Relationship of somatosensory evoked potentials and cerebral oxygen consumption during hypoxic hypoxia in dogs.

Abstract:

:The effects of hypoxic hypoxia on cerebral hemodynamics and somatosensory evoked potential (SEP) were studied in 10 pentobarbital anestheteized dogs. Cerebral blood flow (CBF) was measured using the venous outflow technique and cerebral oxygen consumption (CMRO2) was calculated from the arterio-cerebro-venous oxygen difference times CBF. SEP was evaluated by percutaneous stimulation of an upper extremity nerve and was recorded over the contralateral somatosensory cortex. The latencies of the initial negative wave (N1), second positive wave (P2) and the amplitude of the primary complex (P1N1) were measured. Animals were breathed sequentially with oxygen concentrations of 21, 10, 6, 5, and 4.5% for five minutes each. Animals were returned to room air breathing when the amplitude of the SEP decreased to less than 20% of control and were observed for 30 minutes following reoxygenation. Severe hypoxia (4.5% O2) increased CBF to 200% of control, decreased CMRO2 to 45% of control, decreased amplitude and increased latency of SEP. Following reoxygenation, as CMRO2 increased toward control, latency of SEP decreased and amplitude increased and CBF returned to baseline within 30 min. During hypoxia and reoxygenation, the latencies of N1 and P2 and the amplitude of P1N1 were correlated with CMRO2 in individual animals. We conclude that changes in SEP amplitude and latency reflect changes in CMRO2 despite high CBF during rapidly progressive hypoxic hypoxia and following reoxygenation.

journal_name

Stroke

journal_title

Stroke

authors

McPherson RW,Zeger S,Traystman RJ

doi

10.1161/01.str.17.1.30

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

30-6

issue

1

eissn

0039-2499

issn

1524-4628

journal_volume

17

pub_type

杂志文章

相关文献

STROKE文献大全
  • Characteristics in Non-Vitamin K Antagonist Oral Anticoagulant-Related Intracerebral Hemorrhage.

    abstract::Background and Purpose- Given inconclusive studies, it is debated whether clinical and imaging characteristics, as well as functional outcome, differ among patients with intracerebral hemorrhage (ICH) related to vitamin K antagonists (VKA) versus non-vitamin K antagonist (NOAC)-related ICH. Notably, clinical character...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/STROKEAHA.118.023492

    authors: Gerner ST,Kuramatsu JB,Sembill JA,Sprügel MI,Hagen M,Knappe RU,Endres M,Haeusler KG,Sobesky J,Schurig J,Zweynert S,Bauer M,Vajkoczy P,Ringleb PA,Purrucker JC,Rizos T,Volkmann J,Müllges W,Kraft P,Schubert AL,Erbgut

    更新日期:2019-06-01 00:00:00

  • Functional reorganization of motor cortex increases with greater axonal injury from CADASIL.

    abstract:BACKGROUND AND PURPOSE:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small-artery disease that clinically involves only the brain. Particularly early in the disease, patients can show substantial or complete recovery after individual strokes. Cortic...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/hs0202.103337

    authors: Reddy H,De Stefano N,Mortilla M,Federico A,Matthews PM

    更新日期:2002-02-01 00:00:00

  • Long-term prognosis after a minor stroke: 10-year mortality and major stroke recurrence rates in a hospital-based cohort.

    abstract:BACKGROUND AND PURPOSE:Determinants of long-term outcome are not well defined in minor stroke patients. This study aims to evaluate which factors are independent long-term predictors of death and major stroke recurrence in a cohort of minor ischemic strokes. METHODS:A cohort of 322 patients with first-ever minor ische...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.29.1.126

    authors: Prencipe M,Culasso F,Rasura M,Anzini A,Beccia M,Cao M,Giubilei F,Fieschi C

    更新日期:1998-01-01 00:00:00

  • Impact of Preexisting Cognitive Impairment and Race/Ethnicity on Functional Outcomes Following Intracerebral Hemorrhage.

