a motor speech disorder, which is clinically characterized by the combination of phonemic segmental changes and articulatory distortions. AOS has been believed to arise from impairment in motor speech planning/programming and differentiated from both aphasia and dysarth...


    pub_type: 杂志文章


    authors: Itabashi R,Nishio Y,Kataoka Y,Yazawa Y,Furui E,Matsuda M,Mori E

    更新日期:2016-01-01 00:00:00

  • Stroke mortality maps. United States whites aged 35-74 years, 1962-1982.

    abstract::We mapped average age-adjusted stroke mortality rates for white men and white women aged 35-74 years for state economic areas (counties or groups of counties) in the continental United States for three 7-year periods between 1962 and 1982. Despite the decline of national stroke mortality rates, rates in some areas fai...


    pub_type: 杂志文章


    authors: Wing S,Casper M,Davis WB,Pellom A,Riggan W,Tyroler HA

    更新日期:1988-12-01 00:00:00

  • Association Between Unruptured Intracranial Aneurysms and Downstream Stroke.

    abstract::Background and Purpose- Case reports suggest that unruptured intracranial aneurysms may serve as a nidus for thrombus formation and downstream embolic stroke. However, few data exist to support an association between unruptured aneurysms and ischemic stroke. Methods- We conducted a within-subjects case-control study o...


    pub_type: 杂志文章


    authors: Chen ML,Gupta A,Chatterjee A,Khazanova D,Dou E,Patel H,Gialdini G,Merkler AE,Navi BB,Kamel H

    更新日期:2018-09-01 00:00:00

  • Predicting asymptomatic coronary artery disease in patients with ischemic stroke and transient ischemic attack: the PRECORIS score.

    abstract:BACKGROUND AND PURPOSE:Identifying occult coronary artery stenosis may improve secondary prevention of stroke patients. The aim of this study was to derive and validate a simple score to predict severe occult coronary artery stenosis in stroke patients. METHODS:We derived a score from a French hospital-based cohort of...


    pub_type: 杂志文章


    authors: Calvet D,Song D,Yoo J,Turc G,Sablayrolles JL,Choi BW,Heo JH,Mas JL

    更新日期:2014-01-01 00:00:00

  • Flow-related anaerobic metabolic changes in patients with severe stenosis of the internal carotid artery.

    abstract:BACKGROUND AND PURPOSE:We sought to investigate whether the combination of blood flow measurements in the major cerebral arteries and measurements of cerebral metabolism can provide new insight into the hemodynamic effect of carotid lesions in patients with severe stenosis (> 70% reduction in diameter) of the internal ...


    pub_type: 杂志文章


    authors: van der Grond J,Eikelboom BC,Mali WP

    更新日期:1996-11-01 00:00:00

  • Short-term effects of practice with trunk restraint on reaching movements in patients with chronic stroke: a controlled trial.

    abstract:BACKGROUND AND PURPOSE:In prehension tasks with objects placed within arm's reach, patients with hemiparesis caused by stroke use excessive trunk movement to compensate for arm motor impairments. Compensatory trunk movements may improve motor function in the short term but may limit arm recovery in the long term. Previ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Michaelsen SM,Levin MF

    更新日期:2004-08-01 00:00:00

  • The effect of a thromboxane synthetase inhibitor, OKY-046, on urinary excretion of immunoreactive thromboxane B2 and 6-keto-prostaglandin F1 alpha in patients with ischemic cerebrovascular disease.

    abstract::Thromboxane synthetase activity is selectively inhibited by (E)-3-[4-(1-imidazolylmethyl)phenyl]-2-propenoic acid hydrochloride monohydrate (OKY-046). A single dose of 100 mg OKY-046 was orally administered to patients with ischemic cerebrovascular disease and healthy volunteers. Platelet aggregation and thromboxane B...


    pub_type: 杂志文章


    authors: Uyama O,Nagatsuka K,Nakabayashi S,Isaka Y,Yoneda S,Kimura K,Abe H

    更新日期:1985-03-01 00:00:00

  • Race and gender differences in 1-year outcomes for community-dwelling stroke survivors with family caregivers.

