Abstract:
BACKGROUND AND PURPOSE:Recent Icelandic studies have demonstrated linkage for common forms of stroke to chromosome 5q12 and association between phosphodiesterase4D (PDE4D) and ischemic stroke. Using a candidate region approach, we wanted to test the validity of these findings in a different population from northern Sweden. METHODS:A total of 56 families with 117 affected individuals were included in the linkage study. Genotyping was performed with polymorphic microsatellite markers with an average distance of 4.5 cM on chromosome 5. In the association study, 275 cases of first-ever stroke were included together with 550 matched community controls. Polymorphisms were tested individually for association of PDE4D to stroke. RESULTS:Maximum allele-sharing lod score in favor of linkage was observed at marker locus D5S424 (lod score=2.06; P=0.0010). Conditional logistic regression calculations revealed no significant association of ischemic stroke to the defined at-risk allele in PDE4D (odds ratio, 1.1; 95% confidence interval, 0.84 to 1.45). A protective effect may though be implied for 2 of the polymorphisms analyzed in PDE4D. CONCLUSIONS:Using a candidate region approach in a set of stroke families from northern Sweden, we have replicated linkage of stroke susceptibility to the PDE4D gene region on chromosome 5q. Association studies in an independent nested case-control sample from the same geographically located population suggested that different alleles confer susceptibility/protection to stroke in the Icelandic and the northern Swedish populations.
journal_name
Strokejournal_title
Strokeauthors
Nilsson-Ardnor S,Wiklund PG,Lindgren P,Nilsson AK,Janunger T,Escher SA,Hallbeck B,Stegmayr B,Asplund K,Holmberg Ddoi
10.1161/01.STR.0000174188.04716.8dsubject
Has Abstractpub_date
2005-08-01 00:00:00pages
1666-71issue
8eissn
0039-2499issn
1524-4628pii
01.STR.0000174188.04716.8djournal_volume
36pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Cerebrovascular disease can complicate head and neck radiotherapy and result in transient ischemic attack and ischemic stroke. Although the incidence of radiation vasculopathy is predicted to rise with improvements in median cancer survival, the pathogenesis, natural history, and management of th...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.111.615203
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We assessed whether the load of cerebral small vessel disease (cSVD) and its individual markers, including lacunes, white matter hyperintensities, microbleeds, and enlarged perivascular spaces (EPVS), are associated with arterial stiffness. METHODS:We evaluated cSVD markers in a cohort of 782 hy...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.020163
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patient and radiological characteristics of intracerebral hemorrhage (ICH), surgical treatment, and outcome after ICH are interrelated. Our purpose was to define whether these characteristics or surgical treatment correlate with mortality among young adults. METHODS:We retrospectively reviewed c...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.006020
更新日期:2014-08-01 00:00:00
abstract::Clinicopathologic correlations were reviewed in 100 cases of recent cerebral infarctions in the internal carotid artery distribution. The most frequent cause of death was transtentorial herniation, followed in frequency by pneumonia, cardiac causes, and pulmonary embolism. Thirty-six percent of all patients and 47% of...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.12.4.474
更新日期:1981-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Research has identified a number of factors associated with poststroke recovery, but the prediction of long-term functional outcome remains an uncertain endeavor. In previous work, extinction to tactile, double-simultaneous stimulation has been shown to have short-term predictive utility. The pre...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.10.1973
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We demonstrated previously that treatment with selective kappa-opioid receptor (KOR) agonist BRL 52537 hydrochloride [(+/-)-1-(3,4-dichlorophenyl) acetyl-2-(1-pyrrolidinyl) methylpiperidine] (1) has a long therapeutic window for providing ischemic neuroprotection, and (2) attenuates ischemia-evok...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000169928.76321.3d
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intravenous thrombolysis for acute ischemic stroke is beneficial within 4.5 hours of symptom onset, but the effect rapidly decreases over time, necessitating quick diagnostic in-hospital work-up. Initial time strain occasionally results in treatment of patients with an alternate diagnosis (stroke...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.111.000126
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Microwave Radiometry (MWR) allows in vivo noninvasive assessment of internal temperature of tissues. The aim of the present study was to evaluate in patients with ischemic stroke and bilateral carotid plaques (1) whether ipsilateral carotid arteries exhibit higher temperature differences (ΔT), as...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.007526
更新日期:2015-01-01 00:00:00
abstract::Background and Purpose- Perihemorrhagic edema (PHE) is associated with poor outcome after intracerebral hemorrhage (ICH). Infiltration of immune cells is considered a major contributor of PHE. Recent studies suggest that immunomodulation via S1PR (sphingosine-1-phosphate receptor) modulators improve outcome in ICH. Si...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.027134
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke-associated immunosuppression is an increasingly recognized factor triggering infections and thus potentially influencing outcome after stroke. Specifically, lymphocytopenia after intracerebral hemorrhage (ICH) has only been addressed in small-sized retrospective studies of mixed intracrani...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.013003
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Posttraumatic stress disorder (PTSD) can be triggered by life-threatening medical events such as strokes and transient ischemic attacks (TIAs). Little is known regarding how PTSD triggered by medical events affects patients' adherence to medications. METHODS:We surveyed 535 participants, age ≥40...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.655209
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Embolism is believed to be the major cause of stroke in patients with nonvalvular atrial fibrillation (NVAF). The detection of asymptomatic embolic signals (ES) in individuals with NVAF might allow identification of patients at high risk of stroke and monitoring of therapy in individual subjects....