    abstract:BACKGROUND AND PURPOSE:In intracerebral hemorrhage (ICH), preexisting cognitive impairment has been identified as a risk factor for increased mortality and morbidity. However, previous studies examined predominantly White populations; therefore, the prevalence and effect of preICH cognitive impairment has not been stud...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.120.030084

    authors: Sawyer RP,Yim E,Coleman E,Demel SL,Sekar P,Woo D

    更新日期:2021-01-01 00:00:00

  • Linkage of ischemic stroke to the PDE4D region on 5q in a Swedish population.

    abstract:BACKGROUND AND PURPOSE:Recent Icelandic studies have demonstrated linkage for common forms of stroke to chromosome 5q12 and association between phosphodiesterase4D (PDE4D) and ischemic stroke. Using a candidate region approach, we wanted to test the validity of these findings in a different population from northern Swe...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000174188.04716.8d

    authors: Nilsson-Ardnor S,Wiklund PG,Lindgren P,Nilsson AK,Janunger T,Escher SA,Hallbeck B,Stegmayr B,Asplund K,Holmberg D

    更新日期:2005-08-01 00:00:00

  • ICES (Intraoperative Stereotactic Computed Tomography-Guided Endoscopic Surgery) for Brain Hemorrhage: A Multicenter Randomized Controlled Trial.

    abstract:BACKGROUND AND PURPOSE:Intracerebral hemorrhage (ICH) is a devastating disease without a proven therapy to improve long-term outcome. Considerable controversy about the role of surgery remains. Minimally invasive endoscopic surgery for ICH offers the potential of improved neurological outcome. METHODS:We tested the hy...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/STROKEAHA.116.013837

    authors: Vespa P,Hanley D,Betz J,Hoffer A,Engh J,Carter R,Nakaji P,Ogilvy C,Jallo J,Selman W,Bistran-Hall A,Lane K,McBee N,Saver J,Thompson RE,Martin N,ICES Investigators.

    更新日期:2016-11-01 00:00:00

  • Use of the Health Utilities Index with stroke patients and their caregivers.

    abstract:BACKGROUND AND PURPOSE:Few studies currently assess the health-related quality of life of individuals following a stroke. One of the major challenges of assessing quality of life is the high likelihood that after a stroke a patient will not be able to complete such an assessment. One practical solution is to have a fam...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.10.1888

    authors: Mathias SD,Bates MM,Pasta DJ,Cisternas MG,Feeny D,Patrick DL

    更新日期:1997-10-01 00:00:00

  • Role of potassium channels in regulation of brain arteriolar tone: comparison of cerebrum versus brain stem.

    abstract:BACKGROUND AND PURPOSE:Potassium channels are important regulators of resting tone in large cerebral arteries, but their activity and distribution may vary according to vessel location and species studied. In the cerebral microcirculation in vivo, however, these channels appear to be silent at rest. Our goal was to det...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.32.1.218

    authors: Horiuchi T,Dietrich HH,Tsugane S,Dacey RG Jr

    更新日期:2001-01-01 00:00:00

  • Chronic ischemia alters brain microstructural integrity and cognitive performance in adult moyamoya disease.

    abstract:BACKGROUND AND PURPOSE:The mechanisms underlying frontal lobe dysfunction in moyamoya disease (MMD) are unknown. We aimed to determine whether chronic ischemia induces subtle microstructural brain changes in adult MMD and evaluated the association of changes with neuropsychological performance. METHODS:MRI, including ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.007407

    authors: Kazumata K,Tha KK,Narita H,Kusumi I,Shichinohe H,Ito M,Nakayama N,Houkin K

    更新日期:2015-02-01 00:00:00

  • Heart rate contributes to the vascular effects of chronic mental stress: effects on endothelial function and ischemic brain injury in mice.

    abstract:BACKGROUND AND PURPOSE:Vascular effects of mental stress are only partially understood. Therefore, we studied effects of chronic stress and heart rate (HR) on endothelial function and cerebral ischemia. METHODS:129S6/SvEv mice were randomized to the I(f)-channel inhibitor ivabradine (10 mg/kg per day) or vehicle and u...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.598607

    authors: Custodis F,Gertz K,Balkaya M,Prinz V,Mathar I,Stamm C,Kronenberg G,Kazakov A,Freichel M,Böhm M,Endres M,Laufs U