    abstract:BACKGROUND AND PURPOSE:Previous research has reported worse outcomes after stroke for women and for African Americans, but few prospective population-based studies have systematically examined demographic differences on long-term stroke outcomes. Race and gender differences in 1-year stroke outcomes were examined using...


    pub_type: 杂志文章


    authors: Roth DL,Haley WE,Clay OJ,Perkins M,Grant JS,Rhodes JD,Wadley VG,Kissela B,Howard G

    更新日期:2011-03-01 00:00:00

  • Validation of family history in subarachnoid hemorrhage.

    abstract:BACKGROUND AND PURPOSE:In 6% to 9% of patients with subarachnoid hemorrhage (SAH), familial aggregation occurs; truly familial cases carry a worse prognosis than sporadic cases and raise the question of screening. If relatives have died from SAH, the family history is often the only available clue to the diagnosis, but...


    pub_type: 杂志文章


    authors: Bromberg JE,Rinkel GJ,Algra A,Greebe P,Beldman T,van Gijn J

    更新日期:1996-04-01 00:00:00

  • Transcranial ultrasound brain perfusion assessment with a contrast agent-specific imaging mode: results of a two-center trial.

    abstract:BACKGROUND AND PURPOSE:The purpose of this study was to assess brain perfusion with an ultrasound contrast-specific imaging mode and to prove if the results are comparable between 2 centers using a standardized study protocol. METHODS:A total of 32 individuals without known cerebrovascular disease were included in the...


    pub_type: 杂志文章,多中心研究


    authors: Hölscher T,Wilkening W,Draganski B,Meves SH,Eyding J,Voit H,Bogdahn U,Przuntek H,Postert T

    更新日期:2005-10-01 00:00:00

  • Predictors of hospital readmission after stroke: a systematic review.

    abstract:BACKGROUND AND PURPOSE:Risk-standardized hospital readmission rates are used as publicly reported measures reflecting quality of care. Valid risk-standardized models adjust for differences in patient-level factors across hospitals. We conducted a systematic review of peer-reviewed literature to identify models that com...


    pub_type: 杂志文章,评审


    authors: Lichtman JH,Leifheit-Limson EC,Jones SB,Watanabe E,Bernheim SM,Phipps MS,Bhat KR,Savage SV,Goldstein LB

    更新日期:2010-11-01 00:00:00

  • Validation of Wall Enhancement as a New Imaging Biomarker of Unruptured Cerebral Aneurysm.

    abstract::Background and Purpose- High-resolution vessel wall magnetic resonance imaging is a promising technique for assessing wall structures of unruptured intracranial aneurysms (UIAs). However, the relationship between aneurysmal high-resolution vessel wall magnetic resonance imaging features and their histopathologic mecha...


    pub_type: 杂志文章


    authors: Quan K,Song J,Yang Z,Wang D,An Q,Huang L,Liu P,Li P,Tian Y,Zhou L,Zhu W

    更新日期:2019-06-01 00:00:00

  • Axonal remodeling of the corticospinal tract in the spinal cord contributes to voluntary motor recovery after stroke in adult mice.

    abstract:BACKGROUND AND PURPOSE:We sought to demonstrate the contribution of axonal remodeling of the corticospinal tract (CST) in the spinal cord to functional outcome after stroke. METHODS:Bilateral pyramidotomy (BPT) or sham-BPT was performed in mice with transgenic yellow fluorescent protein labeling in the CST subjected t...


    pub_type: 杂志文章


    authors: Liu Z,Chopp M,Ding X,Cui Y,Li Y

    更新日期:2013-07-01 00:00:00

  • CHA2DS2-VASc Score (Congestive Heart Failure, Hypertension, Age ≥75 [Doubled], Diabetes Mellitus, Prior Stroke or Transient Ischemic Attack [Doubled], Vascular Disease, Age 65-74, Female) for Stroke in Asian Patients With Atrial Fibrillation: A Korean Nat

    abstract:BACKGROUND AND PURPOSE:The CHA2DS2-VASc stroke score (congestive heart failure, hypertension, age ≥75 (doubled), diabetes mellitus, prior stroke or transient ischemic attack (doubled), vascular disease, age 65-74, female) is used in most guidelines for risk stratification in atrial fibrillation (AF), but most data for ...


