Early NT-ProBNP (N-Terminal Probrain Natriuretic Peptide) Elevation Predicts Malignant Edema and Death After Reperfusion Therapy in Acute Ischemic Stroke Patients.


BACKGROUND AND PURPOSE:We aimed to investigate the relationship between early NT-proBNP (N-terminal probrain natriuretic peptide) and all-cause death in patients receiving reperfusion therapy, including intravenous thrombolysis and endovascular thrombectomy (EVT). METHODS:This study included 1039 acute ischemic stroke patients with early NT-proBNP data at 2 hours after the beginning of alteplase infusion for those with intravenous thrombolysis only or immediately at the end of EVT for those with EVT. We performed natural log transformation for NT-proBNP (Ln(NT-proBNP)). Malignant brain edema was ascertained by using the SITS-MOST (Safe Implementation of Thrombolysis in Stroke-Monitoring Study) criteria. RESULTS:Median serum NT-proBNP level was 349 pg/mL (interquartile range, 89-1250 pg/mL). One hundred twenty-one (11.6%) patients died. Malignant edema was observed in 78 (7.5%) patients. Ln(NT-proBNP) was independently associated with 3-month mortality in patients with intravenous thrombolysis only (odds ratio, 1.465 [95% CI, 1.169-1.836]; P=0.001) and in those receiving EVT (odds ratio, 1.563 [95% CI, 1.139-2.145]; P=0.006). The elevation of Ln(NT-proBNP) was also independently associated with malignant edema in patients with intravenous thrombolysis only (odds ratio, 1.334 [95% CI, 1.020-1.745]; P=0.036), and in those with EVT (odds ratio, 1.455 [95% CI, 1.057-2.003]; P=0.022). CONCLUSIONS:An early increase in NT-proBNP levels was related to malignant edema and stroke mortality after reperfusion therapy.






Zhang X,Yan S,Zhong W,Yu Y,Lou M




Has Abstract


2021-01-01 00:00:00














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    pub_type: 杂志文章


    authors: Cujec B,Polasek P,Voll C,Shuaib A

    更新日期:1991-06-01 00:00:00

  • Targeted Infarction of the Internal Capsule in the Rat Using Microstimulation Guidance.

    abstract::Background and Purpose- Lacunar strokes are subcortical infarcts with small size and high disability rates, largely due to injury of the corticospinal tract in the internal capsule (IC). Current rodent models of lacunar infarcts are created based on stereotactic coordinates. We tested the hypothesis that better unders...


    pub_type: 杂志文章


    authors: Wen TC,Sindhurakar A,Ramirez VC,Park H,Gupta D,Carmel JB

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    abstract:BACKGROUND AND PURPOSE:Release of excitatory amino acids (EAA) is considered a cause of neuronal damage in ischemia. We investigated the sources and mechanisms of EAA release using microdialysis in regions of incomplete ischemia where perfusion was reduced by 50% to 80%, by applying inhibitors of volume-regulated anion...


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    authors: Feustel PJ,Jin Y,Kimelberg HK

    更新日期:2004-05-01 00:00:00

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    authors: Tran ND,Correale J,Schreiber SS,Fisher M

    更新日期:1999-08-01 00:00:00

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    authors: Ten VS,Wu EX,Tang H,Bradley-Moore M,Fedarau MV,Ratner VI,Stark RI,Gingrich JA,Pinsky DJ

    更新日期:2004-09-01 00:00:00

  • Complex plaques in the proximal descending aorta: an underestimated embolic source of stroke.

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    pub_type: 杂志文章


    authors: Harloff A,Simon J,Brendecke S,Assefa D,Helbing T,Frydrychowicz A,Weber J,Olschewski M,Strecker C,Hennig J,Weiller C,Markl M

    更新日期:2010-06-01 00:00:00

  • Plasma endothelin-1 levels neither increase nor correlate with neurological scores, stroke risk factors, or outcome in patients with ischemic stroke.

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    pub_type: 杂志文章


    authors: Haapaniemi E,Tatlisumak T,Hamel K,Soinne L,Lanni C,Opgenorth TJ,Kaste M

    更新日期:2000-03-01 00:00:00

  • Quality of life of stroke in younger individuals. Utility assessment in patients with arteriovenous malformations.

    abstract:BACKGROUND AND PURPOSE:Patients with arteriovenous malformations are younger individuals who are at risk of a stroke or have experienced one. Our objective was to determine these patients' perceptions of quality of life with a stroke by eliciting utility values. METHODS:Utility values were obtained with the standard g...


    pub_type: 杂志文章,评审


    authors: Shin AY,Porter PJ,Wallace MC,Naglie G

    更新日期:1997-12-01 00:00:00

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    authors: Dae MW,Gao DW,Ursell PC,Stillson CA,Sessler DI