    更新日期:2011-06-01 00:00:00

  • Randomized Sham-Controlled Trial of Navigated Repetitive Transcranial Magnetic Stimulation for Motor Recovery in Stroke.

    abstract::Background and Purpose- We aimed to determine whether low-frequency electric field navigated repetitive transcranial magnetic stimulation to noninjured motor cortex versus sham repetitive transcranial magnetic stimulation avoiding motor cortex could improve arm motor function in hemiplegic stroke patients when combine...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.117.020607

    authors: Harvey RL,Edwards D,Dunning K,Fregni F,Stein J,Laine J,Rogers LM,Vox F,Durand-Sanchez A,Bockbrader M,Goldstein LB,Francisco GE,Kinney CL,Liu CY,NICHE Trial Investigators *.

    更新日期:2018-09-01 00:00:00

  • Cigarette smoking and risk of stroke in the chinese adult population.

    abstract:BACKGROUND AND PURPOSE:We studied the relationship between cigarette smoking and stroke incidence and mortality in the Chinese adult population. METHODS:We conducted a prospective cohort study in a nationally representative sample of 169 871 Chinese men and women aged 40 years and older. Data on cigarette smoking and ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.505305

    authors: Kelly TN,Gu D,Chen J,Huang JF,Chen JC,Duan X,Wu X,Chen CS,He J

    更新日期:2008-06-01 00:00:00

  • Flow patterns in the human carotid artery bifurcation.

    abstract::To elucidate the connection between blood flow and the localized genesis and development of atherosclerosis and thrombosis at the human carotid artery bifurcation, detailed studies of the flow patterns and distributions of fluid velocity and wall shear rate in this region were carried out using a transparent segment o...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.15.1.50

    authors: Motomiya M,Karino T

    更新日期:1984-01-01 00:00:00

  • Fluoxetine treatment in poststroke depression, emotional incontinence, and anger proneness: a double-blind, placebo-controlled study.

    abstract:BACKGROUND AND PURPOSE:The efficacy and safety of the selective serotonin reuptake inhibitor fluoxetine have rarely been studied in the treatment of poststroke emotional disturbances. METHODS:Stroke patients (152) who had poststroke depression (PSD), emotional incontinence (PSEI), or anger proneness (PSAP) were studie...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/01.STR.0000190892.93663.e2

    authors: Choi-Kwon S,Han SW,Kwon SU,Kang DW,Choi JM,Kim JS

    更新日期:2006-01-01 00:00:00

  • Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging.

    abstract:BACKGROUND AND PURPOSE:Angiotensin II produces oxidative stress and endothelial dysfunction in cerebral arteries, and angiotensin II type I receptors may play a role in longevity and vascular aging. Angiotensin-converting enzyme type 2 (ACE2) converts angiotensin II to angiotensin (1-7) and thus, may protect against ef...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.112.667063

    authors: Peña Silva RA,Chu Y,Miller JD,Mitchell IJ,Penninger JM,Faraci FM,Heistad DD

    更新日期:2012-12-01 00:00:00

  • Translesional Pressure Gradient Alters Relationship Between Blood Pressure and Recurrent Stroke in Intracranial Stenosis.

    abstract::Background and Purpose- There is debate over an optimal systolic blood pressure (SBP) in secondary stroke prevention of patients with symptomatic intracranial atherosclerotic stenosis (sICAS). We investigated whether translesional pressure gradient across sICAS would alter the relationship between SBP and risk of recu...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/STROKEAHA.119.028616

    authors: Feng X,Chan KL,Lan L,Abrigo J,Ip VHL,Soo YOY,Leung TW,Leng X

    更新日期:2020-06-01 00:00:00

  • Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W).

    abstract:BACKGROUND AND PURPOSE:In ACTIVE-W, oral anticoagulation (OAC) was more efficacious than combined clopidogrel plus aspirin (C+A) in preventing vascular events in patients with atrial fibrillation. However, because OAC carries important bleeding complications, risk stratification schemes have been devised to identify pa...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.107.500199

    authors: Healey JS,Hart RG,Pogue J,Pfeffer MA,Hohnloser SH,De Caterina R,Flaker G,Yusuf S,Connolly SJ