    pub_type: 杂志文章


    authors: Kim TH,Yang PS,Uhm JS,Kim JY,Pak HN,Lee MH,Joung B,Lip GYH

    更新日期:2017-06-01 00:00:00

  • Tumor-Like Presentation of Primary Angiitis of the Central Nervous System.

    abstract:BACKGROUND AND PURPOSE:We aimed to describe the clinical and imaging features of patients with tumor-like presentation of primary angiitis of the central nervous system. METHODS:We retrospectively analyzed 10 patients enrolled in the French primary angiitis of the central nervous system cohort, who initially presented...


    pub_type: 杂志文章


    authors: de Boysson H,Boulouis G,Dequatre N,Godard S,Néel A,Arquizan C,Detante O,Bloch-Queyrat C,Zuber M,Touzé E,Bienvenu B,Aouba A,Guillevin L,Naggara O,Pagnoux C,French Vasculitis Study Group.

    更新日期:2016-09-01 00:00:00

  • Conditions for pharmacologic evaluation in the gerbil model of forebrain ischemia.

    abstract::We looked at FiO2, choice of anesthetic, nutritional status, and body temperature in a gerbil model of forebrain ischemia to determine their effect on data interpretation, ischemic outcome, and extent of pharmacologic protection. We subjected 484 gerbils to 5 minutes of forebrain ischemia under different experimental ...


    pub_type: 杂志文章


    authors: Clifton GL,Taft WC,Blair RE,Choi SC,DeLorenzo RJ

    更新日期:1989-11-01 00:00:00

  • CT cerebral blood flow maps optimally correlate with admission diffusion-weighted imaging in acute stroke but thresholds vary by postprocessing platform.

    abstract:BACKGROUND AND PURPOSE:Admission infarct core lesion size is an important determinant of management and outcome in acute (<9 hours) stroke. Our purposes were to: (1) determine the optimal CT perfusion parameter to define infarct core using various postprocessing platforms; and (2) establish the degree of variability in...


    pub_type: 杂志文章


    authors: Kamalian S,Kamalian S,Maas MB,Goldmacher GV,Payabvash S,Akbar A,Schaefer PW,Furie KL,Gonzalez RG,Lev MH

    更新日期:2011-07-01 00:00:00

  • Nonsteroidal lazaroid U78517F in models of focal and global ischemia.

    abstract::U78517F is a novel inhibitor of iron-catalyzed lipid peroxidation that combines the tetramethylchroman antioxidant ring portion of alpha-tocopherol with the amine of the previously described 21-aminosteroids (e.g., U74006F). U78517F inhibited 200 microM FeCl2-initiated lipid peroxidation in rat brain homogenates by 50...


    pub_type: 杂志文章


    authors: Hall ED,Pazara KE,Braughler JM,Linseman KL,Jacobsen EJ

    更新日期:1990-11-01 00:00:00

  • Stroke awareness and knowledge retention in children: The Brain Child Project.

    abstract:BACKGROUND AND PURPOSE:Efforts at public education to improve adults' response to stroke symptoms continue to be disappointing, and very little has been developed to improve the knowledge base of children regarding brain attacks. Children may be able to exert a positive influence on adult behavior and to learn positive...


    pub_type: 杂志文章


    authors: Dressman LA,Hunter J

    更新日期:2002-02-01 00:00:00

  • Symptomatic intracranial hemorrhage after stroke thrombolysis: comparison of prediction scores.

    abstract:BACKGROUND AND PURPOSE:Several prognostic scores have been developed to predict the risk of symptomatic intracranial hemorrhage (sICH) after ischemic stroke thrombolysis. We compared the performance of these scores in a multicenter cohort. METHODS:We merged prospectively collected data of patients with consecutive isc...


    pub_type: 杂志文章,多中心研究


    authors: Strbian D,Michel P,Seiffge DJ,Saver JL,Numminen H,Meretoja A,Murao K,Weder B,Forss N,Parkkila AK,Eskandari A,Cordonnier C,Davis SM,Engelter ST,Tatlisumak T

    更新日期:2014-03-01 00:00:00

  • Clinical severity in CADASIL related to ultrastructural damage in white matter: in vivo study with diffusion tensor MRI.

