Tacrolimus (FK506) attenuates leukocyte accumulation after transient retinal ischemia.

abstract：BACKGROUND AND PURPOSE:A significant number of patients with aneurysmal subarachnoid hemorrhage are active smokers and at risk for acute nicotine withdrawal. There is conflicting literature regarding the vascular effects of nicotine and theoretical concern that it may worsen vasospasm. The literature on the safety of n...

journal_title：Stroke

authors： Carandang RA,Barton B,Rordorf GA,Ogilvy CS,Sims JR

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Deteriorating glucose tolerance is associated with an increased cardiovascular disease (CVD) risk. The underlying mechanisms remain unclear. Arterial remodeling is the change in structural properties through time in response to atherogenic and/or hemodynamic alterations and aims to maintain circu...

journal_title：Stroke

authors： Henry RM,Kostense PJ,Dekker JM,Nijpels G,Heine RJ,Kamp O,Bouter LM,Stehouwer CD

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Anecdotal evidence suggests that the coronavirus disease 2019 (COVID-19) pandemic mitigation efforts may inadvertently discourage patients from seeking treatment for stroke with resultant increased morbidity and mortality. Analysis of regional data, while hospital capacities for acute stroke care...

journal_title：Stroke

authors： Hsiao J,Sayles E,Antzoulatos E,Stanton RJ,Sucharew H,Broderick JP,Demel SL,Flaherty ML,Grossman AW,Kircher C,Kreitzer N,Peariso K,Prestigiacomo CJ,Shirani P,Walsh KB,Lampton H,Adeoye O,Khatri P

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Electrocardiographic abnormalities are common after subarachnoid hemorrhage, but their significance remains uncertain. The aim of this study was to determine whether any specific electrocardiographic abnormalities are independently associated with adverse neurological outcomes. METHODS:This was ...

journal_title：Stroke

authors： Coghlan LA,Hindman BJ,Bayman EO,Banki NM,Gelb AW,Todd MM,Zaroff JG,IHAST Investigators.

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The overall burden of prior infections may contribute to atherosclerosis and stroke risk. We hypothesized that serological evidence of common infections would be associated with carotid plaque thickness in a multiethnic cohort. METHODS:Antibody titers to 5 common infectious microorganisms (ie, C...

journal_title：Stroke

authors： Elkind MS,Luna JM,Moon YP,Boden-Albala B,Liu KM,Spitalnik S,Rundek T,Sacco RL,Paik MC

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Osteogenic protein-1 (OP1) not only possesses trophic activity on bone tissue but also influences neuronal survival and differentiation in vitro. Specific receptors for OP1 are present in brain and spinal cord and can be upregulated during cerebral contusion. OP1 is a member of the transforming g...

journal_title：Stroke

authors： Lin SZ,Hoffer BJ,Kaplan P,Wang Y

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Several studies have reported a better functional outcome in lobar intracerebral hemorrhage (ICH) compared with deep location. However, among lobar ICH, a correlation of hemorrhage site-involving the specific lobes-with functional outcome has not been established. METHODS:Conservatively treated ...

journal_title：Stroke

authors： Gerner ST,Kuramatsu JB,Moeller S,Huber A,Lücking H,Kloska SP,Madžar D,Sembill JA,Schwab S,Huttner HB

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We studied six patients suffering from pure, unilateral brain stem infarction to explore the association of remote cerebral and cerebellar blood flow changes with damage at different sites of this region of the brain. METHODS:We used single-photon emission computed tomography and [123I]iodoamphe...

journal_title：Stroke

authors： Fazekas F,Payer F,Valetitsch H,Schmidt R,Flooh E

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Several hundred small RNAs called microRNAs (miRNAs) have been identified and characterized from various organisms, including humans. In humans, some of these miRNAs have been found to regulate (patho)physiologic conditions such as tumor progression/regression, cholesterol and glucose homeostasis...

journal_title：Stroke

authors： Jeyaseelan K,Lim KY,Armugam A

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The neuroprotective role of mild therapeutic hypothermia was established in animal models of cerebral ischemia. Still, several issues, including optimal target temperature, remain unclear. The optimal depth of hypothermia in a rat model of focal cerebral ischemia was investigated. METHODS:Eighty...