    更新日期:2008-05-01 00:00:00

  • Patent foramen ovale in cryptogenic stroke: incidental or pathogenic?

    abstract:BACKGROUND AND PURPOSE:Patent foramen ovale (PFO) is significantly associated with cryptogenic stroke (CS). However, even in patients with CS, a PFO can be an incidental finding. We sought to estimate the probability that a PFO in a patient with CS is incidental. METHODS:A systematic search identified 23 case-control ...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析

    doi:10.1161/STROKEAHA.109.547828

    authors: Alsheikh-Ali AA,Thaler DE,Kent DM

    更新日期:2009-07-01 00:00:00

  • Geographic variation in stroke risk in the United States. Region, urbanization, and hypertension in the Third National Health and Nutrition Examination Survey.

    abstract:BACKGROUND:In the United States, stroke mortality is higher in the south than in other regions. Hypertension is the main risk factor for stroke among older adults; however, few studies have examined group-specific regional and urbanization differences in hypertension prevalence. METHODS:Data from the Third National He...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.31.1.19

    authors: Obisesan TO,Vargas CM,Gillum RF

    更新日期:2000-01-01 00:00:00

  • Delayed paraplegia after spinal cord ischemic injury requires caspase-3 activation in mice.

    abstract:BACKGROUND AND PURPOSE:Delayed paraplegia remains a devastating complication after ischemic spinal cord injury associated with aortic surgery and trauma. Although apoptosis has been implicated in the pathogenesis of delayed neurodegeneration, mechanisms responsible for the delayed paraplegia remain incompletely underst...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.600429

    authors: Kakinohana M,Kida K,Minamishima S,Atochin DN,Huang PL,Kaneki M,Ichinose F

    更新日期:2011-08-01 00:00:00

  • Increased lipid peroxidation in vulnerable brain regions after transient forebrain ischemia in rats.

    abstract::We examined cerebral lipid peroxidation, estimated by a thiobarbituric acid test, in rat brain regions after 30 minutes of severe forebrain ischemia and at recirculation periods of up to 72 hours. The lipid peroxide levels remained unaltered in all brain regions during ischemia and during the first hour of recirculati...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.20.7.918

    authors: Bromont C,Marie C,Bralet J

    更新日期:1989-07-01 00:00:00

  • Complication rates and center enrollment volume in the carotid revascularization endarterectomy versus stenting trial.

    abstract:BACKGROUND AND PURPOSE:Evidence indicates that center volume of cases affects outcomes for both carotid endarterectomy and stenting. We evaluated the effect of enrollment volume by site on complication rates in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST). METHODS:The primary composite en...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/STROKEAHA.114.006228

    authors: Gonzales NR,Demaerschalk BM,Voeks JH,Tom M,Howard G,Sheffet AJ,Garcia L,Clair DG,Barr J,Orlow S,Brott TG,CREST Investigators.

    更新日期:2014-11-01 00:00:00

  • Black-white differences in stroke risk among young adults.

    abstract:BACKGROUND AND PURPOSE:Little information is available regarding black-white differences in stroke incidence in young adults. METHODS:Cerebral infarction and intracerebral hemorrhage rates among adults 15 to 44 years of age were studied in Baltimore City and Baltimore County for 1988. Diagnoses were based on neurologi...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:

    authors: Kittner SJ,McCarter RJ,Sherwin RW,Sloan MA,Stern BJ,Johnson CJ,Buchholz D,Seipp MJ,Price TR

    更新日期:1993-12-01 00:00:00

  • Prevalence of asymptomatic retinal emboli in an Australian urban community.

