Abstract:
BACKGROUND AND PURPOSE:To establish a less invasive and reproducible focal ischemia model in the rat, we adopted a 2-laser system (ie, photothrombosis and YAG laser-induced reperfusion). METHODS:The distal middle cerebral artery (MCA) of spontaneously hypertensive rats was occluded by 568-nm krypton laser and intravenous infusion of the photosensitizing dye rose bengal and was recanalized by 355-nm ultraviolet laser irradiation. Cerebral blood flow was determined by laser-Doppler flowmetry at the penumbral cortex. Infarct volume was determined at 3 days after distal MCA occlusion. RESULTS:Brain temperature determined with infrared thermography was maintained within an acceptable range of approximately 1 degrees C upper shift of the center of brain temperature distribution during krypton or YAG laser irradiation. The average of the values (23 experiments; n=163) of coefficient of variation of infarct volume was 21+/-6%, indicating high reproducibility of this model. After distal MCA occlusion, cerebral blood flow was decreased to 32+/-16% of the control values and was increased to 98+/-21% after YAG laser-induced reperfusion. Infarct volume in these rats was 61+/-18 mm3 (coefficient of variation=30%; n=6). CONCLUSIONS:We have characterized a highly reproducible focal ischemia model utilizing a 2-laser system, one to induce thrombotic MCA occlusion and the other to facilitate reperfusion.
journal_name
Strokejournal_title
Strokeauthors
Yao H,Sugimori H,Fukuda K,Takada J,Ooboshi H,Kitazono T,Ibayashi S,Iida Mdoi
10.1161/01.STR.0000094730.38343.73subject
Has Abstractpub_date
2003-11-01 00:00:00pages
2716-21issue
11eissn
0039-2499issn
1524-4628pii
01.STR.0000094730.38343.73journal_volume
34pub_type
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