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.9.1810
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The mechanisms underlying frontal lobe dysfunction in moyamoya disease (MMD) are unknown. We aimed to determine whether chronic ischemia induces subtle microstructural brain changes in adult MMD and evaluated the association of changes with neuropsychological performance. METHODS:MRI, including ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.007407
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Endothelin receptor antagonists such as clazosentan decrease large-artery vasospasm after experimental and clinical subarachnoid hemorrhage. We used clazosentan to gain insight into the pathophysiology of subarachnoid hemorrhage by determining if decreasing vasospasm is associated with alleviatio...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.604728
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The National Institutes of Health Stroke Scale (NIHSS) is a valid, reproducible scale that measures neurological deficit. Of 42 possible points, 7 points are directly related to measurement of language compared with only 2 points related to neglect. METHODS:We examined the placebo arm of the NIN...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.11.2355
更新日期:1999-11-01 00:00:00
abstract::Background and Purpose- Persistent depression after ischemic stroke is common in stroke survivors and may be even higher in family caregivers, but few studies have examined depressive symptom levels and their predictors in patient and caregiver groups simultaneously. Methods- Stroke survivors and their family caregive...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.027039
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral venous thrombosis (CVT) may be a manifestation of underlying autoimmune disease. Antibodies against annexin A2 (anti-A2Ab) coincide with antiphospholipid syndrome, in which antiphospholipid antibodies (aPLA) are associated with thrombosis in any vascular bed. Annexin A2, a profibrinolyti...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.592121
更新日期:2011-02-01 00:00:00
abstract::The effect of respiration on the cerebrovascular response to elevated intracranial pressure (ICP) was studied in anesthetized dogs. Total and regional cerebral blood flows were measured using labelled microspheres. In spontaneously breathing dogs total and regional cerebral blood flows increased when cerebral perfusio...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.8.2.243
更新日期:1977-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The *2 allele of the aldehyde dehydrogenase 2 gene (ALDH2) is the most common variant in Asian populations. The variant resulting in enzyme dysfunction was highly related to coronary artery disease. Recently, genome-wide association studies also discovered that the 12q24 locus near ALDH2 gene was...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.013204
更新日期:2016-09-01 00:00:00
abstract::We investigated the effects of phenytoin on the rate of enzymatic release of free fatty acids and on the levels of energy metabolites and nucleoside phosphates in ischemic brain. Phenytoin (10 mg/kg i.v.) was administered 30 minutes before the onset of ischemia induced in 30 male Wistar rats by occluding the basilar a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.9.1326
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although left atrial enlargement (LAE) increases incident stroke risk, the association with recurrent stroke is less clear. Our aim was to determine the association of LAE with recurrent stroke most likely related to embolism (cryptogenic and cardioembolic) and all ischemic stroke recurrences. M...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/STROKEAHA.115.008711
更新日期:2015-06-01 00:00:00
abstract::Various studies indicate that after a latent interval, a progressive focal deterioration of microvascular perfusion can develop in zones of acute damage to the central nervous system (CNS). In order to obtain reliable information concerning the possibility of platelet participation in this phenomenon, platelet deposit...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.16.2.224
更新日期:1985-03-01 00:00:00
abstract:OBJECTIVE:To determine the incidence of dysphagia and associated pulmonary compromise in stroke patients through a systematic review of the published literature. METHODS:Databases were searched (1966 through May 2005) using terms "cerebrovascular disorders," "deglutition disorders," and limited to "humans" for origina...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.STR.0000190056.76543.eb
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is proposed that 20% to 40% of the decline in first-ever stroke incidence is attributed to the improvement of risk factor control. We estimated the impact of modifiable cardiovascular risk factors on the changing incidence of ischemic stroke (IS) between 1995 and 2012, using individual person ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.014377
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Stroke Health and Risk Education Project was a cluster-randomized, faith-based, culturally sensitive, theory-based multicomponent behavioral intervention trial to reduce key stroke risk factor behaviors in Hispanics/Latinos and European Americans. METHODS:Ten Catholic churches were randomize...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.115.010678
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Emergency medical services routing of patients with acute stroke to designated centers may increase the proportion of patients receiving care at facilities meeting national standards and augment recruitment for prehospital stroke research. METHODS:We analyzed consecutive patients enrolled within...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.010264
更新日期:2015-10-01 00:00:00
abstract::U78517F is a novel inhibitor of iron-catalyzed lipid peroxidation that combines the tetramethylchroman antioxidant ring portion of alpha-tocopherol with the amine of the previously described 21-aminosteroids (e.g., U74006F). U78517F inhibited 200 microM FeCl2-initiated lipid peroxidation in rat brain homogenates by 50...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Antiplatelet therapy is currently one of the methods for preventing transient ischemic attacks and cerebral thrombosis. Because antiplatelet agents are generally administered on a long-term basis, patient compliance is an important factor. The purpose of this study was to determine the compliance...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.25.12.2337
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Persons with early stages of chronic kidney disease, defined by a decreased glomerular filtration rate (GFR), have an increased risk of cardiovascular disease. It is unclear whether decreased GFR is a risk factor for stroke. We assessed the association between GFR and stroke in a prospective popu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.489807
更新日期:2007-12-01 00:00:00
abstract::We studied a possible relation between stroke and an enhanced susceptibility to rupture of the arterial internal elastic lamina by comparing stroke-prone spontaneously hypertensive rats with spontaneously hypertensive rats, which have a very low incidence of stroke. We quantified interruptions in the internal elastic ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.4.510
更新日期:1991-04-01 00:00:00