    abstract:BACKGROUND AND PURPOSE:Because no population-based estimates are available for asymptomatic retinal emboli, we aimed to assess prevalence and associations of this sign in a defined older Australian urban population. METHODS:A total of 3654 persons aged 49 years or older, representing 82% of residents in an urban area ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.1.63

    authors: Mitchell P,Wang JJ,Li W,Leeder SR,Smith W

    更新日期:1997-01-01 00:00:00

  • The beta-hCG+erythropoietin in acute stroke (BETAS) study: a 3-center, single-dose, open-label, noncontrolled, phase IIa safety trial.

    abstract:BACKGROUND AND PURPOSE:Animal data suggest the use of beta-human chorionic gonadotropin followed by erythropoietin to promote brain repair after stroke. The current study directly translated these results by evaluating safety of this sequential growth factor therapy through a 3-center, single-dose, open-label, noncontr...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.109.574343

    authors: Cramer SC,Fitzpatrick C,Warren M,Hill MD,Brown D,Whitaker L,Ryckborst KJ,Plon L

    更新日期:2010-05-01 00:00:00

  • Inhibition of glutamate release via recovery of ATP levels accounts for a neuroprotective effect of aspirin in rat cortical neurons exposed to oxygen-glucose deprivation.

    abstract:BACKGROUND AND PURPOSE:Aspirin is preventive against stroke not only because of its antithrombotic properties but also by other direct effects. The aim of this study was to elucidate its direct neuroprotective effects. METHODS:Viability parameters, glutamate release and uptake, and ATP levels were measured in cultured...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/hs0102.101299

    authors: De Cristóbal J,Cárdenas A,Lizasoain I,Leza JC,Fernández-Tomé P,Lorenzo P,Moro MA

    更新日期:2002-01-01 00:00:00

  • Copeptin for the prediction of recurrent cerebrovascular events after transient ischemic attack: results from the CoRisk study.

    abstract:BACKGROUND AND PURPOSE:Copeptin has been associated with recurrent cerebrovascular events after transient ischemic attack (TIA). In an independent cohort, we evaluated copeptin for the prediction of recurrent cerebrovascular events within 3 months after TIA and assessed the incremental value of copeptin compared with t...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/STROKEAHA.114.005584

    authors: De Marchis GM,Weck A,Audebert H,Benik S,Foerch C,Buhl D,Schuetz P,Jung S,Seiler M,Morgenthaler NG,Mattle HP,Mueller B,Christ-Crain M,Arnold M,Katan M

    更新日期:2014-10-01 00:00:00

  • Delayed cerebral ischemia following arteriography.

    abstract::Cerebral ischemic events associated with arteriography are usually attributed to catheter-induced emboli. We present three patients with cerebral ischemia occurring 6 to 48 hours post-arteriography. We suspected that alternate pathogenic mechanisms were in effect. To evaluate the possibility that sustained platelet ac...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.16.3.431

    authors: Fisher M,Sandler R,Weiner JM

    更新日期:1985-05-01 00:00:00

  • Thromboxane prostaglandin receptor antagonist and carotid atherosclerosis progression in patients with cerebrovascular disease of ischemic origin: a randomized controlled trial.

    abstract:BACKGROUND AND PURPOSE:Thromboxane prostaglandin receptors have been implicated to be involved in the atherosclerotic process. We assessed whether Terutroban, a thromboxane prostaglandin receptor antagonist, affects the progression of atherosclerosis, as measured by common carotid intima-media thickness and carotid pla...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.114.004775

    authors: Bots ML,Ford I,Lloyd SM,Laurent S,Touboul PJ,Hennerici MG,Prevention of Cerebrovascular and Cardiovascular Events of Ischemic Origin With Terutroban in Patients With a History of Ischemic Stroke or Transient Ischemic Attack Vascular Ultrasou

    更新日期:2014-08-01 00:00:00

  • Stroke mortality maps. United States whites aged 35-74 years, 1962-1982.

    abstract::We mapped average age-adjusted stroke mortality rates for white men and white women aged 35-74 years for state economic areas (counties or groups of counties) in the continental United States for three 7-year periods between 1962 and 1982. Despite the decline of national stroke mortality rates, rates in some areas fai...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.19.12.1507

    authors: Wing S,Casper M,Davis WB,Pellom A,Riggan W,Tyroler HA

    更新日期:1988-12-01 00:00:00