journal_title：Stroke

authors： Kollmar R,Blank T,Han JL,Georgiadis D,Schwab S

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To evaluate the impact of proximal flow control on efficacy and safety of mechanical thrombectomy in an in vitro middle cerebral artery occlusion. METHODS:Three independent variables, including clot type, device (Merci Retriever, Solitaire FR, and Trevo devices), and use of a balloon guide cathe...

journal_title：Stroke

authors： Chueh JY,Kühn AL,Puri AS,Wilson SD,Wakhloo AK,Gounis MJ

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The absence of a widely available and sensitive diagnostic test for acute cerebral ischemia remains a significant limitation in the diagnosis and management of stroke. The objective of this study was to examine the feasibility of developing a diagnostic panel of blood-borne biochemical markers of...

journal_title：Stroke

authors： Lynch JR,Blessing R,White WD,Grocott HP,Newman MF,Laskowitz DT

更新日期：2004-01-01 00:00:00

abstract：:Internal carotid blood flow, taken as an index of cerebral blood flow (CBF); arterial pressure; and respiratory O2 and CO2 concentrations, were measured in halothane (1%)-anesthetized, paralyzed and mechanically ventilated rabbits. CBF was determined at end-tidal CO2 of 4% (normocapnia) and 8%, as inspired O2 [O2]I) w...

journal_title：Stroke

authors： Quint SR,Scremin OU,Sonnenschein RR,Rubinstein EH

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Plasminogen activator inhibitor type 1 (PAI-1) is the main inhibitor of fibrinolysis, and high levels may increase the risk of cardiovascular disease. The 4G/5G polymorphism affects PAI-1 gene transcription with lower levels of plasma PAI-1 in the presence of the 5G allele. We investigated whethe...

journal_title：Stroke

authors： Hoekstra T,Geleijnse JM,Kluft C,Giltay EJ,Kok FJ,Schouten EG

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Diffusion-weighted imaging (DWI) is the most sensitive MR sequence in acute arterial ischemic stroke but has not yet been evaluated in venous cerebral ischemia. We describe a patient with DWI performed at the acute phase of a venous ischemic stroke. CASE DESCRIPTION:A rapid cerebral MRI including DWI and fa...

journal_title：Stroke

authors： Corvol JC,Oppenheim C,Manaï R,Logak M,Dormont D,Samson Y,Marsault C,Rancurel G

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The use of thrombolysis in acute minor ischemic stroke (MIS) remains controversial. We sought to determine the safety and efficacy of intravenous tissue-type plasminogen activator (IV-tPA) in acute MIS patients with demonstrable penumbra on computed tomographic perfusion study. METHODS:Consecuti...

journal_title：Stroke

authors： Ng FC,Coote S,Frost T,Bladin C,Choi PM

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Little is known about how regions vary in their use of thrombolysis (intravenous tissue-type plasminogen activator and intra-arterial treatment) for acute stroke. We sought to determine regional variation in thrombolysis treatment and investigate the extent to which regional variation is accounte...

journal_title：Stroke

authors： Skolarus LE,Meurer WJ,Shanmugasundaram K,Adelman EE,Scott PA,Burke JF

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke leads to a reduction in bone mineral density, altered calcium homeostasis, and an increase in hip fractures. Vitamin D deficiency is well documented in long-term stroke survivors and is associated with post-stroke hip fractures. Less is known regarding levels in acute stroke. METHODS:We c...

journal_title：Stroke

authors： Poole KE,Loveridge N,Barker PJ,Halsall DJ,Rose C,Reeve J,Warburton EA

更新日期：2006-01-01 00:00:00

abstract：:Neurogenically caused cardiac arrhythmias and their correlation to lesions within the central nervous system were examined prospectively in 54 patients with spontaneous intracerebral hemorrhage. All patients were examined neurologically daily for 3 weeks, with special attention given to signs of brainstem compression ...

journal_title：Stroke

authors： Stober T,Sen S,Anstätt T,Bette L

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Time elapsed from last-known well (LKW) and baseline imaging results are influential on endovascular thrombectomy (EVT) outcomes. METHODS:In a prospective multicenter cohort study of imaging selection for endovascular thrombectomy (SELECT [Optimizing Patient's Selection for Endovascular Treatmen...

journal_title：Stroke

authors： Sarraj A,Hassan AE,Grotta J,Blackburn S,Day A,Abraham M,Sitton C,Dannenbaum M,Cai C,Pujara D,Hicks W,Vora N,Budzik R,Shaker F,Arora A,Riascos RF,Kamal H,Martin-Schild S,Lansberg M,Gupta R,Albers GW,SELECT Invest

