Autoantibodies against the fibrinolytic receptor, annexin A2, in cerebral venous thrombosis.

Abstract:

BACKGROUND AND PURPOSE:Cerebral venous thrombosis (CVT) may be a manifestation of underlying autoimmune disease. Antibodies against annexin A2 (anti-A2Ab) coincide with antiphospholipid syndrome, in which antiphospholipid antibodies (aPLA) are associated with thrombosis in any vascular bed. Annexin A2, a profibrinolytic receptor and binding site for β2-glycoprotein-I, the main target for aPLA, is highly expressed on cerebral endothelium. Here we evaluate the prevalence of anti-A2Ab in CVT. METHODS:Forty individuals with objectively documented CVT (33 women and 7 men) and 145 healthy controls were prospectively studied for hereditary and acquired prothrombotic risk factors, classical aPLA, and anti-A2Ab. RESULTS:One or more prothrombotic risk factors were found in 85% of CVT subjects, (pregnancy/puerperium in 57.5%, classical aPLA in 22.5%, and hereditary procoagulant risk factors in 17.5%). Anti-A2Ab (titer >3 SD) were significantly more prevalent in patients with CVT (12.5%) than in healthy individuals (2.1%, P<0.01, OR, 5.9). CONCLUSIONS:Anti-A2Ab are significantly associated with CVT and may define a subset of individuals with immune-mediated cerebral thrombosis.

journal_name

Stroke

journal_title

Stroke

authors

Cesarman-Maus G,Cantú-Brito C,Barinagarrementeria F,Villa R,Reyes E,Sanchez-Guerrero J,Hajjar KA,Latorre EG

doi

10.1161/STROKEAHA.110.592121

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

501-3

issue

2

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.110.592121

journal_volume

42

pub_type

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