    更新日期:2003-03-01 00:00:00

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    abstract:BACKGROUND AND PURPOSE:Stroke is the leading cause of disability in the Western world; however, few therapies are at hand to decrease this burden. SUMMARY OF REVIEW:Endothelial progenitor cells (EPCs) have been introduced in cardiovascular medicine as factotums. EPCs can repair damaged endothelium and attenuate the de...


    pub_type: 杂志文章


    authors: Rouhl RP,van Oostenbrugge RJ,Damoiseaux J,Tervaert JW,Lodder J

    更新日期:2008-07-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wahlgren NG,Díez-Tejedor E,Teitelbaum J,Arboix A,Leys D,Ashwood T,Grossman E

    更新日期:2000-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Khaffaf N,Karnik R,Winkler WB,Valentin A,Slany J

    更新日期:1994-05-01 00:00:00

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    abstract::Background and Purpose- Imaging is frequently used to select acute stroke patients for intra-arterial therapy. Quantitative cerebral blood flow can be measured noninvasively with arterial spin labeling magnetic resonance imaging. Cerebral blood flow levels in the contralateral (unaffected) hemisphere may affect capaci...


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    authors: Thamm T,Guo J,Rosenberg J,Liang T,Marks MP,Christensen S,Do HM,Kemp SM,Adair E,Eyngorn I,Mlynash M,Jovin TG,Keogh BP,Chen HJ,Lansberg MG,Albers GW,Zaharchuk G

    更新日期:2019-12-01 00:00:00

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    authors: Tomlinson FH,Anderson RE,Meyer FB

    更新日期:1993-03-01 00:00:00

  • Global Survey of the Frequency of Atrial Fibrillation-Associated Stroke: Embolic Stroke of Undetermined Source Global Registry.

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    更新日期:2016-09-01 00:00:00

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    更新日期:2020-01-01 00:00:00

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    abstract:BACKGROUND AND PURPOSE:A potential way to improve prehospital stroke care and patient handoff is hospital-directed feedback for emergency medical service (EMS) providers. We evaluated whether a hospital-directed EMS stroke follow-up tool improved documentation of adherence to the Rhode Island state prehospital stroke p...


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    authors: Choi B,Tsai D,McGillivray CG,Amedee C,Sarafin JA,Silver B

    更新日期:2014-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Agrell B,Dehlin O

    更新日期:1989-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Mueller SM,Black WL Jr

    更新日期:1985-01-01 00:00:00

  • Induction of mucosal tolerance to E-selectin prevents ischemic and hemorrhagic stroke in spontaneously hypertensive genetically stroke-prone rats.

    abstract:BACKGROUND AND PURPOSE:Inflammatory and immune mechanisms can precipitate cerebrovascular thrombosis and hemorrhage. Immunologic tolerance can be induced to a specific antigen by intranasal instillation of that antigen. Lymphocytes tolerized in this way provide local immunosuppression on restimulation with the same ant...


    pub_type: 杂志文章


    authors: Takeda H,Spatz M,Ruetzler C,McCarron R,Becker K,Hallenbeck J

    更新日期:2002-09-01 00:00:00

  • Aspirin use and incident stroke in the cardiovascular health study. CHS Collaborative Research Group.

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    authors: Kronmal RA,Hart RG,Manolio TA,Talbert RL,Beauchamp NJ,Newman A

    更新日期:1998-05-01 00:00:00

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    authors: Aoki T,Kataoka H,Morimoto M,Nozaki K,Hashimoto N

    更新日期:2007-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Grond-Ginsbach C,Thomas-Feles C,Werner I,Weber R,Wigger F,Hausser I,Brandt T

    更新日期:2000-08-01 00:00:00

  • Prevalence of apolipoprotein E phenotypes in ischemic cerebrovascular disease. A case-control study.

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    pub_type: 杂志文章


    authors: Couderc R,Mahieux F,Bailleul S,Fenelon G,Mary R,Fermanian J

    更新日期:1993-05-01 00:00:00

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    pub_type: 杂志文章


    authors: Gulli G,Khan S,Markus HS

    更新日期:2009-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Toro-González G,Navarro-Román L,Román GC,Cantillo J,Serrano B,Herrera M,Vergara I

    更新日期:1993-05-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2010-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Stummer W,Weber K,Tranmer B,Baethmann A,Kempski O

    更新日期:1994-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Winter Y,Rohrmann S,Linseisen J,Lanczik O,Ringleb PA,Hebebrand J,Back T

    更新日期:2008-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Webb AJ,Rothwell PM

    更新日期:2014-02-01 00:00:00