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Reliable data on the risk of carotid endarterectomy (CEA) in relation to clinical indication and timing of surgery are necessary to target CEA more effectively, to inform patients, to adjust risks for case mix, and to understand the mechanisms of operative stroke. METHODS:We performed a systemat...

journal_title：Stroke

authors： Bond R,Rerkasem K,Rothwell PM

更新日期：2003-09-01 00:00:00

abstract：:Brief episodes of ischemia can protect against subsequent damaging ischemic events; however, the molecular mechanisms responsible for protection are poorly understood. Identifying genes involved in this process could provide insight into cell survival and treatment of stroke. We developed a murine model of ischemic pr...

journal_title：Stroke

authors： Stenzel-Poore MP,Stevens SL,Simon RP

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sonic hedgehog (Shh) protein is required for the maintenance of neural progenitor cells (NPCs) in the embryonic and adult hippocampus. Brain ischemia causes increased proliferation of hippocampal NPCs. We therefore examined whether Shh regulates the increase in proliferation of NPCs after ischemi...

journal_title：Stroke

authors： Sims JR,Lee SW,Topalkara K,Qiu J,Xu J,Zhou Z,Moskowitz MA

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is scant population-based information on incidence and risk factors for ischemic stroke subtypes. METHODS:We identified all 454 residents of Rochester, Minn, with a first ischemic stroke between 1985 and 1989 from the Rochester Epidemiology Project medical records linkage system. We used S...

journal_title：Stroke

authors： Petty GW,Brown RD Jr,Whisnant JP,Sicks JD,O'Fallon WM,Wiebers DO

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transient ischemic attacks (TIA) are not well described in children. We assessed the prevalence of risk factors for TIA requiring hospitalization in children in a large national database. METHODS:Using the Healthcare Cost and Utilization Project Kids' Inpatient Database, children aged 1 to 18 ye...

journal_title：Stroke

authors： Adil MM,Qureshi AI,Beslow LA,Jordan LC

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:To judge the efficacy of new, putative stroke therapies, we need a method to measure neurological deficit accurately in groups of patients before and after treatment. No single measurement technique has yet proven to be universally acceptable, but one approach is the use of rating instruments that summarize ...

journal_title：Stroke

authors： Lyden PD,Lau GT

更新日期：1991-11-01 00:00:00

abstract：:Background and Purpose- To test the hypothesis that covert brain infarcts (CBIs) are more likely to be located in noneloquent brain areas compared with clinical strokes and that CBI etiological subtypes carry a differential risk of vascular events compared with people without CBI. Methods- We used brain magnetic reson...

journal_title：Stroke

authors： Gutierrez J,Gil-Guevara A,Ramaswamy S,DeRosa J,Di Tullio MR,Cheung K,Rundek T,Sacco RL,Wright CB,Elkind MSV

更新日期：2020-01-01 00:00:00

abstract：:An ocular pneumoplethysmograph was devised to measure the systolic pressure in the ophthalmic artery and to obtain calibrated pulse volume changes from the ocular globe, with simultaneous recording from both eyes. The instrument is self-contained and portable. It can be applied by paramedical personnel, and the graphi...

journal_title：Stroke

authors： Gee W,Oller DW,Wylie EJ

更新日期：1976-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to define the influence of feeding mean arterial pressure (FMAP) in conjunction with other morphological or clinical risk factors in determining the probability of hemorrhagic presentation in patients with cerebral arteriovenous malformations (AVMs). METHODS:Clinical and angiograp...

journal_title：Stroke

authors： Duong DH,Young WL,Vang MC,Sciacca RR,Mast H,Koennecke HC,Hartmann A,Joshi S,Mohr JP,Pile-Spellman J

更新日期：1998-06-01 00:00:00

abstract：:Cerebral venous blood gas tensions were correlated with elevated intracranial pressure in spontaneously breathing dogs lightly anesthetized with nitrous oxide/halothane. Intracranial pressure was elevated by infusion of artificial cerebrospinal fluid into a lateral ventricle. Respiration and blood pressure were monito...

journal_title：Stroke

authors： Grady PA,Blaumanis OR

更新日期：1986-09-01 00:00:00