    abstract:BACKGROUND AND PURPOSE:CADASIL is a newly recognized cause of subcortical ischemic strokes that progressively leads to dementia associated with pseudobulbar palsy and severe motor disability. This deleterious progression and the severity of clinical presentation are widely variable among affected subjects. The exact ro...


    pub_type: 杂志文章


    authors: Chabriat H,Pappata S,Poupon C,Clark CA,Vahedi K,Poupon F,Mangin JF,Pachot-Clouard M,Jobert A,Le Bihan D,Bousser MG

    更新日期:1999-12-01 00:00:00

  • Risk of thromboembolic events in controlled trials of rFVIIa in spontaneous intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Recombinant activated factor VII (rFVIIa) reduces hematoma expansion and improves outcome after intracerebral hemorrhage (ICH), with an apparent increase in nonfatal thromboembolic events (TEs) with higher doses. Despite low incidences of such events in rFVIIa-treated hemophiliacs, the frequency ...


    pub_type: 杂志文章,meta分析


    authors: Diringer MN,Skolnick BE,Mayer SA,Steiner T,Davis SM,Brun NC,Broderick JP

    更新日期:2008-03-01 00:00:00

  • Shunt-associated migraine responds favorably to atrial septal repair: a case-control study.

    abstract:BACKGROUND AND PURPOSE:Transcatheter closure of patent foramen ovale (PFO) has been reported to improve migraine in patients with cerebrovascular disorders in noncontrolled studies. The aim of the study was to compare the course of migraine assessed prospectively over a 12-month period in symptomatic (for cerebrovascul...


    pub_type: 杂志文章


    authors: Anzola GP,Frisoni GB,Morandi E,Casilli F,Onorato E

    更新日期:2006-02-01 00:00:00

  • Contrast-enhanced transcranial color-coded sonography in acute hemispheric brain infarction.

    abstract:PURPOSE:The aim of the present study was to investigate the diagnostic potential of contrast-enhanced transcranial color-coded real-time sonography (CE-TCCS) in otherwise ultrasound-refractory acute stroke patients with an ischemia in the territory of the middle cerebral artery (MCA). Furthermore, correlations of CE-TC...


    pub_type: 杂志文章


    authors: Postert T,Braun B,Meves S,Köster O,Przuntek H,Weber S,Büttner T

    更新日期:1999-09-01 00:00:00

  • Subarachnoid hemorrhage without detectable aneurysm. A review of the causes.

    abstract:BACKGROUND:In 15% to 20% of patients with a spontaneous subarachnoid hemorrhage, no aneurysm is found on the first angiogram. This review emphasizes that this group of patients is in fact heterogeneous and describes the clinical features, pattern of hemorrhage on early computed tomographic (CT) scan, prognosis, and pro...


    pub_type: 杂志文章,评审


    authors: Rinkel GJ,van Gijn J,Wijdicks EF

    更新日期:1993-09-01 00:00:00

  • Tactile extinction and functional status after stroke. A preliminary investigation.

    abstract:BACKGROUND AND PURPOSE:Research has identified a number of factors associated with poststroke recovery, but the prediction of long-term functional outcome remains an uncertain endeavor. In previous work, extinction to tactile, double-simultaneous stimulation has been shown to have short-term predictive utility. The pre...


    pub_type: 杂志文章


    authors: Rose L,Bakal DA,Fung TS,Farn P,Weaver LE

    更新日期:1994-10-01 00:00:00

  • Intracerebral transplantation of porcine choroid plexus provides structural and functional neuroprotection in a rodent model of stroke.

    abstract:BACKGROUND AND PURPOSE:Choroid plexus (CP) secretes a cocktail of neurotrophic factors. In the present study, CP from neonatal pigs was encapsulated within alginate microcapsules for in vitro and in vivo neuroprotective studies. METHODS:In vitro studies involved serum deprivation of rat embryonic cortical neurons and ...


    pub_type: 杂志文章


    authors: Borlongan CV,Skinner SJ,Geaney M,Vasconcellos AV,Elliott RB,Emerich DF

    更新日期:2004-09-01 00:00:00